Preconditioning of isolated rabbit cardiomyocytes: Induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor

Cardiovascular Research

Volumn 28, Issue 1, 1994, Pages 72-77

  Armstrong, Stephen ^a,b   Downey, James M ^a,b   Ganote, Charles E ^a,b  

^a EAST TENNESSEE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Adenosine agonists; Adenosine antagonists; Adenosine receptors; Calphostin C; Heart; Ischaemic injury; Ischaemic preconditioning; Protein kinase C; Reperfusion

Indexed keywords

ADENOSINE DERIVATIVE; AMOBARBITAL; CALPHOSTIN; GLUCOSE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADENOSINE; ANIMAL; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; COMPARATIVE STUDY; GLUCOSE; HEART; MYOCARDIAL ISCHEMIA; MYOCARDIUM; POLYCYCLIC HYDROCARBONS; PROTEIN KINASE C; RABBITS; SUPPORT, U.S. GOV'T, NON-P.H.S.; THEOPHYLLINE; TIME FACTORS;

EID: 85047680361     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1093/cvr/28.1.72     Document Type: Article

References (33)

1. Walker DM, Yellon DM. Ischaemic preconditioning: from mechanisms to exploitation. Cardiovasc Res 1992;26:734–9.
2. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischaemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124–36.
3. Thornton JD, Liu GS, Olsson RA, Downey JM. Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction. Circulation 1992;85:659–65.
4. Toombs CF, McGee DS, Johnston WE, Vinton-Johanson J. Myocardial protective effects of adenosine: infarct size reduction with pretreatment and continued receptor stimulation during ischemia. Circulation 1992;86:986–94.
5. Liu GS, Thornton J, Van Winkle DM, Stanley AWH, Olsson RA. Downey JM. Protection against infarction afforded by preconditioning is mediated by Al adenosine receptors in rabbit heart. Circulation 1991;84:350–6.
6. Cave AC, Downey JM, Hearse DJ. Adenosine fails to substitute for preconditioning in the globally ischemic isolated rat heart. (Abstract) J Mol Cell Cardiol 1991;23:III–a76.
7. Ganote CE, Armstrong SE, Downey JM. Adenosine and Al-selective agonists offer minimal protection against ischaemic injury to isolated rat cardiomyocytes. Cardiovasc Res 1993;27:1670–7.
8. Vander Heide RS, Angelo JP, Altschuld RA, Ganote CE. Energy dependence of contraction band formation in perfused hearts and isolated adult myocytes. Am J Pathol 1986;125:55–68.
9. Shizukuda Y, Mallet RT, Lee S-C, Downey HF. Hypoxic preconditioning of ischaemic canine myocardium. Cardiovasc Res 1992;26:534–42.
10. Thornton JD, Thornton CS, Downey JM. Effect of adenosine receptor blockade: preventing protective preconditioning depends on time of initiation. Am J Physiol 1993;265:H504–6.
11. Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res 1990;66:913–31.
12. Armstrong SC, Ganote CE. Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on metabolically inhibited and ischemic isolated myocytes. J Mol Cell Cardiol 1992;24:869–84.
13. Li Y, Kloner RA. Cardioprotective effects of ischaemic “preconditioning” are not mediated by prostanoids. Cardiovasc Res 1992;26:226–31.
14. Liu Y, Downey JM. Ischemic preconditioning protects against infarction in rat heart. Am J Physiol 1992;263:H1107–12.
15. Liu Y, Downey JM. Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein. Cardiovasc Res 1993;27:608–11.
16. Lawson CS, Downey JM. Preconditioning: state of the art protection. Cardiovasc Res 1993;27:542–50.
17. Thornton JD, Liu GS, Downey J. Pretreatment with pertussis toxin blocks the protective effects of preconditioning. Evidence for a G protein mechanism. J Mol Cell Cardiol 1993;25:311–20.
18. Lasley RD, Barakat O, Van Wylin DGL, Mentzer RD. Pertussis toxin inhibits adenosine-mediated preservation of postischemic myocardial function. (Abstract) Circulation 1991;84:11–307.
19. Lasley RD, Van Wylen DGL, Mentzer RM. Evidence for the role of Gi proteins in attenuating myocardial ischemic damage. (Abstract) Circulation 1990;82:111–759.
20. 2+ transport in guinea pig ventricles. J Biol Chem 1985;260:13122–9.
21. George EE, Romano FD, Dobson JGJ. Adenosine and acetylcholine reduce isoproterenol-induced protein phosphorylation of rat myocytes. J Mol Cell Cardiol 1991;23:749–64.
22. 6-phenylisopropropyladenosine on myocardial inositol phosphate content and force of contraction. Br J Pharmacol 1990;101:829–34.
23. Fleming JW, Wisler PL, Watanabe AM. Signal transduction by G proteins in cardiac tissues. Circulation 1992;85:420–33.
24. Kohout TA, Rogers TR. Use of a PCR-based method to characterize protein kinase C isoform expression in cardiac cells. Am J PhysioI 1993;264(Cell Physiol 33):C1350–9.
25. Kikkawa U, Kishimoto A, Nishizuka Y. The protein kinase C family: heterogeneity and its implications. Annu Rev Biochem 1989;58:31–44.
26. Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL. p63 Fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C. Biochemistry 1992;31:8120–4.
27. Mochly-Rosen D, Henrich CJ, Cheever L, Kah H, Simpson PC. A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regul 1990;1:693–706.
28. Mochly-Rosen D, Khaner H, Smith BL. Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme. J Biol Chem 1992;266:14866–8.
29. Murti KG, Kaur K, Goorha RM. Protein kinase C associates with intermediate filaments and stress fibers. Exp Cell Res 1992;202:36–44.
30. Hagmann J, Burger MM. Phosphorylation of vinculin in human platelets spreading on a solid surface. J Cell Biochem 1992;50:237–44.
31. Ytrehus K, Liu Y, Downey JM. Preconditioning protects the rabbit heart by protein kinase C activation. (Abstract) FASEB J 1993;7:A418.
32. Bruns RF, Miller FD, Merriman RL, et al Inhibition of protein kinase C by calphostin C is light-dependent. Biochem Biophys Res Commun 1991;176:288–93.
33. Kobayashi E, Nakano H, Morimoto M, Tamaoki T. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 1989;159:548–53.