Identical twins with cervical myelopathy: A case for hereditary cervical spondylosis? Report of two cases and review of the literature

Journal of Neurosurgery: Spine

Volumn 6, Issue 4, 2007, Pages 344-349

  Mukerji, Nitin ^a   Sinar, Ernest J ^a  

^a JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Cervical spondylosis; Genetics; Myelopathy

Indexed keywords

CERVICAL MYELOPATHY; CERVICAL SPINAL CORD INJURY; CERVICAL SPONDYLOSIS; GENETIC DISORDER; HUMAN; INTERVERTEBRAL DISK HERNIA; INTERVERTEBRAL DISKECTOMY; MONOZYGOTIC TWINS; MOTOR PERFORMANCE; NECK INJURY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARESTHESIA; REVIEW; SPINE FUSION; ADULT; AGE; CASE REPORT; CERVICAL SPINE; GENETICS; MALE; PATHOLOGY; SPINAL CORD COMPRESSION; SPONDYLOSIS;

ADULT; AGE FACTORS; CERVICAL VERTEBRAE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; SPINAL CORD COMPRESSION; SPINAL OSTEOPHYTOSIS; TWINS, MONOZYGOTIC;

EID: 85047699788     PISSN: 15475654     EISSN: None     Source Type: Journal    
DOI: 10.3171/spi.2007.6.4.10     Document Type: Review

References (40)

