High incidence of symptomatic hyperammonemia in children with acute lymphoblastic leukemia receiving pegylated asparaginase

JIMD Reports

Volumn 7, Issue , 2013, Pages 103-108

  Heitink Pollé, Katja M J ^a   Prinsen, Berthil H C M T ^a   de Koning, Tom J ^a   van Hasselt, Peter M ^a   Bierings, Marc B ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Acute lymphoblastic leukemia; Ammonia concentration; Orotic acid; Plasma amino acid; Urea cycle

Indexed keywords

EID: 85055051620     PISSN: 21928304     EISSN: 21928312     Source Type: Book Series    
DOI: 10.1007/8904_2012_156     Document Type: Chapter

References (13)

1. Alvarez OA, Zimmerman G (2000) Pegaspargase-induced pancreati-tis. Med Pediatr Oncol 34:200–205
2. Asselin BL, Whitin JC, Coppola DJ, Rupp IP, Sallan SE, Cohen HJ (1993) Comparative pharmacokinetic studies of three asparaginase preparations. J Clin Oncol 11:1780–1786
3. Cohn RM, Roth KS (2004) Hyperammonemia, bane of the brain. Clin Pediatr (Phila) 43:683–689
4. Earl M (2009) Incidence and management of asparaginase-associated adverse events in patients with acute lymphoblastic leukemia. Clin Adv Hematol Oncol 7:600–606
5. Jorck C, Kiess W, Weigel JF, Mutze U, Bierbach U, Beblo S (2011) Transient hyperammonemia due to L-asparaginase therapy in children with acute lymphoblastic leukemia or non-Hodgkin lymphoma. Pediatr Hematol Oncol 28:3–9
6. Kamps WA, van der Pal-de Bruin KM, Veerman AJ, Fiocco M, Bierings M, Pieters R (2010) Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004. Leukemia 24:309–319
7. Laterza OF, Gerhardt G, Sokoll LJ (2003) Measurement of plasma ammonia is affected in patients receiving asparaginase therapy. Clin Chem 49:1710–1711
8. Leonard JV, Kay JD (1986) Acute encephalopathy and hyperammo-naemia complicating treatment of acute lymphoblastic leukaemia with asparaginase. Lancet 1:162–163
9. Lockwood AH, McDonald JM, Reiman RE, Gelbard AS, Laughlin JS, Duffy TE, Plum F (1979) The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. J Clin Invest 63:449–460
10. Muller HJ, Boos J (1998) Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol 28:97–113
11. Prager MD, Bachynsky N (1968) Asparagine synthetase in normal and malignant tissues: correlation with tumor sensitivity to asparaginase. Arch Biochem Biophys 127:645–654
12. Rytting M (2010) Peg-asparaginase for acute lymphoblastic leukemia. Expert Opin Biol Ther 10:833–839
13. Steiner M, Attarbaschi A, Kastner U, Dworzak M, Haas OA, Gadner H, Mann G (2007) Distinct fluctuations of ammonia levels during asparaginase therapy for childhood acute leukemia. Pediatr Blood Cancer 49:640–642