Perioperative myocardial injury after noncardiac surgery incidence, mortality, and characterization

Circulation

Volumn 137, Issue 12, 2018, Pages 1221-1232

  Puelacher, Christian ^a   Buse, Giovanna Lurati ^b,c   Seeberger, Daniela ^b   Sazgary, Lorraine ^b   Marbot, Stella ^b   Lampart, Andreas ^b   Espinola, Jaqueline ^b   Prof, Christoph Kindler ^a   Hammerer, Angelika ^c   Seeberger, Esther ^b   Strebel, Ivo ^d   Wildi, Karin ^b   Twerenbold, Raphael ^b   Du Fay De Lavallaz, Jeanne ^a   Prof, Luzius Steiner ^a   Gurke, Lorenz ^a   Breidthardt, Tobias ^a   Rentsch, Katharina ^a   Buser, Andreas ^a   Gualandro, Danielle M ^e   Prof, Stefan Osswald ^a   Mueller, Christian ^a   more..

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Department of Anesthesiology ^*  (United States)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d CANTONAL HOSPITAL AARAU   (Switzerland)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Biomarkers; Heart injuries; Hospital mortality; Noncardiac surgery; Perioperative care; Prognosis; Prospective studies; Troponin T

Indexed keywords

TROPONIN T; BIOLOGICAL MARKER;

ACUTE HEART INFARCTION; AGED; ARTICLE; CARDIOVASCULAR DISEASE ASSESSMENT; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; COMORBIDITY; CONTROLLED STUDY; DIAGNOSTIC STUDY; DISEASE ASSOCIATION; EUROPEAN SOCIETY OF ANAESTHESIOLOGY RISK; EUROPEAN SOCIETY OF CARDIOLOGY RISK; FEMALE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HIGH RISK PATIENT; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; MORTALITY RATE; PEROPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVISED CARDIAC RISK INDEX; RISK ASSESSMENT; ST SEGMENT DEPRESSION; T WAVE INVERSION; THORAX PAIN; VERY ELDERLY; BLOOD; CARDIAC MUSCLE; EARLY DIAGNOSIS; ELECTROCARDIOGRAPHY; HEART DISEASE; METABOLISM; MORTALITY; PATHOLOGY; PREDICTIVE VALUE; RISK FACTOR; SURGERY; SWITZERLAND; TIME FACTOR; TISSUE SURVIVAL; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; BIOMARKERS; EARLY DIAGNOSIS; ELECTROCARDIOGRAPHY; FEMALE; HEART DISEASES; HUMANS; INCIDENCE; MALE; MYOCARDIUM; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SURGICAL PROCEDURES, OPERATIVE; SWITZERLAND; TIME FACTORS; TISSUE SURVIVAL; TREATMENT OUTCOME; TROPONIN T;

EID: 85048152861     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.117.030114     Document Type: Article

References (23)

