The indirect health effects of malaria estimated from health advantages of the sickle cell trait

Nature Communications

Volumn 10, Issue 1, 2019, Pages

  Uyoga, Sophie ^a   Macharia, Alex W ^a   Ndila, Carolyne M ^a   Nyutu, Gideon ^a   Shebe, Mohammed ^a   Awuondo, Kennedy O ^a   Mturi, Neema ^a   Peshu, Norbert ^a   Tsofa, Benjamin ^a   Scott, J Anthony G ^a,b   Maitland, Kathryn ^a,c   Williams, Thomas N ^a,c  

^a KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN BETA CHAIN; HEMOGLOBIN AS; HEMOGLOBIN S;

CELL COMPONENT; MALARIA; MALNUTRITION; NEONATE; PUBLIC HEALTH;

ADOLESCENT; ARTICLE; BACTEREMIA; BLOOD TRANSFUSION; CONTROLLED STUDY; DISEASE CLASSIFICATION; GENOTYPE; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MALARIA FALCIPARUM; MALNUTRITION; PHENOTYPE; SICKLE CELL TRAIT; CASE CONTROL STUDY; DISEASE RESISTANCE; GENETICS; IMMUNOLOGY; INFANT; ODDS RATIO; PARASITOLOGY; PHYSIOLOGY; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; STATISTICS AND NUMERICAL DATA;

KENYA; KILIFI;

BACTEREMIA; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; DISEASE RESISTANCE; GENOTYPE; HEMOGLOBIN, SICKLE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALNUTRITION; ODDS RATIO; PATIENT ADMISSION; PLASMODIUM FALCIPARUM; SICKLE CELL TRAIT;

EID: 85061817129     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-019-08775-0     Document Type: Article

References (39)

