Oral bioavailability enhancement of a hydrophilic drug delivered via folic acid-coupled liposomes in rats

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 4, 2009, Pages 445-449

  Ling, Sharon Sheue Nee ^a   Yuen, Kah Hay ^a   Magosso, Enrico ^a   Barker, Susan Anne ^b  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Cefotaxime; Folic acid; Liposomes

Indexed keywords

CEFOTAXIME; FOLIC ACID; LIPOSOME; PEPTIDOMIMETIC AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG UPTAKE; ENDOCYTOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IN VIVO STUDY; MALE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; ANIMAL; BIOAVAILABILITY; CHEMISTRY; CROSSOVER PROCEDURE; DRUG EFFECT; ORAL DRUG ADMINISTRATION; RANDOMIZATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CEFOTAXIME; CROSS-OVER STUDIES; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; FOLIC ACID; LIPOSOMES; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 85047682410     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.04.0005     Document Type: Article

References (27)

1. Schiffelers RM et al. Therapeutic efficacy of liposomal gentamicin in clinically relevant rat models. Int J Pharm 2001; 214: 103-105.
2. Gangadharam PR et al. Therapy of Mycobacterium avium complex infections in beige mice with streptomycin encapsulated in sterically stabilized liposomes. Antimicrob Agents Chemother 1995; 39(3): 725-730.
3. Kim A et al. Pharmacodynamics of insulin in polyethylene glycol-coated liposomes. Int J Pharm 1999; 180: 75-81.
4. Iwanaga K et al. Oral delivery of insulin by using surface coating liposomes. Improvement of stability of insulin in G.I. tract. Int J Pharm 1997; 157: 73-80.
5. Kamen BA, Capdevila A. Receptor-mediated folate accumulation is regulated by the cellular folate content. Proc Natl Acad Sci U S A 1986; 83(16): 5983-5987.
6. Tamai, I., Tsuji, A. Carrier mediated approaches for oral drug delivery. Adv Drug Deliv Rev 1996; 20: 5-32.
7. Wang X et al. Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates. Biochem Pharmacol 1992; 44(9): 1898-1901.
8. Rui Y et al. Displasmenylcholine-folate liposomes: an efficient vehicle for intracellular drug delivery. J Am Chem Soc 1998; 120(44): 11213-11218.
9. Lu YJ, Low PS. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Biochemistry 2002; 28(19): 675-693.
10. Leamon CP, Low PS. Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis. Proc Natl Acad Sci USA 1991; 88: 5572-5576.
11. Coney LR et al. Cloning of tumour associated antigen: MOv 18 and MOv 19 antibodies recognize a folate-binding protein. Cancer Res 1991; 51: 6125-6132.
12. Weitman SD et al. Distribution of the folate receptor GP 38 in normal and malignant cell lines and tissues. Cancer Res 1992; 52(12): 3396-3401.
13. Lee RJ, Low PS. Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J Biol Chem 1994; 269(5): 3198-3204.
14. Wang S et al. Delivery of antisense oligodeoxyribonucleotides against human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc Natl Acad Sci USA 1995; 92: 3318-3322.
15. Vogel K et al. Peptide-mediated release of folate-targeted liposome contents from endosomal compartments. J Am Chem Soc 1996; 118(7): 1581-1586.
16. Goren D et al. Nucelar delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin Cancer Res 2000; 6: 1949-1957.
17. Reddy JA, Low PS. Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation. J Control Release 2000; 64: 27-37.
18. Kulkarni SB et al. Factors affecting microencapsulation of drugs in liposomes. J Microencapsul 1995; 12(3): 229-246.
19. Ling SS et al. Simple liquid chromatographic method for the determination of cefotaxime in human and rat plasma. J Chromatogr B 2003; 783: 297-301.
20. Weiner DL. Design and analysis of bioavailability studies. In: Buncher CR, Tsay JY, eds. Statistics in the Pharmaceutical Industry. New York: Marcel Dekker, 1981: 2005-2229.
21. Schefler WC. Student's t and two-group designs. In: Statistics for Health Professionals. Lebanon, Indiana: Addison-Wesley Publishing Company Inc, 1984: 151-177.
22. Ling SSN et al. Enhanced oral bioavailability and intestinal lymphatic transport of a hydrophilic drug using liposomes. Drug Dev Ind Pharm 2006; 32: 335-345.
23. Lee RJ, Low PS. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. Biochim Biophys Acta 1995; 1223(2): 134-144.
24. Antony AC. Folate receptors. Annu Rev Nutr 1996; 16: 501-521.
25. Anderson KE et al. Formulation and evaluation of a folic acid receptor-targeted oral vancomycin liposomal dosage form. Pharm Res 2001; 18(3): 316-322.
26. Turek JJ et al. Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells. J Cell Sci 1993; 106: 423-430.
27. Russell-Jones GJ. The potential use of receptor-mediated endocytosis for oral drug delivery. Adv Drug Deliv Rev 2001; 46: 59-73.