1. Devereaux PJ, Chan MT V, Alonso-Coello P, Walsh M, Berwanger O, Vil-lar JC, Wang CY, Garutti RI, Jacka MJ, Sigamani A, Srinathan S, Biccard BM, Chow CK, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G, Heels-Ansdell D, Sessler DI, Thorlund K, Garg AX, Mrkobrada M, Thomas S, Rodseth RN, Pearse RM, Thabane L, McQueen MJ, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S. Association Between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA. 2012;307:2295-2304.
2. Devereaux PJ, Xavier D, Pogue J, Guyatt G, Sigamani A, Garutti I, Leslie K, Rao-Melacini P, Chrolavicius S, Yang H, Macdonald C, Avezum A, Lanthier L, Hu W, Yusuf S; POISE (PeriOperative ISchemic Evaluation) Investigators. Characteristics and short-term prognosis of perioperative myocar-dial infarction in patients undergoing noncardiac surgery: a cohort study. Ann Intern Med. 2011;154:523-528. doi: 10.7326/0003-4819-154-8-201104190-00003.
3. Ekeloef S, Alamili M, Devereaux PJ, Gögenur I. Troponin elevations after non-cardiac, non-vascular surgery are predictive of major adverse cardiac events and mortality: a systematic review and meta-analysis. Br J Anaesth. 2016;117:559-568. doi: 10.1093/bja/aew321.
4. van Waes JA, Nathoe HM, de Graaff JC, Kemperman H, de Borst GJ, Peelen LM, van Klei WA; Cardiac Health After Surgery (CHASE) Investigators. Myocardial injury after noncardiac surgery and its association with short-term mortality. Circulation. 2013;127:2264-2271. doi: 10.1161/CIRCULATIONAHA.113.002128.
5. Devereaux PJ, Biccard BM, Sigamani A, Xavier D, Chan MT V., Srinathan SK, Walsh M, Abraham V, Pearse R, Wang CY, Sessler DI, Kurz A, Szcze-klik W, Berwanger O, Villar JC, Malaga G, Garg AX, Chow CK, Ackland G, Patel A, Borges FK, Belley-Cote E P, Duceppe E, Spence J, Tandon V, Williams C, Sapsford RJ, Polanczyk CA, Tiboni M, Alonso-Coello P, Fa-ruqui A, Heels-Ansdell D, Lamy A, Whitlock R, LeManach Y, Roshanov PS, McGillion M, Kavsak P, McQueen MJ, Thabane L, Rodseth RN, Buse GAL, Bhandari M, Garutti I, Jacka MJ, Schünemann HJ, Cortes OL, Co-riat P, Dvirnik N, Botto F, Pettit S, Jaffe AS, Guyatt GH. Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery. JAMA. 2017;317:1642-1651.
6. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guy-att G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Ger-stein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes H P, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott H P, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S, Coriat P, Monneret D, Goarin J P, Esteve CI, Royer C, Daas G, Chan M T, Choi G Y, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A, Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T, Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T; Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Writing Group, on behalf of The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Investigators; Appendix 1. The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators Writing Group; Appendix 2. The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Operations Committee; Vascular Events in Noncardiac Surgery Patients Cohort Evaluation VISION Study Investigators. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology. 2014;120:564-578. doi: 10.1097/ALN.0000000000000113.
7. Kristensen SD, Knuuti J, Saraste A, Anker S, Botker HE, De Hert S, Ford I, Gonzalez-Juanatey JR, Gorenek B, Heyndrickx GR, Hoeft A, Huber K, Iung B, Kjeldsen K P, Longrois D, Luscher T F, Pierard L, Pocock S, Price S, Roff M, Sirnes PA, Sousa-Uva M, Voudris V, Funck-Brentano C, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes a. W, Kirchhof P, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli M F, Ponikowski P, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Solca M, Brichant J-F, de Robertis E, Langenecker SK, Wichelewski J, Agewall S, Ceconi C, Coca A, Corra U, De Caterina R, Di Mario C, Edvardsen T, Germano G, Guarracino F, Hoes A, Joergensen T, Juni P, Marques-Vidal P, Mueller C, Oto O, Pibarot P, Sellevold O F, Triposkiadis F, Wouters P. 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesth. Eur Heart J. 2014;35:2383-2431.
8. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Thygesen K, Alpert JS, White HD, Jaffe AS, Katus HA, Apple FS, Lindahl B, Morrow DA, Chaitman BR, Clemmensen PM, Johanson P, Hod H, Underwood R, Bax JJ, Bonow JJ, Pinto F, Gibbons RJ, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Uretsky BF, Steg PG, Wijns W, Bassand J P, Menasche P, Ravkilde J, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Simoons ML, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Mendis S, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, Morais J, Aguiar C, Almahmeed W, Arnar DO, Barili F, Bloch KD, Bolger AF, Botker HE, Bozkurt B, Bugiardini R, Cannon C, de Lemos J, Eberli FR, Escobar E, Hlatky M, James S, Kern KB, Moliterno DJ, Mueller C, Neskovic AN, Pieske BM, Schulman S P, Storey RF, Taubert KA, Vranckx P, Wagner DR; Joint ESC/ACCF/AHA/WHF Task Force for Universal Defni-tion of Myocardial Infarction; Authors/Task Force Members Chairpersons; Biomarker Subcommittee; ECG Subcommittee; Imaging Subcommittee; Classifcation Subcommittee; Intervention Subcommittee; Trials & Registries Subcommittee; Trials & Registries Subcommittee; Trials & Registries Subcommittee; Trials & Registries Subcommittee; ESC Committee for Practice Guidelines (CPG); Document Reviewers. Third universal defni-tion of myocardial infarction. J Am Coll Cardiol. 2012;60:1581-1598. doi: 10.1016/j.jacc.2012.08.001.
9. Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ, Hill SA, Thomas S, Mrkobrada M, Alonso-Coello P, Ber-wanger O, Biccard BM, Cembrowski G, Chan MT, Chow CK, de Miguel A, Garcia M, Graham MM, Jacka MJ, Kueh JH, Li SC, Lit LC, Martínez-Brú C, Naidoo P, Nagele P, Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier D, Devereaux PJ. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study. Clin Biochem. 2011;44:1021-1024. doi: 10.1016/j.clinbiochem.2011.05.017.
10. Kavsak PA, MacRae AR, Yerna MJ, Jaffe AS. Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury. Clin Chem. 2009;55:573-577. doi: 10.1373/clinchem.2008.116020.
11. Weber M, Luchner A, Seeberger M, Manfred S, Mueller C, Liebetrau C, Schlitt A, Apostolovic S, Jankovic R, Bankovic D, Jovic M, Mitrovic V, Nef H, Mollmann H, Hamm CW. Incremental value of high-sensitive troponin T in addition to the revised cardiac index for peri-operative risk stratifca-tion in non-cardiac surgery. Eur Heart J. 2013;34:853-862. doi: 10.1093/eurheartj/ehs445.
12. Irfan A, Reichlin T, Twerenbold R, Meister M, Moehring B, Wildi K, Bassetti S, Zellweger C, Gimenez MR, Hoeller R, Murray K, Sou SM, Mueller M, Mosimann T, Reiter M, Haaf P, Ziller R, Freidank H, Osswald S, Mueller C. Early diagnosis of myocardial infarction using absolute and relative changes in cardiac troponin concentrations. Am J Med. 2013;126:781-788.e2. doi: 10.1016/j.amjmed.2013.02.031.
13. Reichlin T, Irfan A, Twerenbold R, Reiter M, Hochholzer W, Burkhalter H, Bassetti S, Steuer S, Winkler K, Peter F, Meissner J, Haaf P, Potocki M, Drexler B, Osswald S, Mueller C. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation. 2011;124:136-145. doi: 10.1161/CIRCU-LATIONAHA.111.023937.
14. Hicks KA, Tcheng JE, Bozkurt B, Chaitman BR, Cutlip DE, Farb A, Fon-arow GC, Jacobs JP, Jaff MR, Lichtman JH, Limacher MC, Mahaffey KW, Mehran R, Nissen SE, Smith EE, Targum SL; American College of Cardiology; American Heart Association. 2014 ACC/AHA Key Data Elements and Defnitions for Cardiovascular Endpoint Events in Clinical Trials: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Cardio-vascular Endpoints Data Standards). Circulation. 2015;132:302-361. doi: 10.1161/CIR.0000000000000156.
15. Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Polanczyk CA, Cook EF, Sugarbaker DJ, Donaldson MC, Poss R, Ho KK, Ludwig LE, Pedan A, Goldman L. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation. 1999;100:1043-1049.
16. Apple FS. A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem. 2009;55:1303-1306. doi: 10.1373/clinchem.2009.128363.
17. Agresti A, Coull BA. Approximate is better than "exact" for interval estimation of binomial proportions. Am Stat. 1998;52:119-126.
18. Bagley SC, White H, Golomb BA. Logistic regression in the medical literature: standards for use and reporting, with particular attention to one medical domain. J Clin Epidemiol. 2001;54:979-985.
19. Noordzij PG, van Geffen O, Dijkstra IM, Boerma D, Meinders AJ, Rettig TC, Eefting FD, van Loon D, van de Garde EM, van Dongen E P. High-sensitive cardiac troponin T measurements in prediction of non-cardiac complications after major abdominal surgery. Br J Anaesth. 2015;114:909-918. doi: 10.1093/bja/aev027.
20. Roff M, Patrono C, Collet J-P, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey R F, Windecker S. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2015;32:2999-3054.
21. Landesberg G, Beattie WS, Mosseri M, Jaffe AS, Alpert JS. Perioperative myocardial infarction. Circulation. 2009;119:2936-2944. doi: 10.1161/CIRCULATIONAHA.108.828228.
22. Gualandro DM, Campos CA, Calderaro D, Yu PC, Marques AC, Pastana AF, Lemos PA, Caramelli B. Coronary plaque rupture in patients with myocardial infarction after noncardiac surgery: frequent and dangerous. Atherosclerosis. 2012;222:191-195. doi: 10.1016/j.atherosclero-sis.2012.02.021.
23. Foucrier A, Rodseth R, Aissaoui M, Ibanes C, Goarin J P, Landais P, Co-riat P, Le Manach Y. The long-term impact of early cardiovascular therapy intensifcation for postoperative troponin elevation after major vascular surgery. Anesth Analg. 2014;119:1053-1063. doi: 10.1213/ANE.0000000000000302.