Relationships of variations in the tongue microbiota and pneumonia mortality in nursing home residents

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 73, Issue 8, 2018, Pages 1097-1102

  Kageyama, Shinya ^a   Takeshita, Toru ^a   Furuta, Michiko ^a   Tomioka, Mikiko ^a   Asakawa, Mikari ^a   Suma, Shino ^a   Takeuchi, Kenji ^a   Shibata, Yukie ^a   Iwasa, Yasuyuki ^b   Yamashita, Yoshihisa ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Haradoi Hospital   (Japan)

Author keywords

Aspiration pneumonia; Mortality risk; Oral cavity; Prospective cohort; Tongue microbiota

Indexed keywords

RNA 16S;

AGED; BACTERIAL PNEUMONIA; CAUSE OF DEATH; FEMALE; GENETICS; HUMAN; MALE; MICROBIOLOGY; MICROFLORA; MIDDLE AGED; MORTALITY; NURSING HOME; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SEQUENCE ANALYSIS; STATISTICS AND NUMERICAL DATA; TONGUE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CAUSE OF DEATH; FEMALE; HUMANS; MALE; MICROBIOTA; MIDDLE AGED; NURSING HOMES; PNEUMONIA, BACTERIAL; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, RNA; TONGUE;

EID: 85049861324     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glx205     Document Type: Article

References (39)

