Conditioning on a Collider May Induce Spurious Associations: Do the Results of Gale et al. (2017) Support a Health-Protective Effect of Neuroticism in Population Subgroups?

Psychological Science

Volumn 30, Issue 4, 2019, Pages 629-632

  Richardson, Tom G ^a,b   Davey Smith, George ^a,b   Munafò, Marcus R ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOBANK; NEUROSIS; UNITED KINGDOM;

BIOLOGICAL SPECIMEN BANKS; NEUROTICISM; UNITED KINGDOM;

EID: 85061967395     PISSN: 09567976     EISSN: 14679280     Source Type: Journal    
DOI: 10.1177/0956797618774532     Document Type: Note

References (12)

1. Davey Smith G., Ebrahim S. (2003). ‘Mendelian randomization’: Can genetic epidemiology contribute to understanding environmental determinants of disease? International Journal of Epidemiology, 32, 1–22.
2. Davey Smith G., Hemani G. (2014). Mendelian randomization: Genetic anchors for causal inference in epidemiological studies. Human Molecular Genetics, 23(R1), R89–R98.
3. Gale C. R., Cˇukić I., Batty G. D., McIntosh A. M., Weiss A., Deary I. J., (2017). When is higher neuroticism protective against death? Findings from UK Biobank. Psychological Science, 28, 1345–1357. doi:10.1177/0956797617709813
4. Greenland S., (2003). Quantifying biases in causal models: Classical confounding vs collider-stratification bias. Epidemiology, 14, 300–306.
5. Hernan M. A., Clayton D., Keiding N., (2011). The Simpson’s paradox unraveled. International Journal of Epidemiology, 40, 780–785.
6. Hill W. D., Weiss A., McIntosh A. M., Gale C. R., Deary I. J., (2017). Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life. Retrieved from bioRxiv: https://www.biorxiv.org/content/10.1101/146787v1
7. Lawlor D. A., Tilling K., Davey Smith G., (2016). Triangulation in aetiological epidemiology. International Journal of Epidemiology, 45, 1866–1886.
8. Macmillan A., (2017, July 25). Being neurotic may help you live longer. Time. http://time.com/4872545/neurotic-longer-life/
9. Munafò M. R., Tilling K., Taylor A. E., Evans D. M., Davey Smith G., (2018). Collider scope: When selection bias can substantially influence observed associations. International Journal of Epidemiology, 47, 226–235. doi:10.1093/ije/dyx206
10. Rohrer J. M., (2018). Thinking clearly about correlations and causation: Graphical causal models for observational data. Advances in Methods and Practices in Psychological Science, 1, 27–42. doi:10.1177/2515245917745629
11. Simpson E. H., (1951). The interpretation of interaction in contingency tables. Journal of the Royal Statistical Society B: Methodological, 13, 238–241.
12. Sudlow C., Gallacher J., Allen N., Beral V., Burton P., Danesh J... Collins R., (2015). UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLOS Medicine, 12(3), Article e1001779. doi:10.1371/journal.pmed.1001779