Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: Clearance after immunization, susceptibility to primaquine, and contribution to blood-stage infection

Infection and Immunity

Volumn 80, Issue 6, 2012, Pages 2158-2164

  Voza, Tatiana ^a,c   Miller, Jessica L ^b   Kappe, Stefan H I ^b   Sinnis, Photini ^a,d  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c NEW YORK CITY COLLEGE OF TECHNOLOGY   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRIMAQUINE; ANTIMALARIAL AGENT; LIVE VACCINE; MALARIA VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOODSTREAM INFECTION; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; INFECTION SENSITIVITY; INOCULATION; LIVER CELL; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM YOELII; PRIORITY JOURNAL; ANIMAL; ANOPHELES; C57BL MOUSE; CELL LINE; DRUG EFFECT; IMMUNOLOGY; INSECT BITE; PARASITOLOGY; SKIN; SPOROZOITE;

ANIMALS; ANOPHELES; ANTIMALARIALS; CELL LINE; FEMALE; IMMUNIZATION; INSECT BITES AND STINGS; MALARIA; MALARIA VACCINES; MICE; MICE, INBRED C57BL; PLASMODIUM BERGHEI; PLASMODIUM YOELII; PRIMAQUINE; SKIN; SPOROZOITES; VACCINES, ATTENUATED;

EID: 85047688209     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00246-12     Document Type: Article

References (32)

1. Amino R, et al. 2006. Quantitative imaging of Plasmodium transmission from mosquito to mammal. Nat. Med. 12:220 -224.
2. Baird JK. 2005. Effectiveness of antimalarial drugs. N. Engl. J. Med. 352: 1565-1577.
3. Bruna-Romero O, et al. 2001. Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int. J. Parasitol. 31:1499 -1502.
4. Calvo-Calle JM, Moreno A, Eling WMC, Nardin EH. 1994. In vitro development of infectious liver stages of P. yoelii and P. berghei malaria in human cell lines. Exp. Parasitol. 79:362-373.
5. Chakravarty S, et al. 2007. CD8(+) T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat. Med. 13:1035-1041.
6. Epstein JE, Giersing B, Mullen G, Moorthy V, Richie TL. 2007. Malaria vaccines: are we getting closer? Curr. Opin. Mol. Ther. 9:12-24.
7. Franke-Fayard B, et al. 2004. A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle. Mol. Biochem. Parasitol. 137:23-33.
8. Freshney R. 2000. Primary culture, p 149-175. In Freshney R (ed), Culture of animal cells: a manual of basic techniques. Wiley and Sons, New York, NY.
9. Gueirard P, et al. 2010. Development of the malaria parasite in the skin of the mammalian host. Proc. Natl. Acad. Sci. U. S. A. 107:18640 -18645.
10. Hollingdale MR, Leland P, Leef JL, Schwartz AL. 1983. Entry of Plasmodium berghei sporozoites into cultured cells and their transformation into trophozoites. Am. J. Trop. Med. Hyg. 32:685- 690.
11. Jin Y, Kebaier C, Vanderberg J. 2007. Direct microscopic quantification of dynamics of Plasmodium berghei sporozoite transmission from mosquitoes to mice. Infect. Immun. 75:5532-5539.
12. Kappe SH, Vaughan AM, Boddey JA, Cowman AF. 2010. That was then but this is now: malaria research in the time of an eradication agenda. Science 328:862- 866.
13. Khan ZM, Vanderberg JP. 1991. Role of host cellular response in differential susceptibility of nonimmunized BALB/c mice to Plasmodium berghei and Plasmodium yoelii sporozoites. Infect. Immun. 59:2529 -2534.
14. Kumar KA, Oliveira GA, Edelman R, Nardin E, Nussenzweig V. 2004. Quantitative Plasmodium sporozoite neutralization assay. J. Immunol. Methods 292:157-164.
15. Medica DL, Sinnis P. 2005. Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected Anopheline mosquitoes feeding on vertebrate hosts. Infect. Immun. 73:4363- 4369.
16. Mueller AK, et al. 2005. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface. Proc. Natl. Acad. Sci. U. S. A. 102:3022-3027.
17. Overstreet MG, Cockburn IA, Chen Y, Zavala F. 2008. Protective CD8+ T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response. Immunol. Rev. 225:272-282.
18. Prudêncio M, Rodriguez A, Mota MM. 2006. The silent path to thousands of merozoites: the Plasmodium liver stage. Nat. Rev. Microbiol. 4:849-856.
19. Pukrittayakamee S, et al. 2010. A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand. Am. J. Trop. Med. Hyg. 82:542-547.
20. Sinden RE, Smith J. 1980. Culture of the liver stages (exoerythrocytic schizonts) of rodent malaria parasites from sporozoites in vitro. Trans. R. Soc. Trop. Med. Hyg. 74:134 -136.
21. Sinden RE, et al. 1990. The development and routine application of high-density exoerythrocytic-stage cultures of Plasmodium berghei. Bull. World Health Organ. 68(Suppl.):115-125.
22. Sinnis P, Nardin E. 2002. Sporozoite antigens: biology and immunology of the circumsporozoite protein and thrombospondin related anonymous protein, p 70-91. In Perlmann P and Troye-Blomberg M (ed), Malaria mmunology. S. Karger Press, Basel, Switzerland.
23. Sinnis P, Zavala F. 2008. The skin stage of malaria infection: biology and relevance to the malaria vaccine effort. Future Microbiol. 3:275-278.
24. Sturm A, et al. 2006. Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids. Science 313:1287-1290.
25. Tarun AS, et al. 2006. Quantitative isolation and in vivo imaging of malaria parasite liver stages. Int. J. Parasitol. 36:1283-1293.
26. Tsuji M, Mattei D, Nussenzweig RS, Eichinger D, Zavala F. 1994. Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites. Parasitol. Res. 80:16 -21.
27. Tsuji M, Zavala F. 2003. T cells as mediators of protective immunity against liver stages of Plasmodium. Trends Parasitol. 19:88 -93.
28. Vale N, Moreira R, Gomes P. 2009. Primaquine revisited six decades after its discovery. Eur. J. Med. Chem. 44:937-953.
29. Vanderberg J, Frevert U. 2004. Intravital microscopy demonstrating antibody-mediated immobilisation of Plasmodium berghei sporozoites injected into skin by mosquitoes. Int. J. Parasitol. 34:991-996.
30. Voza T, Kebaier C, Vanderberg JP. 2010. Intradermal immunization of mice with radiation-attenuated sporozoites of Plasmodium yoelii induces effective protective immunity. Malar. J. 9:362.
31. World Health Organization. 2010. World malaria report 2010. World Health Organization, Geneva, Switzerland. http://whqlibdoc.who.int/publications/2010/9789241564106_eng.pdf.
32. Yamauchi LM, Coppi A, Snounou G, Sinnis P. 2007. Plasmodium sporozoites trickle out of the injection site. Cell. Microbiol. 9:1215-1222.