1. Kaplan V, Angus DC, Griffin MF, Clermont G, Scott Watson R, Linde-Zwirble WT. Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med. 2002;165:766-772. doi:10.1164/ ajrccm.165.6.2103038
2. Janssens JP, Krause KH. Pneumonia in the very old. Lancet Infect Dis. 2004;4:112-124. doi:10.1016/S1473-3099(04)00931-4
3. El-Solh AA, Sikka P, Ramadan F, Davies J. Etiology of severe pneumonia in the very elderly. Am J Respir Crit Care Med. 2001;163(3 Pt 1):645-651. doi:10.1164/ajrccm.163.3.2005075
4. Teramoto S, Fukuchi Y, Sasaki H, Sato K, Sekizawa K, Matsuse T; Japanese Study Group on Aspiration Pulmonary Disease. High incidence of aspiration pneumonia in community- and hospital-acquired pneumonia in hospitalized patients: a multicenter, prospective study in Japan. J Am Geriatr Soc. 2008;56:577-579. doi:10.1111/j.1532-5415.2008.01597.x
5. Statistics Bureau, Ministry of Internal Affairs and Communications. Ranking for cause of death by sex and age. http://www.e-stat.go.jp/SG1/estat/List.do?lid=000001158057#TOP. Date last update: December 5, 2016. Date last accessed: Jun 30, 2017.
6. Gomes-Filho IS, Passos JS, Da Cruz SS. Respiratory disease and the role of oral bacteria. J Oral Microbiol. 2010;2:5811. doi:10.3402/jom.v2i0.5811
7. Terpenning MS, Taylor GW, Lopatin DE, Kerr CK, Dominguez BL, Loesche WJ. Aspiration pneumonia: dental and oral risk factors in an older veteran population. J Am Geriatr Soc. 2001;49:557-563. doi:10.1046/j.1532-5415.2001.49113.x
8. Scannapieco FA. Role of oral bacteria in respiratory infection. J Periodontol. 1999;70:793-802. doi:10.1902/jop.1999.70.7.793
9. Bassim CW, Gibson G, Ward T, Paphides BM, Denucci DJ. Modification of the risk of mortality from pneumonia with oral hygiene care. J Am Geriatr Soc. 2008;56:1601-1607. doi:10.1111/j.1532-5415.2008.01825.x
10. Sjögren P, Nilsson E, Forsell M, Johansson O, Hoogstraate J. A systematic review of the preventive effect of oral hygiene on pneumonia and respiratory tract infection in elderly people in hospitals and nursing homes: effect estimates and methodological quality of randomized controlled trials. J Am Geriatr Soc. 2008;56:2124-2130. doi:10.1111/j.1532-5415.2008.01926.x
11. Sjögren P, Wårdh I, Zimmerman M, Almståhl A, Wikström M. Oral care and mortality in older adults with pneumonia in hospitals or nursing homes: systematic review and meta-analysis. J Am Geriatr Soc. 2016;64:2109-2115. doi:10.1111/jgs.14260
12. Abe S, Ishihara K, Adachi M, Okuda K. Oral hygiene evaluation for effective oral care in preventing pneumonia in dentate elderly. Arch Gerontol Geriatr. 2006;43:53-64. doi:10.1016/j.archger.2005.09.002
13. Kageyama S, Takeshita T, Asakawa M, et al. Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis. PLoS One. 2017;12:e0174782. doi:10.1371/journal.pone.0174782
14. Zhou Y, Gao H, Mihindukulasuriya KA, et al. Biogeography of the ecosystems of the healthy human body. Genome Biol. 2013;14:R1. doi:10.1186/ gb-2013-14-1-r1
15. Segata N, Haake SK, Mannon P, et al. Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biol. 2012;13:R42. doi:10.1186/gb-2012-13-6-r42
16. Mager DL, Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Distribution of selected bacterial species on intraoral surfaces. J Clin Periodontol. 2003;30:644-654. doi:10.1034/j.1600-051X.2003.00376.x
17. Zaura E, Keijser BJ, Huse SM, Crielaard W. Defining the healthy “core microbiome” of oral microbial communities. BMC Microbiol. 2009;9:259. doi:10.1186/1471-2180-9-259
18. Abe S, Ishihara K, Adachi M, Okuda K. Tongue-coating as risk indicator for aspiration pneumonia in edentate elderly. Arch Gerontol Geriatr. 2008;47:267-275. doi:10.1016/j.archger.2007.08.005
19. Oho T, Yoshida Y, Shimazaki Y, Yamashita Y, Koga T. Characteristics of patients complaining of halitosis and the usefulness of gas chromatography for diagnosing halitosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:531-534. doi:10.1067/moe.2001.112543
20. Takeshita T, Suzuki N, Nakano Y, et al. Relationship between oral malodor and the global composition of indigenous bacterial populations in saliva. Appl Environ Microbiol. 2010;76:2806-2814. doi:10.1128/AEM.02304-09
21. Kakinoki Y, Nishihara T, Arita M, Shibuya K , Ishikawa M. Usefulnessofnew wetnesstesterfordiagnosisofdrymouthindisabledpatients.Gerodontology. 2004;21:229-231. doi:10.1111/j.1741-2358.2004.00037.x
22. Zenner PM, Losinski DS, Mills RH. Using cervical auscultation in the clinical dysphagia examination in long-term care. Dysphagia. 1995;10:27-31. doi:10.1007/BF00261276
23. Tsutsui T, Muramatsu N. Care-needs certification in the long-term care insurance system of Japan. J Am Geriatr Soc. 2005;53:522-527. doi:10.1111/j.1532-5415.2005.53175.x
24. Kaiser MJ, Bauer JM, Ramsch C, et al.; MNA-International Group. Validation of the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. J Nutr Health Aging. 2009;13:782-788. doi:10.1007/s12603-009-0214-7
25. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412-2414. doi:10.1212/ WNL.43.11.2412-a
26. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373-383. doi:10.1016/0021-9681(87)90171-8
27. Driver JA, Kurth T, Buring JE, Gaziano JM, Logroscino G. Parkinson disease and risk of mortality: a prospective comorbidity-matched cohort study. Neurology. 2008;70(16 Pt 2):1423-1430. doi:10.1212/01. wnl.0000310414.85144.ee
28. Yamanaka W, Takeshita T, Shibata Y, et al. Compositional stability of a salivary bacterial population against supragingival microbiota shift following periodontal therapy. PLoS One. 2012;7:e42806. doi:10.1371/jour-nal.pone.0042806
29. Takeshita T, Kageyama S, Furuta M, et al. Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study. Sci Rep. 2016;6:22164. doi:10.1038/srep22164
30. Edgar RC. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods. 2013;10:996-998. doi:10.1038/nmeth.2604
31. Chen T, Yu WH, Izard J, Baranova OV, Lakshmanan A, Dewhirst FE. The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database (Oxford). 2010;2010:baq013. doi:10.1093/database/baq013
32. Arumugam M, Raes J, Pelletier E, et al.; MetaHIT Consortium. Enterotypes of the human gut microbiome. Nature. 2011;473:174-180. doi:10.1038/ nature09944
33. Segata N, Izard J, Waldron L, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60. doi:10.1186/gb-2011-12-6-r60
34. Paganini-Hill A, White SC, Atchison KA. Dental health behaviors, dentition, and mortality in the elderly: the leisure world cohort study. J Aging Res. 2011;2011:156061. doi:10.4061/2011/156061
35. Hämäläinen P, Meurman JH, Keskinen M, Heikkinen E. Relationship between dental health and 10-year mortality in a cohort of community-dwelling elderly people. Eur J Oral Sci. 2003;111:291-296. doi:10.1034/j.1600-0722.2003.00055.x
36. Sumi Y, Miura H, Nagaya M, Michiwaki Y, Uematsu H. Colonisation on the tongue surface by respiratory pathogens in residents of a nursing home-a pilot study. Gerodontology. 2006;23:55-59. doi: 10.1111/j.1741-2358.2006.00093.x
37. Takeshita T, Tomioka M, Shimazaki Y, et al. Microfloral characterization of the tongue coating and associated risk for pneumonia-related health problems in institutionalized older adults. J Am Geriatr Soc. 2010;58:1050-1057. doi:10.1111/j.1532-5415.2010.02867.x
38. Zaura E, Brandt BW, Prodan A, et al. On the ecosystemic network of saliva in healthy young adults. ISME J. 2017;11:1218-1231. doi:10.1038/ ismej.2016.199
39. Torres A, Blasi F, Peetermans WE, Viegi G, Welte T. The aetiology and antibiotic management of community-acquired pneumonia in adults in Europe: a literature review. Eur J Clin Microbiol Infect Dis. 2014;33:1065-1079. doi:10.1007/s10096-014-2067-1