Erythropoietin-induced excessive erythrocytosis activates the tissue endothelin system in mice

FASEB Journal

Volumn 17, Issue 2, 2003, Pages 259-261

  Quaschning, Thomas ^a,b   Ruschitzka, Frank ^a   Stallmach, Thomas ^c   Shaw, Sidney ^d   Morawietz, Henning ^e   Goettsch, Winfried ^e   Hermann, Matthias ^a   Slowinski, Torsten ^f,g   Theuring, Franz ^f   Hocher, Berthold ^f,g   Lüscher, Thomas F ^a   Gassmann, Max ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

^e MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Blood pressure; Endothelium; Hematocrit; Nitric oxide

Indexed keywords

DARUSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ERYTHROPOIETIN; GENOMIC DNA; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; ENDOTHELIN; ENDOTHELIN RECEPTOR; ENZYME INHIBITOR; NITRIC OXIDE SYNTHASE; PHENYLPROPIONIC ACID DERIVATIVE; PROTEIN PRECURSOR; PYRIMIDINE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR EFFECT; COMPARATIVE STUDY; CONTROLLED STUDY; ERYTHROCYTOSIS; FEMALE; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; POLYCYTHEMIA; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RNA ISOLATION; SURGICAL TECHNIQUE; SYSTOLIC BLOOD PRESSURE; TISSUE HOMOGENATE; TREATMENT DURATION; VASODILATATION; ANIMAL; AORTA; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HEART MUSCLE; IN VITRO STUDY; KIDNEY; LIVER; METABOLISM; PHYSIOLOGY; PULMONARY ARTERY; TRANSGENIC MOUSE; VASOCONSTRICTION;

ANIMALS; AORTA; ENDOTHELIN-1; ENDOTHELINS; ENZYME INHIBITORS; ERYTHROPOIETIN; KIDNEY; LIVER; MICE; MICE, TRANSGENIC; MYOCARDIUM; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHENYLPROPIONATES; POLYCYTHEMIA; PROTEIN PRECURSORS; PULMONARY ARTERY; PYRIMIDINES; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; VASOCONSTRICTION;

EID: 85048550370     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.02-0296fje     Document Type: Article

References (41)

