Loneliness and social isolation causal association with health-related lifestyle risk in older adults: A systematic review and meta-analysis protocol

Systematic Reviews

Volumn 8, Issue 1, 2019, Pages

  Malcolm, Martin ^a   Frost, Helen ^b   Cowie, Julie ^c  

^a UNIVERSITY OF STIRLING   (United Kingdom)

^b EDINBURGH NAPIER UNIVERSITY   (United Kingdom)

^c GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

Author keywords

Alcohol; Health behaviours; Loneliness; Meta analysis; Obesity; Older adults; Physical activity; Smoking; Social isolation; Systematic review

Indexed keywords

ARTICLE; CAUSALITY; DATA EXTRACTION; EXPOSURE; HEALTH BEHAVIOR; HEALTHY LIFESTYLE; HUMAN; LONELINESS; MENTAL HEALTH; META ANALYSIS; MORTALITY; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; QUALITY CONTROL; RISK FACTOR; SOCIAL ISOLATION; SYSTEMATIC REVIEW; AGED; META ANALYSIS (TOPIC); METHODOLOGY; MIDDLE AGED; PSYCHOLOGY;

AGED; HEALTHY LIFESTYLE; HUMANS; LONELINESS; META-ANALYSIS AS TOPIC; MIDDLE AGED; RESEARCH DESIGN; RISK FACTORS; SOCIAL ISOLATION; SYSTEMATIC REVIEWS AS TOPIC;

EID: 85061196491     PISSN: None     EISSN: 20464053     Source Type: Journal    
DOI: 10.1186/s13643-019-0968-x     Document Type: Article

References (98)

