Question 2: What are the effects of inhaled corticosteroids on growth in children?

Paediatric Respiratory Reviews

Volumn 28, Issue , 2018, Pages 33-40

  Camargos, Paulo ^a   Zhang, Linjie ^b   Lasmar, Laura ^a   Brand, Paul ^c,d  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

^c ISALA HOSPITAL   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Growth; Growth velocity; Inhaled corticosteroids

Indexed keywords

BECLOMETASONE; BUDESONIDE; BUDESONIDE PLUS FORMOTEROL; CICLESONIDE; CORTICOSTEROID; FLUTICASONE; FLUTICASONE PROPIONATE PLUS SALMETEROL; MOMETASONE FUROATE; PLACEBO;

ASTHMA; BODY HEIGHT; CATCH UP GROWTH; CHILD; CHILD GROWTH; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG WITHDRAWAL; GROWTH CURVE; GROWTH DISORDER; GROWTH RATE; GROWTH RETARDATION; HUMAN; MILD PERSISTENT ASTHMA; MODERATE PERSISTENT ASTHMA; PATIENT COMPLIANCE; PREPUBERTY; PRIORITY JOURNAL; REVIEW; SEVERE PERSISTENT ASTHMA;

EID: 85048448451     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2018.03.008     Document Type: Review

References (42)

