A comparison of haemostatic biomarkers during low-risk patients undergoing cardiopulmonary bypass using either conventional centrifugal cell salvage or the HemoSep device

Perfusion (United Kingdom)

Volumn 34, Issue 1, 2019, Pages 76-83

  Boyle, Gethin ^a   Kuffel, Agnieszka ^b   Parmar, Kiran ^b   Gibson, Kirsty ^a   Smith, Megan ^a   Grehan, Aidan ^a   Hunt, Beverley J ^a,b   Chambers, David J ^c  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b Rayne Institute   (United Kingdom)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

autologous; blood; blood transfusion; bypass; cardiac surgery; cardiopulmonary; coagulation; platelets; thrombin

Indexed keywords

BIOLOGICAL MARKER; D DIMER; FIBRINOGEN; HEMOGLOBIN;

ACTIVATED PARTIAL THROMBOPLASTIN TIME; ADULT; AORTIC VALVE REPLACEMENT; ARTICLE; BACTERIUM CONTAMINATION; BLOOD ANALYSIS; BLOOD AUTOTRANSFUSION; BLOOD CELL COUNT; BLOOD CLOTTING DISORDER; BLOOD SALVAGE; BLOOD SAMPLING; BLOOD VOLUME; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DISEASE COURSE; ERYTHROCYTE; FEMALE; FIBRINOGEN METABOLISM; HEMOCONCENTRATION; HEMOSTASIS; HUMAN; HUMAN CELL; LOW RISK PATIENT; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT; ADOLESCENT; AGED; CLINICAL TRIAL; DEVICES; HEART SURGERY; METABOLISM; MIDDLE AGED; OPERATIVE BLOOD LOSS; PROCEDURES;

ADOLESCENT; ADULT; AGED; BIOMARKERS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION, AUTOLOGOUS; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; ERYTHROCYTES; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; OPERATIVE BLOOD SALVAGE; YOUNG ADULT;

EID: 85052225476     PISSN: 02676591     EISSN: 1477111X     Source Type: Journal    
DOI: 10.1177/0267659118789051     Document Type: Article

References (12)

1. NICE, 2014. NICE recommends new tests for bleeding problems during and after cardiac surgery [online] Available at: http://www.nice.org.uk/news/press-and-media/nice-recommends-new-tests-for-bleeding-problems-during-and-after-cardiac-surgery [Accessed: 19th April 2015]
2. Samolyk KA, Beckmann SR, Bissinger RC., A new practical technique to reduce allogenic blood exposure and hospital costs while preserving clotting factors after cardiopulmonary bypass: the Hemobag. Perfusion 2005; 20: 343–349
3. Yarham G, Clements A, Oliver M. Evaluating the next generation of cell salvage – will it make a difference? Perfusion 2011; 26: 263–270
4. Gunaydin S, Gourlay T., Novel ultrafiltration technique for blood conservation in cardiac operations. Ann Thorac Surg 2013; 95: 2148–2151
5. Hogan M, Needham A, Ortmann E. Haemoconcentration of residual cardiopulmonary bypass blood using HemoSep: a randomised controlled trial. Anaesthesia 2015; 70: 563–570
6. Coakley M, Hall JE, Evans C. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with post-operative bleeding. J Thromb Haemost 2011; 9: 282–292
7. Raivio P, Kuitunen A, Suojaranta-Ylinen R, Lassila R, Petäjä J., Thrombin generation during reperfusion after coronary artery bypass surgery associates with post-operative myocardial damage. J Thromb Haemost 2006; 4: 1523–1529
8. Raivio P., Lassila R., Petäjä J., Thrombin in myocardial ischemia-reperfusion during cardiac surgery. Ann Thorac Surg 2009; 88: 318–325
9. Scrascia G, Rotunno C, Nanna D. Pump blood processing, salvage and re-transfusion improves haemoglobin levels after coronary artery bypass grafting, but affects coagulative and fibrinolytic systems. Perfusion 2012; 27: 270–277
10. Daane CR, Golab HD, Meeder JH, Wijers MJ, Bogers AJ., Processing and transfusion of residual cardiopulmonary bypass volume: effects on haemostasis, complement activation, post-operative blood loss and transfusion. Perfusion 2009; 18: 115–121
11. Mittermayr M, Velik-Salchner C, Stalzer B. Detection of protamine and heparin after termination of cardiopulmonary bypass by thrombelastometry (ROTEM): results of a pilot study. Anesth Analg 2009; 108; 3: 743–750
12. Nitescu N, Bengtsson A, Bengtson JP., Blood salvage with continuous autotransfusion system compared with a haemofiltration system. Perfusion 2002; 17: 357–362