H3Africa: Current perspectives

Pharmacogenomics and Personalized Medicine

Volumn 11, Issue , 2018, Pages 59-66

  Mulder, Nicola ^a   Abimiku, Alash’Le ^b   Adebamowo, Sally N ^c   de Vries, Jantina ^a   Matimba, Alice ^d   Olowoyo, Paul ^e   Ramsay, Michele ^f   Skelton, Michelle ^a   Stein, Dan J ^a,g  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b INSTITUTE OF HUMAN VIROLOGY NIGERIA   (Nigeria)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d Advanced Courses and Scientific Conferences   (United Kingdom)

^e AFE BABALOLA UNIVERSITY   (Nigeria)

^f UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^g South Africa xanthe sunacza   (South Africa)

Author keywords

Disease; Genomic medicine; H3Africa; Population genetics; Precision medicine; Training

Indexed keywords

ASSESSMENT OF HUMANS; BIOINFORMATICS; ENVIRONMENTAL FACTOR; FEASIBILITY STUDY; GENETIC ASSOCIATION STUDY; GENETIC VARIATION; GENOTYPE PHENOTYPE CORRELATION; HEREDITY; HUMAN; HUMAN HEREDITY AND HEALTH IN AFRICA; MEDICAL ETHICS; MEDICAL RESEARCH; MICROBIOME; PERSONALIZED MEDICINE; PHARMACOGENOMICS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 85054132960     PISSN: None     EISSN: 11787066     Source Type: Journal    
DOI: 10.2147/PGPM.S141546     Document Type: Review

References (34)

1. Biankin AV. The road to precision oncology. Nat Genet. 2017; 49(3):320–321.
2. Gómez-López G, Dopazo J, Cigudosa JC, Valencia A, Al-Shahrour F. Precision medicine needs pioneering clinical bioinformaticians. Brief Bioinform. Epub 2017 Oct 25.
3. Petrovski S, Goldstein DB. Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine. Genome Biol. 2016;17(1):157.
4. Rotimi C, Abayomi A, Abimiku A, et al. Enabling the genomic revolution in Africa. Science. 2014;344(6190):1346–1348.
5. Mulder NJ, Adebiyi E, Alami R, et al. H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa. Genome Res. 2015;26(2):271–277.
6. McKee M, Haines A, Ebrahim S, et al. Towards a comprehensive global approach to prevention and control of NCDs. Global Health. 2014;10:74.
7. Owolabi MO, Mensah GA, Kimmel PL, et al. Understanding the rise in cardiovascular diseases in Africa: harmonising H3Africa genomic epidemiological teams and tools. Cardiovasc J Afr. 2014;25(3): 134–136.
8. Peprah E, Wiley K, Troyer J, et al. Building a platform to enable NCD research to address population health in Africa: CVD working group discussion at the Sixth H3Africa Consortium Meeting in Zambia. Glob Heart. 2016;11(1):165–170.
9. Ramsay M, Crowther N, Tambo E, et al. H3Africa AWI-Gen collaborative centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries. Glob Health Epidemiol Genom. 2016;1:e20.
10. Gómez-Olivé FX, Ali SA, Made F, et al. Stark regional and sex differences in the prevalence and awareness of hypertension: an H3Africa AWI-Gen study across 6 sites in sub-Saharan Africa. Glob Heart. 2017;12(2): 81–90.
11. Akinyemi R, Arnett DK, Tiwari HK, et al. Interleukin-6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous west African men. J Neurol Sci. 2017;379:229–235.
12. Owolabi M, Salaam K, Ogunniyi A, et al. SIREN: Aim on Clear Canvas Enriched Stroke phenotyping (ACCESS) [software]. Nigeria patent NG/ PT/NC/2016/2007. 2016.
13. Campbell MM, Sibeko G, Mall S, et al. The content of delusions in a sample of South African Xhosa people with schizophrenia. BMC Psychiatry. 2017;17:41.
14. Campbell MM, Susser E, de Vries J, et al. Exploring researchers’ experiences of working with a researcher-driven, population-specific community advisory board in a South African schizophrenia genomics study. BMC Ethics. 2015;16:45.
15. World Health Organization. Ebola Situation Reports. Available from: http://www.who.int/csr/disease/ebola/situation-reports/archive/en/. Accessed November 28, 2017.
16. Yozwiak NL, Happi CT, Grant DS, et al. Roots, not parachutes: research collaborations combat outbreaks. Cell. 2016;166(1):5–8.
17. Schieffelin JS, Shaffer JG, Goba A, et al. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med. 2014; 371(22):2092–2100.
18. Selber-Hnatiw S, Rukundo B, Ahmadi M, et al. Human gut microbiota: toward an ecology of disease. Front Microbiol. 2017;8:1265.
19. Hall AB, Tolonen AC, Xavier RJ. Human genetic variation and the gut microbiome in disease. Nat Rev Genet. 2017;18(11):690–699.
20. Arrieta MC, Stiemsma LT, Amenyogbe N, Brown EM, Finlay B. The intestinal microbiome in early life: health and disease. Front Immunol. 2014;5:427.
21. Adebamowo SN, Dareng EO, Famooto AO, et al. Cohort profile: African Collaborative Center for Microbiome and Genomics Research’s (ACCME) human papillomavirus (HPV) and cervical cancer study. Int J Epidemiol. 2017;46(6):1745.
22. Dareng EO, Ma B, Famooto AO, et al. Prevalent high-risk HPV infection and vaginal microbiota in Nigerian women. Epidemiol Infect. 2016;144(1):123–137.
23. Adebamowo SN, Ma B, Zella D, et al. Mycoplasma hominis and Mycoplasma genitalium in the vaginal microbiota and persistent high-risk human papillomavirus infection. Front Public Health. 2017;5:140.
24. Popejoy AB, Fullerton SM. Genomics is failing on diversity. Nature. 2016;538(7624):161–164.
25. Auton A, Brooks LD, Durbin RM, et al. A global reference for human genetic variation. Nature. 2015;526(7571):68–74.
26. Gurdasani D, Carstensen T, Tekola-Ayele F, et al. The African Genome Variation Project shapes medical genetics in Africa. Nature. 2015;517(7534):327–332.
27. Abimiku A, Mayne E, Jaloba M, et al. H3Africa biorepository program: supporting genomics research on African populations by sharing high-quality biospecimens. Biopreserv Biobank. 2017;15(2):99–102.
28. Croxton T, Swanepoel C, Musinguzi H, et al. Lessons learned from biospecimen shipping among the Human Heredity and Health in Africa (H3Africa) biorepositories. Biopreserv Biobank. 2017;15(2):104–111.
29. Kyobe S, Musinguzi H, Lwanga N et al. Selecting a laboratory information management system for biorepositories in low-and middle-income countries: the H3Africa experience and lessons learned. Biopreserv Biobank. 2017;15(2):111–115.
30. Beiswanger C, Abimiku A, Carstens N, et al. Accessing biospecimens from the H3Africa consortium. Biopreserv Biobank 2017;15(2):95–98.
31. Korngiebel DM, Thummel KE, Burke W. Implementing precision medicine: the ethical challenges. Trends Pharmacol Sci. 2017;38(1):8–14.
32. Folarin OA, Happi AN, Happi CT. Empowering African genomics for infectious disease control. Genome Biol. 2014;15(11):515.
33. Gire SK, Goba A, Andersen KG, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 2014;345(6202):1369–1372.
34. Pratt B, Hyder A. Governance of transnational global health research consortia and health equity. Am J Bioeth. 2016;16(10):29–45.