Prevalence of pain in patients with breast cancer post-treatment: A systematic review

Breast

Volumn 42, Issue , 2018, Pages 113-127

  Wang, Katie ^a   Yee, Caitlin ^a   Tam, Samantha ^a   Drost, Leah ^a   Chan, Stephanie ^a   Zaki, Pearl ^a   Rico, Victoria ^a   Ariello, Krista ^a   Dasios, Mark ^a   Lam, Henry ^a   DeAngelis, Carlo ^a   Chow, Edward ^a  

^a DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

Author keywords

Breast cancer; Oncology; Pain; Pain management; Radiotherapy; Surgery

Indexed keywords

FLURBIPROFEN; LIDOCAINE; LIDOCAINE PLUS PRILOCAINE; NEFOPAM; PROPOFOL; ROPIVACAINE;

BREAST CANCER; BREAST SURGERY; CANCER PAIN; CANCER RADIOTHERAPY; CANCER SURVIVOR; CHRONIC POST SURGICAL PAIN; DISEASE SEVERITY; HUMAN; INCIDENCE; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PATIENT CARE; PERSISTENT PAIN AFTER BREAST CANCER TREATMENT; PERSISTENT POST SURGICAL PAIN; POST MASTECTOMY PAIN SYNDROME; POSTOPERATIVE PAIN; PREVALENCE; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; BREAST TUMOR; CHRONIC PAIN; FEMALE; MASTECTOMY; NEURALGIA; PSYCHOLOGY; QUALITY OF LIFE;

BREAST NEOPLASMS; CHRONIC PAIN; FEMALE; HUMANS; MASTECTOMY; NEURALGIA; PAIN, POSTOPERATIVE; QUALITY OF LIFE;

EID: 85054607206     PISSN: 09609776     EISSN: 15323080     Source Type: Journal    
DOI: 10.1016/j.breast.2018.08.105     Document Type: Review

References (193)

1. Juhl, A.A., Christiansen, P., Damsgaard, T.E., Persistent pain after breast cancer treatment: a questionnaire-based study on the prevalence, associated treatment variables, and pain type. J Breast Can, 19(4), 2016, 447 https://doi.org/10.4048/jbc.2016.19.4.447.
2. Andersen, K.G., Kehlet, H., Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention. J Pain 12:7 (2011), 725–746 https://doi.org/10.1016/j.jpain.2010.12.005.
3. Wang, L., Guyatt, G.H., Kennedy, S.A., et al. Predictors of persistent pain after breast cancer surgery: a systematic review and meta-analysis of observational studies. Can Med Assoc J 11:14 (2016;July), 1–10 https://doi.org/10.1503/cmaj.151276/-/DC1.
4. Gartner, R., Jensen, M.-B., Nielsen, J., Ewertz, M., Kroman, N., Kehlet, H., Prevalence of and factors associated with persistent pain following breast cancer surgery. J Am Med Assoc 302:18 (2009), 1985–1992 https://doi.org/10.1001/jama.2009.1568.
5. Lancaster, R.B., Balkin, D., Esserman, L., Post mastectomy pain syndrome management. Curr Surg Rep, 4(1), 2016, 6 https://doi.org/10.1007/s40137-016-0133-6.
6. Rietman, J.S., Dijkstra, P.U., Hoekstra, H.J., et al. Late morbidity after treatment of breast cancer in relation to daily activities and quality of life: a systematic review. Eur J Surg Oncol 29:3 (2003), 229–238, 10.1053/ejso.2002.1403.
7. Ryan, J.L., Ionizing radiation: the good, the bad, and the ugly. J Invest Dermatol 132:3 PART 2 (2012), 985–993, 10.1038/jid.2011.411.
8. Cooney, M.A., Culleton-Quinn, E., Stokes, E., Current knowledge of pain after breast cancer treatment: a systematic review. Pain Manag Nurs 14:2 (2013), 110–123, 10.1016/j.pmn.2010.09.002.
9. Leysen, L., Beckwée, D., Nijs, J., et al. Risk factors of pain in breast cancer survivors: a systematic review and meta-analysis. Support Care Canc 25:12 (2017), 3607–3643, 10.1007/s00520-017-3824-3.
10. Armer, J.M., Hulett, J.M., Bernas, M., Ostby, P., Stewart, B.R., Cormier, J.N., Best-practice guidelines in assessment, risk reduction, management, and surveillance for post-breast cancer lymphedema. Curr Breast Canc Rep 5:2 (2013), 134–144, 10.1007/s12609-013-0105-0.
11. Ilhan, E., Chee, E., Hush, J., Moloney, N., The prevalence of neuropathic pain is high after treatment for breast cancer. Pain 158:11 (2017), 2082–2091, 10.1097/j.pain.0000000000001004.
12. Hidding, J.T., Beurskens, C.H.G., van der Wees, P.J., van Laarhoven, H.W.M., Nijhuis-van der Sanden MWG. Treatment Related Impairments in Arm and Shoulder in Patients with Breast Cancer: a Systematic Review. PLoS One, 9(5), 2014, e96748, 10.1371/journal.pone.0096748.
13. Smith, H.S., Wu, S., Persistent pain after breast cancer treatment. Ann Palliat Med 1:3 (2012), 182–194, 10.3978/j.issn.2224-5820.2012.10.13.
14. Serlin, R.C., Mendoza, T.R., Nakamura, Y., Edwards, K.R., Cleeland, C.S., When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain 61 (1995), 277–284.
15. Ajkay, N., Collett, A.E., Bloomquist, E.V., Gracely, E.J., Frazier, T.G., Barrio, A.V., A comparison of complication rates in early-stage breast cancer patients treated with brachytherapy versus whole-breast irradiation. Ann Surg Oncol 22:4 (2015), 1140–1145, 10.1245/s10434-014-4131-6.
16. Bourgier, C., Acevedo-Henao, C., Dunant, A., et al. Higher toxicity with 42 Gy in 10 fractions as a total dose for 3D-conformal accelerated partial breast irradiation: results from a dose escalation phase II trial. Radiat Oncol 7:1 (2012), 1–8, 10.1186/1748-717X-7-141.
17. Fehlauer, F., Tribius, S., Alberti, W., Rades, D., Late effects and cosmetic results of conventional versus hypofractionated irradiation in breast-conserving therapy. Strahlenther Onkol 181:10 (2005), 625–631, 10.1007/s00066-005-1404-9.
18. Sperk, E., Welzel, G., Keller, A., et al. Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A. Breast Canc Res Treat 135:1 (2012), 253–260, 10.1007/s10549-012-2168-4.
19. Polgár, C., Ott, O.J., Hildebrandt, G., et al. Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year results. Lancet Oncol 18:2 (2017), 259–268, 10.1016/S1470-2045(17)30011-6.
20. Fekete, G., Újhidy, D., Együd, Z., et al. Partial breast radiotherapy with simple teletherapy techniques. Med Dosim 40:4 (2015), 290–295, 10.1016/j.meddos.2015.03.006.