1. Green BH, Copeland JR, Dewey ME, Sharma V, Saunders PA, Davidson IA, et al. Risk factors for depression in elderly people: a prospective study. Acta Psychiatr Scand. 1992;86(3):213-7.
2. Prince MJ, Harwood RH, Blizard RA, Thomas A, Mann AH. Social support deficits, loneliness and life events as risk factors for depression in old age. The Gospel Oak Project VI. Psychol Med 1997;27(2):323-32.
3. Heikkinen R, Kauppinen M. Depressive symptoms in late life: a 10-year follow-up. Arch Gerontol Geriatr. 2004;38(3):239-50.
4. Cacioppo JT, Hughes ME, Waite LJ, Hawkley LC, Thisted RA. Loneliness as a specific risk factor for depressive symptoms: cross-sectional and longitudinal analyses. Psychol Aging. 2006;21(1):140-51.
5. Cacioppo JT, Hawkley LC, Thisted RA. Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. Psychol Aging. 2010;25(2):453-63.
6. Alpass FM, Neville S. Loneliness, health and depression in older males. Aging Ment Health. 2003;7(3):212-6.
7. Adams KB, Sanders S, Auth EA. Loneliness and depression in independent living retirement communities: risk and resilience factors. Aging Ment Health. 2004;8(6):475-85.
8. Anderson CA, Harvey RJ. Brief report: discriminating between problems in living: an examination of measures of depression, loneliness, shyness, and social anxiety. J Soc Clin Psychol. 1988;6(3-4):482-91.
9. Deniro DA. Perceived alienation in Individs with residual-type schizophrenia. Issues in Mental Health Nursing. 1995;16(3):185-200.
10. Neeleman J, Power MJ. Social support and depression in three groups of psychiatric patients and a group of medical controls. Soc Psychiatry Psychiatr Epidemiol. 1994;29:46-51.
11. Heinrich LM, Gullone E. The clinical significance of loneliness: a literature review. Clin Psychol Rev. 2006 October;26(6):695-718.
12. Bancroft JH, Skrimshire AM, Simkin S. The reasons people give for taking overdoses. Br J Psychiatry J Ment Sci. 1976;128:538-48.
13. Birtchnell J, Alarcon J. Depression and attempted suicide: a study of 91 cases seen in a casualty department. Br J Psychiatry J Ment Sci. 1971;118(544):289-96.
14. Nordentoft M, Rubin P. Mental illness and social integration among suicide attempters in Copenhagen. Comparison with the general population and a four-year follow-up study of 100 patients. Acta Psychiatr Scand. 1993;88(4):278-85.
15. Tilvis RS, Kahonen-Vare MH, Jolkkonen J, Valvanne J, Pitkala KH, Strandberg TE. Predictors of cognitive decline and mortality of aged people over a 10-year period. J Gerontol Ser A Biol Med Sci. 2004;59(3):M268-74.
16. Wilson RS, Krueger KR, Arnold SE, Schneider JA, Kelly JF, Barnes LL, Tang Y, Bennett DA. Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry. 2007;64(2):234-40.
17. Kane M, Cook L. Dementia 2013: the hidden voice of loneliness. London: Alzheimer's Society; 2013.
18. Heikkinen RL, Berg S, Avlund K, Timo T. Depressed mood: changes during a five-year followup in 75 year-old men and women in three Nordic localities. Aging Clin Exp Res. 2002;14:16-28.
19. Orth-Gomer K, Unden A, Edwards M. Social isolation and mortality in ischemic heart disease. Acta Medica Scandinavica. 1988;224(3):205-15.
20. Herlitz J, Wiklund I, Caidahl K, Hartford M, Haglid M, Karlsson BW, et al. The feeling of loneliness prior to coronary artery bypass grafting might be a predictor of short- and long-term postoperative mortality. Eur J Vasc Endovasc Surg. 1998;16(2):120-5.
21. Sorkin D, Rook KS, Lu JL. Loneliness, lack of emotional support, lack of companionship, and the likelihood of having a heart condition in an elderly sample. Ann Behav Med. 2002;24(4):290-8.
22. Fox CM, Harper AP, Hyner GC, Lyle RM. Loneliness, emotional repression, marital quality, and major life events in women who develop breast cancer. J Community Health. 1994;19(6):467-82.
23. Steptoe A, Owen N, Kunz-Ebrecht SR, Brydon L. Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women. Psychoneuroendocrinology. 2004 June;29(5):593-611.
24. Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol. 2005;24(3):297.
25. Perlman D, Peplau LA. Toward a social psychology of loneliness. Pers Relat. 1981;3:31-56.
26. de Jong GJ, van Tilburg T, Dykstra P, Vangelisti A, Perlman D. Loneliness and social isolation. The Cambridge handbook of personal relationships. 2005:485-500.
27. Victor CR, Scambler SJ, Bowling A, Bond J. The prevalence of, and risk factors for, loneliness in later life: a survey of older people in Great Britain. Ageing & Society. 2005;25(6):357-75.
28. Victor C, Scambler S, Bond J, Bowling A. Being alone in later life: loneliness, social isolation and living alone. Rev Clin Gerontol. 2000;10(04):407-17.
29. Dykstra PA, Van Tilburg TG. Gierveld JdJ. Changes in older adult loneliness: results from a seven-year longitudinal study. Research on aging. 2005;27(6):725-47.
30. Wenger GC, Burholt V. Changes in levels of social isolation and loneliness among older people in a rural area: a twenty-year longitudinal study. Can J Aging. 2004;23(2):115-27.
