Polygenic prediction of the phenome, across ancestry, in emerging adulthood

Psychological Medicine

Volumn 48, Issue 11, 2018, Pages 1814-1823

  Docherty, Anna R ^a,b   Moscati, Arden ^c,d   Dick, Danielle ^e   Savage, Jeanne E ^c,f   Salvatore, Jessica E ^c,e   Cooke, Megan ^c   Aliev, Fazil ^e,g   Moore, Ashlee A ^c   Edwards, Alexis C ^c   Riley, Brien P ^c   Adkins, Daniel E ^a,b   Peterson, Roseann ^c   Webb, Bradley T ^c   Bacanu, Silviu A ^c   Kendler, Kenneth S ^c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f VU UNIVERSITY AMSTERDAM   (Netherlands)

^g KARABUK UNIVERSITY   (Turkey)

Author keywords

Cardiovascular; genetic; neuroticism; phenome; polygenic; schizophrenia

Indexed keywords

ADOLESCENT; ADULT; FEMALE; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MULTIFACTORIAL INHERITANCE; NEUROSIS; PHENOTYPE; SCHIZOPHRENIA; STATISTICS AND NUMERICAL DATA; UNITED STATES; YOUNG ADULT;

ADOLESCENT; ADULT; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MENTAL DISORDERS; MID-ATLANTIC REGION; MULTIFACTORIAL INHERITANCE; NEUROTICISM; PHENOTYPE; SCHIZOPHRENIA; YOUNG ADULT;

EID: 85050662403     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291717003312     Document Type: Article

References (31)

