Intensive care management of acute pancreatitis

Digestive Surgery

Volumn 11, Issue 3-6, 1994, Pages 231-241

  Sigurdsson, Gisli H ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Acute pancreatitis; Adult respiratory distress syndrome; Intensive care unit; Multiple organ failure; Necrotizing pancreatitis; Sepsis

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; ENZYME INHIBITOR; IMIPENEM;

ACUTE HEMORRHAGIC PANCREATITIS; ACUTE PANCREATITIS; ADULT RESPIRATORY DISTRESS SYNDROME; ANALGESIA; ANTIBIOTIC PROPHYLAXIS; ASSISTED VENTILATION; BLEEDING; CONFERENCE PAPER; CRYSTALLOID; FLUID THERAPY; HUMAN; INFECTION; INTENSIVE CARE; MICROCIRCULATION; MULTIPLE ORGAN FAILURE; NITROGEN BALANCE; NUTRITIONAL SUPPORT; ORGAN BLOOD FLOW; OXYGEN TRANSPORT; PANCREAS NECROSIS; PANCREAS PSEUDOCYST; PATIENT MONITORING; SEPSIS;

EID: 85047697902     PISSN: 02534886     EISSN: None     Source Type: Journal    
DOI: 10.1159/000172260     Document Type: Article

References (144)

1. Wilson C, Imrie CW: Current concepts in the management of pancreatitis. Drugs 1991:41: 358-366
2. Fernandes-del Castillo C, Rattner DW, Warschaw AL: Acute pancreatitis. Lancet 1993: 342:475-478
3. Levi JU: Admission indications and care implications of pancratic disease: in Civetta JM, Taylor RW, Kirby RY (eds): Critical Care. Philadelphia. Lippincott. 1988. pp 1291-1299
4. Schmidt E, Schmidt F: Advances in the enzyme diagnosis of pancreatic diseases. Clin Biochem 1990:23:383-394
5. Gerzof SG, Banks PA, Robbins AH, Johnson WC, Spechler SJ, Wetzner SM. Snider JM. Langevin RE, Jay ME: Early diagnosis of pancreatic infection by computed tomography guided aspiration. Gastroenterology 1987:93: 1315-1320
6. Reynaert MS, Dugernier T. Kestens PJ: Current therapeutic strategies in severe acute pancreatitis. Intensive Care Med 1990; 16:352-362
7. Marshall JB: Acute pancreatitis. Arch Intern Med 1993;153:1185-1198
8. Pederzopli P, Bassi C, Vesentini S, lacono C, Nicoli N, Mangiante G, Corra S, Falconi M, Nifosi F, Girelli R: Necrosectomy by lavage in the surgical treatment of severe necrotizing pancreatitis. Results in 263 patients. Acta Chir Scand 1990;156:775-780
9. Vega J, Karlezi RA, Galvez S: Prolonged hospitalization in the intensive care unit: A worthless effort? Rev Med Chil 1991:118:643-648
10. KuvshinoIT BW, McFadden DW: Acute pancreatitis necrosis; infected pancreatic necrosis and pancreatic abscess: in Rippe JM, Irwin RS, Alpert JS, Fink MP (eds): Intensive Care Medicine. ed 2. Boston. Little. Brown. 1991. pp 1326-1332
11. Switz DM: Pancreatitis: in Shoemaker WC. Avres S, Grenvik A, Holbrook PR, Leigh Thompson W (eds): Textbook of Critical Care, ed 2. Philadelphia. Saunders. 1989, pp 732-736
12. Neoptolemos J, Carr-Locke DL, London NJ, Bailey IA, James D, Fossard P: Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988;ii:979-983
13. Ladas SD, Raptis SA: Conservative treatment of acute pancreatitis: The use of somatostatin. Hepatogastroenterology 1992:39:466-469
14. Beger HG: Operative management of necrotizing pancreatitis – necrosectomy and continuous closed postoperative lavage of the lesser sac. Hepatogastroenterology 1991:38:129-133
15. Beger HG, Bittner R, Silvia B, Büchler M: Bacterial contamination of pancreatic necrosis. A prospective clinical study. Gastroenterology 1986:91:433-438
16. Büchler M, Malfertheiner P, Friess H, Isenmann R, Vanek E, Grimm H, Schlegel P, Friess T, Beger HG: Human pancreatic tissue concentration of bactericidal antibiotics. Gastroenterology 1992:103:1902-1908
17. Dickson AP, Foulis AK, Imrie CW: Histology and bacteriology of closed duodenal loop models of experimental acute pancreatitis in the rat. Digestion 1986:34:15-20
