Developmental origins of the bronchial vasculature: Experimental approaches to study the structure and function of bronchial vasculature

Bronchial Vascular Remodeling in Asthma and COPD

Volumn , Issue , 2006, Pages 1-23

  Demello, Daphne E ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

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EID: 85057443289     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (131)

1. Wagner EM. Bronchial circulation. In: Crystal RG, West JB, Weibel ER, Barnes PJ, eds. The Lung: Scientific Foundations. 2nd ed. Philadelphia: Lippincott-Raven, 1997: 1093-1105.
2. Deffebach ME, Widdicombe J. The bronchial circulation. In: Crystal RG, West JB, Barnes PJ, Neil SC, eds. The Lung: Scientific Foundations. New York: Raven Press Ltd. 1991: 741-757.
3. Wanner A. Circulation of the airway mucosa. J Appl Physiol 1989; 67: 917-925.
4. Baile EM. The anatomy and physiology of the bronchial circulation. J Aerosol Med 1996; 9: 1.
5. Magno M. Comparative anatomy of the tracheobronchial circulation. Eur Respir J Suppl 1990; 12: 557s-562s.
6. Boyden EA. The developing bronchial arteries in a fetus of the 12th week. Am J Anat 1970; 129a: 357-368.
7. Fishman AP. Pulmonary Diseases and Disorders. New York: McGraw Hill, 1980: 400.
8. Song JW, Im YS, Park JH, Yeon KM, Han MG. Hypertrophied bronchial artery at thin-section CT in patients with bronchiectasis: correlation with CT angiographic findings. Radiology 1998; 208: 187-191.
9. Lakshminarayan S, Kowalski TF, Kirk W, Graham MM, Butler J. The drainage routes of the bronchial blood flow in anesthetized dogs. Respir Physiol 1990; 82: 65-73.
10. Deffebach ME, Charan NB, Lakshminarayan S, Butler J. The bronchial circulation. Small, but a vital attribute of the lung. Am Rev Respir Dis 1987; 135: 463-481.
11. Wagenvoort CA, Wagenvoort N. Arterial anastomoses, bronchopulmonary arteries and pulmobronchial arteries in perinatal lungs. Lab Invest 1967; 16: 13-24.
12. Tobin CE. The bronchial arteries and their connections with other vessels in the human lung. Surg Gynecol Obstet 1952; 95: 741-750.
13. Noden DM. Embryonic origins and assembly of blood vessels. Am Rev Respir Dis 1989; 140: 1097-1103.
14. deMello DE, Sawyer D, Galvin N, Reid LR. Early fetal development of the mouse pulmonary vasculature. Am J Respir Cell Mol Biol 1997; 16: 568-581.
15. deMello DE. Structural elements of human fetal and neonatal lung vascular development. In: Weir EK, Archer SL, Reeves JT, eds. The Fetal and Neonatal Pulmonary Circulations. New York: Futura Publishing Company, 2000: 37-64.
16. O’Rahilly R, Muller F. Developmental Stages in Human Embryos. Washington: Carnegie Institution of Washington, 1987.
17. deMello DE, Reid L. Embryonic and early fetal development of human lung vasculature and its functional implications. Pediatr Dev Pathol 2000; 3: 439-449.
18. Drake CJ, Little CD. Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc Natl Acad Sci 1995; 92: 7657-7661.
19. Drake DJ, Hungerford JE, Little CD. Morphogenesis of the first blood vessels. Ann NY Acad Sci 1998; 857: 155-179.
20. Kaipainen A, Korhonen J, Pajusola K, et al. The related flt4, flt1, and kdr receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells. J Exp Med 1993; 178: 2077-2088.
21. Breier G, Clauss M, Risau W. Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development. Dev Dyn 1995; 204: 228-239.
22. Beck L, Jr., D’Amore PA. Vascular development: cellular and molecular regulation. FASEB J 1997; 11: 365-373.
23. Shifren JL, Doldi N, Ferrara N, Mesiano S, Jaffe RB. In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: Implications for mode of action. J Clin Endocrinol Metab 1994; 79: 316-322.
24. Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (London) 1996; 380: 439-442.
25. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (London) 1996; 380: 435-439.
26. Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (London) 1995; 376: 66-70.
27. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML. Failure of blood-island formation and vasculogenesisin Flk-1 deficient mice. Nature (London) 1995; 376: 62-66.
28. Heimark RL, Twardzik DR, Schwartz SM. Inhibition of endothelial regeneration by type-β transforming growth factor from platelets. Science 1986; 233: 1078-1080.
29. Antonelli-Orlidge A, Saunders KB, Smith SR, d’Amore PA. An activated form of transforming growth factor β is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci USA 1989; 86: 4544-4548.
30. Battegay EJ, Raines EW, Seifert RA, Bowen-Pope DF, Ross R. TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 1990; 63: 515-524.
31. Dickson MC, Martin JS, Cousins FM, Kulkarni AB, Karlsson S, Akhurst RJ. Defective hematopoiesis and vasculogenesis in transforming growth factor-β 1 knock-out mice. Development 1995; 121: 1845-1854.
32. Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cell: activation of a latent transforming growth factor-β 1-like molecule by plasmin during co-culture. J Cell Biol 1989; 109: 309-315.
33. Korhonen J, Polvi A, Partanen J, Alitalo K. The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis. Oncogene 1994; 9: 395-403.
34. Partanen J, Puri MC, Schwartz L, Fischer KD, Bernstain A, Rossant J. Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development. Development 1996; 122: 3013-3021.
35. D’Amore PA, Ng YS, Darland DC. Angiogenesis. Sci Med 1999; 6: 44-53.
36. Folkman J, D’Amore PA. Blood vessel formation: what is its molecular basis? Cell 1996; 87: 1153-1155.
37. Schraufnagel DE, Arzouman DA, Sekosan M, Ho YK. The effect of transforming growth factor-alpha on airway angiogenesis. J Thorac Cardiovasc Surg 1992; 104: 1582-1588.
38. Baffert F, Thurston G, Rochon-Duck M, Le T, Brekken R, McDonald DM. Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels. Circ Res 2004; 94: 984-992.
39. Baluk P, Lee CG, Link H, et al. Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways. Am J Pathol. 2004; 165: 1071-1085.
40. Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, Isner JM. Mouse model of angiogenesis. Am J Pathol 1998; 152: 1667-1679.
41. Schraufnagel DE. Monocrotaline-induced angiogenesis: differences in the bronchial and pulmonary vasculature. Am J Pathol 1990; 137: 1083-1090.
42. Hislop AA, Zhao YD, Springall DR, Polak JM, Haworth SG. Postnatal changes in endothelin-1 binding in porcine pulmonary vessels and airways. Am J Respir Cell Mol Biol 1995; 12: 557-566.
43. Suzuki T, Kasai T. Morphological and embryological characteristics of bronchial arteries in the rat. Anat Embryol 2003; 207: 95-99.
44. Kuwano K, Bosken CH, Pare PD, Bai TR, Wiggs BR, Hogg JC. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 148: 1220-1225.
45. Pietra GG, Magno M. Pharmacological factors influencing permeability of the bronchial circulation. Fed Proc 1978; 37: 2466-2470.
46. Pietra GG, Fishman AP. In: Staub NC, ed. In: Lung Water and Solute Exchange, Vol. 7. New York: Marcel Dekker, 1978.
47. Hirabayashi M, Yamamoto T. An electron-microscopic study of the endothelium in mammalian bronchial microvasculature. Cell Tissue Res 1984; 236: 19-25.
48. Schraufnagel DE. Microvascular casting of the lung: bronchial versus pulmonary artery filling. Scanning Microsc 1989; 3: 575-578.
