Primary Reninism: Hypertension, Hyperreninemia, and Secondary Aldosteronism Due to Renin-Producing Juxtaglomerular Cell Tumors

Archives of Internal Medicine

Volumn 130, Issue 5, 1972, Pages 682-696

  Conn, Jerome W ^a   Cohen, Edwin L ^a   Lucas, Charles P ^a   Mcdonald, Walter J ^a   Mayor, Gilbert H ^a   Blough, William M ^a   Eveland, Warren C ^a   Bookstein, Joseph J ^a   Lapides, Jack ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; RENIN; SODIUM;

ADOLESCENT; ARTICLE; BLOOD; BODY POSTURE; CIRCADIAN RHYTHM; ELECTRON MICROSCOPY; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; JUXTAGLOMERULAR APPARATUS; KIDNEY TUMOR; MALE; METABOLISM; SYNDROME;

ADOLESCENT; ANGIOTENSIN II; CIRCADIAN RHYTHM; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; JUXTAGLOMERULAR APPARATUS; KIDNEY NEOPLASMS; MALE; MICROSCOPY, ELECTRON; POSTURE; RENIN; SODIUM; SYNDROME;

EID: 85047691425     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.130.5.682     Document Type: Article

References (39)

1. Robertson PW, Klidjian A, Harding LK, et al: Hypertension due to a renin-secreting renal tumour. Amer J Med 43:963-976, 1967.
2. Kihara I, Kitamura S, Hoshino T, et al: A hitherto unreported vascular tumor of the kidney: A proposal of “juxtaglomerular cell tumor.” Acta Path Jap 18:197-206, 1968.
3. Eddy RL, Sanchez SA: Renin-secreting renal neoplasm and hypertension with hypokalemia. Ann Intern Med 75:725-729, 1971.
4. Bonnin JM, Hodge RL, Lumbers ER: A renin-secreting renal tumor associated with hypertension. Aust New Zeal J Med 2:178-181, 1972.
5. Cohen EL, Grim CE, Conn JW, et al: Accurate and rapid measurement of plasma renin activity by radioimmunoassay: Results in normal and hypertensive people. J Lab Clin Med 77:1025-1038,1971.
6. Barajas L: The development and ultrastructure of the juxtaglomerular cell granule. J Ultrastruct Res 15:400-413, 1966.
7. Biava CG, West M: Fine structure of normal human juxtaglomerular cells: II. Specific and nonspecific cytoplasmic granules. Amer J Path 49:955-979, 1966.
8. Conn JW, Morita R, Cohen EL, et al: Primary aldosteronism: Photoscanning of tumors after administration of 131I-19-iodocholesterol. Arch Intern Med 129:417-425, 1972.
9. Cohen EL, Conn JW, Lucas CP, et al: Radioimmunoassay for angiotensin I: Measurement of plasma renin activity, plasma renin concentration, renin substrate concentration, and angiotensin I, in normal and hypertensive people, in Genest J, Koiw E (eds.): Hypertension '72. New York, Springer Verlag, 1972, pp 569-582.
10. Whalen JD, Tyler FJ, West CD: A new radioimmunoassay for urinary aldosterone, abstracted. Clin Res 18:172, 1970.
11. Kliman B, Peterson RE: Double isotope derivative assay of aldosterone in biological extracts. J Biol Chem 235:1639-1648, 1960.
12. Marshall JD Jr, Eveland WC, Smith CW: Superiority of fluorescein isothiocyanate for fluorescent antibody technique, with a modification of its application. Proc Soc Exp Biol Med 98:898-900, 1958.
13. Riggs JL, Loh PC, Eveland WC: A simple fractionation method for preparation of fluorescein-labeled gamma globulin. Proc Soc Exp Biol Med 105:655-658, 1960.
14. Hall CT, Hansen PA: Chelated azodges used as counterstains in the fluorescent antibody technique. Zbl Bakt 184:548-554, 1962.
15. Conn JW, Cohen EL: Primary aldosteronism: Importance of the level of plasma renin as an adjunct in diagnosis, in Bumpus FM, and Page IH (eds.): Handbook of Experimental Pharmacology New York, Springer-Verlag, to be published.