1. Marsh, K., English, M., Crawley, J. & Peshu, N. The pathogenesis of severe malaria in African children. Ann. Trop. Med. Parasitol. 90, 395–402 (1996).
2. Snow, R. W. Sixty years trying to define the malaria burden in Africa: have we made any progress? BMC Med. 12, 227 (2014).
3. Shanks, G. D., Hay, S. I. & Bradley, D. J. Malaria’s indirect contribution to all-cause mortality in the Andaman Islands during the colonial era. Lancet Infect. Dis. 8, 564–570 (2008).
4. McGregor, I. A. Malaria: Nutritional implications. Rev. Infect. Dis. 4, 798–804 (1982).
5. Pelletier, D. L., Frongillo, E. A. Jr., Schroeder, D. G. & Habicht, J. P. The effects of malnutrition on child mortality in developing countries. Bull. World Health Organ 73, 443–448 (1995).
6. Church, J. & Maitland, K. Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review. BMC Med. 12, 31 (2014).
7. Snow, R. W., Korenromp, E. L. & Gouws, E. Pediatric mortality in Africa: plasmodium falciparum malaria as a cause or risk? Am. J. Trop. Med. Hyg. 71, 16–24 (2004).
8. Taylor, S. M., Parobek, C. M. & Fairhurst, R. M. Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis. Lancet Infect. Dis. 12, 457–468 (2012).
9. Piel, F. B. et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis. Nat. Commun. 1, 104 (2010).
10. Scott, J. A. et al. Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study. Lancet 378, 1316–1323 (2011).
11. Grosse, S. D. et al. Sickle cell disease in Africa: a neglected cause of early child mortality. Am. J. Prev. Med. 41, S398–S405 (2011).
12. Piel, F. B., Hay, S. I., Gupta, S., Weatherall, D. J. & Williams, T. N. Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions. PLoS Med. 10, e1001484 (2013).
13. The Malaria Genomic Epidemiology Network. Reappraisal of known malaria resistance loci in a large multicenter study. Nat. Genet. 46, 1197–1204 (2014).
14. Malaria Genomic Epidemiology Network. A novel locus of resistance to severe malaria in a region of ancient balancing selection. Nature 526, 253–257 (2015).
15. Gibson, J. S. & Rees, D. C. How benign is sickle cell trait? eBioMedicine 11, 21–22 (2016).
16. Goldsmith, J. C. et al. Framing the research agenda for sickle cell trait: building on the current understanding of clinical events and their potential implications. Am. J. Hematol. 87, 340–346 (2012).
17. Ashcroft, M. T. & Desai, P. Mortality and morbidity in Jamaican adults with sickle-cell trait and with normal haemoglobin followed up for twelve years. Lancet 2, 784–786 (1976).
18. Eeckels, R., Gatti, F. & Renoirte, A. M. Abnormal distribution of haemoglobin genotypes in Negro children with severe bacterial infections. Nature 216, 382 (1967).
19. Greenwood, B. M. et al. Comparison of two drug strategies for control of malaria within a primary health care programme in The Gambia, West Africa. Lancet 1, 1121–1127 (1988).
20. Kleinschmidt, I. et al. Marked increase in child survival after four years of intensive malaria control. Am. J. Trop. Med. Hyg. 80, 882–888 (2009).
21. Alonso, P. L. et al. A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, west Africa. 6. The impact of the interventions on mortality and morbidity from malaria. Trans. R. Soc. Trop. Med. Hyg. 87(Suppl 2), 37–44 (1993).
22. Nyakeriga, A. M., Troye-Blomberg, M., Chemtai, A. K., Marsh, K. & Williams, T. N. Malaria and nutritional status in children living on the coast of Kenya. Am. J. Clin. Nutr. 80, 1604–1610 (2004).
23. Friedman, J. F. et al. Impact of permethrin-treated bed nets on growth, nutritional status, and body composition of primary school children in Western Kenya. Am. J. Trop. Med. Hyg. 68, 78–85 (2003).
24. Pasvol, G. & Weatherall, D. J. Fetal haemoglobin and malaria. Lancet 1, 1269–1272 (1976).
25. Eisele, T. P. et al. Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa. Lancet Infect. Dis. 12, 942–949 (2012).
26. Patel, J. C. et al. Absence of association between sickle trait hemoglobin and placental malaria outcomes. Am. J. Trop. Med. Hyg. 5, 1002–1007 (2016).
27. Adeyemi, A. B., Adediran, I. A., Kuti, O., Owolabi, A. T. & Durosimi, M. A. Outcome of pregnancy in a population of Nigerian women with sickle cell trait. J. Obstet. Gynaecol. 26, 133–137 (2006).
28. Mockenhaupt, F. P. et al. Anaemia in pregnant Ghanaian women: importance of malaria, iron deficiency, and haemoglobinopathies. Trans. R. Soc. Trop. Med. Hyg. 94, 477–483 (2000).
29. Fleming, A. F. et al. Anaemia in young primigravidae in the guinea savanna of Nigeria: sickle-cell trait gives partial protection against malaria. Ann. Trop. Med. Parasitol. 78, 395–404 (1984).
30. Molineaux, L. Malaria and mortality: some epidemiological considerations. Ann. Trop. Med. Parasitol. 91, 811–825 (1997).
31. Berkley, J. A. et al. Bacteremia among children admitted to a rural hospital in Kenya. N. Engl. J. Med. 352, 39–47 (2005).
32. Scott, J. A. et al. Profile: the kilifi health and demographic surveillance system (KHDSS). Int J. Epidemiol. 41, 650–657 (2012).
33. Williams, T. N. et al. Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases. J. Infect. Dis. 192, 178–186 (2005).
34. Scott, J. A. et al. The definition of pneumonia, the assessment of severity, and clinical standardization in the Pneumonia Etiology Research for Child Health study. Clin. Infect. Dis. 54, S109–S116 (2012).
35. Nokes, D. J. et al. Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya. Clin. Infect. Dis. 46, 50–57 (2008).
36. Khor, C. C. et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat. Genet 39, 523–528 (2007).
37. Mwangi, T. W., Ross, A. K., Snow, R. W. & Marsh, K. Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya. J. Infect. Dis. 191, 1932–1939 (2005).
38. + thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya. Blood 106, 368–371 (2005).
39. Waterfall, C. M. & Cobb, B. D. Single tube genotyping of sickle cell anaemia using PCR-based SNP analysis. Nucleic Acids Res. 29, E119 (2001).