49. Viamonte M, Jr., Viamonte M, Camacho M, Liebow AA. Corrosion cast studies of the bronchial arteries. Surg Radiol Anat 1989; 11: 215-219.
50. Schraufnagel DE, Pearse DB, Mitzner WA, Wagner EM. Three-dimensional structure of the bronchial microcirculation in sheep. Anat Rec 1995; 243: 357-366.
51. Von Hayek H. The human Lung (Translated by V. Krahl). New York: Hafner Publishing Company, 1960.
52. Csete ME, Chediak AD, Abraham WM, Wanner A. Airway blood flow modifies allergic airway smooth muscle contraction. Am Rev Respir Dis 1991; 144: 59-63.
53. Kelly L, Kolbe J, Mitzner W, Spannhake EW, Bromberger-Barnea B, Menkes H. Bronchial blood flow affects recovery from constriction in dog lung periphery. J Appl Physiol 1986; 60: 1954-1959.
54. Wagner EM, Mitzner WA. Bronchial circulatory reversal of methacholine-induced airway constriction. J Appl Physiol 1990; 69: 1220-1224.
55. Rizk NW, Luce JM, Hoeffel JM, Price DC, Murray JF. Site of deposition and factors affecting clearance of aerosolized solute from canine lungs. J Appl Physiol 1984; 56: 723-729.
56. White DA, Parsons GH. Tracheal blood flow during spontaneous and mechanical ventilation of dry gases in sheep. J Appl Physiol 1990; 69: 1117-1122.
57. Garland A, Ray DW, Doerschuk CM, et al. Role of tachykinins in hyperpneainduced bronchovascular hyperpermeability in guinea pigs. J Appl Physiol 1991; 70: 27-35.
58. Salonen RO, Webber SE, Deffebach ME, Widdicombe JG. Tracheal vascular and smooth muscle responses to air temperature and humidity in dogs. J Appl Physiol 1991; 71: 50-59.
59. Baile EM, Dahlby RW, Wiggs BR, Pare PD. Role of tracheal and bronchial circulation in respiratory heat exchange. J Appl Physiol 1985; 58: 217-222.
60. Baile Em, Godden DJ, Pare PD. Mechanism for increase in tracheobronchial blood flow induced by hyperventilation of dry air in dogs. J Appl Physiol 1990; 68: 105-112.
61. Solway J, Pichurk O, Ingenito EP, et al. Breathing pattern affects airway wall temperature during cold air hyperpnea in humans. Am Rev Respir Dis 1985; 132: 853-857.
62. Horisberger B, Rodbard S. Direct measurement of bronchial artery flow. Circ Res 1960; 8: 1149-1156.
63. Bruner HD, Schmidt CF. Blood flow in the bronchial artery of the anesthetized dog. Am J Physiol 1947; 148: 648-666.
64. Link DP, Parsons GH, Lantz BMT, Gunther RA, Green JF, Cross CE. Measurement of bronchial blood flow in the sheep by videodilution technique. Thorax 1985; 40: 143-149.
65. Parsons GH, Kramer GE, Lind DP, et al. Studies of reactivity and distribution of bronchial blood flow in sheep. Chest 1985; 87: 180-182.
66. Corfield DR, Deffebach ME, Erjefalt I, Salonen RO, Webber SE, Widdicombe JG. Laser-Doppler measurement of tracheal mucosal blood flow: comparison with tracheal arterial flow. J Appl Physiol 1991; 70: 274-281.
67. Ashley KD, Herndon DN, Traber LD, et al. Systemic blood flow to sheep lung: comparison of flow probes and microspheres. J Appl Physiol 1992; 73: 1996-2003.
68. Rudolf AM, Heyman MA. The circulation of the fetus in utero: methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 1967; 21: 163-184.
69. Hale SL, Alker KJ, Kloner RA. Evaluation of nonradioactive, colored microspheres for measurement of regional myocardial blood flow in dogs. Circulation 1988; 78: 428-434.
