Expression of Rift Valley fever virus N-protein in Nicotiana benthamiana for use as a diagnostic antigen

BMC Biotechnology

Volumn 18, Issue 1, 2018, Pages

  Mbewana, Sandiswa ^a   Meyers, Ann E ^a   Weber, Brandon ^a   Mareledwane, Vuyokazi ^b   Ferreira, Maryke L ^b   Majiwa, Phelix A O ^b   Rybicki, Edward P ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b ONDERSTEPOORT VETERINARY INSTITUTE   (South Africa)

Author keywords

Diagnostic; DIVA; ELISA; Molecular farming; N protein; Plant production; Rift Valley fever virus

Indexed keywords

ABILITY TESTING; ANTIBODIES; ANTIGENS; COST EFFECTIVENESS; DEVELOPING COUNTRIES; DIAGNOSIS; DIMERS; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; LANDFORMS; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; PLANTS (BOTANY); TRANSMISSION ELECTRON MICROSCOPY; VIRUSES;

DIAGNOSTIC; DIVA; ELISA; FEVER VIRUS; MOLECULAR FARMING; PLANT PRODUCTION;

RECOMBINANT PROTEINS;

DIMER; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G; MONOMER; NICOTIANA BENTHAMIANA EXTRACT; NUCLEOCAPSID PROTEIN; PLANT EXTRACT; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

AGROBACTERIUM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CODON; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEASIBILITY STUDY; HETEROLOGOUS EXPRESSION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NICOTIANA BENTHAMIANA; NONHUMAN; PLANT LEAF; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RIFT VALLEY FEVER; RIFT VALLEY FEVER VIRUS; TRANSMISSION ELECTRON MICROSCOPY; VIRUS DETECTION; ANIMAL; BLOOD; GENE EXPRESSION; GENETICS; METABOLISM; PROCEDURES; SHEEP; SHEEP DISEASE; TOBACCO; VIROLOGY;

ANIMALS; ANTIGENS, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; NUCLEOCAPSID PROTEINS; RIFT VALLEY FEVER; RIFT VALLEY FEVER VIRUS; SHEEP; SHEEP DISEASES; TOBACCO;

EID: 85058331613     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/s12896-018-0489-z     Document Type: Article

References (51)

