Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

The Lancet

Volumn 392, Issue 10157, 2018, Pages 1519-1529

  Hernandez, Adrian F ^a,h   Green, Jennifer B ^a,h   Janmohamed, Salim ^b,h   D'Agostino, Ralph B ^c,h   Granger, Christopher B ^a,h   Jones, Nigel P ^b,h   Leiter, Lawrence A ^d,h   Rosenberg, Anne E ^a,h   Sigmon, Kristina N ^a,h   Somerville, Matthew C ^e,h   Thorpe, Karl M ^b,h   McMurray, John J V ^f,h   Del Prato, Stefano ^g,h   Califf, Robert M ^h   Holman, Rury ^h   DeMets, David ^h   Riddle, Matthew ^h   Goodman, Shaun ^h   McGuire, Darren ^h   Alexander, Karen ^h   Devore, Adam ^h   Melloni, Chiara ^h   Patel, Chetan ^h   Kong, David ^h   Bloomfield, Gerald ^h   Roe, Matthew ^h   Tricoci, Pierluigi ^h   Harrison, Rob ^h   Lopes, Renato ^h   Mathews, Robin ^h   Mehta, Rajendra ^h   Schuyler Jones, William ^h   Vemulapalli, Sreekanth ^h   Povsic, Thomas ^h   Eapen, Zubin ^h   Dombrowski, Keith ^h   Kolls, Brad ^h   Jordan, Dedrick ^h   Ambrosy, Andrew ^h   Greene, Stephen ^h   Mandawat, Aditya ^h   Shavadia, Jay ^h   Cooper, Lauren ^h   Sharma, Abhinav ^h   Guimaraes, Patricia ^h   Friedman, Daniel ^h   Wilson, Matt ^h   Endsley, Patricia ^h   Gentry, Tracy ^h   Collier, Jeannie ^h   Perez, Kathleen ^h   James, Kourtnei ^h   Roush, Jennifer ^h   Pope, Connie ^h   Howell, Christina ^h   Johnson, Megan ^h   Bailey, Matt ^h   Cole, Joanna ^h   Akers, Teresa ^h   Vandyne, Beth ^h   Thomas, Betsy ^h   Rich, Jenny ^h   Bartone, Susan ^h   Beaulieu, Gail ^h   Brown, Kim ^h   Chau, Tuan ^h   Christian, Tamra ^h   Coker, Rebecca ^h   Greene, Deb ^h   Haddock, Trevorlyn ^h   Jenkins, Wendy ^h   Haque, Ghazala ^h   Marquess, Marsha ^h   Pesarchick, Jean ^h   Rethaford, Renee ^h   Stone, Allegra ^h   Al Kawas, Firas ^h   Anderson, Michelle ^h   Enns, Robert ^h   Sinay, Isaac ^h   Mathieu, Chantal ^h   Yordanov, Victor ^h   Hramiak, Irene ^h   Haluzik, Martin ^h   Galatius, Søren ^h   Guerci, Bruno ^h   Nauck, Michael ^h   Migdalis, Ilias ^h   Tan, Choon Beng Kathryn ^h   Kocsis, Gyozo ^h   Giaccari, Andrea ^h   Lee, Moon Kyu ^h   Muñoz, Ernesto German Cardona ^h   Cornel, Jan ^h   Birkeland, Kare ^h   Pinto, Miguel ^h   Tirador, Louie ^h   Olesinska Mader, Martyna ^h   Shestakova, Marina ^h   Distiller, Larry ^h   Lopez Sendon, Jose ^h   Eliasson, Bjorn ^h   Chiang, Chern En ^h   Srimahachota, Suphot ^h   Mankovsky, Boris ^h   Bethel, M Angelyn ^h   Dungan, Kathleen ^h   Kosiborod, Mikhail ^h   Alvarisqueta, Andres ^h   Baldovino, Jorge ^h   Besada, Diego ^h   Calella, Pedro ^h   Cantero, Maria Cecilia ^h   Castaño, Patricia ^h   Chertkoff, Alejandro ^h   Cuadrado, Jesus ^h   De Loredo, Luis ^h   Dominguez, Andrea ^h   Español, Maria Vanesa ^h   Finkelstein, Hernan ^h   Frechtel, Gustavo ^h   Fretes, Jose ^h   Garrido Santos, Natalia ^h   Gonzalez, Joaquin ^h   Litvak, Marcos ^h   Loureyro, Juan ^h   Maffei, Laura ^h   Maldonado, Natacha ^h   Mohr Gasparini, Diego ^h   Orio, Silvia ^h   Perez Manghi, Federico ^h   Rodriguez Papini, Nelson ^h   Sala, Jorgelina ^h   Schygiel, Pablo ^h   Sposetti, Georgina ^h   Ulla, Maria ^h   Verra, Fernando ^h   Zabalua, Silvina ^h   Zaidman, Cesar ^h   Crenier, Laurent ^h   Debroye, Corinne ^h   Duyck, Francis ^h   Scheen, André ^h   Van Gaal, Luc ^h   Vercammen, Chris ^h   Damyanova, Velichka ^h   Dimitrov, Stefan ^h   Kovacheva, Snezhina ^h   Lozanov, Lachezar ^h   Margaritov, Viktor ^h   Mihaylova Shumkova, Rositsa ^h   Nikolaeva, Antoaneta ^h   Stoyanova, Zhasmina ^h   Akhras, Ronald ^h   Beaudry, Yves ^h   Bedard, Jacques ^h   Berlingieri, Joseph ^h   Chehayeb, Raja ^h   Cheung, Stephen ^h   Conway, James ^h   Cusson, Jean ^h   Della Siega, Anthony ^h   Dumas, Richard ^h   Dzongowski, Peter ^h   Ferguson, Murdo ^h   Gaudet, Daniel ^h   Grondin, Francois ^h   Gupta, Anil ^h   Gupta, Milan ^h   Halperin, Frank ^h   Houle, Pierre Alain ^h   Jones, Michael ^h   Kouz, Simon ^h   Kovacs, Christopher ^h   Landry, Daniel ^h   Lonn, Eva ^h   O'Mahony, William ^h   Peterson, Sean ^h   Reich, Dennis ^h   Rosenbloom, Alan ^h   St Maurice, Francois ^h   Tugwell, Barna ^h   Vizel, Saul ^h   Woo, Vincent ^h   Brychta, Tomas ^h   Cech, Vladimir ^h   Dvorakova, Eva ^h   Edelsberger, Tomas ^h   Halciakova, Katarina ^h   Krizova, Jarmila ^h   Lastuvka, Jiri ^h   Piperek, Martin ^h   Prymkova, Vera ^h   Raclavska, Lea ^h   Silhova, Elena ^h   Urbanek, Robin ^h   Vrkoc, Jan ^h   Andersen, Ulla ^h   Brønnum Schou, Jens ^h   Hove, Jens ^h   Jensen, Jan Skov ^h   Kober, Lars ^h   Kristiansen, Ole Peter ^h   Lund, Per ^h   Melchior, Thomas ^h   Nyvad, Ole ^h   Schou, Morten ^h   Boye, Alain ^h   Cadinot, Didier ^h   Gouet, Didier ^h   Henry, Patrick ^h   Kessler, Laurence ^h   Lalau, Jean Daniel ^h   Petit, Catherine ^h   Thuan, Jean Francois ^h   Voinot, Christel ^h   Vouillarmet, Julien ^h   Axthelm, Christoph ^h   Berger, Dirk ^h   Bieler, Tasso ^h   Birkenfeld, Andreas ^h   Bott, Jochen ^h   Busch, Klaus ^h   Caca, Karel ^h   Chevts, Julia ^h   Donaubauer, Torsten ^h   Erlinger, Rudolf ^h   Funke, Klaus ^h   Grosskopf, Josef ^h   Hagenow, Andreas ^h   Hamann, Monika ^h   Hartard, Manfred ^h   Heymer, Peter ^h   Huppertz, Wolfgang ^h   Illies, Gabriele ^h   Jacob, Stephan ^h   Jung, Thomas ^h   Kahrmann, Gerd ^h   Kast, Petra ^h   Kellerer, Monika ^h   Kempe, Hans Peter ^h   Khariouzov, Andrei ^h   Klausmann, Gerhard ^h   Klein, Christiane ^h   Kleinecke Pohl, Uwe ^h   Kleinertz, Klaus ^h   Koch, Thorsten ^h   Kosch, Christine ^h   Lorra, Babette ^h   Luedemann, Joerg ^h   Luttermann, Matthias ^h   Maxeiner, Stephan ^h   Milek, Karsten ^h   Moelle, Andrea ^h   Neumann, Gerhard ^h   Nischik, Ruth ^h   Oehrig Pohl, Edith ^h   Plassmann, Georg ^h   Pohlmeier, Lars ^h   Proepper, Felix ^h   Regner, Stefan ^h   Rieker, Werner ^h   Rose, Ludger ^h   Samer, Holger ^h   Sauter, Joachim ^h   Schaper, Frank ^h   Schiffer, Clemens ^h   Schmidt, Juergen ^h   Scholz, Bernd M ^h   Schulze, Joerg ^h   Segner, Alexander ^h   Seufert, Jochen ^h   Sigal, Helena ^h   Steindorf, Joerg ^h   Stockhausen, Juergen ^h   Stuebler, Petra ^h   Taeschner, Heidrun ^h   Tews, Dietrich ^h   Tschoepe, Diethelm ^h   Wilhelm, Karl ^h   Zeller Stefan, Helga ^h   Avramidis, Iakovos ^h   Bousboulas, Stavros ^h   Bristianou, Magdalini ^h   Dimitriadis, Georgios ^h   Elisaf, Moses ^h   Kotsa, Kalliopi ^h   Melidonis, Andreas ^h   Mitrakou, Asimina ^h   Pagkalos, Emmanouil ^h   Papanas, Nikolaos ^h   Pappas, Angelos ^h   Sampanis, Christos ^h   Tentolouris, Nikolaos ^h   Tsapas, Apostolos ^h   Tzatzagou, Glykeria ^h   Ozaki, Risa ^h   Hajdú, Csaba ^h   Harcsa, Eleonóra ^h   Konyves, Laszlo ^h   Mucsi, János ^h   Pauker, Zsolt ^h   Petró, Gizella ^h   Plés, Zsolt ^h   Revesz, Katalin ^h   Sándor, Vangel ^h   Vass, Viktor ^h   Avogaro, Angelo ^h   Boemi, Massimo ^h   Bonadonna, Riccardo ^h   Consoli, Agostino ^h   De Cosmo, Salvatore ^h   Di Bartolo, Paolo ^h   Dotta, Francesco ^h   Frontoni, Simona ^h   Galetta, Marianna ^h   Gambineri, Alessandra ^h   Gazzaruso, Carmine ^h   Giorgino, Francesco ^h   Lauro, Davide ^h   Orsi, Emanuela ^h   Paolisso, Giuseppe ^h   Perriello, Gabriele ^h   Piatti, Piermarco ^h   Pontiroli, Antonio ^h   Ponzani, Paola ^h   Rivellese, Angela Albarosa ^h   Sesti, Giorgio ^h   Tonolo, Giancarlo ^h   Trevisan, Roberto ^h   Ahn, Chul Woo ^h   Baik, Sei Hyun ^h   Cha, Bong Soo ^h   Chung, Choon Hee ^h   Jang, Hak Chul ^h   Kim, Chong Jin ^h   Kim, Hye Soon ^h   Kim, In Joo ^h   Lee, Eun Young ^h   Lee, Hyoung Woo ^h   Lee, Kwan Woo ^h   Moon, Keon Woong ^h   Namgung, June ^h   Park, Kyong Soo ^h   Yoo, Soon Jib ^h   Yu, Jaemyung ^h   Llamas, Edmundo Alfredo Bayram ^h   Cervantes Escárcega, Jose Luis ^h   Flota Cervera, Luis Fernando ^h   González González, José Gerardo ^h   Pascoe Gonzalez, Sara ^h   Pelayo Orozco, Emilia Susana ^h   Ramirez Diaz, Santiago Paulino ^h   Saldana Mendoza, Arturo ^h   Jerjes Díaz, Carlos Sánchez ^h   Torres Colores, Jose Juan ^h   Vidrio Velázquez, Maricela ^h   Villagordoa Mesa, Juan ^h   Beijerbacht, Hugo Peter ^h   Groutars, Reginald G E J ^h   Hoek, Boudewijn A ^h   Hoogslag, Pieter A M ^h   Kooy, Adriaan ^h   Kragten, Johannes A ^h   Lieverse, Aloysius G ^h   Swart, Hendrik P ^h   Viergever, Eric P ^h   Ahlqvist, Jørn ^h   Cooper, John ^h   