70. Glenny RW, Bernard S, Brinkley M. Validation of fluorescent labeled microspheres for measurement of regional organ perfusion. L Appl Physiol 1993; 74: 2585-2597.
71. Bernard SL, Obermiller T, Polissar NL, Mendenhall JM, Butler J, Lakshminarayan S. Fifteen micrometer microspheres reflux up the pulmonary veins during pulmonary artery occlusion. Microvasc Res 1993; 45: 262-268.
72. Modell HI, Beck K, Butler J. Functional aspects of canine bronchial-pulmonary vascular communications. J Appl Physiol 1981; 50: 1045-1051.
73. Hill P, Goulding D, Webber SE, Widdicombe JG. Blood sinuses in the submucosa of the large airways of the sheep. J Anat 1989; 162: 235-247.
74. Agostonin P, Arena V, Doria E, Susini G. Inspired gas relative humidity affects systemic to pulmonary blood flow in humans. Chest 1990; 97: 1377-1380.
75. Onorato DJ, Demirozu MC, Breitenbucher A, Atkins ND, Chediak AD, Wanner A. Airway mucosal blood flow in humans. Am J Respir Crit Care Med 1994; 149: 1132-1137.
76. McDonald DM. The ultrastructure and permeability of tracheobronchial blood vessels in health and disease. Eur Respir J Suppl 1990; 12: 572s-585s.
77. Wagner EM, Mitzner WA. Effect of hypoxia on bronchial circulation. J Appl Physiol 1988; 65: 1627-1633.
78. Baile EM, Pare PD. Response of the bronchial circulation to acute hypoxemia and hypercarbia in the dog. J Appl Physio 1983; 55: 1474-1479.
79. Charan NB, Lakshminarayan S, Albert RK, Kirk W, Butler J. Hypoxia and hypercarbia increase bronchial blood flow through bronchopulmonary anastomoses in anesthetized dogs. Am Rev Respir Dis 1986; 134: 89-92.
80. Charan NB, Albert RK, Lakshminarayan S, Kirk W, Butler J. Factors affecting bronchial blood flow through bronchopulmonary anastomoses in dogs. Am Rev Respir Dis 1986; 134: 85-88.
81. Sanders EA, Gleed RD, Hackett RP, Dobson A. Action of sympathomimetic drugs on the bronchial circulation of the horse. Exp Physiol 1991; 76: 301-304.
82. Barker JA, Chediak AD, Baier HJ, Wanner A. Tracheal mucosal blood flow responses. J Appl Physiol 1988; 65: 829-834.
83. Salonen RO, Webber SE, Widdicombe JG. Effects of neurotransmitters on tracheobronchial blood flow. Eur Respir J Suppl 1990; 12: 630s-636s.
84. Baile EM, Osborne S, Pare PD. Effect of autonomic blockade on tracheobronchial blood flow. J Appl Physiol 1986; 62: 520-525.
85. Matran R, Alving K, Martling CR, Lacroix JS, Lundberg JM. Vagally mediated vasodilatation by motor and sensory nerves in the tracheal and bronchial circulation of the pig. Acta Physiol Scand 1989; 135: 29-37.
86. Laitinen LA, Laitinen MVA, Widdicombe JG. Parasympathetic nervous control of tracheal vascular resistance in the dog. J Physiol 1987; 385: 135-146.
87. Salonen RO, Webber SE, Widdicombe JG. Effects of neuropeptides and capsaicin on the canine tracheal vasculature in vivo. Br J Pharmacol 1988; 95: 1262-1270.
88. Pisarri TE, Coleridge HM, Coleridge JCG. Reflex bronchial vasodilation in dogs evoked by injection of a small volume of water into a bronchus. J Appl Physiol 1993; 75: 2195-2202.
89. Matran R, Alving K, Lundberg JM. Cigarette smoke, nicotine and capsaicin aerosol-induced vasodilatation in pig respiratory mucosa. Br J Pharma 1990; 100: 535-541.
