Suspected acute coronary syndrome in the emergency room: Limited added value of heart type fatty acid binding protein point of care or ELISA tests: The FAME-ER (fatty acid binding protein in myocardial infarction evaluation in the emergency room) study

European Heart Journal: Acute Cardiovascular Care

Volumn 5, Issue 4, 2016, Pages 364-374

  Bank, Ingrid E M ^a,b   Dekker, Marieke S ^b,c   Hoes, Arno W ^b   Zuithoff, Nicolaas P A ^b   Verheggen, Peter W H M ^a   De Vrey, Evelyn A ^a   Wildbergh, Thierry X ^a   Timmers, Leo ^b   De Kleijn, Dominique P V ^b,d,e   Glatz, Jan F C ^f   Mosterd, Arend ^a,b  

^a MEANDER MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ISALA HOSPITAL   (Netherlands)

^d Institute of the Netherlands   (Netherlands)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Acute coronary syndrome (ACS); Biomarker; Heart type fatty acid binding protein (H FABP); High sensitivity troponin; Point of care test

Indexed keywords

HEART TYPE FATTY ACID BINDING PROTEIN; PEPTIDES AND PROTEINS; TROPONIN T; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; FABP3 PROTEIN, HUMAN; FATTY ACID BINDING PROTEIN;

ACUTE CORONARY SYNDROME; ADULT; ARTICLE; ATRIAL FIBRILLATION; CARDIAC TROPONIN 1 CLIA; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; PERICARDITIS; POINT OF CARE TESTING; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; AGED; EARLY DIAGNOSIS; HOSPITAL EMERGENCY SERVICE; METABOLISM; POINT OF CARE SYSTEM; PROSPECTIVE STUDY;

ACUTE CORONARY SYNDROME; AGED; BIOMARKERS; EARLY DIAGNOSIS; EMERGENCY SERVICE, HOSPITAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY ACID-BINDING PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; POINT-OF-CARE SYSTEMS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TROPONIN T;

EID: 85050578936     PISSN: 20488726     EISSN: 20488734     Source Type: Journal    
DOI: 10.1177/2048872615584077     Document Type: Article

References (27)

1. Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. Eur Heart J 2012; 33: 2551-2567.
2. Keller T, Zeller T, Peetz D, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009; 361: 868–877.
3. Hamm CW, Bassand J-P, Agewall S, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevatio. Eur Heart J 2011; 32: 2999–3054.
4. Bruins Slot MHE, Reitsma JB, Rutten FH, et al. Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction: A systematic review and meta-analysis. Heart 2010; 96: 1957–1963.
5. Carroll C, Al Khalaf M, Stevens JW, et al. Heart-type fatty acid binding protein as an early marker for myocardial infarction: Systematic review and meta-analysis. Emerg Med J 2013; 30: 280–286.
6. Lippi G, Mattiuzzi C and Cervellin G. Critical review and meta-analysis on the combination of heart-type fatty acid binding protein (H-FABP) and troponin for early diagnosis of acute myocardial infarction. Clin Biochem 2013; 46: 26–30.
7. McCann CJ, Glover BM, Menown IB, et al. Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur Heart J 2008; 29: 2843–2850.
8. McMahon CG, Lamont J V, Curtin E, et al. Diagnostic accuracy of heart-type fatty acid-binding protein for the early diagnosis of acute myocardial infarction. Am J Emerg Med 2012; 30: 267–274.
9. Pelsers MMAL, Hermens WT and Glatz JFC. Fatty acidbinding proteins as plasma markers of tissue injury. Clin Chim Acta 2005; 352: 15–35.
10. Charpentier S, Maupas-Schwalm F, Cournot M, et al. Diagnostic accuracy of quantitative heart-fatty acid binding protein assays compared with Cardiodetect (®) in the early detection of acute coronary syndrome. Arch Cardiovasc Dis 2011; 104: 524–529.
11. Glatz JFC and Renneberg R. Added value of H-FABP as plasma biomarker for the early evaluation of suspected acute coronary syndrome. Clin Lipidol 2014; 9: 205–220.
12. Reiter M, Twerenbold R, Reichlin T, et al. Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction. Heart 2013; 99: 708–714.
13. Eggers KM, Venge P and Lindahl B. High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain. Clin Chim Acta 2012; 413: 1135–1140.
14. Collinson P, Gaze D and Goodacre S. Comparison of contemporary troponin assays with the novel biomarkers, heart fatty acid binding protein and copeptin, for the early confirmation or exclusion of myocardial infarction in patients presenting to the emergency department with chest pain. Heart 2014; 100: 140–145.
15. Aldous S, Pemberton C, Troughton R, et al. Heart fatty acid binding protein and myoglobin do not improve early rule out of acute myocardial infarction when highly sensitive troponin assays are used. Resuscitation 2012; 83: e27–e28; author reply e29–e30.
16. Ruff CT, Bonaca MP, Kosowsky JM, et al. Evaluation of the diagnostic performance of heart-type fatty acid binding protein in the BWH-TIMI ED chest pain study. J Thromb Thrombolysis 2013; 36: 361–367.
17. Bossuyt PM, Reitsma JB, Bruns DE, et al. Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD initiative. Fam Pract 2004; 21: 4–10.
18. Donders a RT, van der Heijden GJMG, Stijnen T, et al. Review: A gentle introduction to imputation of missing values. J Clin Epidemiol 2006; 59: 1087–1091.
19. Pencina MJ, D’Agostino RB and Steyerberg EW. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med 2011; 30: 11–21.
20. Harrell FE, Lee KL and Mark DB. Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996; 15: 361–387.
21. Raskovalova T, Twerenbold R, Collinson PO, et al. Diagnostic accuracy of combined cardiac troponin and copeptin assessment for early rule-out of myocardial infarction: A systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care 2014; 3: 18–27.
22. Searle J, Slagman A, Stockburger M, et al. Use of copeptin in emergency patients with cardiac chief complaints. Eur Heart J Acute Cardiovasc Care. Epub ahead of print 15 October 2014. DOI:10.177/2048872614554197.
23. Bandstein N, Ljung R, Johansson M, et al. Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction. J Am Coll Cardiol 2014; 63: 2569–2578.
24. Body R, Carley S, McDowell G, et al. The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: Derivation and external validation. Heart 2014; 100: 1462–1468.
25. Möckel M, Searle J, Hamm C, et al. Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): A randomized, controlled clinical process study. Eur Heart J 2014; 369-376.
26. Bohyn E, Dubie E, Lebrun C, et al. Expeditious exclusion of acute coronary syndrome diagnosis by combined measurements of copeptin, high-sensitivity troponin, and GRACE score. Am J Emerg Med 2014; 32: 293–296.
27. Forberg JL, Henriksen LS, Edenbrandt L, et al. Direct hospital costs of chest pain patients attending the emergency department: A retrospective study. BMC Emerg Med 2006; 6: 6.