Gulseth, Hanne ^h   Guttormsen, Gaute ^h   Wium, Cecilie ^h   Arbañil, Hugo ^h   Calderon, Jorge ^h   Camacho, Luis ^h   Espinoza, Augusto Dextre ^h   Garrido, Elizabeth ^h   Luna, Alejandro ^h   Manrique, Helard ^h   Revoredo, Frederick Massucco ^h   Gonzales, Rolando Vargas ^h   Rincon, Luis Zapata ^h   Zubiate, Carlos ^h   Ebo, Geraldine ^h   Morales Palomares, Ellen ^h   Arciszewska, Malgorzata ^h   Banach, Marek ^h   Bijata Bronisz, Renata ^h   Derezinski, Tadeusz ^h   Gadzinski, Waldemar ^h   Gajek, Jacek ^h   Klodawska, Katarzyna ^h   Krzyzagorska, Ewa ^h   Madej, Andrzej ^h   Miekus, Pawel ^h   Opiela, Jaroslaw ^h   Romanczuk, Piotr ^h   Siegel, Anna ^h   Skokowska, Ewa ^h   Stankiewicz, Andrzej ^h   Stasinska, Teresa ^h   Trznadel Morawska, Iwona ^h   Witek, Robert ^h   Aksentyev, Sergey ^h   Bondar, Irina ^h   Demidova, Irina ^h   Dreval, Alexander ^h   Ershova, Olga ^h   Galstyan, Gagik ^h   Garganeeva, Alla ^h   Izmozherova, Nadezhda ^h   Karetnikova, Victoria ^h   Kharakhulakh, Marina ^h   Khokhlov, Aleksandr ^h   Kobalava, Zhanna ^h   Koshelskaya, Olga ^h   Kosmacheva, Elena ^h   Kostin, Vladimir ^h   Koziolova, Natalia ^h   Kuzin, Anatoly ^h   Lesnov, Victor ^h   Lysenko, Tatyana ^h   Markov, Valentin ^h   Mayorov, Alexander ^h   Moiseev, Sergey ^h   Myasoedova, Svetlana ^h   Petunina, Nina ^h   Rebrov, Andrey ^h   Ruyatkina, Ludmila ^h   Samoylova, Julia ^h   Sazonova, Olga ^h   Shilkina, Natalia ^h   Sokolova, Nadezhda ^h   Vasilevskaya, Olga ^h   Verbovaya, Nelli ^h   Vishneva, Elena ^h   Vorobyev, Sergey ^h   Vorokhobina, Natalya ^h   Zanozina, Olga ^h   Zhdanova, Elena ^h   Zykova, Tatyana ^h   Burgess, Lesley ^h   Coetzee, Kathleen ^h   Dawood, Saleem ^h   Lombard, Landman ^h   Makotoko, Ellen ^h   Moodley, Rajendran ^h   Oosthuysen, Wessels ^h   Sarvan, Mohamed ^h   Calvo Gómez, Carlos ^h   Cano Rodríguez, Isidoro ^h   Castro Conde, Almudena ^h   Cequier Fillat, Angel ^h   Cuatrecasas Cambra, Guillem ^h   de Álvaro Moreno, Fernando ^h   De Teresa Parreño, Luis ^h   Delgado Lista, Javier ^h   Domínguez Escribano, José Ramón ^h   Durán García, Santiago ^h   Elvira González, Javier ^h   Fernández Rodríguez, José María ^h   Goday Arno, Alberto ^h   Gomez Huelgas, Ricardo ^h   González Juanatey, José Ramón ^h   Hernandez Mijares, Antonio ^h   Jiménez Díaz, Víctor Alfonso ^h   Jodar Gimeno, Esteban ^h   Lucas Morante, Tomás ^h   Marazuela, Monica ^h   Martell Claros, Nieves ^h   Mauricio Puente, Didac ^h   Mena Ribas, Elena ^h   Merino Torres, Juan Francisco ^h   Mezquita Raya, Pedro ^h   Nubiola Calonge, Andreu ^h   Ordoñez Sánchez, Xavier ^h   Pascual Izuel, Jose Maria ^h   Perea Castilla, Verónica ^h   Pérez Pérez, Antonio ^h   Perez Soto, Isabel ^h   Quesada Charneco, Miguel ^h   