Autoradiographic comparison of [125I]epidepride and [125I]NCQ 298 binding to human brain extrastriated dopamine receptors

Nuclear Medicine and Biology

Volumn 24, Issue 5, 1997, Pages 389-393

  Hall, Håkan ^a   Halldin, Christer ^a   Jerning, Eva ^b   Österlund, Marie ^a   Farde, Lars ^a   Sedvall, Göran ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Astra Arcus AB   (Sweden)

Author keywords

Autoradiography; D2 dopamine receptors; Epidepride; Extrastriatal receptors; Human brain; NCQ 298

Indexed keywords

BENZAMIDE DERIVATIVE; DOPAMINE 2 RECEPTOR; EPIDEPRIDE I 125; ISOREMOXIPRIDE; ISOREMOXIPRIDE BR 76; N [(1 ETHYL 2 PYRROLIDINYL)METHYL] 3 IODO 5,6 DIMETHOXYSALICYLAMIDE; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; EPIDEPRIDE; PYRROLIDINE DERIVATIVE; RADIOACTIVE IODINE; SALICYLAMIDE DERIVATIVE;

ARTICLE; AUTORADIOGRAPHY; CAUDATE NUCLEUS; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG BINDING; HUMAN; HUMAN TISSUE; PUTAMEN; RECEPTOR BINDING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; BRAIN LEVEL; COMPARATIVE STUDY; FEMALE; MALE; MIDDLE AGED;

AUTORADIOGRAPHY; BENZAMIDES; BRAIN CHEMISTRY; DOPAMINE AGONISTS; FEMALE; HUMANS; IODINE RADIOISOTOPES; MALE; MIDDLE AGED; PYRROLIDINES; RECEPTORS, DOPAMINE D2; SALICYLAMIDES;

EID: 85047677839     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(97)80004-2     Document Type: Article

References (25)

1. 11C-raclopride. Psychopharmacology 92, 278-284.
2. Farde L., Halldin C., Suhara T., Nyberg S., Karlsson P., Högberg T., Hall H. and Swahn C.-G. (1994) [C-11]FLB 457, a selective PET radioligand for examination of extrastriatal dopamine D2 receptors. J. Nucl. Med. 35, 84P-85P.
3. 125I]epidepride. Synapse 23, 115-123.
4. 3H-raclopride. J. Neural Transm. 73, 7-21.
5. 3H]PD128907. Psychopharmacology 128, 240-247.
6. 2 receptors. Psychopharmacology 103, 6-18.
7. 2-dopamine receptors, and dopamine and its metabolites in the human brain. Neuropsychopharmacolagy 11, 245-256.
8. 2 receptors in the rat striatum. Acta Pharmacol. Toxicol. 58, 368-373.
9. Halldin C., Farde L., Högberg T., Mohell N., Hall H., Suhara T., Karlsson P., Nakashima Y. and Swahn C.-G. (1995) Carbon-11-FLB 457: A radioligand for extrastriatal D2 dopamine receptors. J. Nucl. Med. 36, 1275-1281.
10. Högberg T., Bengtsson S., de Paulis T., Johansson L., Ström P., Hall H. and Ögren S. O. (1990) Potential antipsychotic agents. 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicyiamides and related compounds. J. Med. Chem. 33, 1155-1163.
11. Högberg T., de Paulis T., Johansson L., Kumar Y., Hall H. and Ögren S. O. (1990) Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study. J. Med. Chem. 33, 2305-2309.
12. 2 ligand for PET. Acta Pharm. Nord. 4, 297-300.
13. 125I]-and unlabelled (S)-3-iodo-5,6-dimethoxy-N-[1-ethyl-2-pyrrolidinyl)methyl]salicylamide (NCQ 298), selective ligands for the study of dopamine D-2 receptors. Acta Pharm. Nord. 2, 53-60.
14. 125I]NCQ-298: Methodological considerations of high affinity binding. J. Recept. Res. 15, 503-515.
15. 2 receptors. Life Sci. 49, 617-628.
16. 2 receptors in the human brain. Eur. Pharmacol. 223, 105-107.
17. 125I]epidepride. Brain Res. 609, 237-243.
18. 3H]raclopride. Proc. Natl. Acad. Sci. USA 86, 6412-6416.
19. 76Br]FLB 463 for examination of striatal and extrastriatal dopamine D2 receptors with PET. Nucl. Med. Biol. 23, 813-819.
20. 2 extrastriatal binding of I-123 epidepride in the human brain. Eur. J. Nucl. Med. 22, 824.
21. 3 receptors. Mol. Pharmacol. 43, 749-754.
22. Munson P. J. and Rodbard D. (1980) Ligand: A versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107, 220-239.
23. 125I]epidepride. Eur. J. Pharmacol. 227, 443-445.
24. 11C-Ro 15-1788 binding to human brain sections. J. Neurosci. Methods 36, 53-61.
25. Seeman P. (1980) Brain dopamine receptors. Pharmacol. Rev. 32, 229-313.