18. Bradley EL: Later complications of acute pancreatitis: in Glazer G, Ranson JHC (eds): Acute Pancreatitis. London. Baillière. Tindall, 1988. pp 390-431
19. Cerra F: Multiple organ failure. Dis Mon 1991: 38:843-947
20. Dugernier T, Reynaert MS: Management of Severe Acute Pancreatitis; in Vincent IL (ed): Update in Intensive Care and Emergency Median: 1990. Berlin. Springer. 1990, pp 696-705
21. Neale D: Updates in advanced life support protocols. Curr Opin Anaesthesiol 1994;7:213-218
22. Wo C, Shoemaker W, Appel P, Bishop M, Kram H, Hardin F: Unreliability of blood pressure and heart rate to evaluate cardiac output in emergency resuscitation and critical illness. Crit Care Med 1993:21:218-223
23. Rackow EC, Falk JL, Fein A: Fluid resuscitation in circulatory shock: A comparison of the cardiorespiratory effccts of albumin, hetastarch and saline solutions in patients with hypovolemic and septic shock. Crit Care Med 1983;11:839-844
24. Shoemaker WC, Kram MB: Crystalloid and colloid fluid therapy in resuscitation and subsequent ICIJ management. BaillièresClin Anaesthesiol 1988:2:509-544
25. Trentz O, Friedl HP: Fluid resuscitation in acute trauma and multiple injuries. Curr Opin Anaesthesiol 1992:5:255-257
26. Sigurdsson GH, Christenson JT, El-Rakshy MB, Sadek S: Intestinal platelet sequestration after traumatic and septic shock. An early sign of sepsis and multiple organ failure in critically ill patients? Crit Care Med 1992:20:458-467
27. Renner JG, Savage WTI, Pantoja JL, Rentier VJ: Death due to acute pancreatitis: A retrospective analvsis of 405 autopsy cases. Dig Dis Sci 1985:30:1005-1011
28. Nolte D, Bayer M, Lehr H-A. Becker M, Krombach F, Kreimeier U, Messmer K: Attenuation of postischemic microvascular disturbances in striated muscle by hyperosmolar saline dextran. AmJ Physiol 1992:263:HI411-HI416
29. Hankeln KB: Oxygen and transport. Curr Opin Anaestesiol 1992:5:230-234
30. Vincent J-L: A rationale for the use of inotropic and vasoactive drugs during fluid loading. Baillières Clin Anaesthesiol 1988:2:499-507
31. 2 uptake duringendotoxemia. J Appl Physiol 1988:64:2410-2419
32. Shoemaker W, Appel P, Kram H: Hemodynamic and oxygen transport responses in survivors and nonsurvivorsof high risk surgery. Crit Care Med 1993:21:977-990
33. Prys-Roberts C: Regulation of the circulation; in Prys-Roberts C (ed): The Circulation in Anaesthesia: Applied Physiology and Pharmacology. Oxford. Blackwell Scientific. 1990. pp 179-207
34. Sigurdsson GH: Perioperative fluid therapy in microvascular surgery. J Reconstr Microsurg. in press
35. Sigurdsson GH, Thomson D: Anesthesia and microvascsular surgery: Clinical practice and research. Eur J Anaesthesiol. in press
36. Noble MIM: Cardiovascular response to fluid loading. Baillièrcs Clin Anaesthesiol 1988:2: 483-497
37. Messmer K, Kreimer U, Intaglietta M: Present state of intentional hemodilulion. Eur Surg Res 1986:18:254-263
38. Messmer K: Acute preoperative hemodilulion: Physiological basis and clinical application: in Tuma RF, White JV. Messmer K (eds): The Role of Hemodilulion in Optimal Patient Care.München. Zuckschwerdt, 1989. pp 54-73
39. Gray S, Oduro A, Latimer RD: Inotropic drugs, calcium, phosphodiesterase inhibitors. Curr Opin Anaesthesiol 1993;6:158-163
40. Lundberg J, Norgren L, Thomson D, Werner O: Hemodynamic effects of dopamine during thoracic epidural analgesia in man. Anesthesiology 1987:66:641-646
41. Prys-Roberts C: Strange bedfellows: Amidarone. adenosine, and dopamine. Curr Opin Anaesthesiol 1993:6:144-151