1. Bartholow, A.K., Deshaies, D.M., Skoner, J.M., Skoner, D.P., A critical review of the effects of inhaled corticosteroids on growth. Allergy Asthma Proc 34 (2013), 391–407, 10.2500/aap.2013.34.3689.
2. Pedersen, S., Do inhaled corticosteroids inhibit growth in children?. Am J Respir Crit Care Med 164 (2001), 521–535.
3. Brand, P.L.P., Inhaled corticosteroids reduce growth. Or do they?. Eur Respir J 17 (2001), 287–294.
4. Agertoft, L., Pedersen, S., Short term lower leg growth in children during treatment with fluticasone propionate and budesonide: a dose response study. Eur Respir J 10 (1997), 1507–1512.
5. Bisgaard, H., Systemic activity from inhaled topical steroid in toddlers studied by knemometry. Acta Paediatr 82 (1993), 1066–1071.
6. Wolthers, O., Pedersen, S., Growth of asthmatic children during treatment with budesonide: a double blind trial. BMJ 303 (1991), 163–165.
7. Wolthers, O., Pedersen, S., Short-term growth during treatment with inhaled fluticasone propionate and beclomethasone dipropionate. Arch Dis Child 68 (1993), 673–676.
8. Chawes, B., Nilsson, E., Nørgaard, S., Dossing, A., Mortensen, L., Bisgaard, H., Knemometry is more sensitive to systemic effects of inhaled corticosteroids in children with asthma than 24-hour urine cortisol excretion. J Allergy Clin Immunol 140 (2017), 431–436, 10.1016/j.jaci.2016.09.041.
9. Zhang, L., Prietsch, S.O.M., Ducharme, F.M., Inhaled corticosteroids in children with persistent asthma: effects on growth. Cochrane Database Syst Rev(7), 2014, 10.1002/14651858.CD009471.pub2 CD009471.
10. Bensch, G.W., Greos, L.S., Gawchik, S., Kpamegan, E., Newman, K.B., Linear growth and bone maturation are unaffected by 1 year of therapy with inhaled flunisolide hydrofluoroalkane in prepubescent children with mild persistent asthma: a randomized, double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol 107 (2011), 323–329, 10.1016/j.anai.2011.07.017.
11. Bisgaard, H., Allen, D., Milanowski, J., Kalev, I., Willits, L., Davies, P., Twelve-month safety and efficacy of Inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing. Pediatrics, 113, 2004, e87.
12. Pedersen, S., Potter, P., Dachev, S., Bosheva, M., Kaczmarek, J., Springer, E., et al. Efficacy and safety of three ciclesonide doses vs placebo in children with asthma: the RAINBOW study. Respir Med 104 (2010), 1618–1628, 10.1016/j.rmed.2010.06.012.
13. Skoner, D.P., Maspero, J., Banerji, D., Ciclesonide Pediatric Growth Study Group. Assessment of the long-term safety of inhaled ciclesonide on growth in children with asthma. Pediatrics 121 (2008), e1–14.
14. Wasserman, R.L., Baker, J.W., Kim, K.T., Blake, K.V., Scott, C.A., Wu, W., et al. Efficacy and safety of inhaled fluticasone propionate chlorofluorocarbon in 2- to 4-year-old patients with asthma: results of a double-blind, placebo-controlled study. Ann Allergy Asthma Immunol 96 (2006), 808–818.
15. Doull, I.J., Freezer, N.J., Holgate, S.T., Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. Am J Respir Crit Care Med 151 (1995), 1715–1719.
16. Guilbert, T.W., Morgan, W.J., Zeiger, R.S., Mauger, D.T., Boehmer, S.J., Szefler, S.J., et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 354 (2006), 1985–1997.
17. Gradman, J., Wolthers, O.D., A randomized trial of lower leg and height growth in children with asthma treated with inhaled budesonide from a new dry powder inhaler. Pediatr Allergy Immunol 2 (2010), e206–12, 10.1111/j.1399-3038.2009.00875.x.
18. Storr, J., Lenney, C.A., Lenney, W., Nebulised beclomethasone dipropionate in preschool asthma. Arch Dis Childhood 61 (1986), 270–273.
19. Pruteanu, A.I., Chauhan, B.F., Zhang, L., Prietsch, S.O.M., Ducharme, F.M., Inhaled corticosteroids in children with persistent asthma: dose–response effects on growth. Cochrane Database Syst Rev, 7, 2014, 10.1002/14651858.CD009878.pub2 CD009878.
20. de Benedictis, F.M., Teper, A., Green, R.J., Boner, A.L., Williams, L., Medley, H., International Study Group. Effects of 2 inhaled corticosteroids on growth: results of a randomized controlled trial. Arch Pediatr Adolesc Med 155 (2001), 1248–1254.
21. Ferguson, A.C., Spier, S., Manjra, A., Versteegh, F.G., Mark, S., Zhang, P., Efficacy and safety of high-dose inhaled steroids in children with asthma: a comparison of fluticasone propionate with budesonide. J Pediatr 134 (1999), 422–427.
22. Ferguson, A.C., Van Bever, H.P., Teper, A.M., Lasytsya, O., Goldfrad, C.H., Whitehead, P.J., A comparison of the relative growth velocities with budesonide and fluticasone propionate in children with asthma. Respir Med 101 (2007), 118–129.
23. Fitzgerald, D., Van Asperen, P., Mellis, C., Honner, M., Smith, L., Ambler, G., Fluticasone propionate 750 micrograms/day versus beclomethasone dipropionate 1500 micrograms/day: comparison of efficacy and adrenal function in paediatric asthma. Thorax 53 (1998), 656–661.
24. Rao, R., Gregson, R.K., Jones, A.C., Miles, E.A., Campbell, M.J., Warner, J.O., Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: a comparison of fluticasone with beclomethasone. Eur Respir J 13 (1999), 87–94.
25. Jónasson, G., Carlsen, K.H., Jonasson, C., Mowinckel, P., Low dose inhaled budesonide once or twice daily for 27 months in children with mild asthma. Allergy 55 (2000), 740–748.
26. Roux, C., Kolta, S., Desfougères, J.L., Minini, P., Bidat, E., Long term safety of fluticasone propionate and nedocromil sodium on bone in children with asthma. Pediatrics 111 (2003), e706–13.
27. Pauwels, R.A., Pedersen, S., Busse, W.W., Tan, W.C., Chen, Y.Z., Ohlsson, S.V., et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet 361 (2003), 1071–1076.
28. Childhood Asthma Management Program Research Group, Szefler, S., Weiss, S., Tonascia, J., Adkinson, N.F., Bender, B., Cherniack, R., et al. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 343 (2000), 1054–1063.
29. Wardenier, N.R., Klok, T., de Groot, E.P., Brand, P.L., Height growth in children with asthma treated with guideline-recommended dosages of fluticasone and electronically assessed adherence. Arch Dis Child 101 (2016), 637–639, 10.1136/archdischild-2015-309654.
30. Skoner, D.P., Meltzer, E.O., Milgrom, H., Stryszak, P., Teper, A., Staudinger, H., Effects of inhaled mometasone furoate on growth velocity and adrenal function: a placebo-controlled trial in children 4–9 years old with mild persistent asthma. J Asthma 48 (2011), 848–859, 10.3109/02770903.2011.604883.
31. Agertoft, L., Pedersen, S., Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 88 (1994), 373–381.
32. Agertoft, L., Pedersen, S., Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med 343 (2000), 1064–1069.
33. Anthracopoulos, M.B., Papadimitriou, A., Panagiotakos, D.B., Syridou, G., Giannakopoulou, E., Fretzayas, A., et al. Growth deceleration of children on inhaled corticosteroids is compensated for after the first 12 months of treatment. Pediatr Pulmonol 42 (2007), 465–470.
34. Arend, E.E., Fischer, G.B., Debiasi, M., Schmid, H., Inhaled corticosteroid treatment and growth of asthmatic children seen at outpatient clinics. J Pediatr (Rio J) 82 (2006), 197–203, 10.2223/JPED.1486.
35. Camargos, P.A., Lasmar, L.M., Effects of beclomethasone and factors related to asthma on the growth of prepubertal children. Respir Med 104 (2010), 951–956, 10.1016/j.rmed.2010.02.002.
36. Lasmar, L., Brand, P.L., Lima, A.C., Maciel, M.F., Camargos, P., Growth velocity in prepubertal children using both inhaled and intranasal corticosteroids. Ann Allergy Asthma Immunol 116 (2016), 368–370, 10.1016/j.anai.2016.01.011.
37. McCowan, C., Neville, R.G., Thomas, G.E., Crombie, I.K., Clark, R.A., Ricketts, I.W., et al. Effect of asthma and its treatment on growth: four year follow up of cohort of children from general practices in Tayside, Scotland. BMJ 316 (1998), 668–672.
38. Ninan, T.K., Russell, G., Asthma, inhaled corticosteroid treatment, and growth. Arch Dis Child 67 (1992), 703–705.
39. Protudjer, J.L.P., Lundholm, C., Bergstrom, A., Kull, I., Almqvist, C., The influence of childhood asthma on puberty and height in Swedish adolescents. Pediatr Allergy Immunol 26 (2015), 474–481, 10.1111/pai.12398.
40. Volovitz, B., Amir, J., Malik, H., Kauscghansky, A., Varsano, I., Growth and pituitary adrenal function in children with severe asthma treated with inhaled budesonide. N Engl J Med 329 (1993), 1703–1708.
41. Doull, I.J.M., The effect of asthma and its treatment on growth. Arch Dis Child 89 (2004), 60–63, 10.1136/adc.2003.014365.
42. Lipworth, B.J., Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis. Arch Intern Med 159 (1999), 941–955.