90. Pisarri TE, Jonzon A, Coleridge HM, Coleridge JCG. Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs. J Appl Physiol 1992; 73: 2305-2313.
91. Prazma J, Coleman CC, Shockley WW, Boucher RC. Tracheal vascular response to hypertonic and hypotonic solutions. J Appl Physiol 1994; 76: 2275-2280.
92. Schlege ES, Gunther RA, Parsons GH, Colbert SR, Yousef MAA, Cross CE. Acute ozone exposure increases bronchial blood flow in conscious sheep. Resp Physiol 1990; 82: 325-336.
93. Alsberge M, Magno M, Lipschutz M. Carotid body control of bronchial circulation in sheep. J Appl Physiol 1988; 65: 1152-1156.
94. Sahin G, Webber SE, Widdicombe JG. Chemical control of tracheal vascular resistance in dogs. J Appl Physiol 1987; 63: 988-995.
95. Agostini P, Arena V, Biglioli P, Doria E, Sala A, Susini G. Increase in alveolar pressure reduces systemic-pulmonary bronchial blood flow in humans. Chest 1989; 96: 1081-1085.
96. Agostoni PG, Deffebach ME, Kirk W, Lakshminarayan S, Butler J. Mechanism by which end-expiratory pressure (PEEP) decreases anastomotic bronchial blood flow. Am Rev Respir Dis 1986; 133: A162.
97. Cassidy SS, Haynes MS. The effects of ventilation with positive end-expiratory pressure on the bronchial circulation. Respir Physiol 1986; 66: 269-278.
98. Charan NB, Albert RK, Lakshminarayan S, Kirk W, Butler J. Factors affecting bronchial blood flow through bronchopulmonary anastomoses in dogs. Am Rev Respir Dis 1986; 134: 85-88.
99. Wagner EM, Mitzner WA, Bleeker ER. Affects of airway pressure on bronchial blood flow. J Appl Physiol 1987; 62: 561-566.
100. Wagner EM, Mitzner W. Active constriction of the bronchial vasculature in response to left atrial pressure elevation. Am Rev Respir Dis 1988; 137: 370s.
101. Blosser S, Mitzner W, Wagner E. Effects of increased bronchial blood flow on airway morphometry, resistance, and reactivity. J Appl Physiol 1994; 76: 1624-1629.
102. Wagner EM, Mitzner W. Effects of bronchial vascular engorgement on airway dimensions. J Appl Physiol 1996; 81: 293-301.
103. Laitinen LA, Robinson NP, Laitinen A, Widdicombe JG. Relationship between tracheal mucosal thickness and vascular resistance in dogs. J Appl Physiol 1986; 61: 2186-2193.
104. Wiggs BR, Bosken C, Pare PD, James A, Hogg JC. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992; 145: 1251-1258.
105. McFadden ER. Hypothesis: exercise-induced asthma as a vascular phenomenon. Lancet 1990; 335: 880-883.
106. Wilson JW, Kotsimbos T. Airway vascular remodeling in asthma. Curr Allergy Asthma Rep 2003; 3: 153-158.
107. Hoshino M, Aoike N, Takahashi M, Nakamura Y, Nakagawa T. Increased immunoreactivity of stromal cell-derived factor-1 and angiogenesis in asthma. Eur Respir J 2003; 21: 804-809.
108. Salvato G. Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 2001; 56: 902-906.
109. Cabanes LR, Weber SN, Matran R, et al. Bronchial hyperresponsiveness to methacholine in patients with impaired left ventricular function. N Eng J Med 1989; 320: 1317-1322.
110. Dinh XAT, Chaussain M, Regnard J, Lockhart A. Pretreatment with an inhaled a1- adrenergic agonist, methoxamine, reduces exercise-induced asthma. Eur Respir J 1989;409-414.
111. Piedimonte G, Umeno E, McDonald DM, Nadel JA. Sendai virus infection potentiates neurogenic inflammation in the rat trachea. Am Rev Respir Dis 1989; 139: A230.
