Binding of [3H]progesterone to the human progesterone receptor: Differences between individual and mixed isoforms

Endocrinology

Volumn 137, Issue 6, 1996, Pages 2339-2346

  Carbajo, P ^a   Christensen, K ^b   Edwards, D P ^b   Skafar, D F ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROGESTERONE; PROGESTERONE RECEPTOR; MIFEPRISTONE; TRITIUM;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; HORMONE RECEPTOR INTERACTION; HUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; CATTLE; COMPARATIVE STUDY; FEMALE; KINETICS; MACROMOLECULE; METABOLISM; UTERUS;

ANIMALS; CATTLE; FEMALE; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MIFEPRISTONE; PROGESTERONE; RECEPTORS, PROGESTERONE; TRITIUM; UTERUS;

EID: 85047678506     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.6.8641184     Document Type: Article

References (33)

1. Horwitz KB, Francis MD, Wei LL 1985 Hormone-dependent covalent modification and processing of human progesterone receptors in the nucleus. DNA 4:451-460
2. Horwitz KB, Alexander PS 1983 In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation. Endocrinology 113: 2195-2201
3. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P 1990 Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9:1603-1614
4. Vegeto E, Shabaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP 1993 Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 7:1244-1255
5. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB 1993 Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 7:1256-1265
6. McDonnell DP, Goldman ME 1994 RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. J Biol Chem 269:11945-11949
7. Wen DW, Xu Y-F, Mais DE, Goldman ME, McDonnell DP 1994 The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol 14:8356-8364
8. Boyd PA, Spelsberg TC 1979 Seasonal changes in the molecular species and nuclear binding of the chick oviduct progesterone receptor. Biochemistry 18:3685-3690
9. Shyamala G, Schneider W, Schott D 1990 Developmental regulation of murine mammary progesterone receptor gene expression. Endocrinology 126:2882-2889
10. Shyamala G, McBlain WA 1979 Distinction between progestin and glucocorticoid binding sites in mammary glands. Biochem J 178: 345-352
11. Bayard F, Damilano S, Robel P, Baulieu EE 1978 Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium. J Clin Endocrinol Metab 46:635-64823
12. Wiehle RD, Manga R, Poindexter III AM, Weigel NL, Human progesterone receptor A and B expression during the menstrual cycle. 77th Annual Meeting of The Endocrine Society, Washington DC, 1995, p 224 (Abstract)
13. Evans RM 1988 The steroid and thyroid hormone receptor superfamily. Science 240:889-895
14. Beato M 1989 Gene regulation by steroid hormones. Cell 56:335-344
15. DeMarzo AM, Beck CA, Onate SA, Edwards DP 1991 Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90 k-Da heat shock protein. Proc Natl Acad Sci USA 88:72-76
16. El-Ashry D, Onate SA, Nordeen SK, Edwards DP 1989 Human progesterone receptor complexed with the antagonist RU486 binds to hormone response elements in a structurally altered form. Mol Endocrinol 3:1545-1558
17. Skafar DF 1991 Differences in the binding mechanism of RU486 and progesterone to the progesterone receptor. Biochemistry 30:10829-10832
18. Notides AC, Lerner N, Hamilton DE 1981 Positive cooperativity of the estrogen receptor. Proc Natl Acad Sci USA 78:4926-4930
19. Notides AC, Sasson S, Callison S 1985 An allosteric regulatory mechanism for estrogen receptor activation. In: Moudgil VK (ed) Molecular Mechanism of Steroid Hormone Action, de Gruyter, New York, pp 173-197
20. Allan GF, Leng X, Tsai SY, Weigel NL, Edwards DP, Tsai M-J, O'Malley BW 1992 Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation. J Biol Chem 267:19513-19520
21. Weigel NL, Beck CA, Estes PA, Prendergast P, Altmann M, Christensen K, Edwards DP 1992 Ligands induce conformational changes in the carboxy-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody. Mol Endocrinol 6:1585-1597
22. Linstedt AD, West NB, Brenner RM 1986 Analysis of monomericdimeric states of the estrogen receptor with monoclonal antiestrophilins. J Steroid Biochem 24:677-686
23. Kumar V, Chambon P 1988 The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55:145-156
24. Theofan G, Notides AC 1984 Characterization of the calf uterine progesterone receptor and its stabilization by nucleic acids. Endocrinology 114:1173-1179
25. Skafar DF 1991 Differential DNA binding by calf uterine estrogen and progesterone receptors results from differences in oligomeric states. Biochemistry 30:6148-6154
26. Skafar DF 1993 Dimerization of the RU486-bound calf uterine progesterone receptor. J Steroid Biochem Mol Biol 44:39-43
27. Christensen K, Estes PA, Onate SA, Beck CA, DeMarzo A, Altmann M, Lieberman BA, St. John J, Nordeen SK, Edwards DP 1991 Characterization and functional properties of the A and B forms of human progesterone receptors synthesized in a baculovirus system. Mol Endocrinol 5:1755-1770
28. Scatchard G 1949 The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51:660-672
29. Hill AV 1910 The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol (Lond) 40:iv-vi30
30. Wyman J, Gill SJ 1990 Binding and Linkage. University Science Books, Mill Valley, p 61
31. Prendergast P, Onate SA, Christensen K, Edwards DP 1994 Nuclear accessory factors enhance the binding of progesterone receptor to specific target DNA. J Steroid Biochem Mol Biol 48:1-13
32. Obourn JD, Koszewski NJ, Notides AC 1993 Hormone- and DNA-binding mechanisms of the recombinant human estrogen receptor Biochemistry 32:6229-6236
33. Mohamed MK, Tung L, Takimoto GS, Horwitz KB 1994 The leucine zippers of c-fos and c-jun for progesterone receptor dimerization: A-dominance in the A/B heterodimer. J Steroid Biochem Mol Biol 51:241-250