31. Hawkley LC, Hughes ME, Waite LJ, Masi CM, Thisted RA, Cacioppo JT. From social structural factors to perceptions of relationship quality and loneliness: the Chicago health, aging, and social relations study. J Gerontol Ser B Psychol Sci Soc Sci. 2008;63(6):S375-84.
32. Cacioppo JT, Cacioppo S. Social relationships and health: the toxic effects of perceived social isolation. Soc Personal Psychol Compass. 2014;8(2):58-72.
33. Luanaigh CÓ, Lawlor BA. Loneliness and the health of older people. Int J Geriatr Psychiatry. 2008;23(12):1213-21.
34. Hawkley LC, Cacioppo JT. Aging and loneliness: downhill quickly? Curr Dir Psychol Sci. 2007;16(4):187-91.
35. Pinquart M, Sorensen S. Influences on loneliness in older adults: a meta-analysis. Basic Appl Soc Psychol. 2001;23(4):245-66.
36. World Health Organization. World report on ageing and health. Luxembourgh: World Health Organization; 2015.
37. World Health Organization. Global Health and Ageing. Geneva: World Health Organization; 2011.
38. Mcann A, Mackie P, Connacher A. Scottish isolation and loneliness: what is the sco;pe for public health action? Edinburgh: Scottish Public Health Network; 2017.
39. House JS, Landis KR, Umberson D. Social relationships and health. Science. 1988;241:545.
40. Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010;7(7):859.
41. House JS, Robbins C, Metzner HL. The association of social relationships and activities with mortality: prospective evidence from the Techumseh community health study. Am J Epidemiol. 1982;116(1):123-40.
42. Barth J, Schneider S, von Kanel R. Lack of social support in the etiology and the prognosis of coronary heart disease: a systematic review and meta-analysis. Psychosom Med. 2010;72(3):229-38.
43. Holt-Lunstad J, Smith TB, Baker M, Harris T, Stephenson D. Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci. 2015;10(2):227-37.
44. Equal Opportunities Commisions. Age and Social isolation. Edinburgh: Scottish Government; 2015. Report No.: 5
45. Scottish Government. A connected Scotland: tackling social isolation and loneliness and building stronger communities. Strategy Conslutation Paper. Scottish Government: Edinburgh; 2018.
46. Department for digital, culture, media and sport. Call for evidence on approach to loneliness strategy. Consultation on Government loneliness strategy. London: Department for digital, culture, media and sport, Office for Civil Society; 2018.
47. Department of Health. Adult social care outcomes framework 2017/18: handbook of definitions. London: Department of Health; 2017.
48. Department of Health. Public health outcomes framework for England, 2013-16. London: Department of Health; 2012.
49. Scottish Government. Health and social care standards: my support, my life. Scottish Government: Edinburgh; 2017.
50. Valtorta NK, Kanaan M, Gilbody S, Hanratty B. Loneliness, social isolation and social relationships: what are we measuring? A novel framework for classifying and comparing tools. BMJ Open. 2016;6(4):e010799,2015-010799.
51. Hawkley LC, Cacioppo JT. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann Behav Med. 2010;40(2):218-27.
52. Hawkley LC, Cacioppo JT. Loneliness and pathways to disease. Brain Behav Immun. 2003;17:98-105.
53. Lauder W, Mummery K, Jones M, Caperchione C. A comparison of health behaviours in lonely and non-lonely populations. Psychology, Health & Medicine. 2006;11(2):233-45.
54. Cacioppo JT, Hawkley LC, Crawford LE, Ernst JM, Burleson MH, Kowalewski RB, et al. Loneliness and health: potential mechanisms. Psychosom Med. 2002;64(3):407-17.
55. Kiecolt-Glaser JK, Garner W, Speicher C, Penn GM, Holliday J, Glaser R. Psychosocial modifiers of immunocompetence in medical students. Psychosom Med. 1984;46(1):7-14.
56. Benschop RJ, Geenen R, Mills PJ, Naliboff BD, Kiecolt-Glaser JK, Herbert TB, et al. Cardiovascular and immune responses to acute psychological stress in young and old women: a meta-analysis. Psychosom Med. 1998;60(3):290-6.
57. Cacioppo JT, Hawkley LC, Berntson GG, Ernst JM, Gibbs AC, Stickgold R, et al. Do lonely days invade the nights? Potential social modulation of sleep efficiency. Psychol Sci. 2002;13(4):384-7.
58. Cacioppo JT, Cacioppo S, Capitanio JP, Cole SW. The neuroendocrinology of social isolation. Annu Rev Psychol. 2015;66:733-67.
59. Hawkley LC, Thisted RA, Cacioppo JT. Loneliness predicts reduced physical activity: cross-sectional & longitudinal analyses. Health Psychol. 2009;28(3):354.
60. Åkerlind I, Hörnquist JO. Loneliness and alcohol abuse: a review of evidences of an interplay. Soc Sci Med. 1992;34(4):405-14.
61. Shankar A, McMunn A, Banks J, Steptoe A. Loneliness, social isolation, and behavioral and biological health indicators in older adults. Health Psychol. 2011;30(4):377.
62. Hawkley LC, Burleson MH, Berntson GG, Cacioppo JT. Loneliness in everyday life: cardiovascular activity, psychosocial context, and health behaviors. J Pers Soc Psychol. 2003;85(1):105.
63. de Jong Gierveld J. A review of loneliness: concept and definitions, determinants and consequences. Rev Clin Gerontol. 1998;8(01):73-80.