16. Robertson AL Jr, Smeby RR, Bumpus FM, et al: Production of renin by human juxtaglomerular cells in vitro. Circ Res 18(suppl 1):I131-142, 1966.
17. Conn JW, Cohen EL, Rovner DR: Suppression of plasma renin activity in primary aldosteronism: Distinguishing primary from secondary aldosteronism in hypertensive disease. JAMA 190:213-221, 1964.
18. Conn JW: The evolution of primary aldosteronism—1954-1967. Harvey Led 62:257-291, 1968.
19. Conn JW, Rovner DR, Cohen EL, et al: Preoperative diagnosis of primary aldosteronism: Including a comparison of operative findings and preoperative tumor localization by adrenal phlebography. Arch Intern Med 123:113-123, 1969.
20. Blair-West JR, Coghlan JP, Denton DA, et al: Inhibition of renin secretion by systemic and intra-adrenal angiotensin infusion. J Physiol 220:1309-1315, 1971.
21. Streeten DHP, et al: Studies of the renin-angiotensin-aldosterone system in patients with hypertension and in normal subjects. Am J Med 46:844-861, 1969.
22. Blair-West JR, et al: Aldosterone regulation and biosynthesis, in Progress in Endocrinology: Proceedings of the Third International Congress of Endocrinology. Amsterdam, Excerpta Medica, series No. 184, 1968, p 276.
23. Boyd GW, et al: The role of angiotensin II in the control of aldosterone in man. Clin Sci 42:91-104, 1972.
24. Best JB, et al: Circulating angiotensin II and aldosterone levels during dietary sodium restriction. Lancet 2:1353-1354, 1971.
25. Gross F: The renin-angiotensin system and hypertension. Ann Intern Med 75:777-787, 1971.
26. Blair-West JR, et al: Role of the kidney in experimental renovascular hypertension. Circ Res 27(suppl 2):149-158,1970.
27. Buhler FR, et al: Inhibition of renin secretion by propranolol: A specific treatment for renal hypertension? abstracted. American Society of Clinical Investigation, 64th Annual Meeting, Atlantic City, NJ, May 1, 1972. p. 17a.
28. Conn JW, Knopf RF, Nesbit RM: Clinical characteristics of primary aldosteronism from an analysis of 145 cases. Amer J Surg 107:159-172, 1964.
29. Brunner HR, Laragh JH, Baer L, et al: Essential hypertension: Renin and aldosterone, heart attack and stroke. New Eng J Med 286:441-449, 1972.
30. Bohr DF, Seidel C, Sobieski J: Possible role of sodium-calcium pumps in tension development of vascular smooth muscle. Microvasc Res 1:335-343, 1969.
31. Villamil MF, Nachev P, Kleeman CR: Effect of prolonged infusion of angiotensin II on ionic composition of the arterial wall. Amer J Physiol 218:1281-1286, 1970.
32. Laidlaw JC, Yendt ER, Bird CE: Hypertension due to renal artery occlusion simulating primary aldosteronism. Canad Med Assoc J 90:321-325, 1964.
33. Baer L, Sommers SC, Krakoff LR, et al: Pseudo-primary aldosteronism. Circ Res 27(suppl 1):I203-216, 1970.
34. Mitchell JD, Baxter TJ, Blair-West JR, et al: Renin levels in nephroblastoma (Wilms' tumor). Arch Dis Child 45:376-384, 1970.
35. Voute PA Jr, van der Meer J, Staugaard-Kloosterziel W: Plasma renin activity in Wilms' tumour. Acta Endocr 67:197-202, 1971.
36. White MG: Bartter's syndrome. Arch Intern Med 129:41-47, 1972.
37. Bartter FC, Pronove P, Gill JR Jr, et al: Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis: A new syndrome. Amer J Med 33:811-828, 1962.
38. Schambelan M, Biglieri EG: Regulation and secretion of hyper-reninemia from renin-secreting tumor (RST). Clin Res 20:439, 1972.
39. Schaudel PJ, Beveridge J, Stokes GS: Increased plasma renin activity, secondary aldosteronism, and hypertension. Am J Dis Child 119:159-163, 1970.