VarExp: Estimating variance explained by genome-wide GxE summary statistics

Bioinformatics

Volumn 34, Issue 19, 2018, Pages 3412-3414

  Laville, Vincent ^a   Bentley, Amy R ^b   Privé, Florian ^a,c   Zhu, Xiaofeng ^d   Gauderman, Jim ^e   Winkler, Thomas W ^f   Province, Mike ^g   Rao, D C ^h   Aschard, Hugues ^a  

^a INSTITUT PASTEUR   (France)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIV GRENOBLE ALPES   (France)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF REGENSBURG   (Germany)

^g Division of Statistical Genetics   (Germany)

^h WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; PHENOTYPE; SOFTWARE;

COMPUTATIONAL BIOLOGY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; PHENOTYPE; SOFTWARE;

EID: 85054063394     PISSN: 13674803     EISSN: 14602059     Source Type: Journal    
DOI: 10.1093/bioinformatics/bty379     Document Type: Article

References (6)

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2. Aschard, H. (2016) A perspective on interaction effects in genetic association studies. Genet. Epidemiol., 40, 678-688.
3. Aschard, H. et al. (2012) Challenges and opportunities in genome-wide environmental interaction (GWEI) studies. Hum. Genet., 131, 1591-1613.
4. Pare, G. et al. (2016) A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics. Sci. Rep., 6, 27644.
5. Robinson, M. R. et al. (2017) Genotype-covariate interaction effects and the heritability of adult body mass index. Nat. Genet., 49, 1174-1181.
6. Shi, H. et al. (2016) Contrasting the genetic architecture of 30 complex traits from summary association data. Am. J. Hum. Genet., 99, 139-153.