21. Ko, E.C., Koprowski, C.D., Dickson-Witmer, D., et al. Partial vs. whole breast irradiation in a community hospital: a retrospective cohort analysis of 200 patients. Brachytherapy 9:3 (2010), 248–253, 10.1016/j.brachy.2009.12.002.
22. Pignol, J.P., Truong, P., Rakovitch, E., Sattler, M.G., Whelan, T.J., Olivotto, I.A., Ten years results of the Canadian breast intensity modulated radiation therapy (IMRT) randomized controlled trial. Radiother Oncol 121:3 (2016), 414–419, 10.1016/j.radonc.2016.08.021.
23. Hopwood, P., Haviland, J.S., Sumo, G., Mills, J., Bliss, J.M., Yarnold, J.R., Comparison of patient-reported breast, arm, and shoulder symptoms and body image after radiotherapy for early breast cancer: 5-year follow-up in the randomised Standardisation of Breast Radiotherapy (START) trials. Lancet Oncol 11:3 (2010), 231–240, 10.1016/S1470-2045(09)70382-1.
24. Janssen, S., Glanzmann, C., Lang, S., et al. Hypofractionated radiotherapy for breast cancer acceleration of the START A treatment regime: intermediate tolerance and efficacy. Radiat Oncol 9:1 (2014), 1–6, 10.1186/1748-717X-9-165.
25. Fathers, E., Thrush, D., Huson, S.M., Norman, A., Radiation-induced brachial plexopathy in women treated for carcinoma of the breast. Clin Rehabil 16:2 (2002), 160–165, 10.1191/0269215502cr470oa.
26. Sayan, M., Wilson, K., Nelson, C., Rubin, D.Z., Heimann, R., A novel schedule of accelerated partial breast radiation using intensity modulated radiation therapy in elderly patients: survival and toxicity analysis of a prospective clinical trial. Int J Radiat Oncol, 96(2), 2016, E34, 10.1016/j.ijrobp.2016.06.678.
27. Gatti, M., Ponzone, R., Bresciani, S., et al. Accelerated partial breast irradiation using 3D conformal radiotherapy: toxicity and cosmetic outcome. Breast 22:6 (2013), 1136–1141, 10.1016/j.breast.2013.07.042.
28. Mózsa, E., Mészáros, N., Major, T., et al. Accelerated partial breast irradiation with external beam three-dimensional conformal radiotherapy. Strahlenther Onkol 190:5 (2014), 444–450, 10.1007/s00066-014-0633-1.
29. Chen, P.Y., Wallace, M., Mitchell, C., et al. Four-year efficacy, cosmesis, and toxicity using three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 76:4 (2010), 991–997, 10.1016/j.ijrobp.2009.03.012.
30. Eldeeb, H., Awad, I., Elhanafy, O., Hypofractionation in post-mastectomy breast cancer patients: seven-year follow-up. Med Oncol 29 (2012), 2570–2576, 10.1007/s12032-012-0192-1.
31. Azoury, F., Heymann, S., Acevedo, C., et al. Phase II trial of 3D-conformal accelerated partial breast irradiation: lessons learned from patients and physicians’ evaluation. Radiother Oncol 103:2 (2012), 193–198, 10.1016/j.radonc.2012.03.019.
32. De Rose, F., Fogliata, A., Franceschini, D., et al. Phase II trial of hypofractionated VMAT-based treatment for early stage breast cancer: 2-year toxicity and clinical results. Radiat Oncol 11:1 (2016), 1–9, 10.1186/s13014-016-0701-z.
33. Shaitelman, S.F., Kim, L.H., Grills, I.S., et al. Predictors of long-term toxicity using three-dimensional conformal external beam radiotherapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 81:3 (2011), 788–794, 10.1016/j.ijrobp.2010.06.062.
34. Rahimi, A., Thomas, K., Spangler, A., et al. Preliminary results of a phase 1 dose-escalation trial for early-stage breast cancer using 5-fraction stereotactic body radiation therapy for partial-breast irradiation. Int J Radiat Oncol Biol Phys 98:1 (2017), 196–205, 10.1016/j.ijrobp.2017.01.020 e2.
35. Formenti, S.C., Hsu, H., Fenton-Kerimian, M., et al. Prone accelerated partial breast irradiation after breast-conserving surgery: five-year results of 100 patients. Int J Radiat Oncol Biol Phys 84:3 (2012), 606–611, 10.1016/j.ijrobp.2012.01.039.
36. Bergom, C., Kelly, T., Morrow, N., et al. Prone whole-breast irradiation using three-dimensional conformal radiotherapy in women undergoing breast conservation for early disease yields high rates of excellent to good cosmetic outcomes in patients with large and/or pendulous breasts. Int J Radiat Oncol Biol Phys 83:3 (2012), 821–828, 10.1016/j.ijrobp.2011.08.020.
37. Bronsart, E., Dureau, S., Xu, H.P., et al. Whole breast radiotherapy in the lateral isocentric lateral decubitus position: long-term efficacy and toxicity results. Radiother Oncol 124:2 (2017), 214–219, 10.1016/j.radonc.2017.07.001.
38. Peintinger, F., Reitsamer, R., Stranzl, H., Ralph, G., Comparison of quality of life and arm complaints after axillary lymph node dissection vs sentinel lymph node biopsy in breast cancer patients. Br J Canc, 2003, 10.1038/sj.bjc.6601150.
39. Welzel, G., Hofmann, F., Blank, E., et al. Health-related quality of life after breast-conserving surgery and intraoperative radiotherapy for breast cancer using low-kilovoltage x-rays. Ann Surg Oncol 17:SUPPL. 3 (2010), 19–22, 10.1245/s10434-010-1257-z.
40. Whelan, T., Levine, M., Julian, J., Kirkbride, P., Skingley, P., The effects of radiation therapy on quality of life of women with breast carcinoma: results of a randomized trial. Ontario Clinical Oncology Group. Cancer 88:10 (2000), 2260–2266, 10.1002/%28SICI%291097-0142%2820000515%2988:10%3C2260::AID-CNCR9%3E3.0.CO.
41. Rim, C.H., Ahn, S.-J., Kim, J.H., et al. An assessment of quality of life for early phase after adjuvant radiotherapy in breast cancer survivors: a Korean multicenter survey (KROG 14–09). Health Qual Life Outcome, 15(1), 2017, 96, 10.1186/s12955-017-0673-1.
42. Stanton, A., Krishnan, L., Collins, C., Form or function? Par 1. Subjective cosmetic and function correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy. Cancer 91:12 (2001), 2273–2281.
43. Heneghan, H.M., Prichard, R.S., Lyons, R., et al. Quality of life after immediate breast reconstruction and skin-sparing mastectomy - a comparison with patients undergoing breast conserving surgery. Eur J Surg Oncol 37:11 (2011), 937–943, 10.1016/j.ejso.2011.08.126.
