Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12

JCI insight

Volumn 3, Issue 4, 2018, Pages

  Uribe Herranz, Mireia ^a,b   Bittinger, Kyle ^c   Rafail, Stavros ^a   Guedan, Sonia ^d   Pierini, Stefano ^a,b   Tanes, Ceylan ^c   Ganetsky, Alex ^e   Morgan, Mark A ^a   Gill, Saar ^f   Tanyi, Janos L ^a   Bushman, Frederic D ^d   June, Carl H ^d   Facciabene, Andrea ^a,b  

^a Ovarian Cancer Research Center

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e Department of Pharmacy ^*

^f Department of Medicine

Author keywords

Cancer immunotherapy; Immunology; Microbiology

Indexed keywords

CD8 ANTIGEN; CD8 ANTIGEN, ALPHA CHAIN; INTERLEUKIN 12; NEOMYCIN; VANCOMYCIN;

ADOPTIVE IMMUNOTHERAPY; ADULT; AGED; ANIMAL; BACTERIUM; C57BL MOUSE; COHORT ANALYSIS; DENDRITIC CELL; DISEASE MODEL; DRUG EFFECT; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOLOGY; INTESTINE FLORA; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; MOUSE; NEOPLASM; PROCEDURES; T LYMPHOCYTE; TRANSPLANTATION; TREATMENT OUTCOME; TUMOR CELL LINE;

ADULT; AGED; ANIMALS; BACTERIA; CD8 ANTIGENS; CELL LINE, TUMOR; COHORT STUDIES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GASTROINTESTINAL MICROBIOME; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOST MICROBIAL INTERACTIONS; HUMANS; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN-12; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; NEOMYCIN; NEOPLASMS; T-LYMPHOCYTES; TREATMENT OUTCOME; VANCOMYCIN;

EID: 85048753121     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.94952     Document Type: Article

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