42. Yu M, Levy VI, Smith P, Takiguchi SA, Miyasaki Y, Myers S: Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients: A prospective, randomized. controlled study. Crit Care Med 1993:21: 830-838
43. Flemming A, Bishop M, Shoemaker W, Appel P, SufTicool W, Kuvhenguwha A, Kennedy F, Wo C-J: Prospective trial of supranormal values as goals of resuscitation in severe trauma. Arch Surg 1992:127:1175-1181
44. Bishop M, Schoemaker W, Appel P, Wo C-J, Zwick C, Kram H, Meade P, Kennedy F, Flemming A: Relationship between supranormal circulatory values, time delays, and outcome in severely traumatized patients. Crit Care Med 1993:21:56-63
45. Brown R, Dixon J, Farmer J: Dopexamine: A novel agonist at peripheral dopamine receptors and beta-2 adrenoceptors. Br J Pharmacol 1985:85:599-608
46. Tighe D, Moss R, Haywood G, Webb A, Al Saady N, Heath F, Bennett D: Dopexamine hydrochloride maintains portal blood flow and attenuates hepatic ultastructural changes in porcine peritonitis model of multiple system organ failure. Circ Shock 1993:39:199-206
47. Boyd O, Grounds M, Bennett E: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993:270: 2699-2707
48. Klar E, Foitzik T, Buhr H, Messmer K, llerfarth C: Isovolemic hemodilulion with dextran 60 as treatment of pancreatic ischaemia in acute pancreatitis: Clinical practicability of an experimental concept. Ann Surg 1993:217: 369-374
49. Longnecker DE: The microcirculation: in Prys-Roberts C (ed): The Circulation in Anaesthesia: Applied Physiology and Pharmacology. Oxford. Blackwell Scientific. 1990. pp 167-178
50. Dawidson I, Gelin L-E, Hedman L, Söderberg R: Hemodilulion and recovery from experimental intestinal shock in rats. A comparison of the efficacy of three colloids and one electrolyte solution. Crit Care Med 1981:9:42-46
51. Linko K, Mäkeläinen A: Cardiorespiratory function after replacement of blood loss with hydroxyethvlstarch 120, dextran-70, and Ringer’s acetate in pigs. Crit Care Med 1989:17: 1031-1035
52. Wang P, Chaudry IH: Crystalloid resuscitation restores but does not maintain cardiac output follow ing severe hemorrhage. J Surg Res 1991: 50:163-169
53. Wang P, Ayala A, Dean RE, Hauptman JG, Zheng DVM, De-Jong GK, Chaudry IH: Adequate crystalloid resuscitation restores but fails to maintain the active hepatocellular function following hemorrhagic shock. J Trauma 1991: 31:601-608
54. Haupt MT, Rackow EC: Colloid osmotic pressure and fluid resuscitation with hetastarch. albumin, and saline solutions. Crit Care Med 1982:10:159-163
55. Hankeln K, Rädel C, Beez M, Laniewski P, Bohmert F: Comparison of hydroxyethvl starch and iactated Ringer’s solution on hemodynamics and oxygen transport ofcritically ill patients in prospective crossover studies. Crit Care Med 1989:17:133-135
56. Modig J: Effectiveness of dextran 70 versus Ringer’s acetate in traumatic shock and adult respirtatory distress syndrome. Crit Care Med 1986:14:454-457
57. von Bormann B, Sticher J, Ratthey K, Idelberger L, Hempelmann G: Volume substitution in acute normovolemic hemodilution. 5% human albumin vs. 6% hydroxyethvl starch. Infusionstherapie 1990:17:142-146
58. Vincent JL: Plugging the leaks? New insights into synthetic colloids (editorial). Crit Care Med 1991:19:316-318
59. Dawidson I, Gelin L-E, Haglind E: Plasma volume. intravascular protein content, hemodynamic and oxygen transport changes during intestinal shock in dogs. Crit Care Med 1980:8: 73-80
60. Bombail-Girard D, Boulechfar H, Tangre M, Landillon N, Bussel A: Comparative study of the efficacy and tolerability of 2 plasma substitutes used as vascular loading solutions during plasma exchange. Ann Med Interne 1990:141: 611-614
