Aldosterone and cardiac fibrosis: In vitro studies

Cardiovascular Research

Volumn 28, Issue 12, 1994, Pages 1863-1867

  Fullerton, Meryl J ^a   Funder, John W ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Angiotensin II; Cardiac; Culture; Fibroblast; Glucocorticoid; Mineralocorticoid

Indexed keywords

11BETA,17BETA DIHYDROXY 6 METHYL 17ALPHA (1 PROPYNYL)ANDROSTA 1,4,6 TRIEN 3 ONE; ALDOSTERONE; ANGIOTENSIN; COLLAGEN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROBLAST; HEART MUSCLE FIBROSIS; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ALDOSTERONE; ANDROSTANOLS; ANGIOTENSIN II; ANIMAL; CELLS, CULTURED; COLLAGEN; FIBROBLASTS; FIBROSIS; GLUCOCORTICOIDS; HEART; MALE; MYOCARDIUM; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY;

EID: 85047676796     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1093/cvr/28.12.1863     Document Type: Article

References (15)

1. Mörskin E, Ashford TP. Myocardial DNA synthesis in experimental cardiac hypertrophy. Am J Physiol 1968;215:1409-13.
2. Eghbali M, Tomek R, Sukhatme V, Woods C, Bhambi B. Differential effects of transforming growth factor-ß, and phorbol myristate acetate on cardiac fibroblasts. Circ Res 1991;69:483-90.
3. Ang A, Tachas G, Campbell J, Bateman J, Campbell G. Collagen synthesis by cultured rabbit aortic smooth muscle cells. Biochem J 1990;265:461-9.
4. Borg TK, Bussy J, Sullivan I, Laks J, Terracio L. Morphological and chemical characteristics of the connective tissue network during normal development and hypertrophy. J Mol Cell Cardiol 1986;18(suppl 1):247-53.
5. Eghbali M, Seifter S, Robinson JF, Blumenfeld OO. Enzyme-antibody histochemistry: a method for detection of collagens collectively. Histochemistry 1987;87:257-62.
6. Brilla CG, Weber KT. Mineralocorticoid excess, dietary sodium and myocardial fibrosis. J Lab Clin Med 1992;120:893-901.
7. Young M, Fullerton M, Dilley R, Funder JW. Mineralocorticoids, hypertension and cardiac fibrosis. J Clin Invest 1994, 93: 2578-83.
8. Guarda E, Myers P, Brilla C, Tyagi S, Weber KT. Endothelial cell induced modulation of cardiac fibroblast collagen metabolism. Cardiovasc Res 1993;27:1004-8.
9. Brilla CG, Zhou G, Weber KT, Matsubara L. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol 1994;26:809-20.
10. Wehling M, Armanini D, Strasser T, Weber PC. Effect of aldosterone on sodium and potassium concentrations in human mammalian leukocytes. Am J Physiol 1987;252: E505-8.
11. + exchange and raises cytoplasmic pH in target cells of the amphibian kidney. Proc Natl Acad Sci USA 1987: 84:1464-8.
12. Wehling M, Kasmayr J, Theisen K. Aldosterone influences free intracellular calcium in human mononuclear lymphocytes in vitro. Cell Calcium 1990;11:565-71.
13. Wehling M, Kasmayr J, Theisen K. Rapid effects of mineralo-corticoids on sodium-proton exchange: genomic or non genomic pathway. Am J Physiol 1991;260:E719-26.
14. Christ M, Eisen C, Aktas J, Theisen K, Wehling M. The inositol 1, 4, 5-triphosphate system is involved in rapid effects in aldosterone in human mononuclear leukocytes. J Clin Endocrinol Metah 1993;77:1452-7.
15. Slight S, Ganjam VK, Nonneman D, Weber KT. Glucocorticoid metabolism in the cardiac interstitium: 11 β hydroxysteroid dehydrogenase activity in cardiac fibroblasts. J Lab Clin Med 1993;122:180-7.