No red blood cell damage and no hemolysis in G6PD-deficient subjects after ingestion of low vicine/convicine Vicia faba seeds

Blood

Volumn 131, Issue 14, 2018, Pages 1621-1625

  Gallo, Valentina ^c   Skorokhod, Oleksii A ^c   Simula, Luigi Felice ^a   Marrocco, Tiziana ^c   Tambini, Elisa ^c   Schwarzer, Evelin ^c   Marget, Pascal ^b   Duc, Gérard ^b   Arese, Paolo ^c  

^a Civil Hospital   (Italy)

^b CEMAGREF   (France)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DAMAGE; ERYTHROCYTE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYSIS; HUMAN; INGESTION; LETTER; NONHUMAN; PLANT SEED; PRIORITY JOURNAL; VICIA FABA; ADULT; CHEMISTRY; CHILD; DRUG EFFECT; FEMALE; MALE; METABOLISM; PATHOLOGY; PRESCHOOL CHILD;

GLUCOSIDE; PYRIMIDINONE DERIVATIVE; VICINE;

ADULT; CHILD; CHILD, PRESCHOOL; ERYTHROCYTES; FEMALE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; GLUCOSIDES; HEMOLYSIS; HUMANS; MALE; PYRIMIDINONES; SEEDS; VICIA FABA;

EID: 85047634490     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2017-09-806364     Document Type: Letter

References (26)

1. Mager J, Razin A, Hershko A. Favism. In: Liener IE, ed. Toxic Constituents of Plant Foodstuffs. New York, NY: Academic Press; 1969:293-318.
2. Luzzatto L, Arese P. Favism and glucose-6-phosphate dehydrogenase deficiency. N Engl J Med. 2018;378(1):60-71.
3. Meloni T, Forteleoni G, Dore A, Cutillo S. Favism and hemolytic anemia in glucose-6-phosphate dehydrogenase-deficient subjects in North Sardinia. Acta Haematol. 1983;70(2):83-90.
4. Marcolongo F. [Ictero-hemoglobinuric favism]. Minerva Med. 1953; 44(101):1963-1969.
5. Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis. 2009;42(3): 267-278.
6. Iwai K, Hirono A, Matsuoka H, et al. Distribution of glucose-6-phosphate dehydrogenase mutations in Southeast Asia. Hum Genet. 2001;108(6): 445-449.
7. Crépon K, Marget P, Peyronnet C, et al. Nutritional value of faba bean (Vicia faba L.) seeds for feed and food. Field Crops Res. 2010;115(3): 329-339.
8. Khamassi K, Ben Jeddi F, Hobbs D, et al. A baseline study of vicine–convicine levels in faba bean (Vicia faba L.) germplasm. Plant Genet Resour. 2013;11(3):250-257.
9. Chevion M, Navok T, Glaser G, Mager J. The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione. Eur J Biochem. 1982;127(2):405-409.
10. Arese P, Mannuzzu L, Turrini F, Galiano S, Gaetani GF. Etiological aspects of favism. In: Yoshida A, Beutler E, eds. Glucose-6-Phosphate De-hydrogenase. Orlando, FL: Academic Press; 1986:45-75.
11. Arese P, De Flora A. Pathophysiology of hemolysis in glucose-6-phosphate dehydrogenase deficiency. Semin Hematol. 1990;27(1):1-40.
12. Albano E, Tomasi A, Mannuzzu L, Arese P. Detection of a free radical intermediate from divicine of Vicia faba. Biochem Pharmacol. 1984;33(10): 1701-1704.
13. Winterbourn CC, Benatti U, De Flora A. Contributions of superoxide, hydrogen peroxide, and transition metal ions to auto-oxidation of the favism-inducing pyrimidine aglycone, divicine, and its reactions with haemoglobin. Biochem Pharmacol. 1986;35(12):2009-2015.
14. Monteiro HP, Winterbourn CC. Release of iron from ferritin by divicine, isouramil, acid-hydrolyzed vicine, and dialuric acid and initiation of lipid peroxidation. Arch Biochem Biophys. 1989;271(2):536-545.
15. Gaetani GF, Mareni C, Salvidio E, Galiano S, Meloni T, Arese P. Favism: erythrocyte metabolism during haemolysis and reticulocytosis. Br J Haematol. 1979;43(1):39-48.
16. Arese P, Turrini F, Schwarzer E. Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes. Cell Physiol Biochem. 2005;16(4-6):133-146.
17. Turrini F, Naitana A, Mannuzzu L, Pescarmona G, Arese P. Increased red cell calcium, decreased calcium adenosine triphosphatase, and altered membrane proteins during fava bean hemolysis in glucose-6-phosphate dehydrogenase-deficient (Mediterranean variant) individuals. Blood. 1985;66(2):302-305.
18. Sansone G, Piga AM, Segni G. [Favism]. Torino, Italy: Minerva Medica; 1958.
19. Duc G, Sixdenier G, Lila M, Furstoss V. Search of genetic variability for vicine and convicine content in Vicia faba L. A first report of a gene which codes for nearly zero-vicine and zero-convicine contents. In: Huisman J, van der Poel AFB, Liener IE, eds. Recent Advances of Research in
20. Antinutritional Factors in Legume Seeds. Wageningen, The Netherlands: Pudoc; 1989:305-313.
21. Uyoga S, Skorokhod OA, Opiyo M, et al. Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia. Br J Haematol. 2012;157(1):116-124.
22. Kosterin OE. The lost ancestor of the broad bean (Vicia faba L.) and the origin of plant cultivation in the near east. Vavrilov J Genet Breeding. 2015; 18(4/1):831-840.
23. Duc G, Aleksik J, Marget P, et al. Faba bean. In: De Ron A, ed. Grain Legumes. Handbook of Plant Breeding, vol. 10. New York, NY: Springer; 2015:141-178.
24. Beutler E. Red Cell Metabolism – A Manual of Biochemical Methods. New York, NY: Grune & Stratton; 1986.
25. Gallo V, Schwarzer E, Rahlfs S, et al. Inherited glutathione reductase deficiency and Plasmodium falciparum malaria–a case study. PLoS One. 2009;4(10):e7303.
26. Skorokhod A, Schwarzer E, Gremo G, Arese P. HNE produced by the malaria parasite Plasmodium falciparum generates HNE-protein adducts and decreases erythrocyte deformability. Redox Rep. 2007;12(1-2):73-75.