64. Mullins LC, Elston CH, Gutkowski SM. Social determinants of loneliness among older Americans. Genetic, Social, and General Psychology Monographs. 1996.
65. Krause N. Neighborhood deterioration and social isolation in later life. Int J Aging Hum Dev. 1993;36(1):9-38.
66. Belle DE. The impact of poverty on social networks and supports. Marriage Fam Rev. 1983;5(4):89-103.
67. Havinghurst R. Ageing in western society. The social challenge of ageing. London: Croom Helm; 1978. p. 15-44.
68. Hunt A. The elderly at home: a study of people aged sixty-five and over living in the Community in England in 1976. London: HMSO; 1978. Report No.: Social Survey Division, OPCS
69. Wenger GC, Davies R, Shahtahmasebi S, Scott A. Social isolation and loneliness in old age: review and model refinement. Ageing & Society. 1996;16(3):333-58.
70. Lowenthal MF, Robinson B. Social networks and isolation. Handbook of aging and the social sciences. 1976;5:432-56.
71. Hadley R, Webb AL. Loneliness, social isolation and old people: some implications for social policy. Age Concern; 1974.
72. Wenger CG. The supportive network: coping with old age. London: George Allen & Unwin; 1984.
73. West DA, Kellner R, Moore-West M. The effects of loneliness: a review of the literature. Compr Psychiatry. 1986;27(4):351-63.
74. Chen S, Conwell Y, Chiu HFK. Loneliness and aging in China-a public health problem in need of solutions. Int Psychogeriatr. 2014;26(11):1771-2.
75. Murphy F. Loneliness: a challenge for nurses caring for older people. Nursing older people. 2006;18(5):22-5.
76. Pels F, Kleinert J. Loneliness and physical activity: a systematic review. Int Rev Sport Exerc Psychol. 2016;9(1):231-60.
77. Courtin E, Knapp M. Social isolation, loneliness and health in old age: a scoping review. Health Soc Care Community. 2017;25(3):799-812.
78. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264-9.
79. de Jong GJ, Van Tilburg T. A 6-item scale for overall, emotional, and social loneliness confirmatory tests on survey data. Research on aging. 2006;28(5):582-98.
80. de Jong-Gierveld J, Kamphuls F. The development of a Rasch-type loneliness scale. Appl Psychol Meas. 1985;9(3):289-99.
81. Russell DW. UCLA Loneliness Scale (version 3): reliability, validity, and factor structure. J Pers Assess. 1996;66(1):20-40.
82. Hughs M, Waite L, Hawkley L, Cacioppo J. A short scale for measuring loneliness in large surveys. Research on aging. 2004;26(6):655-72.
83. World Health Organisation Europe. Lifestyle and behaviour change. Copenhagen: World Health Organisation; 1999. Report No.: EUR/ICP/LVNG 01 04 06
84. Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Comprehensive Physiology. 2012;2(2):1143-211.
85. Sampson M, McGowan J, Cogo E, Grimshaw J, Moher D, Lefebvre C. An evidence-based practice guideline for the peer review of electronic search strategies. J Clin Epidemiol. 2009;62(9):944-52.
86. Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
87. Centre for reviews and dissemination. Systematic reviews: CRD's guidance for undertaking reviews in health care. University of York: Centre for Reviews and Dissemination; 2009.
88. Joanna Briggs Institute. Joanna Briggs Institute reviewers' manual: 2014 edition. Australia: The Joanna Briggs Institute; 2014.
89. Wells GA, Shea BB, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses: Ottawa Hospital Research Institute [Internet]; 2014. Available from: http://www.ohri.ca/programs/clinical-epidemiology/nos-manual.pdf.
90. Deeks J, Higgins J, Altman D, Green S. Cochrane handbook for systematic reviews of interventions version 5.1. 0 (updated March 2011). The Cochrane Collaboration. 2011.
91. Popay J, Roberts H, Sowden A, Petticrew M, Arai L, Rodgers M, et al. Guidance on the conduct of narrative synthesis in systematic reviews. A product from the ESRC methods programme.Version. 2006;1.
92. Schünemann H, Brożek J, Guyatt G, Oxman A. GRADE handbook for grading quality of evidence and strength of recommendations. Updated October 2013: The GRADE Working Group, 2013. Available at https://gdt.gradepro.org/app/handbook/handbook.html.
93. HILL AB. The environment and disease: association or causation? Proceedings of the Royal Society of Medicine. 1965;58:295-300.
94. Henriksen M, Creaby MW, Lund H, Juhl C, Christensen R. Is there a causal link between knee loading and knee osteoarthritis progression? A systematic review and meta-analysis of cohort studies and randomised trials. BMJ Open. 2014;4(7):e005368,2014-005368.
95. Mente A, de Koning L, Shannon HS, Anand SS. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med. 2009;169(7):659-69.
96. Doughty S. More than three million elderly people face a life of loneliness because of family break-ups and a lack of friendly neighbour. The Daily Mail2012;15th November 2012.
97. Khaleeli H. Britain's loneliness epidemic. The Guardian2013 22nd January 2013.
98. Tarver N. Half of adults in England experience loneliness. BBC News. 2013 18th October 2013.