Quesada Simón, Angustias ^h   Redón Mas, Josep ^h   Rego Iraeta, Antonia ^h   Rodriguez Alvarez, Maria ^h   Rodríguez Rodríguez, Irene ^h   Sabán Ruiz, José ^h   Soto González, Alfonso ^h   Tinahones Madueno, Francisco ^h   Trescoli Serrano, Carlos ^h   Ulied Armiñana, Angels ^h   Bachus, Erasmus ^h   Berndtsson Blom, Katarina ^h   Eliasson, Ken ^h   Koskinen, Pekka ^h   Larnefeldt, Hans ^h   Lif Tiberg, Cornelia ^h   Linderfalk, Carina ^h   Lund, Gustav ^h   Lundman, Pia ^h   Moris, Linda ^h   Olsson, Åke ^h   Salmonsson, Staffan ^h   Sanmartin Berglund, Johan ^h   Sjöberg, Folke ^h   Söderberg, Stefan ^h   Torstensson, Ingemar ^h   Chen, Jung Fu ^h   Tien, Kai Jen ^h   Tseng, Shih Ting ^h   Tu, Shih Te ^h   Wang, Chih Yuan ^h   Wang, Ji Hung ^h   Phrommintikul, Arintaya ^h   Yamwong, Sukit ^h   Jintapakorn, Woravut ^h   Hutayanon, Pisit ^h   Sansanayudh, Nakarin ^h   Bazhan, Larysa ^h   Fushtey, Ivan ^h   Grachova, Mariya ^h   Katerenchuk, Vitaliy ^h   Korpachev, Vadym ^h   Kravchun, Nonna ^h   Larin, Oleksandr ^h   Mykhalchyshyn, Galyna ^h   Myshanych, Halyna ^h   Oleksyk, Olga ^h   Orlenko, Valeriia ^h   Pashkovska, Nataliia ^h   Pertseva, Nataliia ^h   Petrosyan, Olena ^h   Smirnov, Ivan ^h   Vlasenko, Maryna ^h   Zlova, Tetiana ^h   Aye, Myint ^h   Baksi, Arun ^h   Balasubramani, Mathangi ^h   Beboso, Ronnie ^h   Blagden, Mark ^h   Bundy, Charles ^h   Cookson, Tobias ^h   Copland, Allan ^h   Emslie Smith, Alistair ^h   Green, Fiona ^h   Gunstone, Anthony ^h   Issa, Basil ^h   Jackson Voyzey, Ewart ^h   Johnson, Andrew ^h   Maclean, Malcolm ^h   McKnight, John ^h   Muzulu, Solomon ^h   O'Connell, Ian ^h   Oyesile, Babatunde ^h   Patterson, Catherine ^h   Pearson, Ewan ^h   Philip, Sam ^h   Smith, Paul ^h   Sukumaran, Usha ^h   Abbas, Jalal ^h   Aggarwala, Gaurav ^h   Akhter, Faiq ^h   Andersen, James ^h   Anglade, Moise ^h   Argoud, Georges ^h   Ariani, Mehrdad ^h   Ashdji, Reswan ^h   Bakhtari, Ladan ^h   Banerjee, Subhash ^h   Bartlett, Andrew ^h   Baum, Howard ^h   Bays, Harold ^h   Beasley, Richard ^h   Belfort de Aguiar, Renata ^h   Benjamin, Sabrina ^h   Bhagwat, Ravi ^h   Bhargava, Anuj ^h   Bode, Bruce ^h   Bratcher, Christina ^h   Briskin, Toby ^h   Brockmyre, Andrew ^h   Broughton, Raymond ^h   Brown, Judith ^h   Budhraja, Madhusudan ^h   Cannon, Kevin ^h   Carr, Jewell ^h   Cathcart, Harold ^h   Cavale, Arvind ^h   Chaykin, Louis ^h   Cheung, Deanna ^h   Childress, Richard ^h   Cohen, Allan ^h   Condit, Jonathan ^h   Cooksey, Erin ^h   Cornett, George Mitchell ^h   Dauber, Ira ^h   Davila, William ^h   De Armas, Luis ^h   Dean, Julius ^h   Detweiler, Robert ^h   Diaz, Ernesto ^h   Di Giovanna, Michael ^h   Dor, Isaac ^h   Drummond, Waymon ^h   Eagerton, Donald ^h   Earl, John ^h   