Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial

Intensive Care Medicine

Volumn 44, Issue 11, 2018, Pages 1816-1825

  Liu, Zi Meng ^a   Chen, Juan ^a   Kou, Qiuye ^b   Lin, Qinhan ^c   Huang, Xiaobo ^d   Tang, Zhanhong ^e   Kang, Yan ^f   Li, Ke ^g   Zhou, Lixin ^h   Song, Qing ⁱ   Sun, Tongwen ^j   Zhao, Ling ^k   Wang, Xue ^l   He, Xiandi ^m   Wang, Chunting ⁿ   Wu, Benquan ^o   Lin, Jiandong ^p   Yuan, Shiying ^q   Gu, Qin ^r   Qian, Kejian ^s   Shi, Xianqing ^t   Feng, Yongwen ^u   Lin, Aihua ^a   He, Xiaoshun ^a   Guan, Xiang Dong ^a,v   Zeng, Jie ^v   Huang, Yanlin ^v   Liu, Enhe ^v   Liu, Jianling ^v   Zhang, Xiaoqin ^v   Pan, Yaoping ^v   Chen, Yao ^v   Cheng, Jiji ^v   Qiang, Xinhua ^v   Wang, Li ^v   Zhong, Jiwen ^v   Chen, Hongli ^v   Wu, Qiang ^v   Zeng, Juan ^v   Luo, Jinmei ^v   Fu, Zhaohui ^v   Liu, Ning ^v   Gui, Suiqing ^v   more..

^a SUN YAT SEN UNIVERSITY   (China)

^b THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^e GUANGXI MEDICAL UNIVERSITY   (China)

^f SICHUAN UNIVERSITY   (China)

^g BEIJING 302 HOSPITAL   (China)

^h Foshan First Municipal People s Hospital   (China)

ⁱ CHINESE PLA GENERAL HOSPITAL   (China)

^j THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^k ZHUHAI PEOPLE S HOSPITAL ZHUHAI HOSPITAL AFFILIATED WITH JINAN UNIVERSITY   (China)

^l XI'AN JIAOTONG UNIVERSITY   (China)

^m BENGBU MEDICAL COLLEGE   (China)

ⁿ SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^o THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^p FUJIAN PROVINCIAL HOSPITAL   (China)

^q HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^r THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^s NANCHANG UNIVERSITY   (China)

^t GUIZHOU PROVINCIAL PEOPLE'S HOSPITAL   (China)

^u THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^v NONE

more..

Author keywords

Norepinephrine; Septic shock; SOFA score; Terlipressin

Indexed keywords

NORADRENALIN; TERLIPRESSIN; VASOCONSTRICTOR AGENT;

ACUTE HEART INFARCTION; ADULT; ARTICLE; CHINA; CONTROLLED STUDY; DIARRHEA; DIGITAL ISCHEMIA; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG INFUSION; DRUG SAFETY; FEMALE; HEART ARRHYTHMIA; HEART MUSCLE ISCHEMIA; HEART RATE; HUMAN; HYPONATREMIA; INTENSIVE CARE UNIT; INTESTINE ISCHEMIA; LIMB ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ISCHEMIA; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; OPEN STUDY; RANDOMIZED CONTROLLED TRIAL; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; AGED; CLINICAL TRIAL; COMPARATIVE STUDY; INTENSIVE CARE; INTRAVENOUS DRUG ADMINISTRATION; SURVIVAL RATE; TREATMENT OUTCOME;

ADULT; AGED; CHINA; CRITICAL CARE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NOREPINEPHRINE; SHOCK, SEPTIC; SURVIVAL RATE; TERLIPRESSIN; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS;

EID: 85049591851     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-018-5267-9     Document Type: Article

References (28)

1. Annane D, Aegerter P, Jars-Guincestre MC, Guidet B (2003) Current epidemiology of septic shock: the CUB-Réa network. Am J Respir Crit Care Med 168:165–172
2. Vincent JL, Sakr Y, Sprung CL (2006) Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 34:344
3. Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801–810
4. Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304–377
5. Mullner M, Urbanek B, Havel C, Losert H et al (2004) Vasopressors for shock. Cochrane Datab Syst Rev 3:CD3709
6. Russell JA, Walley KR, Singer J et al (2008) Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358:877–887
7. Gordon AC, Mason AJ, Thirunavukkarasu N et al (2016) Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial. JAMA 316:509–518
8. Lange Matthias, Ertmer Christian, Westphal Martin (2009) Vasopressin vs. terlipressin in the treatment of cardiovascular failure in sepsis. Intensive Care Med 34:821–832
9. Torgersen C, Dunser MW, Wenzel V et al (2010) Comparing two different arginine vasopressin doses in advanced vasodilatory shock: a randomized, controlled, open-label trial. Intensive Care Med 36:57
10. Salazar M, Hu BB, Vazquez J et al (2015) Exogenous vasopressin-induced hyponatremia in patients with vasodilatory shock: two case reports and literature review. J Intensive Care Med 30:253
11. Leone M, Albanèse J, Delmas A et al (2004) Terlipressin in catecholamine-resistant septic shock patients. Shock 22:314–319
12. Morelli A, Ertmer C, Rehberg S et al (2009) Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study. Crit care 13:R130
13. Sepra N, Nassar Junior AP, Cardoso SO et al (2012) Vasopressin and terlipressin in adult vasodilatory shock: a systematic review and meta-analysis of nine randomized controlled trials. Crit Care 16:R154
14. Polito Angelo, Parisini Emilio, Ricci Zaccaria et al (2012) Vasopressin for treatment of vasodilatory shock: an ESICM systematic review and meta-analysis. Intensive Care Med 38:9–19
15. Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Intensive Care Med 39:165–228
16. Gordon Lan KK, Demets DL (1983) Discrete sequential boundaries for clinical trials. Biometrika 70:659–663
17. Fergusson D, Aaron SD, Guyatt G et al (2002) Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis. BMJ 325:652–654
18. SepNet Critical Care Trials Group (2016) Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study. Intensive Care Med 42:1980–1989
19. Vincent JL, de Mendonca A, Cantraine F et al (1998) Working Group on “Sepsis-Related Problems” of the European Society of Intensive Care Medicine. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit Care Med 26:1793–1800
20. Levy MM, Macias WL, Vincent JL et al (2005) Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med 33:2194–2201
21. Ferreira FL, Bota DP, Bross A, Mélot C, Vincent JL (2001) Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 286:1754–1758
22. Lange M, Ertmer C, Rehberg S et al (2011) Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia. Inflamm Res 60:429–437
23. Morelli Andrea, Rocco Monica, Conti Giorgio et al (2004) Effects of terlipressin on systemic and regional haemodynamics in catecholamine-treated hyperkinetic septic shock. Intensive Care Med 30:597–604
24. Rehberg Sebastian, Ertmer Christian, Köhler Gabriele et al (2009) Role of arginine vasopressin and terlipressin as first-line vasopressor agents in fulminant ovine septic shock. Intensive Care Med 35:1286–1296
25. Russell JA, Vincent JL, Kjølbye AL et al (2017) Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care 21:213
26. Ozel Coskun BD, Karaman A, Gorkem H et al (2014) Terlipressin-induced ischemic skin necrosis: a rare association. Am J Case Rep 15:476–479
27. Albanèse J, Leone M, Delmas A, Martin C (2005) Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study. Crit Care Med 33:1897–1902
28. Xiao X, Zhang J, Wang Y et al (2016) Effects of terlipressin on patients with sepsis via improving tissue blood flow. J Surg Res 200:274–282