44. Nesvold, I.-L., Reinertsen, K.V., Fosså S.D., Dahl, A.A., The relation between arm/shoulder problems and quality of life in breast cancer survivors: a cross-sectional and longitudinal study. J Canc Surviv 5:1 (2011), 62–72, 10.1007/s11764-010-0156-4.
45. ® technique in treating radiation-induced skin fibrosis: clinical and profilometric analysis. Skin Res Technol 14:1 (2008), 71–76, 10.1111/j.1600-0846.2007.00263.x.
46. Kim, M.H., Lee, K.Y., Park, S., Kim, S Il, Park, H.S., Yoo, Y.C., Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: a prospective, randomized, double-blind, comparative clinical trial. PLoS One 12:3 (2017), 1–13, 10.1371/journal.pone.0173026.
47. Fassoulaki, A., Triga, A., Melemeni, A., Sarantopoulos, C., Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg 101:5 (2005), 1427–1432, 10.1213/01.ANE.0000180200.11626.8E.
48. Ilfeld, B.M., Madison, S.J., Suresh, P.J., et al. Persistent postmastectomy pain and pain-related physical and emotional functioning with and without a continuous paravertebral nerve block: a prospective 1-year follow-up assessment of a randomized, triple-masked, placebo-controlled study. Ann Surg Oncol 22:6 (2015), 2017–2025, 10.1245/s10434-014-4248-7.
49. Fassoulaki, A., Sarantopoulos, C., Melemeni, A., Hogan, Q., Regional block and mexiletine: the effect on pain after cancer breast surgery. Reg Anesth Pain Med 26:3 (2001), 223–228, 10.1053/rapm.2001.23205.
50. Fassoulaki, A., Patris, K., Sarantopoulos, C., Hogan, Q., The analgesic effect of gabapentin and mexiletine after breast surgery for cancer. Anesth Analg 95:4 (2002), 985–991, 10.1213/00000539-200210000-00036.
51. Cho, A.R., Kwon, J.Y., Kim, K.H., et al. The effects of anesthetics on chronic pain after breast cancer surgery. Anesth Analg 116:3 (2013), 685–693, 10.1213/ANE.0b013e31827ee372.
52. Saksornchai, K., Rojpornpradit, P., Shotelersak, K., Lertbutsayanukul, C., Chakkabat, C., Raiyawa, T., Skin toxicity and cosmesis after hypofractionated whole breast irradiation for early breast cancer. J Med Assoc Thail 95:2 (2012), 229–240.
53. Andersen, K.G., Duriaud, H.M., Jensen, H.E., Kroman, N., Kehlet, H., Predictive factors for the development of persistent pain after breast cancer surgery. Pain 156:12 (2015), 2413–2422, 10.1097/j.pain.0000000000000298.
54. Kudel, I., Edwards, R.R., Kozachik, S., et al. Predictors and consequences of multiple persistent postmastectomy pains. J Pain Symptom Manag 34:6 (2007), 619–627, 10.1016/j.jpainsymman.2007.01.013.
55. Reeder, R., Carter, D.L., Howell, K., et al. Predictors for clinical outcomes after accelerated partial breast intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 74:1 (2009), 92–97, 10.1016/j.ijrobp.2008.06.1917.
56. Bulley, C., Coutts, F., Blyth, C., et al. A Morbidity Screening Tool for identifying fatigue, pain, upper limb dysfunction and lymphedema after breast cancer treatment: a validity study. Eur J Oncol Nurs 18:2 (2014), 218–227, 10.1016/j.ejon.2013.10.006.
57. Sipilä R., Estlander, A.M., Tasmuth, T., Kataja, M., Kalso, E., Development of a screening instrument for risk factors of persistent pain after breast cancer surgery. Br J Canc 107:9 (2012), 1459–1466, 10.1038/bjc.2012.445.
58. Reyes-Gibby, C., Morrow, P.K., Bennett, M.I., Jensen, M.P., Shete, S., Neuropathic pain in breast cancer survivors: using the ID pain as a screening tool. J Pain Symptom Manag 39:5 (2010), 882–889, 10.1016/j.jpainsymman.2009.09.020.
59. Jagsi, R., Griffith, K.A., Boike, T.P., et al. Differences in the acute toxic effects of breast radiotherapy by fractionation schedule: comparative analysis of physician-assessed and patient-reported outcomes in a large multicenter cohort. JAMA Oncol 1:7 (2015), 918–930, 10.1001/jamaoncol.2015.2590.
60. Krøner, K., Krebs, B., Skov, J., Jørgensen, H.S., Immediate and long-term phantom breast syndrome after mastectomy: incidence, clinical characteristics and relationship to pre-mastectomy breast pain. Pain 36 (1989), 327–334, 10.1016/0304-3959(89)90092-4.
61. Tasmuth, T., Blomqvist, C., Kalso, E., Chronic post-treatment symptoms in patients with breast cancer operated in different surgical units. Eur J Surg Oncol 25:1 (1999), 38–43, 10.1053/ejso.1998.0597.
62. Schijven, M.P., Vingerhoets, A.J.J.M., Rutten, H.J.T., et al. Comparison of morbidity between axillary lymph node dissection and sentinel node biopsy. Eur J Surg Oncol 29:4 (2003), 341–350, 10.1053/ejso.2002.1385.
63. Swenson, K.K., Comparison of side effects between sentinel lymph node and axillary lymph node dissection for breast cancer. Ann Surg Oncol, 2002, 10.1245/ASO.2002.02.007.
64. Baron, R.H., Fey, J.V., Borgen, P.I., Stempel, M.M., Hardick, K.R., Van Zee, K.J., Eighteen sensations after breast cancer surgery: a 5-year comparison of sentinel lymph node biopsy and axillary lymph node dissection. Ann Surg Oncol 14:5 (2007), 1653–1661, 10.1245/s10434-006-9334-z.
65. Henderson, J.R., Tao, A., Kirwan, C.C., Barr, L., Immediate breast reconstruction does not increase postmastectomy pain. Ann Surg Oncol 21 (2014), 113–117, 10.1245/s10434-013-3293-y.
66. Shaitelman, S.F., Schlembach, P.J., Arzu, I., et al. Acute and short-term toxic effects of conventionally fractionated vs hypofractionated whole-breast irradiation : a randomized clinical trial. JAMA Oncol 1:7 (2015), 931–941, 10.1001/jamaoncol.2015.2666.
67. Toledano, A., Garaud, P., Serin, D., et al. Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: long-term results of the ARCOSEIN multicenter randomized study. Int J Radiat Oncol Biol Phys 65:2 (2006), 324–332, 10.1016/j.ijrobp.2005.12.020.
68. Olivotto, I.A., Whelan, T.J., Parpia, S., et al. Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy. J Clin Oncol 31:32 (2013), 4038–4045, 10.1200/JCO.2013.50.5511.
69. Galland-Girodet, S., Pashtan, I., Macdonald, S.M., et al. Long-term cosmetic outcomes and toxicities of proton beam therapy compared with photon-based 3-dimensional conformal accelerated partial-breast irradiation: a phase 1 trial. Int J Radiat Oncol Biol Phys 90:3 (2014), 493–500, 10.1016/j.ijrobp.2014.04.008.