61. Lepege JY, Garrec F, Malinovsky JM, Cozian A, Pinaud M: Effects of plasma volume substitution on right ventricle volumes and function using Holies® and Plasmion®. Br J Anaesthesiol 1993:70(suppl I):18
62. Messmer KFW: The use of plasma substitutes with special attention to their side effects. World J Surg 1987:11:69-74
63. Dawidson I, Erikson B, Gelin L-E, Söderberg R: Oxygen consumption and recovery from surgical shock in rats: A comparison of the efficacy of different plasma substitutes. Crit Care Med 1979:7:460-465
64. Klar E, Messmer K, Warshaw AL, Herfarth C: Pancreatic ischaemia in experimental acute pancreatitis: Mechanism, significance and therapy. Br J Surg 1990:77:1205-1210
65. Klar E, Mall G, Messmer K: Improvement of impaired pancreatic microcirculation by isovolemic hemodilution protects pancreatic morphobgiy in acute biliary pancreatitis. Surg Gynecol Obstet 1993:176:144-150
66. Korttila K, Gröhn P, Gordin A, Sundberg S, Salo H, Nissinen E, Mattila MAK: Effects of hydroxyethyl starch and dextran on plasma volume and blood hemostasis and coagulation. J Clin Pharmacol 1984:24:273-282
67. Hess JR, Dubick MA, Summary JJ, Bangal NR, Wade CE: The effects of 7.5% NaCI/6% dextran 70 on coagulation and platelet aggregation in humans. J Trauma 1992:32:40-44
68. Baron JF, De Kegel D, Prost AC, Mundler O, Arthaud M, Basset G, Maistre G, Masson F, Carayon A, Landault C, Barre E, Viars P: Low molecular weight hydroxyethyl starch 6% compared to albumin 4% during intensional hemodilution. Intensive Care Med 1991:17:141-148
69. Boldt J, Zickmann B, Herold C, Ballesteros M, Dapper F, Hempelmann G: Influence of hypertonic volume replacement on the microcirculation in cardiac surgery. Br J Anaesthesiol 1991;67:595-602
70. Bogan RK, Gale GR, Walton RP: Fate of 14C-labclcd hydroxyethyl starch in animals. Toxicol Appl Pharmacol 1969:15:206-211
71. Diens HP, Gerharz DC, Wagner R, Weber M, John HD: Accumulation of hydroxyethyl starch in the liver of patients with renal failure and portal hypertension. J Hepatol 1986:3: 223-226
72. Porter S, Goldberg RJ: Intraoperative allergic- reactions to hydroxyethyl starch: a report of 2 cases. Can Ancsthesiol Soc J 1986:33:394-398
73. Lockwood DNJ, Bullen C, Machin SJ: A severe coagulopathy following volume replacement with hydroxyethyl starch in a Jehovahy’s witness. Anaesthesia 1988:43:391-393
74. Sanfelippo MJ, Suberviiola PD, Geimer NF: Development of a von Willebrand-like syndrome after prolonged use of hydroxyethyl starch. Am J Clin Pathol 1987:88:653-655
75. Strauss RG, Stanfield C, Heriksen RA, Villhauer PJ: Pentastarch may cause fewer effects on coagulation than hetastarch. Transfusion 1988:28:257-260
76. Schell RM, Cole DJ, Schultz RL, Osborne TN: Temporary cerebral ischemia. Effects of pentastarch or albumin on reperfusion injury. Anesthesiology 1992:77:86-92
77. Zikria BA, Subbarao C, Oz M, Shih S, McLeod PF, Sachdev R, Freeman HP, Hardy MA: Macromoleculcs reduce abnormal microvascular permeability in rat limb ischemia-reperfusion injury. Crit Care Med 1989:17:1306-1309
78. Zikria BA, King TC, Stanford J, Freeman HP: A biophysical approach tocpaillary permeability. Surgery 1989:105:625-631
79. Zikria BA, Subbarao C, Oz MC, Popilkis SJ, Sachdev R, Chauhan P, Freeman HP, King TC: Hydroxyethyl starch macromolecules reduce myocardial reperfusion injury . Arch Surg 1990:125:930-934
80. Webb AR, Tighe D, Moss RF, Saady NA, Hvnd JW, Bennett ED: Advantages of a narrow-range. medium molecular weight hydroxyethyl starch for volume maintenance in a porcine model of fecal peritonitis. Crit Care Med 1991:19:409-416
81. Webb AR, Moss RF, Tighe D, Mythen MG, Al-Saady N, Joseph AE, Bennett ED: A narowrange, medium molecular weight pentastarch reduces structural organ damage in a hyperdynamic porcine model of sepsis. Intensive Care Med 1992:18:348-355
