Experimental Infection of Syrian Hamsters with Aerosolized Nipah Virus

Journal of Infectious Diseases

Volumn 218, Issue 10, 2018, Pages 1602-1610

  Escaffre, Olivier ^a   Hill, Terence ^a,b,c   Ikegami, Tetsuro ^a   Juelich, Terry L ^a   Smith, Jennifer K ^a   Zhang, Lihong ^a   Perez, David E ^a   Atkins, Colm ^a   Park, Arnold ^d   Lawrence, William S ^e   Sivasubramani, Satheesh K ^e   Peel, Jennifer E ^e   Peterson, Johnny W ^a,c   Lee, Benhur ^e   Freiberg, Alexander N ^a,b,c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Center for Biodefense and Emerging Infectious Diseasesv   (United States)

^c Institute for Human Infections and Immunity   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

aerosol; animal model; hamster; henipavirus; in vivo imaging.; Nipah virus; pathogenesis

Indexed keywords

FIREFLY LUCIFERASE; RECOMBINANT PROTEIN;

ADMINISTRATION AND DOSAGE; AEROSOL; ANIMAL; DIAGNOSTIC IMAGING; DISEASE MODEL; FLUORESCENCE IMAGING; GENETICS; HAMSTER; HENIPAVIRUS INFECTION; INHALATIONAL DRUG ADMINISTRATION; LUNG; MESOCRICETUS; METABOLISM; NIPAH VIRUS; PATHOGENICITY; PATHOLOGY; VIROLOGY;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; CRICETINAE; DISEASE MODELS, ANIMAL; HENIPAVIRUS INFECTIONS; LUCIFERASES, FIREFLY; LUNG; MESOCRICETUS; NIPAH VIRUS; OPTICAL IMAGING; RECOMBINANT PROTEINS;

EID: 85054438380     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiy357     Document Type: Article

References (42)