1. Meyers A. Diseases with limited research of plant-based vaccines. In: MacDonald J, editor. Prospects of plant-based vaccines in veterinary medicine. Cham: Springer International Publishing; 2018. p. 347-67.
2. Albarino CG, Bird BH, Nichol ST. A shared transcription termination signal on negative and ambisense RNA genome segments of Rift Valley fever, sandfly fever Sicilian, and Toscana viruses. J Virol. 2007;81(10):5246-56.
3. Chengula AA, Kasanga CJ, Mdegela RH, Sallu R, Yongolo M. Molecular detection of Rift Valley fever virus in serum samples from selected areas of Tanzania. Trop Anim Health Prod. 2014;46(4):629-34.
4. Drosten C, Gottig S, Schilling S, Asper M, Panning M, Schmitz H, et al. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J Clin Microbiol. 2002;40(7):2323-30.
5. Garcia S, Crance JM, Billecocq A, Peinnequin A, Jouan A, Bouloy M, et al. Quantitative real-time PCR detection of Rift Valley fever virus and its application to evaluation of antiviral compounds. J Clin Microbiol. 2001;39(12):4456-61.
6. Euler M, Wang Y, Nentwich O, Piepenburg O, Hufert FT, Weidmann M. Recombinase polymerase amplification assay for rapid detection of Rift Valley fever virus. Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology. 2012;54(4):308-12.
7. Le Roux CA, Kubo T, Grobbelaar AA, van Vuren PJ, Weyer J, Nel LH, et al. Development and evaluation of a real-time reverse transcription-loop-mediated isothermal amplification assay for rapid detection of Rift Valley fever virus in clinical specimens. J Clin Microbiol. 2009;47(3):645-51.
8. Peyrefitte CN, Boubis L, Coudrier D, Bouloy M, Grandadam M, Tolou HJ, et al. Real-time reverse-transcription loop-mediated isothermal amplification for rapid detection of rift valley fever virus. J Clin Microbiol. 2008;46(11):3653-9.
9. Drolet BS, Weingartl HM, Jiang J, Neufeld J, Marszal P, Lindsay R, et al. Development and evaluation of one-step rRT-PCR and immunohistochemical methods for detection of Rift Valley fever virus in biosafety level 2 diagnostic laboratories. J Virol Methods. 2012;179(2):373-82.
10. Fafetine JM, Tijhaar E, Paweska JT, Neves LC, Hendriks J, Swanepoel R, et al. Cloning and expression of Rift Valley fever virus nucleocapsid (N) protein and evaluation of a N-protein based indirect ELISA for the detection of specific IgG and IgM antibodies in domestic ruminants. Vet Microbiol. 2007;121(1-2):29-38.
11. Swanepoel R, Struthers JK, Erasmus MJ, Shepherd SP, McGillivray GM, Erasmus BJ, et al. Comparison of techniques for demonstrating antibodies to Rift Valley fever virus. J Hyg. 1986;97(2):317-29.
12. McIntosh BM, Russell D, dos Santos I, Gear JH. Rift Valley fever in humans in South Africa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1980;58(20):803-6.
13. Niklasson B, Peters CJ, Grandien M, Wood O. Detection of human immunoglobulins G and M antibodies to Rift Valley fever virus by enzyme-linked immunosorbent assay. J Clin Microbiol. 1984;19(2):225-9.
14. Paweska JT, Burt FJ, Swanepoel R. Validation of IgG-sandwich and IgM-capture ELISA for the detection of antibody to Rift Valley fever virus in humans. J Virol Methods. 2005;124(1-2):173-81.
15. Paweska JT, Burt FJ, Anthony F, Smith SJ, Grobbelaar AA, Croft JE, et al. IgG-sandwich and IgM-capture enzyme-linked immunosorbent assay for the detection of antibody to Rift Valley fever virus in domestic ruminants. J Virol Methods. 2003;113(2):103-12.
16. van Vuren PJ, Potgieter AC, Paweska JT, van Dijk AA. Preparation and evaluation of a recombinant Rift Valley fever virus N protein for the detection of IgG and IgM antibodies in humans and animals by indirect ELISA. J Virol Methods. 2007;140(1-2):106-14.
17. Fafetine JM, Domingos A, Antunes S, Esteves A, Paweska JT, Coetzer JA, et al. Generation and characterization of monoclonal antibodies against Rift Valley fever virus nucleoprotein. Transbound Emerg Dis. 2013;60(Suppl 2):24-30.
18. Pepin M, Bouloy M, Bird BH, Kemp A, Paweska J. Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Vet Res. 2010;41(6):61.
19. Saijo M, Qing T, Niikura M, Maeda A, Ikegami T, Prehaud C, et al. Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus. J Clin Microbiol. 2002;40(5):1587-91.
20. Zaki A, Coudrier D, Yousef AI, Fakeeh M, Bouloy M, Billecocq A. Production of monoclonal antibodies against Rift Valley fever virus application for rapid diagnosis tests (virus detection and ELISA) in human sera. J Virol Methods. 2006;131(1):34-40.
21. Fukushi S, Nakauchi M, Mizutani T, Saijo M, Kurane I, Morikawa S. Antigen-capture ELISA for the detection of Rift Valley fever virus nucleoprotein using new monoclonal antibodies. J Virol Methods. 2012;180(1-2):68-74.
22. McElroy AK, Albarino CG, Nichol ST. Development of a RVFV ELISA that can distinguish infected from vaccinated animals. Virol J. 2009;6:125.
23. van der Wal FJ, Achterberg RP, de Boer SM, Boshra H, Brun A, Maassen CBM, et al. Bead-based suspension array for simultaneous detection of antibodies against the Rift Valley fever virus nucleocapsid and Gn glycoprotein. J Virol Methods. 2012;183(2):99-105.
