Raising the Dose and Raising the Cost: The Case of Pembrolizumab in Lung Cancer

Journal of the National Cancer Institute

Volumn 109, Issue 11, 2017, Pages

  Bach, Peter B ^a   Saltz, Leonard B ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEMBROLIZUMAB; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

DRUG COST; DRUG DOSE INCREASE; EDITORIAL; HUMAN; LUNG CANCER; PHYSICIAN; PREVALENCE; COST BENEFIT ANALYSIS; ECONOMICS; LUNG TUMOR;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS, IMMUNOLOGICAL; COST-BENEFIT ANALYSIS; HUMANS; LUNG NEOPLASMS;

EID: 85051742202     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djx125     Document Type: Editorial

References (7)

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2. Bennette CS, Richards C, Sullivan SD, Ramsey SD. Steady increase in prices for oral anticancer drugs after market launch suggests a lack of competitive pressure. Health Affairs. 2016;35(5):805–812.
3. Crow D. Cancer pill costs soar as drug companies retain pricing power. Financial Times. April 30, 2017. https://www.ft.com/content/935e6ebe-29a1-11e7-9ec8-168383da43b7. Accessed May 2, 2017.
4. Goldstein DA, Gordon N, Davidescu M, et al. A phamacoeconomic analysis of personalized dosing versus fixed dosing of pembrolizumab in first-line PD-L1 positive non-small cell lung cancer. J Natl Cancer Inst. 2017;109(11): djx063.
5. Bach PB, Conti RM, Muller RJ, Schnorr GC, Saltz LB. Overspending driven by oversized single dose vials of cancer drugs. BMJ. 2016;352.
6. Conti RM, Rosenthal MB, Polite BN, Bach PB, Shih Y-CT. Infused chemotherapy use in the elderly after patent expiration. J Oncol Pract. 2012;8(3S):e18s–e23s.
7. Jain RH, Schleicher SM, Atoria CH, Bach PB. Part B payment for drugs in Medicare: Phase 1 of CMS’ proposed pilot and its impact on oncology care. 2016. Drugpricinglab.org. Accessed May 5, 2017.