Injectable and protease-degradable hydrogel for siRNA sequestration and triggered delivery to the heart

Journal of Controlled Release

Volumn 285, Issue , 2018, Pages 152-161

  Wang, Leo L ^a   Chung, Jennifer J ^b   Li, Elizabeth C ^b   Uman, Selen ^a   Atluri, Pavan ^b   Burdick, Jason A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hydrogel; Matrix metalloprotease; Myocardial infarction; siRNA

Indexed keywords

CARDIOLOGY; CELL CULTURE; CONTROLLED DRUG DELIVERY; ENZYME ACTIVITY; HEART; HYALURONIC ACID; NUCLEIC ACIDS; RAT CONTROL; RNA; SHEAR THINNING; TARGETED DRUG DELIVERY;

FUNCTIONAL IMPROVEMENTS; MATRIX METALLOPROTEASE; MYOCARDIAL INFARCTION; PEPTIDE CROSSLINKERS; PROTEOLYTIC ACTIVITIES; SIRNA; SMALL INTERFERING RNA; THERAPEUTIC POTENTIALS;

HYDROGELS;

ALDEHYDE; BETA CYCLODEXTRIN; GELATINASE A; GELATINASE B; HYALURONIC ACID; HYDRAZIDE; PROTEINASE; SMALL INTERFERING RNA; PEPTIDE HYDROLASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLOW CYTOMETRY; FLOW MEASUREMENT; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE KNOCKDOWN; HEART EJECTION FRACTION; HEART FIBROBLAST; HEART FUNCTION; HEART INFARCTION; HEART OUTPUT; HEART STROKE VOLUME; HYDROGEL; HYDROPHOBICITY; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; CARDIAC MUSCLE; CELL CULTURE; CHEMISTRY; DELAYED RELEASE FORMULATION; GENETICS; INJECTION; MALE; METABOLISM; MOUSE; NIH 3T3 CELL LINE; PATHOLOGY; PROCEDURES; RNAI THERAPEUTICS; WISTAR RAT;

ANIMALS; CELLS, CULTURED; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HYDROGELS; INJECTIONS; MALE; MATRIX METALLOPROTEINASE 2; MICE; MYOCARDIAL INFARCTION; MYOCARDIUM; NIH 3T3 CELLS; PEPTIDE HYDROLASES; RATS, WISTAR; RNA, SMALL INTERFERING; RNAI THERAPEUTICS;

EID: 85049744799     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2018.07.004     Document Type: Article

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