Opioid overdose detection using smartphones

Science Translational Medicine

Volumn 11, Issue 474, 2019, Pages

  Nandakumar, Rajalakshmi ^a   Gollakota, Shyamnath ^a   Sunshine, Jacob E ^b  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NALOXONE; NARCOTIC ANALGESIC AGENT;

ADULT; ALGORITHM; APNEA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG OVERDOSE; EMERGENCY HEALTH SERVICE; FEMALE; GENERAL ANESTHESIA; HEALTH CARE FACILITY; HUMAN; INTERVENTION STUDY; MALE; MOTOR PERFORMANCE; OPIOID OVERDOSE; PRIORITY JOURNAL; RELIABILITY; RESPIRATION DEPRESSION; SELF INJECTION; SENSITIVITY AND SPECIFICITY; SUPERVISED INJECTION FACILITY; ADVERSE EVENT; BREATHING; CENTRAL SLEEP APNEA SYNDROME; SMARTPHONE;

ADULT; ALGORITHMS; ANALGESICS, OPIOID; DRUG OVERDOSE; FEMALE; HUMANS; ILLICIT DRUGS; MALE; RESPIRATION; SLEEP APNEA, CENTRAL; SMARTPHONE;

EID: 85059795872     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aau8914     Document Type: Article

References (57)