Eaton, Charles ^h   Ellison, Howard ^h   Farris, Neil ^h   Fiel, Thomas ^h   Firek, Anthony ^h   First, Brian ^h   Forgosh, Les ^h   French, William ^h   Gandy, Winston ^h   Garcia, Ronald ^h   Gill, Santosh ^h   Gordon, Murray ^h   Guice, Michael ^h   Gummadi, Siva ^h   Hackenyos, Jonathan ^h   Hairston, Kristen ^h   Hanson, Lenita ^h   Harrison, Lindsay ^h   Hartman, Israel ^h   Heitner, John ^h   Hejeebu, Srini ^h   Hermany, Paul ^h   Hernandez Cassis, Carlos ^h   Hidalgo, Horacio ^h   Higgins, Alexander ^h   Ibrahim, Hassan ^h   Jacobs, Shahram ^h   Johnson, David ^h   Joshi, Parag ^h   Kaster, Steven ^h   Kellum, Daniel ^h   Kim, Christopher ^h   Kim, Ellen ^h   Kirby, William ^h   Knouse, Albert ^h   Kulback, Steven ^h   Kumar, Mariananda ^h   Kuruvanka, Tulsidas ^h   Labroo, Ajay ^h   Lasswell, William ^h   Lentz, John ^h   Lenzmeier, Thomas ^h   Lewis, David ^h   Li, Zhaoping ^h   Lillestol, Michael ^h   Little, Raymond ^h   Lorraine, Richard ^h   McKeown Biagas, Cecilia ^h   McNeill, Robert ^h   Mehta, Anand ^h   Miller, Alan ^h   Moran, Joseph ^h   Morawski, Emily ^h   Nadar, Venkatesh ^h   O'Connor, Thomas ^h   Odio, Alberto ^h   Parker, Reginald ^h   Patel, Rajesh ^h   Phillips, Lawrence ^h   Raad, George ^h   Rahman, Aref ^h   Raikhel, Marina ^h   Raisinghani, Ajit ^h   Rajan, Raj ^h   Rasouli, Neda ^h   Rauzi, Frank ^h   Rohr, Kathryn ^h   Roseman, Hal ^h   Rovner, Sergio ^h   Saba, Fadi ^h   Sachson, Richard ^h   Schabauer, Alex ^h   Schneider, Ricky ^h   Schuchard, Timothy ^h   Sensenbrenner, John ^h   Shlesinger, Yshay ^h   Singh, Narendra ^h   Sivalingam, Kanagaratnam ^h   Stonesifer, Larry ^h   Storey, Daniel ^h   Suh, David ^h   Tahir, Mohammed ^h   Tan, Anjanette ^h   Tan, Marilyn ^h   Taylon, Alain ^h   Thakkar, Maitreya ^h   Tripathy, Devjit ^h   Uwaifo, Gabriel ^h   Vedere, Amarnath ^h   Venugopal, Chandra ^h   Vo, Anthony ^h   Welch, Michelle ^h   Welker, James ^h   White, Alexander ^h   Willis, John ^h   Wynne, Alan ^h   Yazdani, Shahram ^h   Price, Lauren ^h   Lokhngina, Yuliya ^h   Xing, Weibing ^h   Overton, Robert ^h   Stewart, Murray ^h   Stead, Janet ^h   Lindsay, Alistair ^h   Patel, Vickas ^h   Ross, Jorge ^h   Soffer, Joseph ^h   Daga, Shruti ^h   Sowell, Margaret ^h   Patel, Prashant ^h   Garvey, Louisa ^h   Ackert, Jessica ^h   Abraham, Sybil ^h   Sabol, Mary Beth ^h   Altobelli, Desma ^h   Ha, JuYoung ^h   Kulkarni, Mangesh ^h   Noronha, Drusilla ^h   Casson, Ed ^h   Zang, Eddie ^h   Sandhu, Chamandeep ^h   Kumar, Rakesh ^h   Chen, David ^h   Taft, Lin ^h   Patel, Rajivkumar ^h   Ye, June ^h   Shannon, Jennifer ^h   Wilson, Tim ^h   Babi, Charleen ^h   Miller, Diane ^h   Russell, Rachael ^h   Bull, Georgina ^h   Hereghty, Belinda ^h   Fernandez Salazar, Eva ^h   