Bone marrow: An extra-pancreatic hideout for the elusive pancreatic stem cell?

Journal of Clinical Investigation

Volumn 111, Issue 6, 2003, Pages 799-801

  Lee, Vivian M ^a   Stoffel, Markus ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW; CELL DIFFERENTIATION; CELL SUBPOPULATION; DIABETES MELLITUS; ENDODERM; NOTE; ORGANOGENESIS; PANCREAS DEVELOPMENT; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PANCREATIC PROGENITOR CELL; PANCREATIC STEM CELL; PRIORITY JOURNAL; STEM CELL; ANIMAL; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL FUSION; CYTOLOGY; MOUSE; PHYSIOLOGY;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL FUSION; ISLETS OF LANGERHANS; MICE; STEM CELLS;

EID: 85047688194     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI17063     Document Type: Note

References (19)

1. Bonner-Weir, S., and Sharma, A. 2002. Pancreatic stem cells. J. Pathol. 197:519-526.
2. Swenne, I. 1992. Pancreatic β-cell growth and diabetes mellitus. Diabetologia. 35:193-201.
3. Fernandes, A., et al. 1997. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology. 138:1750-1762.
4. Pictet, R., and Rutter, W.J. 1972. Development of the embryonic endocrine pancreas. In Handbook of physiology. Volume 1. R.O. Greep, E.B. Astwood, D.F. Steiner, N. Freinkel, and S.R. Geiger, editors. American Physiological Society. Washington, DC, USA. 25-66.
5. Herrera, P.L. 2002. Defining the cell lineages of the islet of langerhans using transgenic mice. Int. J. Dev. Biol. 46:97-103.
6. Finegood, D.T., Scaglia, L., and Bonner-Weir, S. 1995. Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes. 44:249-256.
7. Montanya, E., Nacher, V., Biarnes, M., and Soler, J. 2000. Linear correlation between beta cell mass and body weight throughout life in Lewis rats: role of beta cell hyperplasia and hypertrophy. Diabetes. 49:1341-1346.
8. Waguri, M., et al. 1997. Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes. 46:1281-1290.
9. Gu, G., Dubauskaire, J., and Melton, D.A. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457.
10. Ianus, A., Holz, G.G., Theise, N.D., and Hussain, M.A. 2003. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111:843-850. doi:10.1172/JCI200316502.
11. Lagasse, E., et al. 2000. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 6:1229-1234.
12. Theise, N.D., et al. 2000. Derivation of hepatocytes from bone marrow cells in mice after radiarion-induced myeloablation. Hepatology. 31:235-240.
13. Wagers, A.J., Sherwood, R.I., Christensen, J.L., and Weissman, I.L. 2002. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 297:2256-2259.
14. Jiang, Y., et al. 2002. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41-49.
15. Rachdi, L., et al. 2001. Expression of the receptor tyrosine kinase KIT in mature β-cells and in the pancreas in development. Diabetes. 50:2021-2028.
16. Pipeleers, D.G. 1992. Heterogeneity in pancreatic β-cell population. Diabetes. 41:777-781.
17. Kiekens, R., et al. 1992. Differences in glucose recognition by individual rat pancreatic β-cells are associated with intercellular differences in glucose-induced biosynthetic activity. J. Clin. Invest. 89:117-125.
18. de Vargas, L.M., Sobolewski, J., Siegel, R., and Moss, L.G. 1997. Individual β-cells within the intact islet differentially respond to glucose. J. Biol. Chem. 272:26573-26577.
19. Shapiro, A.M., et al. 2000. Islet transplantation in seven patients with type 1 diabetes using glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 27:230-238.