1. Annunen S, Paassilta P, Lohiniva J, Perala M, Pihlajamaa T, Karppinen J, et al: An allele of COL9A2 associated with intervertebral disc disease. Science 285:409-412, 1999
2. Anonymous: Cervical spondylosis - a genetic factor. Br Med J 2:650, 1969
3. Battie MC, Haynor DR, Fisher LD, Gill K, Gibbons LE, Videman T: Similarities in degenerative findings on magnetic resonance images of the lumbar spines of identical twins. J Bone Joint Surg Am 77:1662-1670, 1995
4. Battie MC, Videman T: Lumbar disc degeneration: epidemiology and genetics. J Bone Joint Surg Am 88 (2 Suppl):3-9, 2006
5. Battie MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K: 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 20:2601-2612, 1995
6. Battie MC, Videman T, Parent E: Lumbar disc degeneration: epidemiology and genetic influences. Spine 29:2679-2690, 2004
7. Bull J, el Gammal T, Popham M: A possible genetic factor in cervical spondylosis. Br J Radiol 42:9-16, 1969
8. Castroviejo IP, Rodriguez-Costa T, Castillo F: Spondylo-thoracic dysplasia in three sisters. Dev Med Child Neurol 15:348-354, 1973
9. Cheung KM, Chan D, Karppinen J, Chen Y, Jim JJ, Yip SP, et al: Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine 31:1143-1148, 2006
10. De Bandt M, Meyer O, Fuster JM, Kahn MF: Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. J Rheumatol 22:1395-1398, 1995
11. Emery AE, Lawrence JS: Genetics of ankylosing spondylitis. J Med Genet 4:239-244, 1967
12. Fiedler J, Bergmann C, Brenner RE: X-linked spondyloepiphyseal dysplasia tarda: molecular cause of a heritable disorder associated with early degenerative joint disease. Acta Orthop Scand 74:737-741, 2003
13. Fiedler J, Frances AM, Le Merrer M, Richter M, Brenner RE: Xlinked spondyloepiphyseal dysplasia tarda: molecular cause of a heritable platyspondyly. Spine 28:E478-E482, 2003
14. Gunzburg R, Fraser RD, Fraser GA: Lumbar intervertebral disc prolapse in teenage twins. A case report and review of the literature. J Bone Joint Surg Br 72:914-916, 1990
15. Jim JJ, Noponen-Hietala N, Cheung KM, Ott J, Karppinen J, Sahraravand A, et al: The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 30:2735-2742, 2005
16. Karppinen J, Paakko E, Paassilta P, Lohiniva J, Kurunlahti M, Tervonen O, et al: Radiologic phenotypes in lumbar MR imaging for a gene defect in the COL9A3 gene of type IX collagen. Radiology 227:143-148, 2003
17. King JB: A radiographic skeletal survey of identical twins. Clin Radiol 17:361-364, 1966
18. King JB: A radiographic survey of nine pairs of elderly identical twins. Clin Radiol 22:375-378, 1971
19. King JB: A second radiographic skeletal survey of identical twins. Clin Radiol 19:315-317, 1968
20. Lestini WF, Wiesel SW: The pathogenesis of cervical spondylosis. Clin Orthop Relat Res 239:69-93, 1989
21. MacKenzie JJ, Fitzpatrick J, Babyn P, Ferrero GB, Ballabio A, Billingsley G, et al: X linked spondyloepiphyseal dysplasia: a clinical, radiological, and molecular study of a large kindred. J Med Genet 33:823-828, 1996
22. Matsui H, Kanamori M, Ishihara H, Yudoh K, Naruse Y, Tsuji H: Familial predisposition for lumbar degenerative disc disease. A case-control study. Spine 23:1029-1034, 1998
23. Matsui H, Terahata N, Tsuji H, Hirano N, Naruse Y: Familial predisposition and clustering for juvenile lumbar disc herniation. Spine 17:1323-1328, 1992
24. Matsui H, Tsuji H, Terahata N: Juvenile lumbar herniated nucleus pulposus in monozygotic twins. Spine 15:1228-1230, 1990
25. Nelson CL, Janecki CJ, Gildenberg PL, Sava G: Disk protrusions in the young. Clin Orthop Relat Res 88:142-150, 1972
26. Paassilta P, Lohiniva J, Goring HH, Perala M, Raina SS, Karppinen J, et al: Identification of a novel common genetic risk factor for lumbar disk disease. JAMA 285:1843-1849, 2001
27. Palmer PE, Stadalnick R, Arnon S: The genetic factor in cervical spondylosis. Skeletal Radiol 11:178-182, 1984
28. Postacchini F, Lami R, Pugliese O: Familial predisposition to discogenic low-back pain. An epidemiologic and immunogenetic study. Spine 13:1403-1406, 1988
29. Roh JS, Teng AL, Yoo JU, Davis J, Furey C, Bohlman HH: Degenerative disorders of the lumbar and cervical spine. Orthop Clin North Am 36:255-262, 2005
30. Ryan MD: L4-5 degenerative spondylolisthesis in monozygous twins. Spine 19:985-986, 1994
31. Sambrook PN, MacGregor AJ, Spector TD: Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins. Arthritis Rheum 42:366-372, 1999
32. Simmons ED Jr, Guntupalli M, Kowalski JM, Braun F, Seidel T: Familial predisposition for degenerative disc disease. A case-control study. Spine 21:1527-1529, 1996
33. Solovieva S, Lohiniva J, Leino-Arjas P, Raininko R, Luoma K, Ala-Kokko L, et al: Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ss gene polymorphisms. Eur Spine J 15:613-619, 2006
34. Takahashi M, Haro H, Wakabayashi Y, Kawa-uchi T, Komori H, Shinomiya K: The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. J Bone Joint Surg Br 83: 491-495, 2001
35. Varlotta GP, Brown MD, Kelsey JL, Golden AL: Familial predisposition for herniation of a lumbar disc in patients who are less than twenty-one years old. J Bone Joint Surg Am 73:124-128, 1991
36. Videman T, Battie MC, Ripatti S, Gill K, Manninen H, Kaprio J: Determinants of the progression in lumbar degeneration: a 5-year follow-up study of adult male monozygotic twins. Spine 31:671-678, 2006
37. Videman T, Leppavuori J, Kaprio J, Battie MC, Gibbons LE, Peltonen L, et al: Intragenic polymorphisms of the vitamin D receptor gene associated with intervertebral disc degeneration. Spine 23:2477-2485, 1998
38. Wynne-Davies R: Familial (idiopathic) scoliosis. A family survey. J Bone Joint Surg Br 50:24-30, 1968
39. Wynne-Davies R, Scott JH: Inheritance and spondylolisthesis: a radiographic family survey. J Bone Joint Surg Br 61:301-305, 1979
40. Yoo K, Origitano TC: Familial cervical spondylosis. Case report. J Neurosurg 89:139-141, 1998