Does low-dose aspirin improve pregnancy rate in women undergoing frozen-thawed embryo transfer cycle? A pilot double-blind, randomized placebo-controlled trial

Journal of Obstetrics and Gynaecology Research

Volumn 45, Issue 1, 2019, Pages 156-163

  Madani, Tahereh ^a   Ahmadi, Firoozeh ^a   Jahangiri, Nadia ^a   Bahmanabadi, Akram ^a   Bagheri Lankarani, Narges ^a  

^a ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

Author keywords

aspirin; frozen thawed embryo transfer cycle; pregnancy rate; pulsatility index; resistance index

Indexed keywords

ACETYLSALICYLIC ACID; PLACEBO; HEMATOLOGIC AGENT;

ADULT; ARTICLE; BIRTH RATE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG RESISTANCE; EMBRYO; EMBRYO TRANSFER; ENDOMETRIUM; FEMALE; HEMODYNAMICS; HUMAN; LIVE BIRTH; LOW DRUG DOSE; MAJOR CLINICAL STUDY; NIDATION; PILOT STUDY; PREGNANCY RATE; PULSATILITY INDEX; RANDOMIZED CONTROLLED TRIAL; RESISTANCE INDEX; SPONTANEOUS ABORTION; TREATMENT OUTCOME; UTERUS BLOOD FLOW; CRYOPRESERVATION; OUTCOME ASSESSMENT; PREGNANCY; PROCEDURES; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ABORTION, SPONTANEOUS; ADULT; ASPIRIN; CRYOPRESERVATION; DOUBLE-BLIND METHOD; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; HEMATOLOGIC AGENTS; HUMANS; LIVE BIRTH; OUTCOME ASSESSMENT (HEALTH CARE); PILOT PROJECTS; PREGNANCY; PREGNANCY RATE; YOUNG ADULT;

EID: 85052935324     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/jog.13802     Document Type: Article

References (43)

