VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice

Cancer Gene Therapy

Volumn 9, Issue 2, 2002, Pages 197-201

  Kamiyama, Masako ^a   Ichikawa, Yasushi ^a   Ishikawa, Takashi ^a   Chishima, Takashi ^a   Hasegawa, Satoshi ^a   Hamaguchi, Yohei ^a   Nagashima, Yoji ^a   Miyagi, Yohei ^a   Mitsuhashi, Masato ^b   Hyndman, David ^c   Hoffman, Robert M ^d   Ohki, Shigeo ^a   Shimada, Hiroshi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b RNAture   (United States)

^c Hitachi Chemical Research Center   (United States)

^d ANTICANCER INC   (United States)

Author keywords

Green fluorescent protein; KDR Flk 1 antisense oligonucleotide; Nude mice; Stomach cancer; VEGF receptor

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE PHOSPHOROTHIOATE; BUFFER; GREEN FLUORESCENT PROTEIN; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; PHOSPHATE; SODIUM CHLORIDE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ARTICLE; CELL COUNT; CELL DENSITY; CONTROLLED STUDY; DRUG EFFICACY; FLUORESCENCE MICROSCOPY; GENE THERAPY; HUMAN; HUMAN CELL; MICROVASCULATURE; PERITONEAL CAVITY; PERITONEUM METASTASIS; PRIORITY JOURNAL; STOMACH CARCINOMA;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; LUMINESCENT PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; OLIGONUCLEOTIDES, ANTISENSE; PERITONEAL NEOPLASMS; PRECIPITIN TESTS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; STOMACH NEOPLASMS; THIONUCLEOTIDES; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 85047695382     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700428     Document Type: Article

References (12)

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3. Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
4. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
5. Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1 dependent
6. KDR/Flk-1 is a major regulator of vascular endothelial growth factor-induced tumor development and angiogenesis in murine hepatocellular carcinoma cells
7. Antitumor effects on human gastric cancer and induction of apoptosis by vascular endothelial growth factor neutralizing antibody
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