82. Runkel NS, Rodrigues LF, La Rocco MT, Moody FG: Mechanisms of pancreatic infection in acute pancreatitis in opossums. Curr Surg 1990:47:460-462
83. Sigurdsson Gil. Youssef H, Stephen S: Multiple organ platelet sequestration, hemodynamics and gas exchange in endotoxin shock and the effects of aspirin-terbutaline treatment. Am J Physiol Imaging 1992:7:66-72
84. Atkinson S, Bihari D: The benefits of enteral feeding in the critically ill patient. Curr Opin Anaesthesiol 1994:7:131-135
85. Heyland D, Cook D, Guyatt G: Enteral nutrition in the critically ill patient: A critical review of the evidence. Intensive Care Med 1993:19: 435-442
86. Niesel HC, Klimpel L, Kaiser II, Bernhardt A.Al-Rafai S, Lang U: Epidural-Blockade zur Analgesie und Behandlung der akuten Pankreatitis. Reg Anaesth 1991:14:97-100
87. Martini M, Büchler M, Uhl W: Pancreasnecroscen cntstehen innerhalb von 96h. Langenbecks Arch Chir 1991:376:345-349
88. Sykes MK, Adams AP, Finlay WEI, Wightman AE, Munroe JP: The cardiorespiratory effects of haemorrhage and overtransl'usion in dogs. Br J Anaesth 1979:42:573-583
89. Abboud FM: Integration of reflex responses in the control of blood pressure and vascular resistance. Am J Cardiol 1979:44:903-911
90. Bassi C, Falconi M, Girelli R, Nifosi F, Elio A, Martini N, Pederzoli P: Microbiological findings in severe pancreatitis. Surg Res Commun 1989:5:1-4
91. Bernet MF, Brassart D, Neeser JR. Servin AL: Lactobacillus acidophilus LAI binds to cultured human intestinal cell lines and inhibits attachment and cell invasion by enterovirulent bacteria. Gut 1994:35:483-489
92. Montgomery A, Borgstrom A, Haglund U: Pancreatic proteases and intestinal mucosal injury after ischemia and reperfusion in the pig. Gastroenterology 1992:102:216-222
93. Blair P, Rowlands B, Lowry K, Webb H, Armstrong P, Smilje J: Selective decontamination of the digestive tract: A stratified, randomized, prospective study in a mixed intensive care unit. Surgery 1991:110:303-310
94. McClelland P, Murray A, Yaqoob M, Van Sane H, Bone J, Mostala S: Prevention of bacterial infection and sepsis in acute severe pancreatitis. Ann R Coll Surg Engl 1992;74:329-334
95. Pederzoli P, Bassi C, Vesentini S, Campedelli A: A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 1993;176:480-483
96. van Deventer S, Gouma D: Bacterial translocation and endotoxin transmigration in intestinal ischaemia and reperfusion. Curr Opin Anaesthesiol 1994;7:126-130
97. Ledingham I, Eastaway A, McKay IC, el al: Triple regimen of selective decontamination of the digestive tract, systemic cefotaxime and microbiological surveillance for prevention of acquired infection in intensive care. Lancet l988;1:786-790
98. Beger HG: Surgical management of necrotizing pancreatitis. Surg Clin North Am 1989;69:529-549
99. Büchler M, Uhl W, Beger HG: Acute pancreatiiis: When and how to operate. Dig Dis 1992;10:354-362
100. Steer M, Meldolesi J, Figarella C: Pancreatitis: The role of lysosomes. Dig Dis Sci 1984;29:934-938
101. Beechey-Newman N: Controlled trial of high-dose octreotide in treatment of acute pancreatilis. Evidence of improvement in disease severity. Dig Dis Sci 1993;38:644-647
102. Gjorup I, Roikjaer O, Andersen B, Burcharth F, Hovendal C, Pedersen S, Creistiansen P, Wara P, Andersen J, Balslev I, Jepsen J, Rokkjaer M: A double-blinded multicenter trial of somatostatin in the treatment of acute pancreatitis. Surg Gynecol Obstet 1992;175:397-400
