Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test

Seminars in Hematology

Volumn 55, Issue 4, 2018, Pages 256-261

  Kulnigg Dabsch, Stefanie ^a   Resch, Maximilian ^a   Oberhuber, Georg ^a   Klinglmueller, Florian ^a   Gasche, Anke ^b   Gasche, Christoph ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Loha for Life Centre of Excellence for Iron Deficiency   (Austria)

Author keywords

Anemia; Autoimmune gastritis; Iron deficiency; Parietal cell antibody

Indexed keywords

ENDOMYSIUM ANTIBODY; FERRITIN; PARIETAL CELL ANTIBODY; TRANSFERRIN; AUTOANTIBODY;

ACHLORHYDRIA; ADULT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE GASTRITIS; CELIAC DISEASE; COHORT ANALYSIS; DIAGNOSTIC TEST ACCURACY STUDY; EARLY DIAGNOSIS; FEMALE; FOLLOW UP; GASTRITIS; GASTROINTESTINAL ENDOSCOPY; GASTROSCOPY; HISTOLOGY; HUMAN; HUMAN TISSUE; INCIDENCE; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; OCCULT BLOOD TEST; PH MEASUREMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SEROLOGY; STOMACH JUICE; STOMACH PARIETAL CELL; STOMACH PH; COMPLICATION; METABOLISM; PATHOLOGY;

ADULT; ANEMIA, IRON-DEFICIENCY; AUTOANTIBODIES; FEMALE; GASTRITIS; HUMANS; INCIDENCE; MALE; PARIETAL CELLS, GASTRIC; RETROSPECTIVE STUDIES;

EID: 85054092645     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2018.07.003     Document Type: Article

References (15)

1. Kassebaum, N.J., Jasrasaria, R., Naghavi, M., et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 123:5 (2014), 615–624 PubMed PMID: 24297872. Pubmed Central PMCID: 3907750.
2. McLean, E., Cogswell, M., Egli, I., Wojdyla, D., de Benoist, B., Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public health nutrition 12:4 (2009), 444–454 PubMed PMID: 18498676.
3. Branca, F., Piwoz, E., Schultink, W., Sullivan, L.M., Nutrition and health in women, children, and adolescent girls. BMJ, 351, 2015, h4173 PubMed PMID: 26371218.
4. Evstatiev, R., Gasche, C., Iron sensing and signalling. Gut 61:6 (2012), 933–952 PubMed PMID: 22016365.
5. Hershko, C., Ronson, A., Souroujon, M., Maschler, I., Heyd, J., Patz, J., Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion. Blood 107:4 (2006), 1673–1679 PubMed PMID: 16239424.
6. Kulnigg-Dabsch, S., Autoimmune gastritis. Wiener medizinische Wochenschrift 166:13-14 (2016), 424–430 PubMed PMID: 27671008. Pubmed Central PMCID: 5065578. Autoimmungastritis.
7. Dickey, W., Kenny, B.D., McMillan, S.A., Porter, K.G., McConnell, J.B., Gastric as well as duodenal biopsies may be useful in the investigation of iron deficiency anaemia. Scand J Gastroenterol 32:5 (1997), 469–472 PubMed PMID: 9175209.
8. Hershko, C., Hoffbrand, A.V., Keret, D., et al. Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica 90:5 (2005), 585–595 PubMed PMID: 15921373.
9. Annibale, B., Capurso, G., Chistolini, A., et al. Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms. Am J Med 111:6 (2001), 439–445 PubMed PMID: 11690568.
10. Goddard, A.F., James, M.W., McIntyre, A.S., Scott, B.B., British society of G. Guidelines for the management of iron deficiency anaemia. Gut 60:10 (2011), 1309–1316 PubMed PMID: 21561874.
11. Pittman, M.E., Voltaggio, L., Bhaijee, F., Robertson, S.A., Montgomery, E.A., Autoimmune metaplastic atrophic gastritis: recognizing precursor lesions for appropriate patient evaluation. Am J Surg Pathol 39:12 (2015), 1611–1620 PubMed PMID: 26291507.
12. Kaye, P.V., Garsed, K., Ragunath, K., Jawhari, A., Pick, B., Atherton, J.C., The clinical utility and diagnostic yield of routine gastric biopsies in the investigation of iron deficiency anemia: a case-control study. Am J Gastroenterol 103:11 (2008), 2883–2889 PubMed PMID: 18775015.
13. Zhang, Y., Weck, M.N., Schottker, B., Rothenbacher, D., Brenner, H., Gastric parietal cell antibodies, Helicobacter pylori infection, and chronic atrophic gastritis: evidence from a large population-based study in Germany. Cancer Epidemiol Biomarkers Prev 22:5 (2013), 821–826 PubMed PMID: 23456556.
14. Vannella, L., Lahner, E., Osborn, J., Annibale, B., Systematic review: gastric cancer incidence in pernicious anaemia. Aliment Pharmacol Ther 37:4 (2013), 375–382 PubMed PMID: 23216458.
15. Creutzfeldt, W., The achlorhydria-carcinoid sequence: role of gastrin. Digestion 39:2 (1988), 61–79 PubMed PMID: 3044896.