Is placebo response in antidepressant trials rising or not? A reanalysis of datasets to conclude this long-lasting controversy

Evidence-Based Mental Health

Volumn 21, Issue 1, 2018, Pages 1-3

  Furukawa, Toshi A ^a   Cipriani, Andrea ^b,c   Leucht, Stefan ^d   Atkinson, Lauren Z ^b,c   Ogawa, Yusuke ^a   Takeshima, Nozomi ^a   Hayasaka, Yu ^a   Chaimani, Anna ^e,f,g   Salanti, Georgia ^h  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c OXFORD HEALTH NHS FOUNDATION TRUST   (United Kingdom)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f PARIS DESCARTES UNIVERSITY   (France)

^g Cochrane France ^*  (France)

^h UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85048561079     PISSN: 13620347     EISSN: None     Source Type: Journal    
DOI: 10.1136/eb-2017-102827     Document Type: Article

References (7)

1. Walsh BT, Seidman SN, Sysko R, et al. Placebo response in studies of major depression: variable, substantial, and growing. JAMA 2002;287:1840-7.
2. Papakostas GI, Fava M. Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD. Eur Neuropsychopharmacol 2009;19:34-40.
3. Turner EH, Matthews AM, Linardatos E, et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 2008;358:252-60.
4. Furukawa TA, Cipriani A, Atkinson LZ, et al. Placebo response rates in antidepressant trials: a systematic review of published and unpublished double-blind randomised controlled studies. Lancet Psychiatry 2016;3:1059-66.
5. Khan A, Fahl Mar K, Faucett J, et al. Has the rising placebo response impacted antidepressant clinical trial outcome? Data from the US Food and Drug Administration 1987-2013. World Psychiatry 2017;16:181-92.
6. Spineli LM, Higgins JP, Cipriani A, et al. Evaluating the impact of imputations for missing participant outcome data in a network meta-analysis. Clin Trials 2013;10:378-88.
7. Furukawa TA, Salanti G, Atkinson LZ, et al. Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis. BMJ Open 2016;6:e010919.