Longley, Troy ^h   Donaldson, Jill ^h   Jarosz, Marie ^h   Murphy, Karen ^h   Adams, Patricia ^h   Smith, Peter ^h   James, Rachel ^h   Richards, Jackie ^h   Sedani, Sangeeta ^h   Althouse, Denise ^h   Watson, David ^h   Lorimer, Jamie ^h   Lauder, Steven ^h   Schultheis, Ron ^h   Womer, Terese ^h   Wraight, Ella ^h   Li, Wenyan ^h   Price Olsen, Emma ^h   Watson, Anthony ^h   Kelly, Aoife ^h   McLaughlin, Patricia ^h   Fleming, John ^h   Schubert, Jessica ^h   Schleiden, Debra ^h   Harris, Tara ^h   Prakash, Rahul ^h   Breneman, Jody ^h   Deshpande, Sameer ^h   Saswadkar, Aarti ^h   Kumari, Aditi ^h   Shitut, Aditi ^h   Raorane, Amruta ^h   Karmalkar, Anisha ^h   Mhambrey, Ankita ^h   Bhosale, Archana ^h   Vaphare, Ashok ^h   Patil, Ashwini P ^h   Khandelwal, Chaitali ^h   Shaik, Fayaz ^h   Nadar, Madhumitha ^h   Karka, Mounika ^h   Kadgaonkar, Neha ^h   Gupta, Nikita ^h   Aher, Nutan ^h   Potnis, Omkar ^h   Naicker, Pallavi ^h   Shinde, Rakesh ^h   Sharma, Richa ^h   Godse, Rupali ^h   Solanki, Sheetal ^h   Sahu, Shruti ^h   Dumbre, Snehal ^h   Kumar, Somesh ^h   Patil, Suradnya ^h   Mandal, Trisha ^h   more..

^a DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Boston University   (United States)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e PAREXEL INTERNATIONAL   (United States)

^f UNIVERSITY OF GLASGOW   (United Kingdom)

^g UNIVERSITY OF PISA   (Italy)

^h NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBIGLUTIDE; BILIRUBIN; PLACEBO; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1; RGLP-1 PROTEIN;

ADULT; ADVERSE EVENT; APPENDICITIS; ARTICLE; ATRIAL FIBRILLATION; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETIC RETINOPATHY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; GASTROINTESTINAL DISEASE; HEART ATRIUM FLUTTER; HEART DEATH; HEART INFARCTION; HEMATOLOGIC DISEASE; HEMATOLOGICAL NEOPLASIA; HEPATOBILIARY DISEASE; HUMAN; HYPERGLYCEMIA; HYPERSENSITIVITY; INCIDENCE; INJECTION SITE REACTION; INTENTION TO TREAT ANALYSIS; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PANCREAS CANCER; PANCREATITIS; PATIENT ASSESSMENT; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; THYROID MEDULLARY CARCINOMA; AGED; ANALOGS AND DERIVATIVES; CLINICAL TRIAL; COMPLICATION; DRUG ADMINISTRATION; KAPLAN MEIER METHOD; MIDDLE AGED; MULTICENTER STUDY; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADULT; AGED; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; STROKE; TREATMENT OUTCOME;

EID: 85055101508     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(18)32261-X     Document Type: Article

References (23)

1. Rawshani, A, Rawshani, A, Franzén, S, et al. Mortality and cardiovascular disease in type 1 and type 2 diabetes. N Engl J Med 376 (2017), 1407–1418.