1. Chua KB, Bellini WJ, Rota PA, et al. Nipah virus: A recently emergent deadly paramyxovirus. Science 2000; 288:1432-5.
2. Eaton BT, Broder CC, Wang LF. Hendra and Nipah viruses: pathogenesis and therapeutics. Curr Mol Med 2005; 5:805-16.
3. Wong KT, Shieh WJ, Kumar S, et al.; Nipah Virus Pathology Working Group. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 2002; 161:2153-67.
4. Chua KB, Lam SK, Goh KJ, et al. The presence of Nipah virus in respiratory secretions and urine of patients during an outbreak of Nipah virus encephalitis in Malaysia. J Infect 2001; 42:40-3.
5. Goh KJ, Tan CT, Chew NK, et al. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N Engl J Med 2000; 342:1229-35.
6. Paton NI, Leo YS, Zaki SR, et al. Outbreak of Nipah-virus infection among abattoir workers in Singapore. Lancet 1999; 354:1253-6.
7. Gurley ES, Montgomery JM, Hossain MJ, et al. Person-toperson transmission of Nipah virus in a Bangladeshi community. Emerg Infect Dis 2007; 13:1031-7.
8. Harit AK, Ichhpujani RL, Gupta S, et al. Nipah/Hendra virus outbreak in Siliguri, West Bengal, India in 2001. Indian J Med Res 2006; 123:553-60.
9. Hossain MJ, Gurley ES, Montgomery JM, et al. Clinical presentation of Nipah virus infection in Bangladesh. Clin Infect Dis 2008; 46:977-84.
10. Hsu VP, Hossain MJ, Parashar UD, et al. Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis 2004; 10:2082-7.
11. Lo MK, Rota PA. The emergence of Nipah virus, a highly pathogenic paramyxovirus. J Clin Virol 2008; 43:396-400.
12. Tan CT, Tan KS. Nosocomial transmissibility of Nipah virus. J Infect Dis 2001; 184:1367.
13. Clayton BA, Middleton D, Arkinstall R, Frazer L, Wang LF, Marsh GA. The nature of exposure drives transmission of Nipah viruses from Malaysia and Bangladesh in ferrets. PLoS Negl Trop Dis 2016; 10:e0004775.
14. Clayton BA, Middleton D, Bergfeld J, et al. Transmission routes for Nipah virus from Malaysia and Bangladesh. Emerg Infect Dis 2012; 18:1983-93.
15. de Wit E, Bushmaker T, Scott D, Feldmann H, Munster VJ. Nipah virus transmission in a hamster model. PLoS Negl Trop Dis 2011; 5:e1432.
16. de Wit E, Prescott J, Falzarano D, et al. Foodborne transmission of Nipah virus in Syrian hamsters. PLoS Pathog 2014; 10:e1004001.
17. Geisbert TW, Daddario-DiCaprio KM, Hickey AC, et al. Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection. PLoS One 2010; 5:e10690.
18. Munster VJ, Prescott JB, Bushmaker T, et al. Rapid Nipah virus entry into the central nervous system of hamsters via the olfactory route. Sci Rep 2012; 2:736.
19. Rockx B, Brining D, Kramer J, et al. Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection. J Virol 2011; 85:7658-71.
20. Chong HT, Kunjapan SR, Thayaparan T, et al. Nipah encephalitis outbreak in Malaysia, clinical features in patients from Seremban. Can J Neurol Sci 2002; 29:83-7.
21. Chua KB. Nipah virus outbreak in Malaysia. J Clin Virol 2003; 26:265-75.
22. Chua KB, Goh KJ, Wong KT, et al. Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia. Lancet 1999; 354:1257-9.
23. Luby SP, Rahman M, Hossain MJ, et al. Foodborne transmission of Nipah virus, Bangladesh. Emerg Infect Dis 2006; 12:1888-94.
24. Mounts AW, Kaur H, Parashar UD, et al. A cohort study of health care workers to assess nosocomial transmissibility of Nipah virus, Malaysia, 1999. J Infect Dis 2001; 183:810-3.
25. Baseler L, Scott DP, Saturday G, et al. Identifying early target cells of Nipah virus infection in Syrian hamsters. PLoS Negl Trop Dis 2016; 10:e0005120.
26. Escaffre O, Borisevich V, Carmical JR, et al. Henipavirus pathogenesis in human respiratory epithelial cells. J Virol 2013; 87:3284-94.
27. Escaffre O, Borisevich V, Vergara LA, Wen JW, Long D, Rockx B. Characterization of Nipah virus infection in a model of human airway epithelial cells cultured at an air-liquid interface. J Gen Virol 2016; 97:1077-86.
28. Luby SP, Gurley ES, Hossain MJ. Transmission of human infection with Nipah virus. Clin Infect Dis 2009; 49:1743-8.
29. Cong Y, Lentz MR, Lara A, et al. Loss in lung volume and changes in the immune response demonstrate disease progression in African green monkeys infected by small-particle aerosol and intratracheal exposure to Nipah virus. PLoS Negl Trop Dis 2017; 11:e0005532.
30. DeBuysscher BL, de Wit E, Munster VJ, Scott D, Feldmann H, Prescott J. Comparison of the pathogenicity of Nipah virus isolates from Bangladesh and Malaysia in the Syrian hamster. PLoS Negl Trop Dis 2013; 7:e2024.
31. Yun T, Park A, Hill TE, et al. Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral spread in small animal models of henipavirus infection. J Virol 2015; 89:1242-53.
32. Roy CJ, Pitt LM. Infectious disease aerobiology: Aerosol challenge methods. In: Swearengen JR, ed. Biodefenseresearch methodology and animal models. Boca Raton, FL: CRC Press, 2012:65-80.
33. Guyton AC. Measurement of the respiratory volumes of laboratory animals. Am J Physiol 1947; 150:70-7.
34. Johnston SC, Briese T, Bell TM, et al. Detailed analysis of the African green monkey model of Nipah virus disease. PLoS One 2015; 10:e0117817.
35. Escaffre O, Saito TB, Juelich TL, et al. Contribution of human lung parenchyma and leukocyte influx to oxidative stress and immune system-mediated pathology following nipah virus infection. J Virol 2017; 91:pii:e00275-17.
36. Valbuena G, Halliday H, Borisevich V, Goez Y, Rockx B. A human lung xenograft mouse model of Nipah virus infection. PLoS Pathog 2014; 10:e1004063.
37. Baseler L, de Wit E, Scott DP, Munster VJ, Feldmann H. Syrian hamsters (Mesocricetus auratus) oronasally inoculated with a Nipah virus isolate from Bangladesh or Malaysia develop similar respiratory tract lesions. Vet Pathol 2015; 52:38-45.
38. Mire CE, Satterfield BA, Geisbert JB, et al. Pathogenic differences between Nipah virus Bangladesh and Malaysia strains in primates: implications for antibody therapy. Sci Rep 2016; 6:30916.
39. Walpita P, Cong Y, Jahrling PB, et al. A VLP-based vaccine provides complete protection against Nipah virus challenge following multiple-dose or single-dose vaccination schedules in a hamster model. NPJ Vaccines 2017; 2:21.
40. Wong KT, Grosjean I, Brisson C, et al. A golden hamster model for human acute Nipah virus infection. Am J Pathol 2003; 163:2127-37.
41. Tsuda A, Henry FS, Butler JP. Particle transport and deposition: basic physics of particle kinetics. Compr Physiol 2013; 3:1437-71.
42. Weingartl H, Czub S, Copps J, et al. Invasion of the central nervous system in a porcine host by Nipah virus. J Virol 2005; 79:7528-34.