CO 2 -related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death

Cardiovascular Pathology

Volumn 38, Issue , 2019, Pages 42-45

  Jaster, J Howard ^a   Zamecnik, Josef ^b   Giannì, Aldo Bruno ^c,d   Ottaviani, Giulia ^d  

^a London Corporation   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

Autonomic nuclei; Brain medulla; Carbon dioxide; CO 2; Heart failure; Ischemia; Sleep apnea; Solitary tract nucleus; Sudden cardiac death; Vagus nerve; Vasculature; Vasoconstriction

Indexed keywords

CARBON DIOXIDE;

ASYMPTOMATIC DISEASE; AUTONOMIC NERVOUS SYSTEM; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN DAMAGE; BRAIN INJURY; BRAIN ISCHEMIA; DEMYELINATION; EDITORIAL; GAS EXCHANGE; HUMAN; HYPERVENTILATION; LUNG ALVEOLUS CARBON DIOXIDE TENSION; LUNG VENTILATION; MEDULLARY NUCLEUS; META ANALYSIS (TOPIC); POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; SOLITARY TRACT NUCLEUS; SUDDEN CARDIAC DEATH; SUDDEN DEATH; UNCONSCIOUSNESS; VASOCONSTRICTION; BLOOD; BRAIN STEM INFARCTION; MEDULLA OBLONGATA; METABOLISM; MORTALITY; PATHOPHYSIOLOGY; RISK FACTOR; SLEEP DISORDERED BREATHING; VASCULARIZATION;

AUTONOMIC NERVOUS SYSTEM; BRAIN STEM INFARCTIONS; CARBON DIOXIDE; CONTINUOUS POSITIVE AIRWAY PRESSURE; DEATH, SUDDEN, CARDIAC; HUMANS; MEDULLA OBLONGATA; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE; SOLITARY NUCLEUS; VASOCONSTRICTION;

EID: 85056702858     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2018.10.009     Document Type: Review

References (31)

