A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication

Nature Microbiology

Volumn 3, Issue 11, 2018, Pages 1214-1223

  Richardson, R Blake ^a   Ohlson, Maikke B ^a   Eitson, Jennifer L ^a   Kumar, Ashwani ^b   McDougal, Matthew B ^a   Boys, Ian N ^a   Mar, Katrina B ^a   De La Cruz Rivera, Pamela C ^a   Douglas, Connor ^a   Konopka, Genevieve ^a   Xing, Chao ^b   Schoggins, John W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; CHAPERONE; HEAT SHOCK PROTEIN 70; INTERFERON REGULATORY FACTOR 6; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR; ALPHA INTERFERON; ANTIVIRUS AGENT; HEAT SHOCK PROTEIN; IFI6 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; MOLECULAR CHAPERONE GRP78; PROTEIN BINDING;

CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FLAVIVIRUS; GENE; GENE FUNCTION; GENETIC SCREENING; HEPATITIS C VIRUS; HSPA5 GENE; IFI6 GENE; LETTER; NONHUMAN; PRIORITY JOURNAL; VIRUS GENOME; VIRUS REPLICATION; CYTOKINE RESPONSE; HUMAN; HUMAN CELL; MOLECULAR CLONING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; ANIMAL; DRUG EFFECT; GENE KNOCKOUT; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; PHYSIOLOGY; SPECIES DIFFERENCE; VIROLOGY; YELLOW FEVER; YELLOW FEVER VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; ENDOPLASMIC RETICULUM; GENE KNOCKOUT TECHNIQUES; GENOME-WIDE ASSOCIATION STUDY; HEAT-SHOCK PROTEINS; HUMANS; INTERFERON-ALPHA; MITOCHONDRIAL PROTEINS; PROTEIN BINDING; SPECIES SPECIFICITY; VIRUS REPLICATION; YELLOW FEVER; YELLOW FEVER VIRUS;

EID: 85053527024     PISSN: None     EISSN: 20585276     Source Type: Journal    
DOI: 10.1038/s41564-018-0244-1     Document Type: Letter

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