Causal inference on electronic health records to assess blood pressure treatment targets: An application of the parametric g formula

Pacific Symposium on Biocomputing

Volumn 0, Issue , 2018, Pages 180-191

  Johnson, Kipp W ^a   Glicksberg, Benjamin S ^a   Hodos, Rachel A ^a,b   Shameer, Khader ^a   Dudley, Joel T ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Blood pressure; Causal inference; Electronic health records; Parametric g formula; Preventative medicine

Indexed keywords

DISEASES; RECORDS MANAGEMENT;

CARDIOVASCULAR DISEASE; CAUSAL INFERENCES; ELECTRONIC HEALTH; ELECTRONIC HEALTH RECORD; HEALTH RECORDS; PARAMETRIC G FORMULA; PRESSURE TREATMENTS; PREVENTATIVE MEDICINES; RISK FACTORS; SYSTOLIC BLOOD PRESSURE;

BLOOD PRESSURE;

ANTIHYPERTENSIVE AGENT;

ALGORITHM; BIOLOGY; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CAUSALITY; CEREBROVASCULAR DISEASE; COMPLICATION; COMPUTER SIMULATION; DRUG EFFECT; ELECTRONIC HEALTH RECORD; HUMAN; HYPERTENSION; MONTE CARLO METHOD; PATHOPHYSIOLOGY; PROCEDURES; RISK FACTOR; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; SURVIVAL ANALYSIS;

ALGORITHMS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CAUSALITY; CEREBROVASCULAR DISORDERS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ELECTRONIC HEALTH RECORDS; HUMANS; HYPERTENSION; MODELS, STATISTICAL; MONTE CARLO METHOD; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 85047505470     PISSN: 23356928     EISSN: 23356936     Source Type: Journal    
DOI: 10.1142/9789813235533_0017     Document Type: Conference Paper

References (17)

1. Mortality GBD, Causes of Death C. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016;388:1459-1544.
2. Blacher J, Levy BI, Mourad JJ, Safar ME, Bakris G. From epidemiological transition to modern cardiovascular epidemiology: hypertension in the 21st century. Lancet 2016;388:530-2.
3. Livingston G, Sommerlad A, Orgeta V et al. Dementia prevention, intervention, and care. Lancet 2017.
4. Kim MJ, Lim NK, Choi SJ, Park HY. Hypertension is an independent risk factor for type 2 diabetes: the Korean genome and epidemiology study. Hypertens Res 2015;38:783-9.
5. Oparil S, Schmieder RE. New approaches in the treatment of hypertension. Circ Res 2015;116:1074-95.
6. James PA, Oparil S, Carter BL et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507-20.
7. Group SR, Wright JT Jr, Williamson JD, et al. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2015;373:2103-16.
8. Cuspidi C, Sala C, Grassi G, Mancia G. White Coat Hypertension: to Treat or Not to Treat? Curr Hypertens Rep 2016;18:80.
9. Flack JM. Method of Blood Pressure Measurement, Interpretation of SPRINT, and the Atlantic Divide. Curr Hypertens Rep 2017;19:19.
10. Bakris GL. The Implications of Blood Pressure Measurement Methods on Treatment Targets for Blood Pressure. Circulation 2016;134:904-5.
11. Myers MG, Cloutier L, Gelfer M, Padwal RS, Kaczorowski J. Blood Pressure Measurement in the Post-SPRINT Era: A Canadian Perspective. Hypertension 2016;68:e1-3.
12. Keil AP, Edwards JK, Richardson DB, Naimi AI, Cole SR. The parametric g-formula for time-to-event data: intuition and a worked example. Epidemiology 2014;25:889-97.
13. Edwards JK, McGrath LJ, Buckley JP, Schubauer-Berigan MK, Cole SR, Richardson DB. Occupational radon exposure and lung cancer mortality: estimating intervention effects using the parametric g-formula. Epidemiology 2014;25:829-34.
14. Westreich D, Cole SR, Young JG et al. The parametric g-formula to estimate the effect of highly active antiretroviral therapy on incident AIDS or death. Stat Med 2012;31:2000-9.
15. Zhang Y, Young JG, Thamer M, Hernan MA. Comparing the Effectiveness of Dynamic Treatment Strategies Using Electronic Health Records: An Application of the Parametric g-Formula to Anemia Management Strategies. Health Serv Res 2017.
16. Nelson SJ, Zeng K, Kilbourne J, Powell T, Moore R. Normalized names for clinical drugs: RxNorm at 6 years. J Am Med Inform Assoc 2011;18:441-8.
17. Su A Ga Y-S. arm: Data Analysis Using Regression and Multilevel/Hierarchical. Models. R package version 1.9-3, 2016.