70. Marcenaro, M., Sacco, S., Pentimalli, S., et al. Measures of late effects in conservative treatment of breast cancer with standard or hypofractionated radiotherapy. Tumori 90:6 (2004), 586–591.
71. Andersen, K.G., Gärtner, R., Kroman, N., Flyger, H., Kehlet, H., Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: a randomized trial. Breast 21:1 (2012), 46–49, 10.1016/j.breast.2011.07.011.
72. Lee, P., McAuliffe, N., Dunlop, C., Palanisamy, M., Shorten, G., A comparison of the effects of two analgesic regimens on the development of persistent post-surgical pain (PPSP) after breast surgery. J Rom Anestezie Ter Intensiva/Rom J Anaesth Intensive Care 20:2 (2013), 83–93.
73. Albi-Feldzer, A., Mouret-Fourme, E.E., Hamouda, S., et al. A double-blind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery. Anesthesiology 118:2 (2013), 318–326.
74. Sun, M., Liao, Q., Wen, L., Yan, X., Zhang, F., Ouyang, W., Effect of perioperative intravenous flurbiprofen axetil on chronic postmastectomy pain. J Cent S Univ Med Sci 38:7 (2013), 653–660, 10.3969/j.issn.1672-7347.2013.07.001.
75. Fassoulaki, A., Sarantopoulos, C., Melemeni, A., Hogan, Q., EMLA reduces acute and chronic pain after breast surgery for cancer. Reg Anesth Pain Med 25:4 (2000), 350–355, 10.1053/rapm.2000.7812.
76. Van Helmond, N., Steegers, M.A., Filippini-De Moor, G.P., Vissers, K.C., Wilder-Smith, O.H., Hyperalgesia and persistent pain after breast cancer surgery: a prospective randomized controlled trial with perioperative COX-2 inhibition. PLoS One 11:12 (2016), 1–21, 10.1371/journal.pone.0166601.
77. Morel, V., Joly, D., Villatte, C., et al. Memantine before mastectomy prevents post-surgery pain: a randomized, blinded clinical trial in surgical patients. PLoS One 11:4 (2016), 1–15, 10.1371/journal.pone.0152741.
78. Gacio, M.F., Lousame, A.M.A., Pereira, S., Castro, C., Santos, J., Paravertebral block for management of acute postoperative pain and intercostobrachial neuralgia in major breast surgery. Braz J Anesthesiol 66:5 (2016), 475–484, 10.1016/j.bjane.2015.02.007 English Ed.
79. De Oliveira, G.S., Bialek, J.M., Turan, A., McCarthy, R.J., Sessler, D.I., Perioperative dexamethasone and the development of chronic postmastectomy pain: a single-center observational cohort study. Reg Anesth Pain Med 40:5 (2015), 539–544, 10.1097/AAP.0000000000000301.
80. Grigoras, A., Lee, P., Sattar, F., Shorten, G., Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. Clin J Pain 28:7 (2012), 567–572, 10.1097/AJP.0b013e31823b9cc8.
81. Terkawi, A.S., Sharma, S., Durieux, M.E., Thammishetti, S., Brenin, D., Tiouririne, M., Perioperative lidocaine infusion reduces the incidence of post-mastectomy chronic pain: a double-blind, placebo-controlled randomized trial. Pain Physician 18:2 (2015), E139–E146.
82. Na, H.S., Oh, A.Y., Koo, B.W., Lim, D.J., Ryu, J.H., Han, J.W., Preventive analgesic efficacy of Nefopam in acute and chronic pain after breast cancer surgery: a prospective, double-blind, and randomized trial. Medicine (Baltim), 95(20), 2016, e3705, 10.1097/MD.0000000000003705.
83. Iohom, G., Abdalla, H., O'Brien, J., et al. The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery. Anesth Analg 103:4 (2006), 995–1000, 10.1213/01.ANE.0000240415.49180.4A.
84. Elkaradawy, S., Nasr, M., Elkerm, Y., El, Deeb M., Yassine, O., The effect of multimodal balanced anaesthesia and long term gabapentin on neuropathic pain, nitric oxide and interleukin-1β following breast surgery. Egypt J Anaesth 28:1 (2012), 67–78, 10.1016/j.egja.2011.10.005.
85. Shimizu, H., Kamiya, Y., Nishimaki, H., Denda, S., Baba, H., Thoracic paravertebral block reduced the incidence of chronic postoperative pain for more than 1 year after breast cancer surgery. J Clin Rep 1:1 (2015), 1–6, 10.1186/s40981-015-0023-4.
86. Mejdahl, M.K., Andersen, K.G., Gärtner, R., Kroman, N., Kehlet, H., Persistent pain and sensory disturbances after treatment for breast cancer: six year nationwide follow-up study. BMJ 346:7907 (2013), 1–14, 10.1136/bmj.f1865.
87. Poleshuck, E.L., Katz, J., Andrus, C.H., et al. Risk factors for chronic pain following breast cancer surgery: a prospective study. J Pain 7:9 (2006), 626–634, 10.1016/j.jpain.2006.02.007.
88. Ververs, J.M., Roumen, R.M., Vingerhoets, A.J., et al. Risk, severity and predictors of physical and psychological morbidity after axillary lymph node dissection for breast cancer. Eur J Canc 37:8 (2001), 991–999 S0959804901000673 [pii].
89. Raza, S., Lymberis, S.C., Ciervide, R., et al. Comparison of acute and late toxicity of two regimens of 3- and 5-week concomitant boost prone IMRT to standard 6-week breast radiotherapy. Front Oncol 2:May (2012), 1–10, 10.3389/fonc.2012.00044.
90. Brar, P., Jain, S., Singh, I., Complications of axillary lymph node dissection in treatment of early breast Cancer ;: a comparison of MRM and BCS., 2(June), 2011, 126–132, 10.1007/s13193-011-0078-2.
91. Hoopfer, D., Holloway, C., Gabos, Z., et al. Three-arm randomized phase III trial: quality aloe and placebo cream versus powder as skin treatment during breast cancer radiation therapy. Clin Breast Canc 15:3 (2015), 181–190, 10.1016/j.clbc.2014.12.006 e4.
92. Schrenk, P., Rieger, R., Shamiyeh, A., Wayand, W., Morbidity following sentinel lymph node biopsy versus axillary lymph node dissection for patients with breast carcinoma. Cancer 88:3 (2000), 608–614, 10.1002/(SICI)1097-0142(20000201)88:3<608::AID-CNCR17>3.0.CO;2-K [pii].
93. Ivens, D., Hoe, A.L., Podd, T.J., Hamilton, C.R., Taylor, I., Royle, G.T., Assessment of morbidity from complete axillary dissection. Br J Canc 66:1 (1992), 136–138, 10.1038/bjc.1992.230.
94. Gahm, J., Wickman, M., Brandberg, Y., Bilateral prophylactic mastectomy in women with inherited risk of breast cancer - prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery. Breast 19:6 (2010), 462–469, 10.1016/j.breast.2010.05.003.
