Inhibition of IκBα phosphorylation prevents glutamate-induced NF-κB activation and neuronal cell death

Acta Neurochirurgica, Supplementum

Volumn , Issue 93, 2005, Pages 59-63

  Pizzi, M ^a   Sarnico, I ^a   Boroni, F ^a   Benetti, A ^b   Benarese, M ^a   Spano, P F ^a  

^a Division of Pharmacology   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Bay 11 7082; Glutamate; IL 1 ; NF B, p65

Indexed keywords

ENZYME INHIBITOR; GLUTAMIC ACID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CEREBELLUM; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CEREBELLUM; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUTAMIC ACID; I-KAPPA B PROTEINS; INTERLEUKIN-1; NEURONS; NF-KAPPA B; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 85052609071     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/3-211-27577-0_8     Document Type: Article

References (23)

1. Andrews NC, Faller DV (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleid Acid Res 19:2499
2. Bethea JR, Castro M, Keane RW, Lee TT, Dietrich WD, Yezierski RP (1998) Traumatic spinal cord injury induces nuclear factor-kappaB activation. J Neurosci 18:3251-3260
3. Cheema ZF, Wade SB, Sata M, Walsh K, Sohrabji F, Miranda RC (1999) Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. J Neurosci 19:1754-1770
4. Dai Y, Pei XY, Rahmani M, Conrad DH, Dent P, Grant S (2004) Interruption of the NF-{kappa}B pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells. Blood 103(7):2761-2770
5. Ferri KF, Kroemer G (2001) Organelle-specific initiation of cell death pathways. Nat Cell Biol 3 (11) : E255-263
6. Grilli M, Pizzi M, Memo M, Spano PF (1996) Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274:1383-1385
7. Hsu YT, Wolter KG, Youle RJ (1997) Cytosol-to-membrane redistribution of Bax and Bcl-x (L) during apoptosis. Proc Natl Acad Sci USA 94(8):3668-3672
8. Hunot S, Brugg B, Ricard D, Michel PP, Muriel MP, Ruberg M, Faucheux BA, Agid Y, Hirsch EC (1997) Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson's disease. Proc Natl Acad Sci USA 94:7531-7536 (Pubitemid 27345350)
9. Jones KH, Senft JA (1985) An improved method to determine cell viability by simultaneous staining with fluorescein diacetatepropidium iodide. J Histochem Cytochem 33:77-79
10. Kopp E, Ghosh S (1994) Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265(5174):956-959
11. Koulic E, Nguyen T, Johnson K, Giardina CA, D'Mello SR (2001) NFκB is involved in the survival of cerebellar granule neurons: association of IκB phosphorylation with cell survival. J Neurochem 76:1188-1198
12. Luo Y, Cao G, Pei W, O'Horo C, Graham SH, Chen J (2002) Induction of caspase-activated deoxyribonuclease activity after focal cerebral ischemia and reperfusion. J Cereb Blood Flow Metab 22(1):15-20
13. Mattson MP, Culmsee C, Yu Z, Camandola S (2000) Roles of nuclear factor kappaB in neuronal survival and plasticity. J Neurochem 74:443-456
14. Middleton G, Hamanoue M, Enokido Y, Wyatt S, Pennica D, Jaffray E, Hay RT, Davies AM (2000) Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. J Cell Biol 148:325-332
15. O'Neill LA, Kaltschmidt C (1997) NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 20:252-258
16. Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, Gerritsen ME (1997) Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272(34):21096-21103
17. Pizzi M, Fallacara C, Arrighi V, Memo M, Spano PF (1993) Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells. J Neurochem 61:683-689
18. Pizzi M, Goffi F, Boroni F, Benarese M, Perkins SE, Liou H, Spano PF (2002) Opposing role for NF-κB/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleuki-1b. J Biol Chem 277(23):20717-20723
19. Qin ZH, Chen RW, Wang Y, Nakay M, De Maw C, Chase TN (1999) Nuclear factor κB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. J Neurosci 19:4023-4035
20. Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M (1999) NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 5:554-559
21. Terai K, Matsuo A, McGeer PL (1996b) Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease. Brain Res 735:159-168
22. Wang L, Miura M, Bergeron L, Zhu H, Yuan J (1994) Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78(5):739-750
23. Yu ZF, Zhou D, Bruce-Keller AJ, Kindy MS, Mattson MP (1999) Lack of the p50 subunit of NF-kB increases vulnerability of hippocampal neurons to excitotoxic injury. J Neurosci 19:8856-8865