Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

JCI insight

Volumn 3, Issue 4, 2018, Pages

  Palam, Lakshmi Reddy ^a   Mali, Raghuveer Singh ^a   Ramdas, Baskar ^a   Srivatsan, Sridhar Nonavinkere ^b   Visconte, Valeria ^c   Tiu, Ramon V ^c   Vanhaesebroeck, Bart ^d   Roers, Axel ^e   Gerbaulet, Alexander ^e   Xu, Mingjiang ^f   Janga, Sarath Chandra ^a,b   Takemoto, Clifford M ^g   Paczesny, Sophie ^a   Kapur, Reuben ^a,h  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Indiana University   (United States)

^c TAUSSIG CANCER INSTITUTE   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^f UNIVERSITY OF MIAMI   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h Department of Biochemistry and Molecular Biology and ^*

Author keywords

Cancer; Hematology; Hematopoietic stem cells

Indexed keywords

ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; STEM CELL FACTOR RECEPTOR; TET2 PROTEIN, MOUSE;

ANIMAL; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; DISEASE MODEL; DNA METHYLATION; DRUG EFFECT; GAIN OF FUNCTION MUTATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCK-IN; GENETIC EPIGENESIS; GENETICS; HUMAN; KNOCKOUT MOUSE; MAST CELL; MASTOCYTOSIS; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; DNA METHYLATION; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; GAIN OF FUNCTION MUTATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCK-IN TECHNIQUES; HUMANS; MAST CELLS; MASTOCYTOSIS; MICE; MICE, KNOCKOUT; MYELOID CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 85057975637     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.94679     Document Type: Article

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