Association of Antenatal Micronutrient Supplementation With Adolescent Intellectual Development in Rural Western China 14-Year Follow-up From a Randomized Clinical Trial

JAMA Pediatrics

Volumn 172, Issue 9, 2018, Pages 832-841

  Zhu, Zhonghai ^a   Cheng, Yue ^a   Zeng, Lingxia ^a   Elhoumed, Mohamed ^a   He, Guobin ^a   Li, Wenhao ^g   Zhang, Min ^g   Li, Wenjing ^g   Li, Danyang ^g   Tsegaye, Sintayehu ^g   Chang, Suying ^b   Yan, Hong ^c   Yu Wang, Emma ^d   Wang, Duolao ^e   Jaffar, Shabbar ^e   Dibley, Michael J ^f  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b United Nations Children's Fund Office for China   (China)

^c Therapeutic Vaccines Engineering Center of Shaanxi Province   (China)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^f UNIVERSITY OF SYDNEY   (Australia)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; IRON; TRACE ELEMENT;

ADOLESCENT; ADOLESCENT DEVELOPMENT; ADULT; ARTICLE; CHILD; CHINA; COGNITION; COGNITIVE DEVELOPMENT; COMPARATIVE STUDY; COMPREHENSION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; GESTATIONAL AGE; HUMAN; INTELLIGENCE QUOTIENT; IRON THERAPY; LIVE BIRTH; MALE; MICROCAPSULE; PERCEPTUAL REASONING; PRENATAL CARE; PRIORITY JOURNAL; PROCESSING SPEED; PROGENY; RANDOMIZED CONTROLLED TRIAL; RURAL AREA; SCHOOL CHILD; VERBAL LEARNING; VITAMIN SUPPLEMENTATION; WECHSLER INTELLIGENCE SCALE FOR CHILDREN; WORKING MEMORY; YOUNG ADULT; CHILD DEVELOPMENT; CHILD HEALTH; DIETARY SUPPLEMENT; MATERNAL NUTRITION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RURAL POPULATION;

ADOLESCENT; CHILD; CHILD DEVELOPMENT; CHILD HEALTH; CHINA; DIETARY SUPPLEMENTS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MICRONUTRIENTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RURAL POPULATION;

EID: 85053020018     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2018.1401     Document Type: Article

References (29)