95. Ernst, M.F., Voogd, A.C., Balder, W., Klinkenbijl, J.H.G., Roukema, J.A., Early and late morbidity associated with axillary levels I-III dissection in breast cancer. J Surg Oncol 79:3 (2002), 151–155, 10.1002/jso.10061.
96. Nozaki, M., Kagami, Y., Mitsumori, M., Hiraoka, M., A multicenter investigation of late adverse events in Japanese women treated with breast-conserving surgery plus conventional fractionated whole-breast radiation therapy. Jpn J Clin Oncol 42:6 (2012), 522–527, 10.1093/jjco/hys050.
97. Chen, P.Y., Vicini, F.A., Benitez, P., et al. Long-term cosmetic results and toxicity after accelerated partial-beam irradiation. Cancer 106:5 (2006), 991–999, 10.1002/cncr.21681.
98. Lundstedt, D., Gustafsson, M., Malmström, P., et al. Symptoms 10-17 years after breast cancer radiotherapy data from the randomised SWEBCG91-RT trial. Radiother Oncol 97:2 (2010), 281–287, 10.1016/j.radonc.2010.09.018.
99. Vera, R., Trombetta, M., Mukhopadhyay, N.D., Packard, M., Arthur, D., Long-term cosmesis and toxicity following 3-dimensional conformal radiation therapy in the delivery of accelerated partial breast irradiation. Pract Radiat Oncol 4:3 (2014), 147–152, 10.1016/j.prro.2013.07.004.
100. Lundstedt, D., Gustafsson, M., Steineck, G., et al. Long-term symptoms after radiotherapy of supraclavicular lymph nodes in breast cancer patients. Radiother Oncol 103:2 (2012), 155–160, 10.1016/j.radonc.2011.12.017.
101. Lundstedt, D., Gustafsson, M., Steineck, G., et al. Risk factors of developing long-lasting breast pain after breast cancer radiotherapy. Int J Radiat Oncol Biol Phys 83:1 (2012), 71–78, 10.1016/j.ijrobp.2011.05.065.
102. Deutsch, M., Flickinger, J., Shoulder and arm problems after radiotherapy for primary breast cancer. Am J Clin Oncol 24:2 (April. 2001), 172–176.
103. Bantema-Joppe, E.J., Schilstra, C., De Bock, G.H., et al. Simultaneous integrated boost irradiation after breast-conserving surgery: physician-rated toxicity and cosmetic outcome at 30 months’ follow-up. Int J Radiat Oncol Biol Phys 83:4 (2012), e471–e477, 10.1016/j.ijrobp.2012.01.050.
104. Fassoulaki, A., Melemeni, A., Staikou, C., Triga, A., Sarantopoulos, C., Acute postoperative pain predicts chronic pain and long-term analgesic requirements after breast surgery for cancer. Acta Anaesthesiol Belg 59:4 (2008), 241–248.
105. Thomas-MacLean, R.L., Hack, T., Kwan, W., Towers, A., Miedema, B., Tilley, A., Arm morbidity and disability after breast cancer: new directions for care. Oncol Nurs Forum 35:1 (2008), 65–71.
106. Klit, A., Mejdahl, M.K., Gärtner, R., Elberg, J.J., Kroman, N., Andersen, K.G., Breast reconstruction with an expander prosthesis following mastectomy does not cause additional persistent pain: a nationwide cross-sectional study. J Plast Reconstr Aesthetic Surg 66:12 (2013), 1652–1658, 10.1016/j.bjps.2013.07.015.
107. Lefebvre-Kuntz, D., Dualé C., Albi-Feldzer, A., et al. General anaesthetic agents do not influence persistent pain after breast cancer surgery: a prospective nationwide cohort study. Eur J Anaesthesiol 32:10 (2015), 697–704, 10.1097/EJA.0000000000000215.
108. Miaskowski, C., Paul, S.M., Cooper, B., et al. Identification of patient subgroups and risk factors for persistent arm/shoulder pain following breast cancer surgery. Eur J Oncol Nurs 18:3 (2014), 242–253, 10.1016/j.ejon.2013.12.002.
109. Miaskowski, C., Cooper, B., Paul, S.M., et al. Identification of patient subgroups and risk factors for persistent breast pain following breast cancer surgery. J Pain 13:12 (2012), 1172–1187, 10.1016/j.jpain.2012.09.013.
110. Stefanic, N., Caputi, P., Iverson, D.C., Investigating physical symptom burden and personal goal interference in early-stage breast cancer patients. Support Care Canc 22:3 (2014), 713–720, 10.1007/s00520-013-2026-x.
111. De Oliveira, G.S., Bialek, J.M., Nicosia, L., et al. Lack of association between breast reconstructive surgery and the development of chronic pain after mastectomy: a propensity matched retrospective cohort analysis. Breast 23:4 (2014), 329–333, 10.1016/j.breast.2014.01.003.
112. Fabro, E.A., Bergmann, A., do Amaral e Silva, B., et al. Post-mastectomy pain syndrome: incidence and risks. Breast 21:3 (2012), 321–325, 10.1016/j.breast.2012.01.019.
113. Beyaz, S.G., Ergönenç J.Ş., Ergönenç T., Sönmez, Ö.U., Erkorkmaz, Ü., Altintoprak, F., Postmastectomy pain: a cross-sectional study of prevalence, pain characteristics, and effects on quality of life. Chin Med J 129:1 (2016), 66–71, 10.4103/0366-6999.172589 (Engl).
114. Langford, D.J., Schmidt, B., Levine, J.D., et al. Preoperative breast pain predicts persistent breast pain and disability after breast cancer surgery. J Pain Symptom Manag 49:6 (2015), 981–994, 10.1016/j.jpainsymman.2014.11.292.
115. de Menezes Couceiro, T.C., Valença, M.M., Raposo, M.C.F., de Orange, F.A., Amorim, M.M.R., Prevalence of post-mastectomy pain syndrome and associated risk factors: a cross-sectional cohort study. Pain Manag Nurs 15:4 (2014), 731–737, 10.1016/j.pmn.2013.07.011.
116. McCredie, M.R.E., Dite, G.S., Porter, L., et al. Prevalence of self-reported arm morbidity following treatment for breast cancer in the Australian Breast Cancer Family Study. Breast 10:6 (2001), 515–522, 10.1054/brst.2000.0291.
117. Fuzier, R., Puel, F., Izard, P., Sommet, A., Pierre, S., Prospective cohort study assessing chronic pain in patients following minor surgery for breast cancer. J Anesth 31:2 (2017), 246–254, 10.1007/s00540-016-2288-9.
118. Nishimura, D., Kosugi, S., Onishi, Y., et al. Psychological and endocrine factors and pain after mastectomy. Eur J Pain (United Kingdom) 21:7 (2017), 1144–1153, 10.1002/ejp.1014.