1. E. Wood, Strategies for reducing opioid-overdose deaths—Lessons from Canada. N. Engl. J. Med. 378, 1565–1567 (2018).
2. C. M. Jones, E. B. Einstein, W. M. Compton, Changes in synthetic opioid involvement in drug overdose deaths in the United States, 2010-2016. JAMA 319, 1819–1821 (2018).
3. J. K. O’Donnell, R. M. Gladden, P. Seth, Trends in deaths involving heroin and synthetic opioids excluding methadone, and law enforcement drug product reports, by census region—United States, 2006–2015. MMWR Morb. Mortal. Wkly Rep. 66, 897–903 (2017).
4. D. Dowell, R. K. Noonan, D. Houry, Underlying factors in drug overdose deaths. JAMA 318, 2295–2296 (2017).
5. N. D. Volkow, F. S. Collins, The role of science in addressing the opioid crisis. N. Engl. J. Med. 377, 391–394 (2017).
6. R. G. Frank, H. A. Pollack, Addressing the fentanyl threat to public health. N. Engl. J. Med. 376, 605–607 (2017).
7. R. A. Rudd, P. Seth, F. David, L. Scholl, Increases in drug and opioid-involved overdose deaths—United States, 2010–2015. MMWR Morb. Mortal. Wkly Rep. 65, 1445–1452 (2016).
8. Provisional counts of drug overdose deaths, as of 8/6/2017 (National Center for Health Statistics, 2017).
9. A. M. Vivolo-Kantor, P. Seth, R. M. Gladden, C. L. Mattson, G. T. Baldwin, A. Kite-Powell, M. A. Coletta, Vital signs: Trends in emergency department visits for suspected opioid overdoses—United States, July 2016–September 2017. MMWR Morb. Mortal. Wkly Rep. 67, 279–285 (2018).
10. I. G. Stiell, D. W. Spaite, B. Field, L. P. Nesbitt, D. Munkley, J. Maloney, J. Dreyer, L. L. Toohey, T. Campeau, E. Dagnone, M. Lyver, G. A. Wells, Advanced life support for out-of-hospital respiratory distress. N. Engl. J. Med. 356, 2156–2164 (2007).
11. R. P. Schwartz, J. Gryczynski, K. E. O’grady, J. M. Sharfstein, G. Warren, Y. Olsen, S. G. Mitchell, J. H. Jaffe, Opioid agonist treatments and heroin overdose deaths in Baltimore, Maryland, 1995–2009. Am. J. Public Health 103, 917–922 (2013).
12. A. Y. Walley, Z. Xuan, H. H. Hackman, E. Quinn, M. Doe-Simkins, A. Sorensen-Alawad, A. Ruiz, A. Ozonoff, Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: Interrupted time series analysis. BMJ 346, f174 (2013).
13. R. E. Giglio, G. Li, C. J. DiMaggio, Effectiveness of bystander naloxone administration and overdose education programs: A meta-analysis. Inj. Epidemiol. 2, 10 (2015).
14. S. Darke, J. Ross, D. Zador, S. Sunjic, Heroin-related deaths in New South Wales, Australia, 1992-1996. Drug Alcohol Depend. 60, 141–150 (2000).
15. J. Milward, E. Day, E. Wadsworth, J. Strang, M. Lynskey, Mobile phone ownership, usage and readiness to use by patients in drug treatment. Drug Alcohol Depend. 146, 111–115 (2015).
16. E. A. McClure, S. P. Acquavita, E. Harding, M. L. Stitzer, Utilization of communication technology by patients enrolled in substance abuse treatment. Drug Alcohol Depend. 129, 145–150 (2013).
17. D. Belz, J. Lieb, T. Rea, M. S. Eisenberg, Naloxone use in a tiered-response emergency medical services system. Prehosp. Emerg. Care 10, 468–471 (2006).
18. R. L. Frank, M. A. Rausch, J. J. Menegazzi, M. Rickens, The locations of nonresidential out-of-hospital cardiac arrests in the city of Pittsburgh over a three-year period: Implications for automated external defibrillator placement. Prehosp. Emerg. Care 5, 247–251 (2001).
19. E. W. Boyer, Management of opioid analgesic overdose. N. Engl. J. Med. 367, 146–155 (2012).
20. M. Folke, L. Cernerud, M. Ekström, B. Hök, Critical review of non-invasive respiratory monitoring in medical care. Med. Biol. Eng. Comput. 41, 377–383 (2003).
21. A. Gaucher, D. Frasca, O. Mimoz, B. Debaene, Accuracy of respiratory rate monitoring by capnometry using the Capnomask® in extubated patients receiving supplemental oxygen after surgery. Br. J. Anaesth. 108, 316–320 (2012).
22. F. Q. AL-Khalidi, R. Saatchi, D. Burke, H. Elphick, S. Tan, Respiration rate monitoring methods: A review. Pediatr. Pulmonol. 46, 523–529 (2011).
23. T. C. Green, R. Heimer, L. E. Grau, Distinguishing signs of opioid overdose and indication for naloxone: An evaluation of six overdose training and naloxone distribution programs in the United States. Addiction 103, 979–989 (2008).
24. P. J. Davidson, A. M. Lopez, A. H. Kral, Using drugs in un/safe spaces: Impact of perceived illegality on an underground supervised injecting facility in the United States. Int. J. Drug Policy 53, 37–44 (2018).
25. T. M. Frost, “An investigation of public injection drug use in New York City: A mixed-methods study,” thesis, CUNY School of Public Health, New York, NY (2017).
26. J. R. Hoffman, D. L. Schriger, J. S. Luo, The empiric use of naloxone in patients with altered mental status: A reappraisal. Ann. Emerg. Med. 20, 246–252 (1991).
27. Anesthesiology and Respiratory Devices Branch, Office of Device Evaluation. Class II Special Controls Guidance Document: Apnea Monitors; Guidance for Industry and FDA (2011).
28. R. Nandakumar, S. Gollakota, N. Watson, Contactless sleep apnea detection on smartphones, in Proceedings of the 13th Annual International Conference on Mobile Systems, Applications, and Services (2015), pp. 45–57.