1. Black MM, Walker SP, Fernald LCH, et al; Lancet Early Childhood Development Series Steering Committee. Early childhood development coming of age: science through the life course. Lancet. 2017;389(10064):77-90. doi:10.1016/S0140-6736 (16)31389-7
2. Black RE, Victora CG, Walker SP, et al; Maternal and Child Nutrition Study Group. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013;382(9890): 427-451. doi:10.1016/S0140-6736(13)60937-X
3. Berti C, Biesalski HK, Gärtner R, et al. Micronutrients in pregnancy: current knowledge and unresolved questions. Clin Nutr. 2011;30(6): 689-701. doi:10.1016/j.clnu.2011.08.004
4. Ruel MT, Alderman H; Maternal and Child Nutrition Study Group. Nutrition-sensitive interventions and programmes: how can they help to accelerate progress in improving maternal and child nutrition? Lancet. 2013;382(9891):536-551. doi:10.1016/S0140-6736(13)60843-0
5. Fox SE, Levitt P, Nelson CA III. How the timing and quality of early experiences influence the development of brain architecture. Child Dev. 2010; 81(1):28-40. doi:10.1111/j.1467-8624.2009.01380.x
6. Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev. 2017;4:CD004905. doi:10.1002/14651858.CD004905.pub5
7. Zeng L, Yan H, Cheng Y, Dibley MJ. Modifying effects of wealth on the response to nutrient supplementation in pregnancy on birth weight, duration of gestation and perinatal mortality in rural western China: double-blind cluster randomized controlled trial. Int J Epidemiol. 2011;40(2):350-362. doi:10.1093/ije/dyq262
8. Zeng L, Dibley MJ, Cheng Y, et al. Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial. BMJ. 2008;337: a2001. doi:10.1136/bmj.a2001
9. Li Q, Yan H, Zeng L, et al. Effects of maternal multimicronutrient supplementation on the mental development of infants in rural western China: follow-up evaluation of a double-blind, randomized, controlled trial. Pediatrics. 2009;123(4):e685-e692. doi:10.1542/peds.2008-3007
10. Li C, Zeng L, Wang D, et al. Prenatal micronutrient supplementation is not associated with intellectual development of young school-aged children. J Nutr. 2015;145(8):1844-1849. doi:10.3945/jn.114.207795
11. Wechsler D. The Wechsler Intelligence Scale for Children. 4th ed. London: Pearson; 2004.
12. Chen H, Keith TZ, Weiss L, Zhu J, Li Y. Testing for multigroup invariance of second-order WISC-IV structure across China, Hong Kong, Macau, and Taiwan. Pers Individ Dif. 2010;49(7):677-682. doi: 10.1016/j.paid.2010.06.004
13. Butte NF, Garza C, de Onis M. Evaluation of the feasibility of international growth standards for school-aged children and adolescents. J Nutr. 2007; 137(1):153-157. doi:10.1093/jn/137.1.153
14. Sterne JA, White IR, Carlin JB, et al. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;338:b2393. doi:10.1136/bmj.b2393
15. Villar J, Cheikh Ismail L, Victora CG, et al; International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st). International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet. 2014;384 (9946):857-868. doi:10.1016/S0140-6736(14) 60932-6
16. Filmer D, Pritchett LH. Estimating wealth effects without expenditure data-or tears: an application to educational enrollments in states of India. Demography. 2001;38(1):115-132.
17. Prado EL, Sebayang SK, Apriatni M, et al. Maternal multiple micronutrient supplementation and other biomedical and socioenvironmental influences on children's cognition at age 9-12 years in Indonesia: follow-up of the SUMMIT randomised trial. Lancet Glob Health. 2017;5(2):e217-e228. doi: 10.1016/S2214-109X(16)30354-0
18. Dulal S, Liégeois F, Osrin D, et al. Does antenatal micronutrient supplementation improve children's cognitive function? evidence from the follow-up of a double-blind randomised controlled trial in Nepal. BMJ Glob Health. 2018;3(1):e000527. doi:10.1136 /bmjgh-2017-000527
19. Prado EL, Alcock KJ, Muadz H, Ullman MT, Shankar AH; SUMMIT Study Group. Maternal multiple micronutrient supplements and child cognition: a randomized trial in Indonesia. Pediatrics. 2012;130(3):e536-e546. doi:10.1542/peds.2012-0412
20. Tofail F, Persson LA, El Arifeen S, et al. Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study. Am J Clin Nutr. 2008;87(3):704-711. doi:10.1093 /ajcn/87.3.704
21. Manji KP, McDonald CM, Kupka R, et al. Effect of multivitamin supplementation on the neurodevelopment of HIV-exposed Tanzanian infants: a randomized, double-blind, placebo-controlled clinical trial. J Trop Pediatr. 2014;60(4):279-286. doi:10.1093/tropej/fmu011
22. Smith ER, Shankar AH, Wu LS, et al. Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries. Lancet Glob Health. 2017;5(11):e1090-e1100. doi:10.1016 /S2214-109X(17)30371-6
23. Christian P, Murray-Kolb LE, Khatry SK, et al. Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal. JAMA. 2010;304(24):2716-2723. doi:10.1001/jama.2010.1861
24. Chang S, Zeng L, Brouwer ID, Kok FJ, Yan H. Effect of iron deficiency anemia in pregnancy on child mental development in rural China. Pediatrics. 2013;131(3):e755-e763. doi:10.1542/peds.2011-3513
25. Dreyfuss ML, Stoltzfus RJ, Shrestha JB, et al. Hookworms, malaria and vitamin A deficiency contribute to anemia and iron deficiency among pregnant women in the plains of Nepal. J Nutr. 2000;130(10):2527-2536. doi:10.1093/jn/130.10.2527
26. Szajewska H, Ruszczynski M, Chmielewska A. Effects of iron supplementation in nonanemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: a systematic review of randomized controlled trials. Am J Clin Nutr. 2010; 91(6):1684-1690. doi:10.3945/ajcn.2010.29191
27. Black RE, Allen LH, Bhutta ZA, et al; Maternal and Child Undernutrition Study Group. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 2008; 371(9608):243-260. doi:10.1016/S0140-6736(07) 61690-0
28. UNICEF, World Health Organization, and United Nations University. Composition of a multi-micronutrient supplement to be used in pilot programmes among pregnant women in developing countries: report of a United Nations Children's Fund (UNICEF), World Health Organization (WHO) and United Nations University Workshop. New York, NY: UNICEF; 1999.
29. Devakumar D, Fall CH, Sachdev HS, et al. Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis. BMC Med. 2016;14:90. doi:10.1186/s12916-016-0633-3