“Ultra-sensitive” cardiac troponins: Requirements for effective implementatioin clinical practice

Biochemia Medica

Volumn 28, Issue 3, 2018, Pages

  Lippi, Giuseppe ^a   Sanchis Gomar, Fabian ^b,c,d  

^a UNIVERSITY OF VERONA   (Italy)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VALENCIA   (Spain)

^d Instituto Universitario IVI INCLIVA   (Spain)

Author keywords

Acute coronary syndrome; Cardiac troponin; Diagnostics; Myocardial infarction

Indexed keywords

TROPONIN; TROPONIN I; TROPONIN T;

ACUTE CORONARY SYNDROME; ALGORITHM; CARDIOVASCULAR DISEASE; CLINICAL DECISION MAKING; CLINICAL PRACTICE; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; HEALTH CARE PLANNING; HUMAN; IMMUNOASSAY; LIMIT OF DETECTION; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; REVIEW; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; CLINICAL CHEMISTRY; PROCEDURES;

ALGORITHMS; CLINICAL CHEMISTRY TESTS; HUMANS; LIMIT OF DETECTION; TROPONIN I; TROPONIN T;

EID: 85055574897     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: 10.11613/BM.2018.030501     Document Type: Review

References (31)

1. Lippi G, Bonfanti L, Dipalo M, Aloe R, Cervellin G. Clinical, organizational and economic analysis of high-sensitivity cardiac troponin testing in the emergency department. Ann Res Hosp. 2017;1:14. https://doi.org/10.21037/arh.2017.09.02
2. Pickering JW, Than MP, Cullen L, Aldous S, Ter Avest E, Body R, et al. Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Ann Intern Med. 2017;166:715-24. https://doi.org/10.7326/M16-2562
3. Sorensen NA, Neumann JT, Ojeda F, Schwemer T, Renne T, Schnabel RB, et al. Challenging the 99th percentile: A lower troponin cutoff leads to low mortality of chest pain patients. Int J Cardiol. 2017;232:289-93. https://doi.org/10.1016/j.ij-card.2016.12.167
4. Cervellin G, Mattiuzzi C, Bovo C, Lippi G. Diagnostic algorithms for acute coronary syndrome-is one better than another? Ann Transl Med. 2016;4:193. https://doi. org/10.21037/atm.2016.05.16
5. Reichlin T, Irfan A, Twerenbold R, Reiter M, Hochholzer W, Burkhalter H, et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation. 2011;124:136-45. https://doi.org/10.1161/CIRCULATIONAHA.111.023937
6. Boeddinghaus J, Reichlin T, Cullen L, Greenslade JH, Parsonage WA, Hammett C, et al. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction by use of high-sensitivity cardiac troponin I. Clin Chem. 2016;62:494-504. https://doi.org/10.1373/clinchem.2015.249508
7. Reichlin T, Cullen L, Parsonage WA, Greenslade J, Twerenbold R, Moehring B, et al. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Am J Med. 2015;128:369–79.e4. https://doi.org/10.1016/j.amj-med.2014.10.032
8. Nestelberger T, Wildi K, Boeddinghaus J, Twerenbold R, Reichlin T, Gimenez MR, et al. Characterization of the observe zone of the ESC 2015 high-sensitivity cardiac troponin 0h/1h-algorithm for the early diagnosis of acute myocardial infarction. Int J Cardiol. 2016;207:238-45. https://doi. org/10.1016/j.ijcard.2016.01.112
9. Rubini Giménez M, Hoeller R, Reichlin T, Zellweger C, Twerenbold R, Reiter M, et al. Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin. Int J Cardiol. 2013;168:3896-901. https://doi. org/10.1016/j.ijcard.2013.06.049
10. Jaeger C, Wildi K, Twerenbold R, Reichlin T, Rubini Gimenez M, Neuhaus JD, et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. Am Heart J. 2016;171:92–102.e1.https://doi. org/10.1016/j.ahj.2015.07.022
11. Krintus M, Kozinski M, Boudry P, Capell NE, Koller U, Lackner K, et al. European multicenter analytical evaluation of the Abbott ARCHITECT STAT high sensitive troponin I immunoassay. Clin Chem Lab Med. 2014;52:1657-65. https://doi. org/10.1515/cclm-2014-0107
12. Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4:256. https://doi. org/10.21037/atm.2016.06.33
13. Lippi G, Cervellin G. Do we really need high-sensitivity troponin immunoassays in the emergency department? Maybe not. Clin Chem Lab Med. 2014;52:205-12. https://doi. org/10.1515/cclm-2013-0524
14. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al. Third universal definition of myocardial infarction. Circulation. 2012;126:2020-35. https://doi. org/10.1161/CIR.0b013e31826e1058
15. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37:267-315. https://doi. org/10.1093/eurheartj/ehv320
16. Alvin MD, Jaffe AS, Ziegelstein RC, Trost JC. Eliminating creatine kinase-myocardial band testing in suspected acute coronary syndrome: A value-based quality improvement. JAMA Intern Med. 2017;177:1508-12. https://doi. org/10.1001/jamainternmed.2017.3597
17. Armbruster DA, Pry T. Limit of blank, limit of detection and limit of quantitation. Clin Biochem Rev. 2008;29(Suppl 1):S49-52.
18. Apple FS, Jaffe AS, Collinson P, Mockel M, Ordonez-Llanos J, Lindahl B et al. IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem. 2015;48:201-3. https://doi.org/10.1016/j.clinbiochem.2014.08.021
19. Apple FS. A new season for cardiac troponin assays: it’s time to keep a scorecard. Clin Chem. 2009;55:1303-6. https://doi. org/10.1373/clinchem.2009.128363
20. Galli C, Lippi G. High-sensitivity cardiac troponin testing in routine practice: economic and organizational advantages. Ann Transl Med. 2016;4:257. https://doi.org/10.21037/atm.2016.07.04
21. Boeckel JN, Palapies L, Zeller T, Reis SM, von Jeinsen B, Tzikas S, et al. estimation of values below the limit of detection of a contemporary sensitive troponin I assay improves diagnosis of acute myocardial infarction. Clin Chem. 2015;61:1197-206. https://doi.org/10.1373/clinchem.2015.238949
22. Shah AS, Anand A, Sandoval Y, Lee KK, Smith SW, Adamson PD, et al. High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study. Lancet. 2015;386:2481-8. https://doi. org/10.1016/S0140-6736(15)00391-8
23. Ferencik M, Mayrhofer T, Lu MT, Woodard PK, Truong QA, Peacock WF, et al. High-sensitivity cardiac troponin I as a gatekeeper for coronary computed tomography angiography and stress testing in patients with acute chest pain. Clin Chem. 2017;63:1724-33. https://doi.org/10.1373/clinchem.2017.275552
24. Koerbin G, Tate JR, Hickman PE. Analytical characteristics of the Roche highly sensitive troponin T assay and its application to a cardio-healthy population. Ann Clin Biochem. 2010;47:524-8. https://doi.org/10.1258/acb.2010.010033
25. Saenger AK, Beyrau R, Braun S, Cooray R, Dolci A, Freidank H, et al. Multicenter analytical evaluation of a high-sensitivity troponin T assay. Clin Chim Acta. 2011;412:748-54. https://doi.org/10.1016/j.cca.2010.12.034
26. Lippi G, Ferrari A, Gandini G, Gelati M, Lo Cascio C, Salvagno GL. Analytical evaluation of the new Beckman Coulter Access high sensitivity cardiac troponin I immunoassay. Clin Chem Lab Med. 2017;56:157-61. https://doi.org/10.1515/cclm-2017-0350
27. Payne RC, Halik L, DiPasquale C, Ma J, Zhang H, Zhang J, et al. Performance evaluation of the high sensitivity cardiac troponin I assay on the ADVIA Centaur XP/XPT immunoassay systems. Eur Heart J. 2017;38(Suppl1):597. https://doi. org/10.1093/eurheartj/ehx502.P2754
28. Lippi G, Salvagno GL, Da Rin G, Giavarina D. Harmonization of contemporary-sensitive troponin I immunoassays: calibration may only be a part of the problem. Riv Ital Med Lab. 2014;10:108-14. https://doi.org/10.1007/s13631-014-0053-3
29. García-Osuna A, Alquezar-Arbe A, Duran-Cambra A, Grau-Almiral M, Perez-Calleja R, Enkhbayar U, et al. Cardiac troponin I measured with the Singulex Sgx Clarity™ cTnI assay: A step forward on high analytical sensitivity. Clin Chem. 2017;63(Suppl10):S23.
30. Ambavane A, Lindahl B, Giannitsis E, Roiz J, Mendivil J, Frankenstein L, et al. Economic evaluation of the one-hour rule-out and rule-in algorithm for acute myocardial infarction using the high-sensitivity cardiac troponin T assay in the emergency department. PLoS One. 2017;12:e0187662. https://doi.org/10.1371/journal.pone.0187662
31. Jaeger C, Wildi K, Twerenbold R, Reichlin T, Rubini Gimenez M, Neuhaus JD, et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. Am Heart J. 2016;171:92–102.e1. https://doi. org/10.1016/j.ahj.2015.07.022