1. Akaike H (1974) A new look at the statistical model identification. IEEE Transactions on Automatic Control 19, 716-723.
2. Benjamini Y and Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological) 57, 289-300.
3. Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh PR, Duncan L, Perry JR, Patterson N, Robinson EB, Daly MJ, Price AL and Neale BM (2015) An atlas of genetic correlations across human diseases and traits. Nature Genetics 47, 1236-1241.
4. Buysse DJ, Reynolds CF, Monk TH, Berman SR and Kupfer DJ (1989) The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research 28, 193-213.
5. Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. Lancet 381, 1371-1379.
6. Cuijpers P, Smit F, Penninx BW, de Graaf R, ten Have M and Beekman AT (2010) Economic costs of neuroticism: A population-based study. Archives of General Psychiatry 67, 1086-1093.
7. Derogatis LR and Cleary PA (1977) Confirmation of the dimensional structure of the SCL-90: A study in construct validation. Journal of Clinical Psychology 33, 981-989.
8. Dick DM, Nasim A, Edwards AC, Salvatore JE, Cho SB, Adkins A, Meyers J, Yan J, Cooke M, Clifford J, Goyal N, Halberstadt L, Ailstock K, Neale Z, Opalesky J, Hancock L, Donovan KK, Sun C, Riley B and Kendler KS (2014) Spit for science: launching a longitudinal study of genetic and environmental influences on substance use and emotional health at a large US university. Fronteirs in Genetics 5, 47.
9. Docherty AR, Moscati A, Peterson R, Edwards AC, Bigdeli TB, Adkins DE, Bacanu SA, Bigdeli TB, Webb BT, Flint J and Kendler KS (2016a). SNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE. Translational Psychiatry 6, e926.
10. Docherty AR, Moscati AA and Fanous AH (2016b). Cross-disorder psychiatric genomics: A review. Current Behavioral Neuroscience Reports 3, 256-263.
11. Docherty AR and Sponheim SR(2008) Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. Journal of Abnormal Psychology 117, 788-798.
12. Docherty AR and Sponheim SR (2014) Anhedonia as an indicator of genetic liability to schizophrenia. In Ritsner M (ed). Anhedonia: A Comprehensive Handbook. Dordecht: Springer, pp. 105-120.
13. Docherty AR, Sponheim SR and Kerns JG (2015) Self-reported affective traits and current affective experiences of biological relatives of people with schizophrenia. Schizophria Research 161, 340-344.
14. Fanous A, Gardner C, Walsh D and Kendler KS (2001) Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives. Archives of General Psychiatry 58, 669-673.
15. Fisher RA (1919) On the correlation between relatives on the supposition of Mendelian inheritance. Transactions of the Royal Society of Edinburgh: Earth and Environmental Science 52, 399-433.
16. Gale CR, Hagenaars SP, Davies G, Hill WD, Liewald DC, Cullen B, Penninx BW, Boomsma Di, Pell J, McIntosh AM, Smith DJ, Deary IJ and Harris SE (2016) Pleiotropy between neuroticism and physical and mental health: findings from 108038 men and women in UK biobank. Translational Psychiatry 6, e791.
17. Genetics of Personality Consortium, de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M and Boomsma Di (2015) Meta-Analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry 72, 642-650.
18. Gray MJ, Litz BT, Hsu JL and Lombardo TW (2004) Psychometric properties of the life events checklist. Assessment 11, 330-341.
19. Hagenaars SP, Harris SE, Davies G, Hill WD, Liewald DC, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Cullen B, Malik R, Worrall BB, Sudlow CL, Wardlaw JM, Gallacher J, Pell J, McIntosh AM, Smith DJ, Gale CR and Deary IJ (2016) Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N =112151) and 24 GWAS consortia. Molecular Psychiatry 21, 1624-1632.
20. Jones HJ, Stergiakouli E, Tansey KE, Hubbard L, Heron J, Cannon M, Holmans P, Lewis G, Linden DE, Jones PB, Davey Smith G, O'Donovan MC, Owen MJ, Walters JT and Zammit S (2016) Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population. JAMA Psychiatry 73, 221-228.
21. Kendler KS (2016) The schizophrenia polygenic risk score: to what does it predispose in adolescence. JAMA Psychiatry 73, 193-194.
22. Kendler KS, Karkowski-Shuman L and Walsh D (1996) The risk for psychiatric illness in siblings of schizophrenics: the impact of psychotic and nonpsychotic affective illness and alcoholism in parents. Acta Psychiatrica Scandinavica 94, 49-55.
23. Kendler KS and Myers J (2010) The genetic and environmental relationship between major depression and the five-factor model of personality. Psychological Medicine 40, 801-806.
24. Kessler RC, Angermeyer M, Anthony JC, R DEG, Demyttenaere K, Gasquet I, G DEG, Gluzman S, Gureje O, Haro JM, Kawakami N, Karam A, Levinson D, Medina Mora ME, Oakley Browne MA, Posada-Villa J, Stein DJ, Adley Tsang CH, Aguilar-Gaxiola S, Alonso J, Lee S, Heeringa S, Pennell BE, Berglund P, Gruber MJ, Petukhova M, Chatterji S and Ustun TB (2007): Lifetime prevalence and age-of-onset distributions of mental disorders in the world health organization's world mental health survey initiative. World Psychiatry 6, 168-176.
25. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR and Walters EE (2005) Lifetime prevalence and age-of-onset distributions ofDSM-IV disorders in the national comorbidity survey replication. Archives of General Psychiatry 62, 593-602.
26. Kokkinos PF and Fernhall B (1999) Physical activity and high density lipoprotein cholesterol levels: what is the relationship. Sports Medicine 28, 307-314.
27. Krapohl E, Euesden J, Zabaneh D, Pingault JB, Rimfeld K, von Stumm S, Dale PS, Breen G, O'Reilly PF and Plomin R (2015) Phenome-wide analysis of genome-wide polygenic scores. Molecular Psychiatry 21, 1188-1193.
28. Rader DJ (2006) Molecular regulation of HDL metabolism and function: implications for novel therapies. The Journal of Clinical Investigation 116, 3090-3100.
29. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman Di, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y, Lee JY, Park T, Kim K, Sim X, Twee-Hee Ong R, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Hua Zhao J, Yuan X, Luan J, Lamina C, Ziegler A, Zhang W, Zee RY, Wright AF, Witteman JC, Wilson JF, Willemsen G, Wichmann HE, Whitfield JB, Waterworth DM, Wareham NJ, Waeber G, Vollenweider P, Voight BF, Vitart V, Uitterlinden AG, Uda M, Tuomilehto J, Thompson JR, Tanaka T, Surakka I, Stringham HM, Spector TD, Soranzo N, Smit JH, Sinisalo J, Silander K, Sijbrands EJ, Scuteri A, Scott J, Schlessinger D, Sanna S, Salomaa V, Saharinen J, Sabatti C, Ruokonen A, Rudan I, Rose LM, Roberts R, Rieder M, Psaty BM, Pramstaller PP, Pichler I, Perola M, Penninx BW, Pedersen NL, Pattaro C, Parker AN, Pare G, Oostra BA, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, Meitinger T, McPherson R, McCarthy MI, McArdle W, Masson D, Martin NG, Marroni F, Mangino M, Magnusson PK, Lucas G, Luben R, Loos RJ, Lokki ML, Lettre G, Langenberg C, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, Kronenberg F, Konig IR, Khaw KT, Kaprio J, Kaplan LM, Johansson A, Jarvelin MR, Janssens AC, Ingelsson E, Igl W, Kees Hovingh G, Hottenga JJ, Hofman A, Hicks AA, Hengstenberg C, Heid IM, Hayward C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Gyllensten U, Guiducci C, Groop LC, Gonzalez E, Gieger C, Freimer NB, Ferrucci L, Erdmann J, Elliott P, Ejebe KG, Doring A, Dominiczak AF, Demissie S, Deloukas P, de Geus EJ, de Faire U, Crawford G, Collins FS, Chen YD, Caulfield MJ, Campbell H, Burtt NP, Bonnycastle LL, Boomsma Di, Boekholdt SM, Bergman RN, Barroso I, Bandinelli S, Ballantyne CM, Assimes TL, Quertermous T, Altshuler D, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Adair LS, Taylor HA Jr., Borecki IB, Gabriel SB, Wilson JG, Holm H, Thorsteinsdottir U, Gudnason V, Krauss RM, Mohlke KL, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJ, Schadt EE, Rotter JI, Boerwinkle E, Strachan DP, Mooser V, Stefansson K, Reilly MP, Samani NJ, Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, van Duijn CM, Peltonen L, Abecasis GR, Boehnke M and Kathiresan S (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713.
30. van den Berg SM, de Moor MH, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppala I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abdellaoui A, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Smith GD, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimaki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Mbarek H, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Nivard MG, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Raback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Raikkonen K, Wilson JF, Keltikangas-Jarvinen L, Bierut LJ, Hettema JM, Grabe HJ, Penninx BW, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Martin NG and Boomsma Di (2016) Meta-Analysis of genome-wide association studies for extraversion: findings from the genetics of personality consortium. Behavior Genetics 46, 170-182.
31. Vilhjalmsson BJ, Yang J, Finucane HK, Gusev A, Lindstrom S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N and Price AL (2015) Modeling linkage disequilibrium increases accuracy of polygenic risk scores. American Journal of Human Genetics 97, 576-592.