1. ResMed, ResMed provides update on phase IV SERVE-HF study of adaptive servo-ventilation (ASV) therapy in central sleep apnea and chronic heart failure. San Diego, CA: May 13, 2015. https://www.resmed.com/epn/en/hospital/resmed-presents-data-on-phase-iv-serve-hf-study-.html. (Accessed 5 August 2018)
2. Cowie, M.R., Wegscheider, K., Teschler, H., Adaptive servo-ventilation for central sleep apnea in heart failure. N Engl J Med 374 (2016), 690–691, 10.1056/NEJMc1515007.
3. Jaster, J.H., Interfacing pathophysiology of respiratory sleep disorders, cardiac dysfunction, and focal autonomic medullary brain ischemia. J Thorac Dis 7 (2015), E646–E647, 10.3978/j.issn.2072-1439.2015.12.30.
4. Jaster, J.H., Medicine in the future — with subspecialists in medullary neurology and brain dentistry. World J Neurol 4 (2015), 107–112, 10.5316/wjn.v5.i4.107.
5. Jaster, J.H., Ischemic lesion formation in solitary tract nuclei during central sleep apnea with heart failure. Circ J, 80, 2016, 1047, 10.1253/circj.CJ-15-1359.
6. Jaster, J.H., Phrenic nerve stimulation — and chorda tympani nerve stimulation — may prevent lethal cardiac arrhythmias during sleep apnea with heart failure. Int J Neurol Res 3 (2017), 323–326 http://www.ghrnet.org/index.php/ijnr/article/view/1805/2331. (Accessed 5 August 2018)
7. Jaster, J.H., Medullary neuropathology in sleep apnoea. Respirology, 22, 2017, 829, 10.1111/resp.12994.
8. McEvoy, R.D., Antic, N.A., Heeley, E., Luo, Y., Ou, Q., Zhang, X., et al. CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med 375 (2016), 919–931, 10.1056/NEJMoa1606599.
9. Jaster, J.H., Porterfield, L.M., Bertorini, T.E., Dohan, F.C., Becske, T., Cardiac arrest following vertebrobasilar stroke. J Tenn Med Assoc, 88, 1995, 309.
10. Jaster, J.H., Porterfield, L.M., Bertorini, T.E., Dohan, F.C., Becske, T., Stroke and cardiac arrest. Neurology, 47, 1996, 1357.
11. Jaster, J.H., Smith, T.W., Arrhythmia mechanism of unexpected sudden death following lateral medullary infarction. Tenn Med, 91, 1998, 284.
12. Jaster, J.H., Smith, T.W., Gleckman, A.M., Currier, R.D., Bebin, J., A medullary syndrome characterized by wild arm ataxia. Neurology, 55, 2000, 321.
13. Jaster, J.H., Some cases of unexpected sudden death are associated with tumors. Arch Dis Child, 82(6), 2000 https://adc.bmj.com/content/82/6/456.responses [eLetter].
14. Jaster, J.H., Unexpected sudden death after lateral medullary infarction. J Neurol Neurosurg Psychiatry, 70, 2001, 137.
15. Jaster, J.H., Fitzek, S., Fitzek, C., Smith, T.W., Becske, T., Myocardial injury after hemorrhage into the lateral medulla oblongata. Neurology, 57, 2001, 1145.
16. Jaster, J.H., Sudden cardiac death of an adolescent during dieting. South Med J 96 (2003), 322–323, 10.1097/01.SMJ.0000061504.81880.DF [author reply].
17. Jaster, J.H., Zamecnik, J., Bartos, A., Dohan, F.C., Smith, T.W., Unexpected sudden death caused by medullary brain lesions involves all age groups and may include 'sudden infant death syndrome’ as a subset. Acta Neuropathol 109 (2005), 552–553, 10.1007/s00401-005-0996-6.
18. Jaster, J.H., Ottaviani, G., Matturri, L., Lavezzi, A.M., Zamecnik, J., Smith, T.W., Sudden unexpected death related to medullary brain lesions. Am J Forensic Med Pathol 29 (2008), 371–374, 10.1097/PAF.0b013e3181847dfc.
19. Jaster, J.H., Novel mechanisms and prevention for sudden unexpected death related to medullary brain lesions. Arch Neurol, 67, 2010, 1288, 10.1001/archneurol.2010.110.
20. Jaster, J.H., Laryngospasm and “sudden unexpected death related to medullary brain lesions”. Arch Neurol, 68, 2011, 399, 10.1001/archneurol.2011.18.
21. De Caro, R., Parenti, A., Montisci, M., Guidolin, D., Macchi, V., Solitary tract nuclei in acute heart failure. Stroke 31 (2000), 1187–1193.
22. Parenti, A., Macchi, V., Snenghi, R., Porzionato, A., Scaravilli, T., Ferrara, S.D., et al. Selective stroke of the solitary tract nuclei in two cases of central sleep apnoea. Clin Neuropathol 24 (2005), 239–246.
23. Hofmann, R., James, S.K., Jernberg, T., Lindahl, B., Erlinge, D., Witt, N., et al. Oxygen therapy in suspected acute myocardial infarction. N Engl J Med 377 (2017), 1240–1249, 10.1056/NEJMoa1706222.
24. Shen, L., Jhund, P.S., Petrie, M.C., Claggett, B.L., Barlera, S., Cleland, J.G.F., et al. Declining risk of sudden death in heart failure. N Engl J Med 377 (2017), 41–51, 10.1056/NEJMoa1609758.
25. Landry, C.H., Allan, K.S., Connelly, K.A., Cunningham, K., Morrison, L.J., Dorian, P., et al. Sudden cardiac arrest during participation in competitive sports. N Engl J Med 377 (2017), 1943–1953, 10.1056/NEJMoa1615710.
26. Hallstrom, A., Cobb, L., Johnson, E., Copass, M., Cardiopulmonary resuscitation by chest compression alone or with mouth-to-mouth ventilation. N Engl J Med 342 (2000), 1546–1553, 10.1056/NEJM200005253422101.
27. Rea, T.D., Fahrenbruch, C., Culley, L., Donohoe, R.T., Hambly, C., Innes, J., et al. CPR with chest compression alone or with rescue breathing. N Engl J Med 363 (2010), 423–433, 10.1056/NEJMoa0908993.
28. Svensson, L., Bohm, K., Castrèn, M., Pettersson, H., Engerström, L., Herlitz, J., et al. Compression-only CPR or standard CPR in out-of-hospital cardiac arrest. N Engl J Med 363 (2010), 434–442, 10.1056/NEJMoa0908991.
29. Nichol, G., Leroux, B., Wang, H., Callaway, C.W., Sopko, G., Weisfeldt, M., et al. Trial of continuous or interrupted chest compressions during CPR. N Engl J Med 373 (2015), 2203–2214, 10.1056/NEJMoa1509139.
30. Kaneko, H., Hara, M., Mizutani, K., Yoshiyama, M., Yokoi, K., Kabata, D., et al. Improving outcomes of witnessed out-of-hospital cardiac arrest after implementation of international liaison committee on resuscitation 2010 consensus: A nationwide prospective observational population-based study. J Am Heart Assoc, 6, 2017, 10.1161/JAHA.116.004959 [pii e004959].
31. 2 -reduced vasoconstriction in sleep apnea. J Thorac Dis 10:S17 (2018), S2029–S2031, 10.21037/jtd.2018.05.70.