103. Sigurdsson GH, Chrislenson T, Al-Mousawi M, Owunnwanne A: The use of indium-111 oxide to study pulmonary and hepatic sequestration of leukocytes in endotoxin shock and the effects of the beta-2 receptor agonist, terbutaline. Am J Physiol Imaging 1989;4:136-142
104. Hecker G, Ney P, Schrörk K: Cytotoxic enzyme release and oxygen centered radical formation in human neutrophils are selectively inhibited by E-type prostaglandins but not by PGI2. Naunyn Schmiedcbergs Arch Pharmacol 1990;342:308-315
105. FitzGerald G, Murray R, Moran N, Funk C, Charman W, Clarke R, Furci L, Fitzgerald D: Mechanisms of eicosanoid action. Adv Prostaglandin Thromboxane Leukot Res 1991;21:577-581
106. Matsuo K, Kushima H, Noguchi M, Sakaguchi Y, Fujiwara T: Continuous intraarterial infusion of prostaglandin F.I and heparin to extend and improve the survival of pedicled musculocutaneous flaps through unusual routines: A clinical preliminary report. Ann Plast Surg 1992;29:314-320
107. Palmer K, Goa K: Defibrotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders. Drugs 1993;45:259-294
108. Biagi G, Legnani C, Rodorigo G, Coccheri S: Modulation of arachidonate metabolite generation in human blood by oral defibrotide. Arzneimitlelforschung 1991;41:511-514
109. Bitterman H, Lefer D, Lefer A: Novel mechanism of action of a prostacyclin enhancing agent in haemorrhagic shock. Naunyn Schmiedebergs Arch Pharmacol 1988;337:679-686
110. Aoki N, Seigfried M, Psao P, Lento P, Lefer A: Beneficial mechanism of action of a prostacyclin enhancing agent in splanchnic artery occlusion shock. Res Commun Chem Pathol Pharmacol 1988;60:275-289
111. Dahlen SF, Kunilin M, Bjork T, Raud J, Hredquist P: Leukotrienesand related eicosanoids. Am Rev Respir Dis 1987;136:524-528
112. Goto F, Watanabe E, Maruyama N, Fujita T: Prevention of the toxic action of tumour necrosis factor by cyclooxygenase inhibitor and leukopenia. Circ Shock 1989;29:179-180
113. Sigurdsson GH, Youssef HAF: Amelioration of respiratory and circulatory changes in established endotoxic shock by ketoprofen. a dual inhibitor of the arachidonic acid metabolism. Acta Anesthesiol Scand 1994;38:33-39
114. Sigurdsson GH, Youssef HAE, Owunnwanne A: Effects of two different inhibitors of the arachidonic acid metabolism on platelet sequestration in endotoxic shock. Res Exp Med 1994;194:287-295
115. Sigurdsson GH, Youssef HAF, Banic A: Effects of ketoprofen on respiratory and circulatory changes in endotoxic shock. Intensive Care Med 1993;19:333-339
116. Banic A, Kouris K, Rajacic N, Nazzal M: Thulesius O: Increased Hap viability after treatment with forskolin or with ridogrcl. a thromboxane synthesis inhibitor and receptor blocker. Res Exp Med 1990:190:223-227
117. Banic A: Assessment and Improvement ofthc Microcirculation in Arterial Skin Flaps: medical dissertation Linköping University. 1990. No 315
118. Deitch E, Bridges W, Baker J, Ma J-W, Ma L, Grisham M, Granger N, Specian R, Berg R: Hemorrhagic shock-induced bacterial translocation is reduced by xanthine oxidase inhibition or inactivation. Surgery 1988:104:191-198
119. Schoenberg M, Büchler M, Beger H: The role of oxygen radicals in experimental acute pancreatitis. Free Radic Biol Med 1992:12:515-522
120. Ryan U: Role of complement inhibitors in hyperacute rejection. Int J MicrocircClin Exp 1994:l4(suppl 1):93
121. Harkema J, Chaydry I: Magnesium-adenosine triphosphate in the treatment of shock, ischemia and sepsis. Crit Care Med 1992:20:263-275
122. Zabel P, Schonhating M, Schade U, Schlaak M: Effects of pentoxifylline in endotoxincmia in human volunteers. Prog Clin Biol Res 1991;367P:207-213
123. Tighe D, Moss R, Hynd J, Bennett D: Pentoxifylline modifies lactcmia in porcine fecal peritonitis. Crit Care Med 1989:17:S48