29. T. Wang, D. Zhang, Y. Zheng, T. Gu, X. Zhou, B. Dorizzi, C-FMCW based contactless respiration detection using acoustic signal. Proc. ACM Interact. Mob. Wearable Ubiquitous Technol. 1, 170 (2017).
30. W. Mao, J. He, L. Qiu, Cat: High-precision acoustic motion tracking, in Proceedings of the 22nd Annual International Conference on Mobile Computing and Networking (2016), pp. 69–81.
31. X. Wang, R. Huang, S. Mao, Sonarbeat: Sonar phase for breathing beat monitoring with smartphones, in Proceedings of the 26th International Conference on Computer Communication and Networks (2017), pp. 1–8.
32. R. Nandakumar, V. Iyer, D. Tan, S. Gollakota, Fingerio: Using active sonar for fine-grained finger tracking, in Proceedings of the 2016 CHI Conference on Human Factors in Computing Systems (2016), pp. 1515–1525.
33. S. Gupta, D. Morris, S. Patel, D. Tan, Soundwave: Using the Doppler effect to sense gestures, in Proceedings of the SIGCHI Conference on Human Factors in Computing Systems (2012), pp. 1911–1914.
34. R. Nandakumar, S. Gollakota, Unleashing the power of active sonar. IEEE Pervasive Comput. 16, 11–15 (2017).
35. P. J. Davidson, K. C. Ochoa, J. A. Hahn, J. L. Evans, A. R. Moss, Witnessing heroin-related overdoses: The experiences of young injectors in San Francisco. Addiction 97, 1511–1516 (2002).
36. J. Strang, B. Powis, D. Best, L. Vingoe, P. Griffiths, C. Taylor, S. Welch, M. Gossop, Preventing opiate overdose fatalities with take-home naloxone: Pre-launch study of possible impact and acceptability. Addiction 94, 199–204 (1999).
37. Health: A safe place. New York Times, published February 8, 2011; https://youtu.be/ v6NJPjpelKM [accessed February 2018].
38. T. Kerr, M. W. Tyndall, C. Lai, J. S. G. Montaner, E. Wood, Drug-related overdoses within a medically supervised safer injection facility. Int. J. Drug Policy 17, 436–441 (2006).
39. Rapid Response Systems. Agency for Healthcare Research and Quality (AHRQ); https://psnet.ahrq.gov/primers/primer/4/rapid-response-systems.
40. M. A. DeVita, R. Bellomo, K. Hillman, J. Kellum, A. Rotondi, D. Teres, A. Auerbach, W.-J. Chen, K. Duncan, G. Kenward, M. Bell, M. Buist, J. Chen, J. Bion, A. Kirby, G. Lighthall, J. Ovreveit, R. S. Braithwaite, J. Gosbee, E. Milbrandt, M. Peberdy, L. Savitz, L. Young, S. Galhotra, Findings of the first consensus conference on medical emergency teams. Crit. Care Med. 34, 2463–2478 (2006).
41. R. D. Miller, L. I. Eriksson, L. A. Fleisher, J. P. Wiener-Kronish, N. H. Cohen, W.L. Young, Miller’s Anesthesia E-Book (Elsevier Health Sciences, 2014).
42. M. Doe-Simkins, A. Y. Walley, A. Epstein, P. Moyer, Saved by the nose: Bystander-administered intranasal naloxone hydrochloride for opioid overdose. Am. J. Public Health 99, 788–791 (2009).
43. K. H. Seal, M. Downing, A. H. Kral, S. Singleton-Banks, J.-P. Hammond, J. Lorvick, D. Ciccarone, B. R. Edlin, Attitudes about prescribing take-home naloxone to injection drug users for the management of heroin overdose: A survey of street-recruited injectors in the San Francisco Bay Area. J. Urban Health 80, 291–301 (2003).
44. C. J. Banta-Green, P. O. Coffin, J. O. Merrill, J. M. Sears, C. Dunn, A. S. Floyd, L. K. Whiteside, N. D. Yanez, D. M. Donovan, Impacts of an opioid overdose prevention intervention delivered subsequent to acute care. Inj. Prev. injuryprev–2017-042676 (2018).
45. European Monitoring Centre for Drugs and Drug Addiction, Preventing fatal overdoses: A systematic review of the effectiveness of take-home naloxone (EMCDDA Papers, Publications Office of the European Union, 2015).
46. T. Kerr, J. A. Stoltz, M. Tyndall, K. Li, R. Zhang, J. Montaner, E. Wood, Impact of a medically supervised safer injection facility on community drug use patterns: A before and after study. BMJ 332, 220–222 (2006).
47. J.-A. Stoltz, E. Wood, W. Small, K. Li, M. Tyndall, J. Montaner, T. Kerr, Changes in injecting practices associated with the use of a medically supervised safer injection facility. J. Public Health 29, 35–39 (2007).
48. K. A. Sporer, Acute heroin overdose. Ann. Intern. Med. 130, 584–590 (1999).
49. J. M. Adams, Increasing naloxone awareness and use: The role of health care practitioners. JAMA 319, 2073–2074 (2018).
50. R. McDonald, J. Strang, Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria. Addiction 111, 1177–1187 (2016).
51. IOS accelerate framework; https://developer.apple.com/documentation/accelerate.
52. Fast FFT library for android; www.fftw.org/#documentation.
53. E. Hurstak, C. Rowe, C. Turner, E. Behar, R. Cabugao, N. P. Lemos, C. Burke, P. Coffin, Using medical examiner case narratives to improve opioid overdose surveillance. Int. J. Drug Policy 54, 35–42 (2018).
54. P. W. H. Peng, A. N. Sandler, A review of the use of fentanyl analgesia in the management of acute pain in adults. Anesthesiology 90, 576–599 (1999).
55. R. Sirian, J. Wills, Physiology of apnoea and the benefits of preoxygenation. Continuing Educ. Anaesth. Crit. Care Pain 9, 105–108 (2009).
56. S. D. Weingart, R. M. Levitan, Preoxygenation and prevention of desaturation during emergency airway management. Ann. Emerg. Med. 59, 165–175.e1 (2012).
57. QGIS Development Team, QGIS Geographic Information System. Open Source Geospatial Foundation Project (2018); https://www.qgis.org/en/site/.