1. Vallance, P., Collier, J., and Moncada, S. (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2, 997–1000
2. Pohl, U., Holtz, J., Busse, R., and Bassenge, E. (1986) Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 8, 37–44
3. Yanagisawa, M., Kurihara, H., Kimura, S., Goto, K., and Masaki, T. (1988) A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels. J. Hypertens. Suppl. 6, S188–S191
4. Barton, M., D'Uscio, L. V., Shaw, S., Meyer, P., Moreau, P., and Lüscher, T. F. (1998) ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension. Hypertension 31, 499–504
5. Furchgott, R. F., and Zawadzki, J. V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288, 373–376
6. Rapoport, R. M., Draznin, M. B., and Murad, F. (1983) Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 306, 174–176
7. Palmer, R. M., Ashton, D. S., and Moncada, S. (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333, 664–666
8. Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., and Chaudhuri, G. (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84, 9265–9269
9. Lüscher, T. F., and Vanhoutte, P. M. (1990). The Endothelium: modulator of cardiovascular function. Boca Ranton: CRC Press.
10. Haynes, W. G., and Webb, D. J. (1994) Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 344, 852–854
11. Noll, G., Wenzel, R. R., Schneider, M., Oesch, V., Binggeli, C., Shaw, S., Weidmann, P., and Lüscher, T. F. (1996) Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. Circulation 93, 866–869
12. Hahn, A. W., Resink, T. J., Scott-Burden, T., Powell, J., Dohi, Y., and Buhler, F. R. (1990) Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function. Cell Regul. 1, 649–659
13. Camenisch, G., Stroka, D. M., Gassmann, M., and Wenger, R. H. (2001) Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression. Eur.J.Physiol. 443, 240–249
14. Boulanger, C., and Lüscher, T. F. (1990) Release of endothelin from the porcine aorta. Inhibition by endothelium- derived nitric oxide. J. Clin. Invest. 85, 587–590
15. Wellings, R. P., Corder, R., Warner, T. D., Cristol, J. P., Thiemermann, C., and Vane, J. R. (1994) Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney. Br. J. Pharmacol. 111, 515–520
16. Fukuroda, T., Fujikawa, T., Ozaki, S., Ishikawa, K., Yano, M., and Nishikibe, M. (1994) Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem. Biophys. Res. Commun. 199, 1461–1465
17. Ruschitzka, F. T., Wenger, R. H., Stallmach, T., Quaschning, T., De Wit, C., Wagner, C., Labugger, R., Kelm, M., Noll, G., Rülicke, T., et al. (2000) Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc. Natl. Acad. Sci. USA 97, 11609–11613
18. Jefferson, J. A., Escudero, E., Hurtado, M. E., Pando, J., Tapia, R., Swenson, E. R., Prchal, J., Schreiner, G. F., Schoene, R. B., Hurtado, A., et al. (2002) Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels. Lancet 359, 407–408
19. Bertinieri, G., Parati, G., Ulian, L., Santucciu, C., Massaro, P., Cosentini, R., Torgano, G., Morganti, A., and Mancia, G. (1998) Hemodilution reduces clinic and ambulatory blood pressure in polycythemic patients. Hypertension 31, 848–853
20. Hart, R. G., and Kanter, M. C. (1990) Hematologic disorders and ischemic stroke. A selective review. Stroke 21, 1111–1121
21. Wagner, K. F., Katschinski, D. M., Hasegawa, J., Schumacher, D., Meller, B., Gembruch, U., Schramm, U., Jelkmann, W., Gassmann, M., and Fandrey, J. (2001) Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin. Blood 97, 536–542
22. Wiessner, C., Allegrini, P. R., Ekatodramis, D., Jewell, U. R., Stallmach, T., and Gassmann, M. (2001) Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin. J. Cereb. Blood Flow Metab. 21, 857–864
23. Waskow C., Paul S., Haller C., Gassmann M., Rodewald H-R. (2002). Viable c-KitW/W Mutants Reveal Pivotal Role for c-Kit in Maintenance of Lymphopoiesis. Immunity 17, 277-288
24. Maurer, M. H., Frietsch, T., Waschke, K. F., Kuschinsky, W., Gassmann, M., and Schneider, A. (2002) Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin. Neurosci. Lett. 327, 181–184
25. Hergersberg, M., Matsuo, K., Gassmann, M., Schaffner, W., Luscher, B., Rülicke, T., and Aguzzi, A. (1995) Tissue-specific expression of a FMR1/b-galactosidase fusion gene in transgenic mice. Hum. Mol. Genet. 4, 359–366
26. Bichet, S., Wenger, R. H., Camenisch, G., Rolfs, A., Ehleben, W., Porwol, T., Acker, H., Fandrey, J., Bauer, C., and Gassmann, M. (1999) Oxygen tension modulates b-globin switching in embryoid bodies. FASEB J. 13, 285–295
27. Sasahara, M., Fries, J. W., Raines, E. W., Gown, A. M., Westrum, L. E., Frosch, M. P., Bonthron, D. T., Ross, R., and Collins, T. (1991) PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell 64, 217–227
28. Webb, R. C., Vander, A. J., and Henry, J. P. (1987) Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice. Hypertension 9, 268–276
29. Quaschning, T., D'Uscio, L. V., Shaw, S., and Lüscher, T. F. (2001) Vasopeptidase inhibition exhibits endothelial protection in salt- induced hypertension. Hypertension 37, 1108–1113
30. D'Uscio, L. V., Moreau, P., Shaw, S., Takase, H., Barton, M., and Lüscher, T. F. (1997) Effects of chronic ETA-receptor blockade in angiotensin II-induced hypertension. Hypertension 29, 435–441
31. Hocher, B., Thone-Reineke, C., Rohmeiss, P., Schmager, F., Slowinski, T., Burst, V., Siegmund, F., Quertermous, T., Bauer, C., Neumayer, H. H., et al. (1997) Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J. Clin. Invest. 99, 1380–1389
32. Chirgwin, J. J., Przbyla, A. E., Mac Donald, R. J., and Rutter, W. J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294–5299
33. Lüscher, T. F., Diederich, D., Siebenmann, R., Lehmann, K., Stulz, P., von Segesser, L., Yang, Z. H., Turina, M., Gradel, E., and Weber, E. (1988) Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N. Engl. J. Med. 319, 462–467
34. Lemoli, R. M., Fortuna, A., Fogli, M., Motta, M. R., Rizzi, S., Benini, C., and Tura, S. (1994) Stem cell factor (c-kit ligand) enhances the interleukin-9- dependent proliferation of human CD34+ and CD34+CD33-DR- cells. Exp. Hematol. 22, 919–923
35. Malek, A. M., Zhang, J., Jiang, J., Alper, S. L., and Izumo, S. (1999) Endothelin-1 gene suppression by shear stress: pharmacological evaluation of the role of tyrosine kinase, intracellular calcium, cytoskeleton, and mechanosensitive channels. J. Mol. Cell. Cardiol. 31, 387–399
36. Morawietz, H., Talanow, R., Szibor, M., Rueckschloss, U., Schubert, A., Bartling, B., Darmer, D., and Holtz, J. (2000) Regulation of the endothelin system by shear stress in human endothelial cells. J. Physiol. (Lond.) 525, 761–770
37. Hofer, T., Wenger, H., and Gassmann, M. (2002) Oxygen sensing, HIF-1alpha stabilization and potential therapeutic strategies. Eur.J.Physiol. 443, 503–507
38. Rakugi, H., Tabuchi, Y., Nakamaru, M., Nagano, M., Higashimori, K., Mikami, H., Ogihara, T., and Suzuki, N. (1990) Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia. Biochem. Biophys. Res. Commun. 169, 973–977
39. Hu, J., Discher, D. J., Bishopric, N. H., and Webster, K. A. (1998) Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem. Biophys. Res. Commun. 245, 894–899
40. Macarthur, H., Warner, T. D., Wood, E. G., Corder, R., and Vane, J. R. (1994) Endothelin-1 release from endothelial cells in culture is elevated both acutely and chronically by short periods of mechanical stretch. Biochem. Biophys. Res. Commun. 200, 395–400
41. Hirata, Y., Emori, T., Eguchi, S., Kanno, K., Imai, T., Ohta, K., and Marumo, F. (1993) Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J. Clin. Invest. 91, 1367–1373