Acute effect of empagliflozin on fractional excretion of sodium and eGFR in youth with type 2 diabetes

Diabetes Care

Volumn 41, Issue 8, 2018, Pages e129-e130

  Bjornstad, Petter ^a   Laffel, Lori ^b   Tamborlane, William V ^c   Simons, Gudrun ^d   Hantel, Stefan ^d   Von Eynatten, Maximilian ^d   George, Jyothis ^d   Marquard, Jan ^d   Cherney, David Z I ^e  

^a Children's Hospital Colorado   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYSTATIN C; EMPAGLIFLOZIN; HEMOGLOBIN A1C; SODIUM;

ADOLESCENT; ANALYSIS OF COVARIANCE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; GLOMERULUS FILTRATION; HUMAN; LETTER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ONSET AGE; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SODIUM EXCRETION; SODIUM URINE LEVEL;

EID: 85056636461     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc18-0394     Document Type: Letter

References (5)

1. Bjornstad P, Nehus E, El Ghormli L, et al.; TODAY Study Group. Insulin sensitivity and diabetic kidney diseasein children and adolescents with type 2diabetes: anobservational analysis of datafrom the TODAY clinical trial. Am J Kidney Dis 2018; 71:65-74
2. Zinman B, Wanner C, Lachin JM, et al.; EMPAREG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015; 373:2117-2128
3. Wanner C, Inzucchi SE, Lachin JM, et al.; EMPA-REGOUTCOME Investigators. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med 2016; 375:323-334
4. Cherney DZ, Perkins BA, Soleymanlou N, et al. Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 2014; 129: 587-597
5. Fadrowski JJ, Neu AM, Schwartz GJ, Furth SL. Pediatric GFR estimating equations applied to adolescents in the general population. Clin J Am Soc Nephrol 2011; 6:1427-1435