1. Haapsamo M, Martikainen H, Rasanen J. Low-dose aspirin and uterine haemodynamics on the day of embryo transfer in women undergoing IVF/ICSI: A randomized, placebo-controlled, double-blind study. Hum Reprod 2009; 24: 861–866
2. Ashrafi M, Tehraninejad ES, Haghiri M, Masomi M, Sadatmahalleh SJ, Arabipoor A. The effect of endometrial scratch injury on pregnancy outcome in women with previous intrauterine insemination failure: A randomized clinical trial. J Obstet Gynaecol Res 2017; 43: 1421–1427
3. Strowitzki T, Germeyer A, Popovici R, von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update 2006; 12: 617–630
4. Zaidi J, Pittrof R, Shaker A, Kyei-Mensah A, Campbell S, Tan SL. Assessment of uterine artery blood flow on the day of human chorionic gonadotropin administration by transvaginal color Doppler ultrasound in an in vitro fertilization program. Fertil Steril 1996; 65: 377–381
5. Chien LW, Au HK, Chen PL, Xiao J, Tzeng CR. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertil Steril 2002; 78: 245–251
6. Merce LT, Barco MJ, Bau S, Troyano J. Are endometrial parameters by three-dimensional ultrasound and power Doppler angiography related to in vitro fertilization/embryo transfer outcome? Fertil Steril 2008; 89: 111–117
7. Zaidi J, Campbell S, Pittrof R, Tan SL. Endometrial thickness, morphology, vascular penetration and velocimetry in predicting implantation in an in vitro fertilization program. Ultrasound Obstet Gynecol 1995; 6: 191–198
8. Yaman C, Ebner T, Sommergruber M, Polz W, Tews G. Role of three-dimensional ultrasonographic measurement of endometrium volume as a predictor of pregnancy outcome in an IVF-ET program: A preliminary study. Fertil Steril 2000; 74: 797–801
9. Puerto B, Creus M, Carmona F, Civico S, Vanrell JA, Balasch J. Ultrasonography as a predictor of embryo implantation after in vitro fertilization: A controlled study. Fertil Steril 2003; 79: 1015–1022
10. Isaksson R, Tiitinen A, Reinikainen LM, Cacciatore B. Comparison of uterine and spiral artery blood flow in women with unexplained and tubal infertility. Ultrasound Obstet Gynecol 2003; 21: 174–180
11. Cacciatore B, Simberg N, Fusaro P, Tiitinen A. Transvaginal Doppler study of uterine artery blood flow in in vitro fertilization-embryo transfer cycles. Fertil Steril 1996; 66: 130–134
12. Dirckx K, Cabri P, Merien A et al. Does low-dose aspirin improve pregnancy rate in IVF/ICSI? A randomized double-blind placebo controlled trial. Hum Reprod 2009; 24: 856–860
13. Ahrens KA, Silver RM, Mumford SL et al. Complications and safety of preconception low-dose aspirin among women with prior pregnancy losses. Obstet Gynecol 2016; 127: 689–698
14. Schisterman EF, Silver RM, Lesher LL et al. Preconception low-dose aspirin and pregnancy outcomes: Results from the EAGeR randomised trial. Lancet 2014; 384: 29–36
15. Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR. The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod 1994; 9: 1954–1957
16. Check JH, Dietterich C, Lurie D, Nazari A, Chuong J. A matched study to determine whether low-dose aspirin without heparin improves pregnancy rates following frozen embryo transfer and/or affects endometrial sonographic parameters. J Assist Reprod Genet 1998; 15: 579–582
17. Madani T, Ashrafi M, Jahangiri N, Abadi AB, Lankarani N. Improvement of pregnancy rate by modification of embryo transfer technique: A randomized clinical trial. Fertil Steril 2010; 94: 2424–2426
18. Moini A, Ahmadi F, Jahangiri N, Ahmadi J, Akhoond MR. A randomized controlled trial evaluating the effect of ethinyl estradiol during clomiphene citrate cycles among women with polycystic ovary syndrome. Int J Gynaecol Obstet 2015; 131: 129–132
19. Baczkowski T, Kurzawa R, Glabowski W. Methods of embryo scoring in in vitro fertilization. Reprod Biol 2004; 4: 5–22
20. Dickey RP. Doppler ultrasound investigation of uterine and ovarian blood flow in infertility and early pregnancy. Hum Reprod Update 1997; 3: 467–503
21. Zegers-Hochschild F, Adamson GD, de Mouzon J et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 2009; 92: 1520–1524
22. Rubinstein M, Marazzi A, Polak de Fried E. Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: A prospective, randomized, double-blind placebo-controlled assay. Fertil Steril 1999; 71: 825–829
23. Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium: Prospective, randomized study. Fertil Steril 1997; 68: 927–930
24. Waldenstrom U, Hellberg D, Nilsson S. Low-dose aspirin in a short regimen as standard treatment in in vitro fertilization: A randomized, prospective study. Fertil Steril 2004; 81: 1560–1564
25. Lok IH, Yip SK, Cheung LP, Yin Leung PH, Haines CJ. Adjuvant low-dose aspirin therapy in poor responders undergoing in vitro fertilization: A prospective, randomized, double-blind, placebo-controlled trial. Fertil Steril 2004; 81: 556–561
26. Dentali F, Ageno W, Rezoagli E et al. Low-dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: A systematic review and a meta-analysis of the literature. J Thromb Haemost 2012; 10: 2075–2085
27. Khairy M, Banerjee K, El-Toukhy T, Coomarasamy A, Khalaf Y. Aspirin in women undergoing in vitro fertilization treatment: A systematic review and meta-analysis. Fertil Steril 2007; 88: 822–831
28. Siristatidis CS, Basios G, Pergialiotis V, Vogiatzi P. Aspirin for in vitro fertilisation. Cochrane Database Syst Rev 2016; (11): CD004832. https://doi.org/10.1002/14651858.CD004832.pub4
29. Bates SM. Anticoagulation and in vitro fertilization and ovarian stimulation. Hematology Am Soc Hematol Educ Program 2014; 2014: 379–386
30. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. High ongoing pregnancy rates after deferred transfer through bipronuclear oocyte cryopreservation and post-thaw extended culture. Fertil Steril 2009; 92: 1594–1599
31. Simon C, Cano F, Valbuena D, Remohi J, Pellicer A. Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients. Hum Reprod 1995; 10: 2432–2437
32. Rott H. Prevention and treatment of venous thromboembolism during HRT: Current perspectives. Int J Gen Med 2014; 7: 433–440
33. Chan WS. The 'ART' of thrombosis: A review of arterial and venous thrombosis in assisted reproductive technology. Curr Opin Obstet Gynecol 2009; 21: 207–218
34. Rova K, Passmark H, Lindqvist PG. Venous thromboembolism in relation to in vitro fertilization: An approach to determining the incidence and increase in risk in successful cycles. Fertil Steril 2012; 97: 95–100
35. Zhao M, Chang C, Liu Z, Chen LM, Chen Q. Treatment with low-dose aspirin increased the level LIF and integrin beta3 expression in mice during the implantation window. Placenta 2010; 31: 1101–1105
36. Lessey BA, Castelbaum AJ. Integrins and implantation in the human. Rev Endocr Metab Disord 2002; 3: 107–117
37. Cheng JG, Chen JR, Hernandez L, Alvord WG, Stewart CL. Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation. Proc Natl Acad Sci U S A 2001; 98: 8680–8685
38. Steer CV, Campbell S, Tan SL et al. The use of transvaginal color flow imaging after in vitro fertilization to identify optimum uterine conditions before embryo transfer. Fertil Steril 1992; 57: 372–376
39. Bassil S, Magritte JP, Roth J, Nisolle M, Donnez J, Gordts S. Uterine vascularity during stimulation and its correlation with implantation in in-vitro fertilization. Hum Reprod 1995; 10: 1497–1501
40. Ng EH, Chan CC, Tang OS, Yeung WS, Ho PC. Relationship between uterine blood flow and endometrial and subendometrial blood flows during stimulated and natural cycles. Fertil Steril 2006; 85: 721–727
41. Aydin T, Kara M, Nurettin T. Relationship between endometrial thickness and in vitro fertilization-intracytoplasmic sperm injection outcome. Int J Fertil Steril 2013; 7: 29–34
42. Wu Y, Gao X, Lu X et al. Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration. Reprod Biol Endocrinol 2014; 12: 96
43. Hsieh YY, Tsai HD, Chang CC, Lo HY, Chen CL. Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: A prospective, randomized study. J Assist Reprod Genet 2000; 17: 174–177