119. Hladiuk, M., Huchcroft, S., Temple, W., Schnurr, B.E., Arm function after axillary dissection for breast cancer: a pilot study to provide parameter estimates. J Surg Oncol 50:1 (1992), 47–52, 10.1002/jso.2930500114.
120. Torres Lacomba, M., Mayoral Del Moral, O., Coperias Zazo, J.L., Yuste Sánchez, M.J., Ferrandez, J.C., Zapico Goñi, Á., Axillary web syndrome after axillary dissection in breast cancer: a prospective study. Breast Canc Res Treat, 2009, 10.1007/s10549-009-0371-8.
121. Wenz, F., Welzel, G., Keller, A., et al. Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer. Breast 17:6 (2008), 617–622, 10.1016/j.breast.2008.05.009.
122. Albert, U.S., Koller, M., Kopp, I., Lorenz, W., Schulz, K.D., Wagner, U., Early self-reported impairments in arm functioning of primary breast cancer patients predict late side effects of axillary lymph node dissection : results from a population-based cohort study. Breast Canc Res Treat 100 (2006), 285–292, 10.1007/s10549-006-9247-3.
123. Baudic, S., Jayr, C., Albi-Feldzer, A., et al. Effect of alexithymia and emotional repression on postsurgical pain in women with breast cancer: a prospective longitudinal 12-month study. J Pain 17:1 (2016), 90–100, 10.1016/j.jpain.2015.10.001.
124. Steegers, M.A., Wolters, B., Evers, A.W., Strobbe, L., Wilder-Smith, O.H., Effect of axillary lymph node dissection on prevalence and intensity of chronic and phantom pain after breast cancer surgery. J Pain 9:9 (2008), 813–822, 10.1016/j.jpain.2008.04.001.
125. Tasmuth, T., Estlanderb, A.M., Kalso, E., Effect of present pain and mood on the memory of past postoperative pain in women treated surgically for breast cancer. Pain 68:2–3 (1996), 343–347, 10.1016/S0304-3959(96)03219-8.
126. De Oliveira, G.S., Chang, R., Khan, S.A., et al. Factors associated with the development of chronic pain after surgery for breast cancer: a prospective cohort from a tertiary center in the United States. Breast J 20:1 (2014), 9–14, 10.1111/tbj.12207.
127. Gulluoglu, B.M., Cingi, A., Cakir, T., Gercek, A., Barlas, A., Eti, Z., Factors related to post-treatment chronic pain in breast cancer survivors: the interference of pain with life functions. Int J Fertil Women's Med 51 (2006), 75–82.
128. van Helmond, N., Timmerman, H., van Dasselaar, N.T., et al. High body mass Index is a potential risk factor for persistent postoperative pain after breast cancer treatment. Pain Physician 20:5 (2017), E661–E671.
129. Segerstrom, K., Bjerle, P., Nystrom2 a. Importance of time in assessing arm a N D hand function after treatment of breast cancer. Scand J Plast Reconstr Hand Surg 25 (1991), 241–244.
130. Wilson, G.C., Quillin, R.C., Hanseman, D.J., Lewis, J.D., Edwards, M.J., Shaughnessy, E.A., Incidence and predictors of neuropathic pain following breast surgery. Ann Surg Oncol 20:10 (2013), 3330–3334, 10.1245/s10434-013-3156-6.
131. Lacomba, M.T., del Moral, O.M., Coperias Zazo, J.L., Gerwin, R.D., Goñí Á.Z., Incidence of myofascial pain syndrome in breast cancer surgery: a prospective study. Clin J Pain 26:4 (2010), 320–325, 10.1097/AJP.0b013e3181c4904a.
132. Soares, E.W., Nagai, H., Bredt, L., da Cunha, A., Andrade, R., Soares, G.V., Morbidity after conventional dissection of axillary lymph nodes in breast cancer patients. World J Surg Oncol, 12(1), 2014, 67, 10.1186/1477-7819-12-67.
133. Del Bianco, P., Zavagno, G., Burelli, P., et al. Morbidity comparison of sentinel lymph node biopsy versus conventional axillary lymph node dissection for breast cancer patients: results of the sentinella-GIVOM Italian randomised clinical trial. Eur J Surg Oncol 34:5 (2008), 508–513, 10.1016/j.ejso.2007.05.017.
134. Langer, I., Guller, U., Berclaz, G., et al. Morbidity of sentinel lymph node biopsy (SLN) alone versus SLN and completion axillary lymph node dissection after breast cancer surgery: a prospective swiss multicenter study on 659 patients. Ann Surg 245:3 (2007), 452–461, 10.1097/01.sla.0000245472.47748.ec.
135. Pereira, S., Fontes, F., Sonin, T., et al. Neurological complications of breast cancer: a prospective cohort study. Breast 24:5 (2015), 582–587, 10.1016/j.breast.2015.05.006.
136. Tasmuth, T., von Smitten, K., Kalso, E., Pain and other symptoms during the first year after radical and conservative surgery for breast cancer. Br J Canc 74:12 (1996), 2024–2031.
137. T.J. M, M.H.K. L, T. T, R. S, Pain at 12 months after surgery for breast cancer. JAMA, J Am Med Assoc 311:1 (2014), 90–92 https://doi.org/10.1001/jama.2013.278795.
138. Shockney, L.D., Pain following breast cancer surgery : a quality-of-life issue. Arch Surg 145:3 (2010), 224–225, 10.1001/archsurg.2010.8.
139. Mertz, B.G., Duriaud, H.M., Kroman, N., Andersen, K.G., Pain, Sensory Disturbances, and Psychological Distress are common sequelae after treatment of ductal carcinoma in situ: a cross-sectional study. Acta Oncol (Madr) 56:5 (2017), 724–729, 10.1016/j.pmn.2017.03.004.
140. Hack, B.T.F., Cohen, L., Katz, J., Robson, L.S., Goss, P., Physical and psychological morbidity after axillary lymph node dissection for breast cancer. J Clin Oncol 17:1 (1999), 143–149.
141. Mejdahl, M., Mertz, B., Bidstrup, P., Preoperative distress predicts persistent pain after breast cancer treatment: a prospective cohort study. Compr Canc 13:8 (2015), 995–1003.
142. Moloney, N., Sung, J.M.W., Kilbreath, S., Dylke, E., Prevalence and risk factors associated with pain 21 months following surgery for breast cancer. Support Care Canc 24:11 (2016), 4533–4539, 10.1007/s00520-016-3292-1.
143. Gärtner, R., Jensen, M.B., Nielsen, J., Ewertz, M., Kroman, N.K.H., Prevalence of and factors associated with persistent pain following breast cancer surgery. Jama 302:18 (2009), 1985–1992.
144. Bruce, J., Thornton, A.J., Powell, R., et al. Psychological, surgical, and sociodemographic predictors of pain outcomes after breast cancer surgery: a population-based cohort study. Pain 155:2 (2014), 232–243, 10.1016/j.pain.2013.09.028.
145. Gho, S.A., Steele, J.R., Jones, S.C., Munro, B.J., Self-reported side effects of breast cancer treatment: a cross-sectional study of incidence, associations, and the influence of exercise. Cancer Causes Control 24:3 (2013), 517–528, 10.1007/s10552-012-0142-4.