24. Kortekaas J, Kant J, Vloet R, Cetre-Sossah C, Marianneau P, Lacote S, et al. European ring trial to evaluate ELISAs for the diagnosis of infection with Rift Valley fever virus. J Virol Methods. 2013;187(1):177-81.
25. Ellis CE, Mareledwane VE, Williams R, Wallace DB, Majiwa PA. Validation of an ELISA for the concurrent detection of total antibodies (IgM and IgG) to Rift Valley fever virus. The Onderstepoort journal of veterinary research. 2014;81(1).
26. Comtet LP, P.; Marie, J-L.; Davoust, B; Cetre-Sossah, C. Preliminary validation of the ID Screen Rift Valley fever competition multi-species ELISA,. EAVLD meeting; 15-17 September; Netherlands 2010.
27. Peternel S, Komel R. Active protein aggregates produced in Escherichia coli. Int J Mol Sci. 2011;12(11):8275-87.
28. Rybicki EP. Plant-made vaccines for humans and animals. Plant Biotechnol J. 2010;8(5):620-37.
29. Regnard GL, Halley-Stott RP, Tanzer FL, Hitzeroth II, Rybicki EP. High level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector. Plant Biotechnol J. 2010;8(1):38-46.
30. Fischer R, Vasilev N, Twyman RM, Schillberg S. High-value products from plants: the challenges of process optimization. Curr Opin Biotechnol. 2015;32:156-62.
31. Rybicki EP. Plant-produced vaccines: promise and reality. Drug Discov Today. 2009;14(1-2):16-24.
32. Merlin M, Gecchele E, Capaldi S, Pezzotti M, Avesani L. Comparative evaluation of recombinant protein production in different biofactories: the green perspective. Biomed Res Int. 2014;2014:136419.
33. Kalbina I, Lagerqvist N, Moiane B, Ahlm C, Andersson S, Strid A, et al. Arabidopsis thaliana plants expressing Rift Valley fever virus antigens: mice exhibit systemic immune responses as the result of oral administration of the transgenic plants. Protein Expr Purif. 2016;127:61-7.
34. Zinsstag J, Mackenzie JS, Jeggo M, Heymann DL, Patz JA, Daszak P. Mainstreaming one health. EcoHealth. 2012;9(2):107-10.
35. Rybicki EP. Plant-made vaccines and reagents for the one health initiative. Hum Vaccin Immunother. 2017:1-6.
36. Rybicki E. History and Promise of plant-made vaccines for animals. In: MacDonald J, editor. Prospects of plant-based vaccines in veterinary medicine. Cham: Springer International Publishing; 2018. p. 1-22.
37. Ferron F, Li Z, Danek EI, Luo D, Wong Y, Coutard B, et al. The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog. 2011;7(5):e1002030.
38. Williams R, Ellis CE, Smith SJ, Potgieter CA, Wallace D, Mareledwane VE, et al. Validation of an IgM antibody capture ELISA based on a recombinant nucleoprotein for identification of domestic ruminants infected with Rift Valley fever virus. J Virol Methods. 2011;177(2):140-6.
39. Archer BN, Thomas J, Weyer J, Cengimbo A, Landoh DE, Jacobs C, et al. Epidemiologic investigations into outbreaks of Rift Valley fever in humans, South Africa, 2008-2011. Emerg Infect Dis. 2013;19(12):1918-25.
40. Mortimer E, Maclean JM, Mbewana S, Buys A, Williamson AL, Hitzeroth II, et al. Setting up a platform for plant-based influenza virus vaccine production in South Africa. BMC Biotechnol. 2012;12:14.
41. Baudin M, Jumaa AM, Jomma HJE, Karsany MS, Bucht G, Näslund J, et al. Association of Rift Valley fever virus infection with miscarriage in Sudanese women: a cross-sectional study. Lancet Glob Health. 2016;4(11):e864-e71.
42. Le May N, Gauliard N, Billecocq A, Bouloy M. The N terminus of Rift Valley fever virus nucleoprotein is essential for dimerization. J Virol. 2005;79(18):11974-80.
43. Liu L, Celma C, Roy P. Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins. Virol J. 2008;5(1):82.
44. Kimple ME, Brill AL, Pasker RL. Overview of affinity tags for protein purification. Curr Protoc Protein Sci 2013;73:Unit 9.
45. Antaloae AV, Montigny C, le Maire M, Watson KA, Sorensen TL. Optimisation of recombinant production of active human cardiac SERCA2a ATPase. PLoS One. 2013;8(8):e71842.
46. de Boer SM, Kortekaas J, Antonis AF, Kant J, van Oploo JL, Rottier PJM, et al. Rift Valley fever virus subunit vaccines confer complete protection against a lethal virus challenge. Vaccine. 2010;28(11):2330-9.
47. Nandi S, Kwong AT, Holtz BR, Erwin RL, Marcel S, McDonald KA. Techno-economic analysis of a transient plant-based platform for monoclonal antibody production. MAbs. 2016;8(8):1456-66.
48. Sainsbury F, Thuenemann EC, Lomonossoff GP. pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants. Plant Biotechnol J. 2009;7(7):682-93.
49. Maclean J, Koekemoer M, Olivier AJ, Stewart D, Hitzeroth II, Rademacher T, et al. Optimization of human papillomavirus type 16 (HPV-16) L1 expression in plants: comparison of the suitability of different HPV-16 L1 gene variants and different cell-compartment localization. The J Gen Virol 2007;88(Pt 5):1460-1469.
50. Atkinson R, Burt F, Rybicki EP, Meyers AE. Plant-produced Crimean-Congo haemorrhagic fever virus nucleoprotein for use in indirect ELISA. J Virol Methods. 2016;236:170-7.
51. Wright PF, Nilsson E, Van Rooij EM, Lelenta M, Jeggo MH. Standardisation and validation of enzyme-linked immunosorbent assay techniques for the detection of antibody in infectious disease diagnosis. Rev Sci Tech. 1993;12(2):435-50.