2. Rao Kondapally Seshasai, S, Kaptoge, S, Thompson, A, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364 (2011), 829–841.
3. Zinman, B, Wanner, C, Lachin, JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373 (2015), 2117–2128.
4. Neal, B, Perkovic, V, Mahaffey, KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377 (2017), 644–657.
5. Marso, SP, Daniels, GH, Brown-Frandsen, K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375 (2016), 311–322.
6. Marso, SP, Bain, SC, Consoli, A, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 375 (2016), 1834–1844.
7. Pfeffer, MA, Claggett, B, Diaz, R, et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373 (2015), 2247–2257.
8. Holman, RR, Bethel, MA, Mentz, RJ, et al. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med 377 (2017), 1228–1239.
9. Tahrani, AA, Barnett, AH, Bailey, CJ, Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat Rev Endocrinol 12 (2016), 566–592.
10. Fisher, M, Petrie, MC, Ambery, PD, Donaldson, J, Ye, J, McMurray, JJ, Cardiovascular safety of albiglutide in the Harmony programme: a meta-analysis. Lancet Diabetes Endocrinol 3 (2015), 697–703.
11. Green, JB, Hernandez, AF, D'Agostino, RB, et al. Harmony Outcomes: a randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus—rationale, design, and baseline characteristics. Am Heart J 203 (2018), 30–38.
12. Dmitrienko, A, D'Agostino, RB Sr, Multiplicity considerations in clinical trials. N Engl J Med 378 (2018), 2115–2122.
13. US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for industry: diabetes mellitus—evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM071627.pdf, December, 2008. (Accessed 22 September 2018)
14. Mauri, L, D'Agostino, RB Sr, Noninferiority trials. N Engl J Med 378 (2018), 304–305.
15. Cox, DR, Regression models and life tables. J Royal Stat Soc 34 (1972), 187–220.
16. Boyle, JG, Livingstone, R, Petrie, JR, Cardiovascular benefits of GLP-1 agonists in type 2 diabetes: a comparative review. Clin Sci 132 (2018), 1699–1709.
17. Bethel, MA, Patel, RA, Merrill, P, et al. Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis. Lancet Diabetes Endocrinol 6 (2018), 105–113.
18. McMurray, JJ, Gerstein, HC, Holman, RR, Pfeffer, MA, Heart failure: a cardiovascular outcome in diabetes that can no longer be ignored. Lancet Diabetes Endocrinol 2 (2014), 843–851.
19. Rizzo, M, Nikolic, D, Patti, AM, et al. GLP-1 receptor agonists and reduction of cardiometabolic risk: potential underlying mechanisms. Biochim Biophys Acta 1864 (2018), 2814–2821.
20. Vilsbøll, T, Bain, SC, Leiter, LA, et al. Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy. Diabetes Obes Metab 20 (2018), 889–897.
21. Leiter, LA, Nauck, MA, Efficacy and safety of GLP-1 receptor agonists across the spectrum of type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 125 (2017), 419–435.
22. Abdul-Ghani, M, DeFronzo, RA, Del Prato, S, Chilton, R, Singh, R, Ryder, REJ, Cardiovascular disease and type 2 diabetes: has the dawn of a new era arrived?. Diabetes Care 40 (2017), 813–820.
23. Lingvay, I, Leiter, LA, Use of GLP-1 RAs in cardiovascular disease prevention: a practical guide. Circulation 137 (2018), 2200–2202.