Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo

Cardiovascular Research

Volumn 23, Issue 12, 1989, Pages 1053-1057

  Vallance, Patrick ^a   Collier, Joe ^a   Moncada, Salvador ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Acetylcholine; Arginine; Bradykinin; Endothelium derived relaxing factor; Glyceryl trinitrate; Human veins; NG monomethyl L arginine; Nitric oxide

Indexed keywords

ACETYLCHOLINE; ARGININE; BRADYKININ; ENDOTHELIUM DERIVED RELAXING FACTOR; GLYCERYL TRINITRATE; NITRIC OXIDE; NORADRENALIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; VASODILATATION; VEIN;

ADULT; ARGININE; HAND; HUMAN; MIDDLE AGE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; SUPPORT, NON-U.S. GOV'T; VASODILATION; VEINS;

EID: 85047678425     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1093/cvr/23.12.1053     Document Type: Review

References (22)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
2. De Mey JG, Vanhoutte P. Heterogeneous behaviour of the canine arterial and venous wall. Circ Res 1982;51:439-47.
3. Seidel C. LaRochelle J. Venous and arterial endothelia: different dilator abilities in dog vessels. Circ Res 1987;60:626-30.
4. Ignarro LJ, Buga GM, Chaudhuri G. EDRF generation and release from perfused bovine pulmonary artery and vein. Eur J Pharmacol 1988;149:79-88.
5. Thom S, Hughes A, Martin G, Sever PS. Endothelium-dependent relaxations in isolated human arteries and veins. Clin Sci 1987;73:547-52.
6. Lüscher TF, Cooke JP, Houston DS, Neves RJ, Vanhoutte PM. Endothelium-dependent relaxations in human arteries. Mayo Clin Proc 1987;62:601-6.
7. Lüscher TF, Diederich D, Siebenmann R, et al. Differences between endothelium-dependent relaxation in arterial and in venous coronary artery bypass grafts. N Engl J Med 1988;319:462-7.
8. Collier J, Vallance P. Endothelium-derived relaxing factor is an endogenous vasodilator in man. Br J Pharmacol 1989;97:639-41.
9. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-6.
10. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-6.
11. Palmer RMJ, Rees DD, Ashton DS, Moncada S. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Comm 1988;153:1251-6.
12. Rees DD, Palmer RMJ, Hodson HF, Moncada S. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 1989;96:418-24.
13. Rees DD, Palmer RMJ, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci (USA) 1989;86:3375-8.
14. Whittle BJR, Lopez-Belmonte J, Rees DD. Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation. Br J Pharmacol 1989;98:646-52.
15. Aisaka K, Gross S, Griffith OW, Levi R. NG-Methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea-pig: does nitric oxide regulate blood pressure in vivo? Biochem Biophys Res Comm 1989;160:881-6.
16. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989 (in press).
17. Nachev C, Collier JG, Robinson BF. Simplified method for measuring compliance of superficial veins. Cardiovasc Res 1971;5:147-56.
18. Aeilig WH. A new technique for recording compliance of human hand veins. Br J Clin Pharmacol 1981;11:237-43.
19. Collier JG, Nachev C, Robinson BF. Effect of catecholamines and other vasoactive substances on superficial hand veins in man. Clin Sci 1972;43:455-67.
20. Collier J, Vallance P. Biphasic response to acetylcholine in human veins in vivo: the role of the endothelium. Clin Sci (in press).
21. Collier JG, Lorge RE, Robinson BF. Comparison of effects of tolmesoxide (RX1107), diazoxide, hydralazine, prazosin, glyceryl trinitrate and sodium nitroprusside on forearm arteries and dorsal hand veins of man. Br J Clin Pharmacol 1978;5:35-44.
22. Moncada S, Palmer RMJ, Higgs EA. The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension 1988;12:365-72.