112. Wagner EM, Mitzner WA, Bleecker ER. Role of the bronchial circulation in cold air induced bronchospasm. Am Rev Respir Dis 1986; 133: A174.
113. Ollerenshaw S, Jarvis D, Woolcock A, Sullivan C, Scheibner T. Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma. N Engl J Med 1989; 320: 1244-1298.
114. Long WM, Yerger LD, Codias EK, et al. Early and late antigen-induced changes in bronchial artery blood flow and bronchomotor tone in allergic sheep. Fed Proc 1986; 44: 1756.
115. Baier H, Long WM, Wanner A. Bronchial circulation in asthma. Respiration 1985;199-205.
116. Long WM, Yerger LD, Martinez H, et al. Modification of bronchial blood flow during allergic airway responses. J Appl Physiol 1988; 65: 272-282.
117. Persson CGA, Erjefalt I, Andersson P. Leakage of macromolecules from guinea pig tracheobronchial microcirculation. Effects of allergen, leukotrienes, tachykinins, and anti-asthma drugs. Acta Physiol Scand 1986; 127: 95-106.
118. Reid L, Jones R. Experimental chronic bronchitis. Int Rev Exp Pathol 1983; 24: 335-382.
119. Liebow AA, Hales MR, Lindskog GE. Enlargement of the bronchial arteries and their anastomoses with the pulmonary arteries in bronchiectasis. Am J Pathol 1949; 25: 211-231.
120. Nakamura T, Katori R, Miyazawa K, et al. Bronchial blood flow in patients with chronic pulmonary disease and its influences upon respiration and circulation. Dis Chest 1961; 39: 193-206.
121. Cudkowicz L. Bronchial arterial circulation in man: normalanatomy and responses to disease. New York: Marcel Dekker, 1979.
122. Cudkowicz L, Armstrong JB. The bronchial arteries in pulmonary emphysema. Thorax 1953; 8: 46-58.
123. Thurston G, Murphy TJ, Baluk P, Russel Lindsey J, McDonald DM. Angiogenesis in mice with chronic airway inflammation. Am J Pathol 1998; 153: 1099-1112.
124. Thurston G, Maas K, Labarbara A, Mclean JW, McDonald DM. Microvascular remodeling in chronic airway inflammation in mice. Clin Exp Pharmacol Physiol 2000; 27: 836-841.
125. McDonald DM. Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med 2001; 164: 39-45.
126. Kwan ML, Gomez AD, Baluk P, Hashizume H, McDonald DM. Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersenstitivity to substance P. Am J Physiol Lung Cell Mol Physiol 2001; 280: L286-L297.
127. Baluk P, Bowden JJ, Lefevre PM, McDonald DM. Upregulation of substance P receptors in angiogenesis associated with chronic airway inflammation in rats. Am J Physiol 1997; 273: L565-L571.
128. McDonald DM, Bowden JJ, Baluk P, Bunnet NW. Neurogenic inflammation. A model for studying efferent actions of sensory nerves. Adv Exp Med Biol 1996; 410: 453-462.
129. Bowden JJ, Scoeb Tr, Lindsey JR, McDonald DM. Dexamethasone and oxytetracycline reverse the potentiation of neurogenic inflammation in airways of rats with mycoplasma pulmonis infection. Am J Respir Crit Care Med 1994; 150: 1391-1401.
130. Dahlqvist K, Umemoto EY, Brokaw JJ, Dupuis M, McDonald DM. Tissue macrophages associated with angiogenesis in chronic airway inflammation. Am J Respir Cell Mol Biol 1999; 20: 237-247.
131. Baluk P, Raymond WW, Ator E, Coussens LM, MsDonald DM, Caughey GH. Matrix metalloproteinase 2 and 9 expression increases in mycoplasma-infected airways but is not required for microvascular remodeling. Am J Physiol Lung Cell Mol Physiol 2004; 287: L307-L317. Apr 9 (Epub).