A two-phase pathogenesis of graft-versus-host disease in mice

Bone Marrow Transplantation

Volumn 29, Issue 2, 2002, Pages 151-158

  van Leeuwen, L ^a   Guiffre, A ^a   Atkinson, K ^a,b   Rainer, S P ^a   Sewell, W A ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b Center for Cellular Therapy   (United States)

Author keywords

Antigen presentation; Cytokines; Graft versus host; MHC; Transplantation

Indexed keywords

INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; BODY WEIGHT; BONE MARROW TRANSPLANTATION; CELL COUNT; CONTROLLED STUDY; DISEASE SEVERITY; DONOR; EUTHANASIA; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HOST CELL; IRRADIATION; LETHALITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MINOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; DISEASE MODELS, ANIMAL; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RNA, MESSENGER; SKIN; SPLEEN; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC; WEIGHT LOSS;

EID: 85047699967     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703328     Document Type: Article

References (33)

1. Unrelated donor hematopoietic stem cell transplantation
2. Allogeneic bone marrow transplantation: Acute and late complications
3. Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow
4. T cell depletion in bone marrow transplantation
5. T cell depletion in bone marrow transplantation for leukemia: Current results and future directions
6. Bone marrow transplantation from related donors other than HLA-identical siblings: Effect of T cell depletion
7. Increased risk of relapse in patients with chronic myelogenous leukemia given T-cell depleted marrow compared to methotrexate combined with cyclosporin or monotherapy for the prevention of graft-versus-host disease
8. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation
9. Human minor histocompatibility antigens: New concepts for marrow transplantation and adoptive immunotherapy
10. Prevention of graft versus host disease by inactivation of host antigen-presenting cells
11. Administration of mycophenolate mofetil in a murine model of acute graft-versus-host disease after bone marrow transplantation
12. Interleukin-2: Inception, impact, and implications
13. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
14. Rapid synthesis of a DNA competitor for use in quantitative polymerase chain reaction analysis using simple molecular techniques
15. Inhibition of interleukin-5 gene expression by dexamethasone
16. Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction
17. Histopathology of hematopoietic stem cell transplantation
18. Interleukin-10 administration decrease survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts
19. Interleukin-12 inhibits murine graft-versus-host disease
20. Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells
21. Total body irradiation and acute graft-versus-host disease the role of gastrointestinal damage and inflammatory cytokines
22. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation
23. Critical role of interleukin-2 in the development of acute graft-versus-host disease
24. In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment
25. Differential cytokine expression in acute and chronic murine graft-versus-host-disease
26. Kinetics of T cell activation in acute and chronic forms of murine graft-versus-host disease
27. Kinetic and organ-specific patterns of cytokine expression in acute graft-versus-host disease
28. Relevance of tumor necrosis factor to graft-versus-host disease after small bowel transplantation
29. Cytokine dysregulation and acute graft-versus-host disease
30. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: Rationale for the use of cytokine shields in allogeneic bone marrow transplantation
31. Selection of cytotoxic T-cell precursors specific for minor histocompatibility determinants. I. Negative selection across H-2 barriers induced with disrupted cells but not with glutaraldehyde-treated processing
32. Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences
33. Persistence of host Langerhans cells following allogeneic bone marrow transplantation: Possible relationship with acute graft-versus-host disease