146. Kim, Z., Kang, S.G., Roh, J.H., et al. Skin-sparing mastectomy and immediate latissimus dorsi flap reconstruction: a retrospective analysis of the surgical and patient-reported outcomes. World J Surg Oncol, 10(1), 2012, 1, 10.1186/1477-7819-10-259.
147. Fenlon, D., Powers, C., Simmonds, P., Clough, J., Addington-Hall, J., The JACS prospective cohort study of newly diagnosed women with breast cancer investigating joint and muscle pain, aches, and stiffness: pain and quality of life after primary surgery and before adjuvant treatment. BMC Canc 14:1 (2014), 1–10, 10.1186/1471-2407-14-467.
148. Vilholm, O.J., Cold, S., Rasmussen, L., Sindrup, S.H., The postmastectomy pain syndrome: an epidemiological study on the prevalence of chronic pain after surgery for breast cancer. Br J Canc 99:4 (2008), 604–610, 10.1038/sj.bjc.6604534.
149. Andersen, K.G., Duriaud, H.M., Kehlet, H., Aasvang, E.K., The relationship between sensory loss and persistent pain 1 Year after breast cancer surgery. J Pain 18:9 (2017), 1129–1138, 10.1016/j.jpain.2017.05.002.
150. Tasmuth, T., Kataja, M., Blomqvist, C., von Smitten, K., Kalso, E., Treatment-related factors predisposing to chronic pain in patients with breast cancer–a multivariate approach. Acta Oncol 36:6 (1997), 625–630, 10.3109/02841869709001326.
151. Husen, M., Paaschburg, B., Flyger, H.L., Two-step axillary operation increases risk of arm morbidity in breast cancer patients. Breast 15:5 (2006), 620–628, 10.1016/j.breast.2006.01.006.
152. Fernández-Lao, C., Cantarero-Villanueva, I., Fernández-De-Las-Peñas, C., Del-Moral-Ávila, R., Menjón-Beltrán, S., Arroyo-Morales, M., Widespread mechanical pain hypersensitivity as a sign of central sensitization after breast cancer surgery: comparison between mastectomy and lumpectomy. Pain Med 12 (2011), 72–78.
153. Johansen, S., Fosså K., Nesvold, I.L., Malinen, E., Fosså S.D., Arm and shoulder morbidity following surgery and radiotherapy for breast cancer. Acta Oncol (Madr) 53:4 (2014), 521–529, 10.3109/0284186X.2014.880512.
154. Nesvold, I., Dahl, A.L.V.A., ELØ Kkevik, Mengshoel, A.M., Fossa, S.D., Arm and shoulder morbidity in breast cancer patients after breast-conserving therapy versus mastectomy., 2008, June 2007, 10.1080/02841860801961257.
155. Tengrup, I., Tennvall-nittby, L., Christiansson, I., Laurin, M., Arm morbidity after breast-conserving therapy for breast cancer. Acta Oncol (Madr) 39 (2000), 393–397.
156. Mukesh, M.B., Barnett, G., Cumming, J., et al. Association of breast tumour bed seroma with post-operative complications and late normal tissue toxicity: results from the Cambridge Breast IMRT trial. Eur J Surg Oncol 38:10 (2012), 918–924, 10.1016/j.ejso.2012.05.008.
157. Feiten, S., Dünnebacke, J., Heymanns, J., et al. Breast cancer morbidity: questionnaire survey of patients on the long term effects of disease and adjuvant therapy. Dtsch Arztebl Int 111:31–32 (2014), 537–544, 10.3238/arztebl.2014.0537.
158. Alkan, A., Guc, Z.G., Senler, F.C., et al. Breast cancer survivors suffer from persistent postmastectomy pain syndrome and posttraumatic stress disorder (ORTHUS study): a study of the palliative care working committee of the Turkish Oncology Group (TOG). Support Care Canc 24:9 (2016), 3747–3755, 10.1007/s00520-016-3202-6.
159. de Vries, J.E., Timmer, P.R., Erftemeier, E.J., van der Weele, L.T., Breast pain after breast conserving therapy. Breast 3:3 (1994), 151–154, 10.1016/0960-9776(94)90067-1.
160. Schou Bredal, I., Smeby, N.A., Ottesen, S., Warncke, T., Schlichting, E., Chronic pain in breast cancer survivors: comparison of psychosocial, surgical, and medical characteristics between survivors with and without pain. J Pain Symptom Manag 48:5 (2014), 852–862, 10.1016/j.jpainsymman.2013.12.239.
161. Warmuth, M.A., Bowen, G., Prosnitz, L.R., et al. Complications of axillary lymph node dissection for carcinoma of the breast: a report based on a patient survey. Cancer 83:7 (1998), 1362–1368, 10.1002/(SICI)1097-0142(19981001)83:7<1362::AID-CNCR13>3.0.CO;2–2.
162. Mak, K.S., Chen, Y.H., Catalano, P.J., et al. Dosimetric inhomogeneity predicts for long-term breast pain after breast-conserving therapy. Int J Radiat Oncol Biol Phys 93:5 (2015), 1087–1095, 10.1016/j.ijrobp.2014.05.021.
163. Shah, C., Ben, Wilkinson J., Lanni, T., et al. Five-year outcomes and toxicities using 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Clin Breast Canc 13:3 (2013), 206–211, 10.1016/j.clbc.2012.09.020.
164. Legeby, M., Segerdahl, M., Sandelin, K., Wickman, M., Immediate reconstruction in breast cancer surgery requires intensive post-operative pain treatment but the effects of axillary dissection may be more predictive of chronic pain. Breast 11 (2002), 156–162, 10.1054/brst.2001.0386.
165. Chafe, S., Moughan, J., McCormick, B., et al. Late toxicity and patient self-assessment of breast appearance/satisfaction on RTOG 0319: a phase 2 trial of 3-dimensional conformal radiation therapy-accelerated partial breast irradiation following lumpectomy for stages i and II breast cancer. Int J Radiat Oncol Biol Phys 86:5 (2013), 854–859, 10.1016/j.ijrobp.2013.04.005.
166. T. T, K.VS, P. H, et al. Pain and other symptoms after different treatment modalities of breast cancer. Ann Oncol 6:5 (1995), 453–459.
167. Bell, R.J., Robinson, P.J., Nazeem, F., et al. Persistent breast pain 5 years after treatment of invasive breast cancer is largely unexplained by factors associated with treatment. J Canc Surviv 8:1 (2014), 1–8, 10.1007/s11764-013-0306-6.
168. Schreiber, K.L., Martel, M.O., Shnol, H., et al. Persistent pain in postmastectomy patients: comparison of psychophysical, medical, surgical, and psychosocial characteristics between patients with and without pain. Pain 154:5 (2013), 660–668, 10.1016/j.pain.2012.11.015.