124. Sigurdsson GH, Youssef HAF: Effects of pentoxifylline on hemodynamics, gas-exchange and multiple organ platelet sequestration in endotoxic shock. Acta Anaesthesiol Scand 1993:37:396-403
125. Sigurdsson GH, Nachbur B, Lejeune FJ: Anesthesiologists' management of isolated limb perfusion with tumor necrosis factor alpha. Anesthesiology 1993:79:1433-1437
126. Lilly CM, Sandhu JS, Ishizaka A, Harda H, Yonemaru M, Larrick JW, Shi TX, O'Hanley PT, Raffin TA: Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am Rev Respir Dis 1989:139:1361-1368
127. Coccia MT, Waxman K, Soliman H, Tominaga G, Pindereski L: Pentoxifylline improves survival following hemorrhagic shock. Crit Care Med 1989:17:36-38
128. Nolte D, Leher H-A, Sack F-U, Messmer K: Reduction of postischaemic reperfusion injury by the vasoactive drug buflomedil. Blood Vessels 199l:28(suppl I):8-14
129. Galla T, Sätzler R, Barker J, Messmer K: Comparative analysis of vasoactive drugs in the prevention of skin necrosis. Handchir Microchir Plast Chir 1992:24:103-109
130. Boisseau M, Freyburger G, Belloc F, Seigneur M: Hemorrheological effects of buflomedil action on shape and function of the human neutrophil. Blood Vessels 1991:28:15-20
131. Curtis SE, Cain SM: Systemic and regional O2 delivery and uptake in bled dogs given hypertonic saline, whole blood, or dextran. Am J Physiol 1992:262:H778-H786
132. Kreimeier U, Frev L, Dentz J, Herbel T, Messmer K: Hypertonic saline dextran resuscitation during the initial phase of acute endo-toxemia: Effects on regional blood flow. Crit Care Med 1991:19:801-809
133. Maningas PA: Resuscitation with 7.5% NaCI in 6% dextran-70 during hemorrhagic shock in swine: Effects on organ blood flow. Crit Care Med 1987:15:1121-1126
134. Paseual JMS, Watson JC, Runyon AE, Wade CE, Kramer GC: Resuscitation of intraoperative hypovolemia: A comparison of normal saline and hypcrosinotic/hvperoncotic solutions in swine. Crit Care Med 1992:20:200-210
135. Shackford SR: Hypertonic saline and dextran for intraoperative fluid therapy: More for less. Crit Care Med 1992:20:160-162
136. Tokyav R, Zeigler ST, Kramer GC, Rogers CS, Heggers JP, Traber DL, Herndon DL: Effects of hypertonic saline dextran resuscitation on oxygen delivery, oxygen consumption, and lipid peroxidation after burn injury. J Trauma 1992;32:704-712
137. Walsh JC, Kramer GC: Resuscitation of hypovolemic sheep with hypertonic saline/dextran: The role of dextran. Circ Shock 1991:34:336-343
138. Behrman S, Fabian T, Kudsk K, Proctor KG: Microcirculatory flow changes after initial resuscitation of hemorrhagic shock with 7.5% hypertonic saline/6% dextran 70. J Trauma 1991:31:589-600
139. Taylor A: Capillary fluid filtration. Starling forces and lymph flow. Circ Res 1981:49: 557-575
140. Sigurdsson G, Youssef H, Al-Mousawi M, Khourshid M: Christenson J: Effects of the beta-2 receptor agonist tcrbutalinc on hemodynamics and gas exchange in endotoxin shock. Acta Chir Scand 1989:155:369-375
141. Sigurdsson G, Christenson J: Influence of terbutaline on endotoxin induced lung injury. Circ Shock 1988:25:153-163
142. Svensjö E, Persson C, Rutili G: Inhibition of bradykinin induced macromolccular leakage from post-capillary venules by a β2-adreno-receptor stimulant, terbutaline. Acta Physiol Scand 1977:101:504-506
143. Persson C, Svensjö E: Vascular responses and the n suppression: Drugs interfering with ve-nular permeability: in Bonta I, Bray M, Parnham M (eds): Handbook of Inflammation. New York, Elsevier Science, 1985, pp 61-82
144. Grände P: The effects of dihydroergotamine in patients with head injury and raised intracranial pressure. Intensive Care Med 1989:15:523-527