Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps

Blood

Volumn 133, Issue 6, 2019, Pages 600-604

  Beristain Covarrubias, Nonantzin ^a   Perez Toledo, Marisol ^a   Flores Langarica, Adriana ^a   Zuidscherwoude, Malou ^b,c   Hitchcock, Jessica R ^a   Channell, Will M ^a   King, Lloyd D W ^a   Thomas, Mark R ^b   Henderson, Ian R ^b   Rayes, Julie ^b   Watson, Steve P ^b,c   Cunningham, Adam F ^a  

^a Institute of Immunology and Immunotherapy   (Australia)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL LOAD; BLOOD CLOTTING; IMMUNOHISTOLOGY; IN VITRO STUDY; KINETICS; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS; SPLEEN; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOSIS; ANIMAL; C57BL MOUSE; COMPLICATION; IMMUNOLOGY; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY;

ANIMALS; LIVER; MICE; MICE, INBRED C57BL; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SPLEEN; THROMBOSIS;

EID: 85061122548     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2018-08-867267     Document Type: Article

References (19)

1. World Health Organization. The top ten causes of death [Fact Sheet]. Vol. 2015. http://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Accessed June 2018.
2. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008;359(9):938-949.
3. Pawlinski R, Pedersen B, Schabbauer G, et al. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood. 2004;103(4):1342-1347.
4. Pawlinski R, Wang JG, Owens AP III, et al. Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood. 2010;116(5): 806-814.
5. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840-851.
6. Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34-45.
7. van der Poll T, Herwald H. The coagulation system and its function in early immune defense. Thromb Haemost. 2014;112(4):640-648.
8. Davis RP, Miller-Dorey S, Jenne CN. Platelets and coagulation in infection. Clin Transl Immunology. 2016;5(7):e89.
9. Hitchcock JR, Cook CN, Bobat S, et al. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J Clin Invest. 2015;125(12):4429-4446.
10. Monack DM, Mueller A, Falkow S. Persistent bacterial infections: the interface of the pathogen and the host immune system. Nat Rev Microbiol. 2004;2(9):747-765.
11. Mastroeni P, Grant A, Restif O, Maskell D. A dynamic view of the spread and intracellular distribution of Salmonella enterica. Nat Rev Microbiol. 2009;7(1):73-80.
12. Cunningham AF, Khan M, Ball J, et al. Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1. Eur J Immunol. 2004;34(11): 2986-2995.
13. Cunningham AF, Gaspal F, Serre K, et al. Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection. J Immunol. 2007;178(10):6200-6207.
14. Flores-Langarica A, Marshall JL, Bobat S, et al. T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella. Eur J Immunol. 2011;41(9): 2654-2665.
15. Buiting AM, Van Rooijen N. Liposome mediated depletion of macrophages: an approach for fundamental studies. J Drug Target. 1994; 2(5):357-362.
16. Van Rooijen N. The liposome-mediated macrophage ‘suicide’ technique. J Immunol Methods. 1989;124(1):1-6.
17. Gil-Cruz C, Bobat S, Marshall JL, et al. The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response. Proc Natl Acad Sci USA. 2009; 106(24):9803-9808.
18. Massberg S, Grahl L, von Bruehl ML, et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010;16(8):887-896.
19. Gaertner F, Ahmad Z, Rosenberger G, et al. Migrating platelets are mechano-scavengers that collect and bundle bacteria. Cell. 2017; 171(6):1368-1382.e1323.