169. Ishiyama, H., Niino, K., Hosoya, T., Hayakawa, K., Results of a questionnaire survey for symptom of late complications caused by radiotherapy in breast conserving therapy. Breast Canc 13:2 (2006), 197–201, 10.2325/jbcs.13.197.
170. Belfer, I., Schreiber, K.L., Shaffer, J.R., et al. Persistent postmastectomy pain in breast cancer survivors: analysis of clinical, demographic, and psychosocial factors. J Pain 14:10 (2013), 1185–1195, 10.1016/j.jpain.2013.05.002.
171. Devoogdt, N., Van Kampen, M., Christiaens, M.R., et al. Short- and long-term recovery of upper limb function after axillary lymph node dissection. Eur J Canc Care 20:1 (2011), 77–86, 10.1111/j.1365-2354.2009.01141.x (Engl).
172. Smith, G.L., Xu, Y., Buchholz, T.A., et al. Association between treatment with brachytherapy vs whole-breast irradiation and subsequent mastectomy, complications, and survival among older women with invasive breast cancer. JAMA, J Am Med Assoc 307:17 (2012), 1827–1837, 10.1001/jama.2012.3481.
173. Peuckmann, V., Ekholm, O., Rasmussen, N.K., et al. Chronic pain and other sequelae in long-term breast cancer survivors: nationwide survey in Denmark. Eur J Pain 13:5 (2009), 478–485, 10.1016/j.ejpain.2008.05.015.
174. Perez, A.R., Carrizosa, M.C.L., Ots, P.M.S., Ortuno, J.Z., Garrido J de, D.S., Martin de Miguel, M.J., Conservative surgery, external radiotherapy, and HDR brachytherapy in a single fraction of 7 Gy in early breast cancer : long-term toxicity and esthetic assessment. Clin Trnasl Oncol 14 (2012), 953–960, 10.1007/s12094-012-0881-4.
175. Vicini, F., Jones, P., Rivers, A., et al. Differences in disease presentation, management techniques, treatment outcome, and toxicities in African-American women with early stage breast cancer treated with breast-conserving therapy. Cancer 116:14 (2010), 3485–3492, 10.1002/cncr.25088.
176. Steyaert, A., Forget, P., Dubois, V., Lavand'homme, P., De Kock, M., Does the perioperative analgesic/anesthetic regimen influence the prevalence of long-term chronic pain after mastectomy?. J Clin Anesth 33 (2016), 20–25, 10.1016/j.jclinane.2015.07.010.
177. Macdonald, L., Bruce, J., Scott, N.W., Smith, W.C.S., Chambers, W.A., Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome. Br J Canc 92 (2005), 225–230, 10.1038/sj.bjc.6602304.
178. Sheridan, D., Foo, I., O'Shea, H., et al. Long-term follow-up of pain and emotional characteristics of women after surgery for breast cancer. J Pain Symptom Manag 44:4 (2012), 608–614, 10.1016/j.jpainsymman.2011.10.021.
179. Fehlauer, F., Tribius, S., Höller, U., et al. Long-term radiation sequelae after breast-conserving therapy in women with early-stage breast cancer: an observational study using the LENT-SOMA scoring system. Int J Radiat Oncol Biol Phys 55:3 (2003), 651–658, 10.1016/S0360-3016(02)04120-2.
180. Romero, A., Torà-Rocamora, I., Baré M., et al. Prevalence of persistent pain after breast cancer treatment by detection mode among participants in population-based screening programs. BMC Canc 16:1 (2016), 1–9, 10.1186/s12885-016-2768-1.
181. Johannsen, M., Christensen, S., Zachariae, R., Jensen, A., Socio-demographic, treatment-related, and health behavioral predictors of persistent pain 15 months and 7–9 years after surgery: a nationwide prospective study of women treated for primary breast cancer. Breast Canc Res Treat 152:3 (2015), 645–658, 10.1007/s10549-015-3497-x.
182. Johansen, J., Overgaard, J., Blichert-Toft, M., Overgaard, M., Treatment morbidity associated with the management of the axilla in breast-conserving therapy. Acta Oncol (Madr) 39:3 (2000), 349–354, 10.1080/028418600750013122.
183. Smith, W.C.S., Bourne, D., Squair, J.,O., Phillips, D., Alastair Chambers, W., A retrospective cohort study of post mastectomy pain syndrome. Pain 83:1 (1999), 91–95, 10.1016/S0304-3959(99)00076-7.
184. Meijuan, Y., Zhiyou, P., Yuwen, T., Ying, F., Xinzhong, C., A retrospective study of postmastectomy pain syndrome: incidence, characteristics, risk factors, and influence on quality of life. Sci World J, 2013, 2013, 10.1155/2013/159732 (May).
185. Keramopoulos, A., Tsionou, C., Minaretzis, D., Michalas, S., Aravantinos, D., Arm morbidity following treatment of breast cancer with total axillary dissection: a multivariated approach. Oncology 50:6 (1993), 445–449.
186. Teo, I., Novy, D.M., Chang, D.W., Cox, M.G., Fingeret, M.C., Examining pain, body image, and depressive symptoms in patients with lymphedema secondary to breast cancer. Psycho Oncol 24:11 (2015), 1377–1383, 10.1002/pon.3745.
187. Hille-Betz, U., Vaske, B., Bremer, M., et al. Late radiation side effects, cosmetic outcomes and pain in breast cancer patients after breast-conserving surgery and three-dimensional conformal radiotherapy: risk-modifying factors. Strahlenther Onkol 192:1 (2016), 8–16, 10.1007/s00066-015-0899-y.
188. Amichetti, M., Caffo, O., Pain after quadrantectomy and radiotherapy for early-stage breast cancer: incidence, characteristics and influence on quality of life. Results from a retrospective study. Oncology 65:1 (2003), 23–28 doi:71201.
189. Caffo, O., Amichetti, M., Ferro, A., Lucenti, A., Valduga, F., Galligioni, E., Pain and quality of life after surgery for breast cancer. Breast Canc Res Treat 80:1 (2003), 39–48, 10.1023/A:1024435101619.
190. Guerreiro Godoy M de, F., Pereira de Godoy, L.M., Barufi, S., de Godoy, J.M.P., Pain in breast cancer treatment: aggravating factors and coping mechanisms. Int J Breast Canc 2014 (2014), 1–4, 10.1155/2014/832164.
191. Carpenter, J.S., Andrykowski, M.A., Sloan, P., et al. Postmastectomy/postlumpectomy pain in breast cancer survivors. J Clin Epidemiol 51:12 (1998), 1285–1292, 10.1016/S0895-4356(98)00121-8.
192. Stevens, P.E., Dibble, S.L., Miaskowski, C., Prevalence, characteristics, and impact of postmastectomy pain syndrome: an investigation of women's experiences. Pain 61 (1995), 61–68.
193. Bosompra, K., Ashikaga, T., O'Brien, P.J., Nelson, L., Skelly, J., Swelling, Numbness, Pain and their relationship to arm function among breast cancer survivors: a disablement process model perspective. Breast J 8:6 (2002), 338–348.