Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain

Quarterly reviews of biophysics

Volumn 51, Issue , 2018, Pages

  Palermo, Giulia ^a   Chen, Janice S ^b   Ricci, Clarisse G ^c,d   Rivalta, Ivan ^e   Jinek, Martin ^f   Batista, Victor S ^g   Doudna, Jennifer A ^b,h   McCammon, J Andrew ^c,d,i,j  

^a University of California Riverside   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d San Diego   (United States)

^e UNIVERSITÉ DE LYON   (France)

^f UNIVERSITY OF ZURICH   (Switzerland)

^g YALE UNIVERSITY   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

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Author keywords

CRISPR Cas9; genome editing; molecular dynamics; protein nucleic acid interactions

Indexed keywords

CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CRISPR CAS SYSTEM; DNA CLEAVAGE; ENZYME ACTIVE SITE; GENE EDITING; HUMAN; MOLECULAR DYNAMICS; PRINCIPAL COMPONENT ANALYSIS;

CATALYTIC DOMAIN; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEIN 9; CRISPR-CAS SYSTEMS; DNA CLEAVAGE; GENE EDITING; HUMANS; MOLECULAR DYNAMICS SIMULATION; PRINCIPAL COMPONENT ANALYSIS;

EID: 85058749644     PISSN: None     EISSN: 14698994     Source Type: Journal    
DOI: 10.1017/S0033583518000070     Document Type: Article

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